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The map label for this gene is uvrC

Identifier: 169824072

GI number: 169824072

Start: 428569

End: 430395

Strand: Direct

Name: uvrC

Synonym: FMG_0375

Alternate gene names: 169824072

Gene position: 428569-430395 (Clockwise)

Preceding gene: 169824071

Following gene: 169824073

Centisome position: 23.84

GC content: 34.54

Gene sequence:

>1827_bases
ATGTTTGATATTAAAAAAGAACTGCAAAAAGTACCTCACAAACCAGGCGTGTACATTATGCACGATAAAAACGATGAGAT
AATCTACGTTGGTAAGGCGATTGATTTGAGAAGACGTGTGGGTCAATATTTCGATTCATCAAAAAAACTCGCAAAGGTCG
CTGCAATGGTAAGCCACGTCGAGTATTTCGAGTATATTATCGTAAATAATGAATGTGAAGCTTTAGTTCTGGAATCAAAC
TTAATCAAGAAAAATAGCCCAAAATACAACATCGTTTTAAGAGACGATAAGCAATATCCATACATTAAAATCACGAACGA
AAAGTTTCCGAGAGTTTTGAAAACTAGACGTGTACTGAAGGATAAGGCAAAGTATTTTGGGCCTTTTCCTAATGCTTATG
CAGTTAATGATATTATAGATTTGATTCACGAAACCTATAAAATCAGGACGTGTAATTTGAATTTTGATAAGGGCCAAAAG
CTTAAGAGACCTTGTTTGAATTATTATATCAATCGTTGTGATGGAATGTGCGTTTACGATGTGAACGAAGAAGATTACAA
CAAAGAATTATTAGAAGTGGAAAATTTCTTGAATGGTCGTGAAGATGAATTGACTAAGAAATTGACCGACAAAATGATGG
CTGCATCTAAGAATTTGAACTTTGAATTGGCAGCGAAACTCAGAGATTCTATCACAAATATTCAAGTGATTTTGGAAAAA
CAAAACATCACCAACACCAAGGGGTTGGATTTGGATATGATATCCATGGCGAGAGAAGCGGAGACTGTATGCGTTCAAGT
ATTTTTCATGAGAAATGGTAAAATCATCGAAAGACAACATTTCATTATCGACAATAAATACGAAGAATCAAACGAACACA
TTGTAGGAGAATTTTTCAAACAATTCTACATTGATTTGACTTACGTTCCGAAACAAATCCTAACTGATATTGAAATCGAA
GACCGTGACCTTATCGAAGAAATGCTGACGGAGAAAAAAGGTTCCAAGGTCGAAATCAAAATTCCTAAACGTGGTAACAA
GACTGACCTCTTGGAAATGGTCAGAGTAAACGCAAAAGAAGGACTGGACAAATACATTTCCAGACATTTGAAAAGAGAAC
GTAATCGTGAAAATGCAATTCTTGATTTACAAGACATCACAGGGGTTAAACCAATTGATAGAATTGAATGCTACGATATT
TCCAACACAAGTGGTGTAGATTCTGTGGGAAGTATGATTGTGTTCAAAAACGGGGCTAAATCTTCTAAAGATTATCGTAA
ATTCAAAATAAAAACTGTAGAAGGTGCAGATGATTACGCATCACACAGGGAAGTATTGACGAGAAGATTCAGAAGACTTT
TGGATTCTGATAAAAAAGACAACAGCTTTGATGAAATGCCATCTATTATTTTGATGGATGGTGGAAAAGGTCAAGTTAAC
ATAGCAAAGGAAGTGCTGAACGAATTTAACTTGGATATTCCGATTCTAGGACTCGTAAAAGATGATAAGCACAGAACGCG
TGGAATAATTTACGAAAACGAAGAAATCAGACTGAAAGTAAATACTCCTTTGTACAGATTGTTGTTCGCAATTCAAGAAG
AAACACACAGGTTTGCAATCAATTATCACAGAAAACTTCACGAAAAAAACTTCAAAAAATCAGAGCTGGACAATATAGCT
TTAATAGGAGAAAAAAGAAAAAAAGCTTTGATGAAACATTTTAAAACGCTTGATAGAATAAAAAAAGCGAGTGTAGAAGA
GCTTTGCGAAGTTGATGGAATGAATGAAAAAGCAGCAGAAAATATAGTGAATTATTTTAAGCAATAA

Upstream 100 bases:

>100_bases
GGTTGAACAATTACAACAAAGAATGCTACGACAAATTATCACCTTATTTGGAAGGATCTGACTTAGAATATCTTGAACAA
CAAACAAAAGCAATATAGAA

Downstream 100 bases:

>100_bases
TTTGCTATATTTTTTATTGTAAAGAAATATTGATTGATGGTAAGATATAAGGTAGTGAACAATGGAGGTTTTATGAACAG
AAATAATTCTACTTTAGTAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MFDIKKELQKVPHKPGVYIMHDKNDEIIYVGKAIDLRRRVGQYFDSSKKLAKVAAMVSHVEYFEYIIVNNECEALVLESN
LIKKNSPKYNIVLRDDKQYPYIKITNEKFPRVLKTRRVLKDKAKYFGPFPNAYAVNDIIDLIHETYKIRTCNLNFDKGQK
LKRPCLNYYINRCDGMCVYDVNEEDYNKELLEVENFLNGREDELTKKLTDKMMAASKNLNFELAAKLRDSITNIQVILEK
QNITNTKGLDLDMISMAREAETVCVQVFFMRNGKIIERQHFIIDNKYEESNEHIVGEFFKQFYIDLTYVPKQILTDIEIE
DRDLIEEMLTEKKGSKVEIKIPKRGNKTDLLEMVRVNAKEGLDKYISRHLKRERNRENAILDLQDITGVKPIDRIECYDI
SNTSGVDSVGSMIVFKNGAKSSKDYRKFKIKTVEGADDYASHREVLTRRFRRLLDSDKKDNSFDEMPSIILMDGGKGQVN
IAKEVLNEFNLDIPILGLVKDDKHRTRGIIYENEEIRLKVNTPLYRLLFAIQEETHRFAINYHRKLHEKNFKKSELDNIA
LIGEKRKKALMKHFKTLDRIKKASVEELCEVDGMNEKAAENIVNYFKQ

Sequences:

>Translated_608_residues
MFDIKKELQKVPHKPGVYIMHDKNDEIIYVGKAIDLRRRVGQYFDSSKKLAKVAAMVSHVEYFEYIIVNNECEALVLESN
LIKKNSPKYNIVLRDDKQYPYIKITNEKFPRVLKTRRVLKDKAKYFGPFPNAYAVNDIIDLIHETYKIRTCNLNFDKGQK
LKRPCLNYYINRCDGMCVYDVNEEDYNKELLEVENFLNGREDELTKKLTDKMMAASKNLNFELAAKLRDSITNIQVILEK
QNITNTKGLDLDMISMAREAETVCVQVFFMRNGKIIERQHFIIDNKYEESNEHIVGEFFKQFYIDLTYVPKQILTDIEIE
DRDLIEEMLTEKKGSKVEIKIPKRGNKTDLLEMVRVNAKEGLDKYISRHLKRERNRENAILDLQDITGVKPIDRIECYDI
SNTSGVDSVGSMIVFKNGAKSSKDYRKFKIKTVEGADDYASHREVLTRRFRRLLDSDKKDNSFDEMPSIILMDGGKGQVN
IAKEVLNEFNLDIPILGLVKDDKHRTRGIIYENEEIRLKVNTPLYRLLFAIQEETHRFAINYHRKLHEKNFKKSELDNIA
LIGEKRKKALMKHFKTLDRIKKASVEELCEVDGMNEKAAENIVNYFKQ
>Mature_608_residues
MFDIKKELQKVPHKPGVYIMHDKNDEIIYVGKAIDLRRRVGQYFDSSKKLAKVAAMVSHVEYFEYIIVNNECEALVLESN
LIKKNSPKYNIVLRDDKQYPYIKITNEKFPRVLKTRRVLKDKAKYFGPFPNAYAVNDIIDLIHETYKIRTCNLNFDKGQK
LKRPCLNYYINRCDGMCVYDVNEEDYNKELLEVENFLNGREDELTKKLTDKMMAASKNLNFELAAKLRDSITNIQVILEK
QNITNTKGLDLDMISMAREAETVCVQVFFMRNGKIIERQHFIIDNKYEESNEHIVGEFFKQFYIDLTYVPKQILTDIEIE
DRDLIEEMLTEKKGSKVEIKIPKRGNKTDLLEMVRVNAKEGLDKYISRHLKRERNRENAILDLQDITGVKPIDRIECYDI
SNTSGVDSVGSMIVFKNGAKSSKDYRKFKIKTVEGADDYASHREVLTRRFRRLLDSDKKDNSFDEMPSIILMDGGKGQVN
IAKEVLNEFNLDIPILGLVKDDKHRTRGIIYENEEIRLKVNTPLYRLLFAIQEETHRFAINYHRKLHEKNFKKSELDNIA
LIGEKRKKALMKHFKTLDRIKKASVEELCEVDGMNEKAAENIVNYFKQ

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=620, Percent_Identity=34.8387096774194, Blast_Score=391, Evalue=1e-110,
Organism=Escherichia coli, GI1788037, Length=189, Percent_Identity=28.042328042328, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_FINM2 (B0S0L4)

Other databases:

- EMBL:   AP008971
- RefSeq:   YP_001691683.1
- ProteinModelPortal:   B0S0L4
- GeneID:   6019252
- GenomeReviews:   AP008971_GR
- KEGG:   fma:FMG_0375
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   CLSK2541961
- BioCyc:   FMAG334413:FMG_0375-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 71186; Mature: 71186

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDIKKELQKVPHKPGVYIMHDKNDEIIYVGKAIDLRRRVGQYFDSSKKLAKVAAMVSHV
CCCHHHHHHHCCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHH
EYFEYIIVNNECEALVLESNLIKKNSPKYNIVLRDDKQYPYIKITNEKFPRVLKTRRVLK
HHHEEEEECCCCCEEEEECCHHCCCCCCEEEEEECCCCCCEEEECCCHHHHHHHHHHHHH
DKAKYFGPFPNAYAVNDIIDLIHETYKIRTCNLNFDKGQKLKRPCLNYYINRCDGMCVYD
HHHHHCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEE
VNEEDYNKELLEVENFLNGREDELTKKLTDKMMAASKNLNFELAAKLRDSITNIQVILEK
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHCCCEEEEEEEE
QNITNTKGLDLDMISMAREAETVCVQVFFMRNGKIIERQHFIIDNKYEESNEHIVGEFFK
CCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCEEEEEEEEECCCCCCCCCHHHHHHHH
QFYIDLTYVPKQILTDIEIEDRDLIEEMLTEKKGSKVEIKIPKRGNKTDLLEMVRVNAKE
HHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHH
GLDKYISRHLKRERNRENAILDLQDITGVKPIDRIECYDISNTSGVDSVGSMIVFKNGAK
HHHHHHHHHHHHHCCCCCCEEEEHHCCCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCC
SSKDYRKFKIKTVEGADDYASHREVLTRRFRRLLDSDKKDNSFDEMPSIILMDGGKGQVN
CCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEECCCCCCH
IAKEVLNEFNLDIPILGLVKDDKHRTRGIIYENEEIRLKVNTPLYRLLFAIQEETHRFAI
HHHHHHHHCCCCCEEEEEEECCCCHHCCEEEECCEEEEEECCHHHHHHHHHHHHHHHHHH
NYHRKLHEKNFKKSELDNIALIGEKRKKALMKHFKTLDRIKKASVEELCEVDGMNEKAAE
HHHHHHHHCCCCHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
NIVNYFKQ
HHHHHHCC
>Mature Secondary Structure
MFDIKKELQKVPHKPGVYIMHDKNDEIIYVGKAIDLRRRVGQYFDSSKKLAKVAAMVSHV
CCCHHHHHHHCCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHH
EYFEYIIVNNECEALVLESNLIKKNSPKYNIVLRDDKQYPYIKITNEKFPRVLKTRRVLK
HHHEEEEECCCCCEEEEECCHHCCCCCCEEEEEECCCCCCEEEECCCHHHHHHHHHHHHH
DKAKYFGPFPNAYAVNDIIDLIHETYKIRTCNLNFDKGQKLKRPCLNYYINRCDGMCVYD
HHHHHCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEE
VNEEDYNKELLEVENFLNGREDELTKKLTDKMMAASKNLNFELAAKLRDSITNIQVILEK
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHCCCEEEEEEEE
QNITNTKGLDLDMISMAREAETVCVQVFFMRNGKIIERQHFIIDNKYEESNEHIVGEFFK
CCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCEEEEEEEEECCCCCCCCCHHHHHHHH
QFYIDLTYVPKQILTDIEIEDRDLIEEMLTEKKGSKVEIKIPKRGNKTDLLEMVRVNAKE
HHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHH
GLDKYISRHLKRERNRENAILDLQDITGVKPIDRIECYDISNTSGVDSVGSMIVFKNGAK
HHHHHHHHHHHHHCCCCCCEEEEHHCCCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCC
SSKDYRKFKIKTVEGADDYASHREVLTRRFRRLLDSDKKDNSFDEMPSIILMDGGKGQVN
CCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEECCCCCCH
IAKEVLNEFNLDIPILGLVKDDKHRTRGIIYENEEIRLKVNTPLYRLLFAIQEETHRFAI
HHHHHHHHCCCCCEEEEEEECCCCHHCCEEEECCEEEEEECCHHHHHHHHHHHHHHHHHH
NYHRKLHEKNFKKSELDNIALIGEKRKKALMKHFKTLDRIKKASVEELCEVDGMNEKAAE
HHHHHHHHCCCCHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
NIVNYFKQ
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA