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The map label for this gene is lytC [H]

Identifier: 169823675

GI number: 169823675

Start: 159064

End: 160704

Strand: Reverse

Name: lytC [H]

Synonym: FMG_P0161

Alternate gene names: 169823675

Gene position: 160704-159064 (Counterclockwise)

Preceding gene: 169823676

Following gene: 169823674

Centisome position: 84.96

GC content: 33.39

Gene sequence:

>1641_bases
GTGAAAAAGAAAAATTTAATGAAGAGAGTTCTTGCTACATCTCTAGCATTGTCAATGTGTATAGCACCGACAATCACAAA
AGCAAGTGTAGAAAAGGTTGAAAGAATTTCTGGAAGAAACAGAATAGAAACATCAGTTAATATTTCTAAAAGTTCTTTTG
AAAGTTCCGATAACGTTGTAATTGCTAATGGTTTTGATTTCCCAGATGCTTTATCATCTGGTCAATTAGCAGCAGCTCTA
AATGCACCTCTGTTATTATCGTCATCTGATAAGCTTGACACAGAGACAAAATCGGAGATAGAAAGGTTAAATCCGAAAAA
TGTCTATATCGTAGGTGGAGAAAAAGCGTTAAATAAGGAAAGAATTGAACCGGAAATAAAGTCAATAACAAAGAACGCAA
AAATTGAAAGACTAGCTGGAAGAGACAGATATGATACTTCGGTCAAAGTCATGGAAAAGACTAAAGAGTTCGTTGATCCT
GAAAATCTACTAATCGTTAGTGGTAATAACTTCCCAGATGCCTTAGCAGCAGCAGGATATATGGCAAGTCATAAGTCTGT
TATGGTCTTAAGTGACGGTGTTAATTATCCAAAATCTGAATTAAATGAGATTGCAATAGGCGGGAAAAACTTGTTGCCAT
TAAATGGTTTCACAGGAGAAAGAATTTCAGGTAAAGATAGATATGAAACAGCTTTAGAAATTGCCAAGAAATCATTTACT
AATAACGATACAGCTATTTTATCAAATGCGAATGTGTTTGCAGATAGCTTATCAGCTGTAAGTCTAACTAAGAAATACAA
TGCACCGATAATACTAACATCTAATAAGAACTTAAATAAATCTTCAAAAGATTATTTAAACGGTTTGAAAAAGATTGTTA
TAGTTGGTGGAAAAGCTTCAGTCGAAGACAATATCTTACAAAACAAAACGATCGAAGAATTAGCAGTAAGACCTTCTAAA
AAAGATACAAAACAACCTCAAAAGAAATTATATAACTTTGAGAAAGCTGTTGTAGAAAGAGTTGTAGACGGAGATATAAT
TGTTGTAAAGAGACAAAATGGTGTTTCTGAAAAAATCAGAATGGTATTAGTTAATACACCGGAAACTAAGCATCCGAAAA
AAGGTGTAGAATACTTTGGTAAAGAGGCAAGTGCTTATACTAAAAAAATGCTACCAGCGGGAAAGACTGTATATTTAGAA
AAGGATGTTTCCGAAAGAGATAGATATTCAAGACTATTAAGATATGTTTGGATAAATGAGCCAACTTCAAAAATAGATAC
AAAAGTATTAACAAACAATTGTTTCAACGCTATGCTTTTGGCTAATGGCTTCGCACAAGTATCAGTATTTCCACCAGATG
TTAAATATGTAAACGAATTTAGACAAATTGAAAAAACAGCAAAAGATAATAATATAGGATTGTGGAAAGGTGGAGTTGTA
GACAATAATACATCCACAAAGGAACCTTCAAATGAGCAAACAAAGCCTGTAGGTAGAGGCGTAATTCGTGGGAATAGAAA
AAGTAAGATTTATCACATGCCGGGTCAAGCGTCCTACGATAAAATAAGCGATAAGAATTTAGTGCTATTCGAAACAGAAC
AAGATGCAATTAATGCGGGTTATAGAAAAGCGAAAAGATAA

Upstream 100 bases:

>100_bases
AAAAATCTTGCTAAAGAAACTAATGTAATTCTAATTGACAGAAGTAAATTAGCGAAGATTTTGTGATAAAATTATATTAA
ATATATTAGAGGAGTTTAGT

Downstream 100 bases:

>100_bases
GATTAAAGGAGCTAGGTTATTACGCCTAGTTCCTTCTTTTTTTTAATTCCCCCGTAAAATCGGGGTTTTCGCTGGCGAAA
AGTGATAAAGCTTGTTCAGT

Product: putative N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MKKKNLMKRVLATSLALSMCIAPTITKASVEKVERISGRNRIETSVNISKSSFESSDNVVIANGFDFPDALSSGQLAAAL
NAPLLLSSSDKLDTETKSEIERLNPKNVYIVGGEKALNKERIEPEIKSITKNAKIERLAGRDRYDTSVKVMEKTKEFVDP
ENLLIVSGNNFPDALAAAGYMASHKSVMVLSDGVNYPKSELNEIAIGGKNLLPLNGFTGERISGKDRYETALEIAKKSFT
NNDTAILSNANVFADSLSAVSLTKKYNAPIILTSNKNLNKSSKDYLNGLKKIVIVGGKASVEDNILQNKTIEELAVRPSK
KDTKQPQKKLYNFEKAVVERVVDGDIIVVKRQNGVSEKIRMVLVNTPETKHPKKGVEYFGKEASAYTKKMLPAGKTVYLE
KDVSERDRYSRLLRYVWINEPTSKIDTKVLTNNCFNAMLLANGFAQVSVFPPDVKYVNEFRQIEKTAKDNNIGLWKGGVV
DNNTSTKEPSNEQTKPVGRGVIRGNRKSKIYHMPGQASYDKISDKNLVLFETEQDAINAGYRKAKR

Sequences:

>Translated_546_residues
MKKKNLMKRVLATSLALSMCIAPTITKASVEKVERISGRNRIETSVNISKSSFESSDNVVIANGFDFPDALSSGQLAAAL
NAPLLLSSSDKLDTETKSEIERLNPKNVYIVGGEKALNKERIEPEIKSITKNAKIERLAGRDRYDTSVKVMEKTKEFVDP
ENLLIVSGNNFPDALAAAGYMASHKSVMVLSDGVNYPKSELNEIAIGGKNLLPLNGFTGERISGKDRYETALEIAKKSFT
NNDTAILSNANVFADSLSAVSLTKKYNAPIILTSNKNLNKSSKDYLNGLKKIVIVGGKASVEDNILQNKTIEELAVRPSK
KDTKQPQKKLYNFEKAVVERVVDGDIIVVKRQNGVSEKIRMVLVNTPETKHPKKGVEYFGKEASAYTKKMLPAGKTVYLE
KDVSERDRYSRLLRYVWINEPTSKIDTKVLTNNCFNAMLLANGFAQVSVFPPDVKYVNEFRQIEKTAKDNNIGLWKGGVV
DNNTSTKEPSNEQTKPVGRGVIRGNRKSKIYHMPGQASYDKISDKNLVLFETEQDAINAGYRKAKR
>Mature_546_residues
MKKKNLMKRVLATSLALSMCIAPTITKASVEKVERISGRNRIETSVNISKSSFESSDNVVIANGFDFPDALSSGQLAAAL
NAPLLLSSSDKLDTETKSEIERLNPKNVYIVGGEKALNKERIEPEIKSITKNAKIERLAGRDRYDTSVKVMEKTKEFVDP
ENLLIVSGNNFPDALAAAGYMASHKSVMVLSDGVNYPKSELNEIAIGGKNLLPLNGFTGERISGKDRYETALEIAKKSFT
NNDTAILSNANVFADSLSAVSLTKKYNAPIILTSNKNLNKSSKDYLNGLKKIVIVGGKASVEDNILQNKTIEELAVRPSK
KDTKQPQKKLYNFEKAVVERVVDGDIIVVKRQNGVSEKIRMVLVNTPETKHPKKGVEYFGKEASAYTKKMLPAGKTVYLE
KDVSERDRYSRLLRYVWINEPTSKIDTKVLTNNCFNAMLLANGFAQVSVFPPDVKYVNEFRQIEKTAKDNNIGLWKGGVV
DNNTSTKEPSNEQTKPVGRGVIRGNRKSKIYHMPGQASYDKISDKNLVLFETEQDAINAGYRKAKR

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 60515; Mature: 60515

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: PS50830 TNASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKNLMKRVLATSLALSMCIAPTITKASVEKVERISGRNRIETSVNISKSSFESSDNVV
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECHHCCCCCCCEE
IANGFDFPDALSSGQLAAALNAPLLLSSSDKLDTETKSEIERLNPKNVYIVGGEKALNKE
EECCCCCCHHCCCCCEEEECCCCEEECCCCCCCCHHHHHHHHCCCCEEEEECCHHHCCHH
RIEPEIKSITKNAKIERLAGRDRYDTSVKVMEKTKEFVDPENLLIVSGNNFPDALAAAGY
HCCHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
MASHKSVMVLSDGVNYPKSELNEIAIGGKNLLPLNGFTGERISGKDRYETALEIAKKSFT
HHCCCEEEEEECCCCCCHHHHHHEEECCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCC
NNDTAILSNANVFADSLSAVSLTKKYNAPIILTSNKNLNKSSKDYLNGLKKIVIVGGKAS
CCCCEEEECCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHCEEEEEECCCCC
VEDNILQNKTIEELAVRPSKKDTKQPQKKLYNFEKAVVERVVDGDIIVVKRQNGVSEKIR
CHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEE
MVLVNTPETKHPKKGVEYFGKEASAYTKKMLPAGKTVYLEKDVSERDRYSRLLRYVWINE
EEEEECCCCCCCHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHEECC
PTSKIDTKVLTNNCFNAMLLANGFAQVSVFPPDVKYVNEFRQIEKTAKDNNIGLWKGGVV
CHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCEE
DNNTSTKEPSNEQTKPVGRGVIRGNRKSKIYHMPGQASYDKISDKNLVLFETEQDAINAG
CCCCCCCCCCCCCCCCCCCHHCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCHHHHHHH
YRKAKR
HHHCCC
>Mature Secondary Structure
MKKKNLMKRVLATSLALSMCIAPTITKASVEKVERISGRNRIETSVNISKSSFESSDNVV
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECHHCCCCCCCEE
IANGFDFPDALSSGQLAAALNAPLLLSSSDKLDTETKSEIERLNPKNVYIVGGEKALNKE
EECCCCCCHHCCCCCEEEECCCCEEECCCCCCCCHHHHHHHHCCCCEEEEECCHHHCCHH
RIEPEIKSITKNAKIERLAGRDRYDTSVKVMEKTKEFVDPENLLIVSGNNFPDALAAAGY
HCCHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
MASHKSVMVLSDGVNYPKSELNEIAIGGKNLLPLNGFTGERISGKDRYETALEIAKKSFT
HHCCCEEEEEECCCCCCHHHHHHEEECCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCC
NNDTAILSNANVFADSLSAVSLTKKYNAPIILTSNKNLNKSSKDYLNGLKKIVIVGGKAS
CCCCEEEECCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHCEEEEEECCCCC
VEDNILQNKTIEELAVRPSKKDTKQPQKKLYNFEKAVVERVVDGDIIVVKRQNGVSEKIR
CHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEE
MVLVNTPETKHPKKGVEYFGKEASAYTKKMLPAGKTVYLEKDVSERDRYSRLLRYVWINE
EEEEECCCCCCCHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHEECC
PTSKIDTKVLTNNCFNAMLLANGFAQVSVFPPDVKYVNEFRQIEKTAKDNNIGLWKGGVV
CHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCEE
DNNTSTKEPSNEQTKPVGRGVIRGNRKSKIYHMPGQASYDKISDKNLVLFETEQDAINAG
CCCCCCCCCCCCCCCCCCCHHCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCHHHHHHH
YRKAKR
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]