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The map label for this gene is cvrA [H]

Identifier: 167626180

GI number: 167626180

Start: 5182810

End: 5184006

Strand: Reverse

Name: cvrA [H]

Synonym: Shal_4275

Alternate gene names: 167626180

Gene position: 5184006-5182810 (Counterclockwise)

Preceding gene: 167626188

Following gene: 167626176

Centisome position: 99.18

GC content: 42.86

Gene sequence:

>1197_bases
ATGACGACTGAAATGATCATGATTGGTATGTCTGTTTTGATCTTAGTCGGAATATTGCTGCATCATCCCTCGCGAACCTT
AGGTATACCGTCACTGCTGATCTTTATGGGTGTCGGGCTTATGTTGGGTAATGGCGAGTTTAACTTTGTCTATGATGATT
TAGATAAGACTGCGTGGATAGGCGGCTTAGCGCTAAACATTATTGTGTTTGTTGGTGGCATCAATACCTCAACAGACAAG
ATAAAAGTGGCTTATAAAGAGGGCGGAATACTTGCTTCTTTTGGAGTGCTATTTACGACGCTGATTTTTGGCGTGATTTT
ATATTGGCTGTTGGATTTTAACTTTATTACCTGCCTACTGTTTGCTGCTATTGTTTCATCGACTGATGCCGCAGCCGTGT
TTTCAATCCTTGAATCTAAAAAGCTTAAGCTAAAAGAGCAAACCGATACCGTATTGGAGTTTGAATCGGCAACTAACGAT
CCCGTTGCCATGCTACTGGTTATATTCTTAACGGATATGGCACTTTCAAGCAGTAAGGCTGTTGTTGCCTCTGAGATAGT
TATGGAGCTAGTAACGCAAATCGGCGTCGCTATGATAGTGGGGTGGGGGATTGCTAAAATAGCCGTCTGGTTACTAAATC
GTATTCATCTATCTGAATTTGGTCTCATTCCTGTATTTGTATTGGCAAGCTTTGTGATTGCGACCTATGGCGCAGAAGTG
TTAGGCGGTAATATTTTATTGGCTTCATATATAGCGGGGGTGGTGATAGGTAACGGCATTAAGCGAGGTCAGCTTGTTAA
TCAGCACTTCTTTAATAGCTTATCTTGGTTAGCGCAGGCATTGATGTTTATCGTGCTGGGCTTACAAATATTCCCACAGT
CATTAGCCACAGTGTTTGTAAGCTCATTATTACCGGCTCTACTATTGATGTTGGTGGCTAGGCCATTAGCTGTGCAGCTT
TGTTACTTGCCTTTTACCAAGGCGAGTTGGAAGAAACGGTTGTTTATCTCCTCTATTGGTCTTAAGGGCGCGACACCTAT
TGTATTCGCATTGATCCCTGCGGCGGCGGGTGTGCCGGGATCTTTAGATATCGTGCATATGGTGTTCTTTATCGTATTGT
TTTCAGTGTTTATTCAGGGGGGAGCTATAGCGCCGCTAGCGAATAAATTGGGTTTAAACAATAGCGACAAAGATTAG

Upstream 100 bases:

>100_bases
TTTATGATCCTAATATCAGTCACTCTTCATCGTAAAATATCCTATATCGATACTCGCTAACTTATATTCATCACACAATT
CACGCAAAAGGTGGCTCTCT

Downstream 100 bases:

>100_bases
GTGGACACAGCTTCCAGTGCGTTTTTAGACTCGATACCTTTCCACACTTTTTCATGGAAGTAGAAAACAACGGTATTCAC
GGCAGGTTCGATTAAGGCTA

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTTEMIMIGMSVLILVGILLHHPSRTLGIPSLLIFMGVGLMLGNGEFNFVYDDLDKTAWIGGLALNIIVFVGGINTSTDK
IKVAYKEGGILASFGVLFTTLIFGVILYWLLDFNFITCLLFAAIVSSTDAAAVFSILESKKLKLKEQTDTVLEFESATND
PVAMLLVIFLTDMALSSSKAVVASEIVMELVTQIGVAMIVGWGIAKIAVWLLNRIHLSEFGLIPVFVLASFVIATYGAEV
LGGNILLASYIAGVVIGNGIKRGQLVNQHFFNSLSWLAQALMFIVLGLQIFPQSLATVFVSSLLPALLLMLVARPLAVQL
CYLPFTKASWKKRLFISSIGLKGATPIVFALIPAAAGVPGSLDIVHMVFFIVLFSVFIQGGAIAPLANKLGLNNSDKD

Sequences:

>Translated_398_residues
MTTEMIMIGMSVLILVGILLHHPSRTLGIPSLLIFMGVGLMLGNGEFNFVYDDLDKTAWIGGLALNIIVFVGGINTSTDK
IKVAYKEGGILASFGVLFTTLIFGVILYWLLDFNFITCLLFAAIVSSTDAAAVFSILESKKLKLKEQTDTVLEFESATND
PVAMLLVIFLTDMALSSSKAVVASEIVMELVTQIGVAMIVGWGIAKIAVWLLNRIHLSEFGLIPVFVLASFVIATYGAEV
LGGNILLASYIAGVVIGNGIKRGQLVNQHFFNSLSWLAQALMFIVLGLQIFPQSLATVFVSSLLPALLLMLVARPLAVQL
CYLPFTKASWKKRLFISSIGLKGATPIVFALIPAAAGVPGSLDIVHMVFFIVLFSVFIQGGAIAPLANKLGLNNSDKD
>Mature_397_residues
TTEMIMIGMSVLILVGILLHHPSRTLGIPSLLIFMGVGLMLGNGEFNFVYDDLDKTAWIGGLALNIIVFVGGINTSTDKI
KVAYKEGGILASFGVLFTTLIFGVILYWLLDFNFITCLLFAAIVSSTDAAAVFSILESKKLKLKEQTDTVLEFESATNDP
VAMLLVIFLTDMALSSSKAVVASEIVMELVTQIGVAMIVGWGIAKIAVWLLNRIHLSEFGLIPVFVLASFVIATYGAEVL
GGNILLASYIAGVVIGNGIKRGQLVNQHFFNSLSWLAQALMFIVLGLQIFPQSLATVFVSSLLPALLLMLVARPLAVQLC
YLPFTKASWKKRLFISSIGLKGATPIVFALIPAAAGVPGSLDIVHMVFFIVLFSVFIQGGAIAPLANKLGLNNSDKD

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=363, Percent_Identity=34.9862258953168, Blast_Score=182, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018421
- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 42735; Mature: 42604

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEMIMIGMSVLILVGILLHHPSRTLGIPSLLIFMGVGLMLGNGEFNFVYDDLDKTAWI
CCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCCCEEEEEECCHHHHHH
GGLALNIIVFVGGINTSTDKIKVAYKEGGILASFGVLFTTLIFGVILYWLLDFNFITCLL
HHHHHHHHHEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAAIVSSTDAAAVFSILESKKLKLKEQTDTVLEFESATNDPVAMLLVIFLTDMALSSSKA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCCH
VVASEIVMELVTQIGVAMIVGWGIAKIAVWLLNRIHLSEFGLIPVFVLASFVIATYGAEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LGGNILLASYIAGVVIGNGIKRGQLVNQHFFNSLSWLAQALMFIVLGLQIFPQSLATVFV
HCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLLPALLLMLVARPLAVQLCYLPFTKASWKKRLFISSIGLKGATPIVFALIPAAAGVPG
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
SLDIVHMVFFIVLFSVFIQGGAIAPLANKLGLNNSDKD
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCC
>Mature Secondary Structure 
TTEMIMIGMSVLILVGILLHHPSRTLGIPSLLIFMGVGLMLGNGEFNFVYDDLDKTAWI
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCCCEEEEEECCHHHHHH
GGLALNIIVFVGGINTSTDKIKVAYKEGGILASFGVLFTTLIFGVILYWLLDFNFITCLL
HHHHHHHHHEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAAIVSSTDAAAVFSILESKKLKLKEQTDTVLEFESATNDPVAMLLVIFLTDMALSSSKA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCCH
VVASEIVMELVTQIGVAMIVGWGIAKIAVWLLNRIHLSEFGLIPVFVLASFVIATYGAEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LGGNILLASYIAGVVIGNGIKRGQLVNQHFFNSLSWLAQALMFIVLGLQIFPQSLATVFV
HCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLLPALLLMLVARPLAVQLCYLPFTKASWKKRLFISSIGLKGATPIVFALIPAAAGVPG
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
SLDIVHMVFFIVLFSVFIQGGAIAPLANKLGLNNSDKD
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA