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The map label for this gene is selB [H]

Identifier: 167622438

GI number: 167622438

Start: 600008

End: 601924

Strand: Direct

Name: selB [H]

Synonym: Shal_0498

Alternate gene names: 167622438

Gene position: 600008-601924 (Clockwise)

Preceding gene: 167622437

Following gene: 167622439

Centisome position: 11.48

GC content: 47.99

Gene sequence:

>1917_bases
ATGATTATCGTCACCTCTGGCCATGTAGATCACGGCAAAACAAGTTTAATTCAAGCACTAACCGGTACAGATGCCGACCG
CTTACCGGAAGAGAAACAGCGTGGCATGACCATAGAATTGGGCTATGCCTTTATGGATTTGGCGGATGATAAACGTCTGG
CCTTTGTCGATGTGCCGGGCCACAGTAAGTTTATCAATACCATGCTCGCAGGAGTGAGCTGCGCCAAGCATGCGCTATTG
ATTATCGCCTGTGATGACGGCGTGATGCCGCAAACCCATGAGCATTTAGCCATCTTACAGCTGCTTAATCTTGAGCACTT
AATCGTGGTGCTGACCAAGCAAGATAAGGTTGACAGCGAACGCGTTGAGATTGTCAAACTTGAGGTGAGTGAACTACTCG
CGCACCATCACAGGCAGAGTGTTATTTATGTGGTGTCAGCGCAGACAGGCTTTGGCATTACTGAGCTTAGCCTTGCCATT
AAACTGCTGGCCGAAGCCCAAACAAAAACGCTGAATCAGTTAAGTGTAGAGTCTAGCTTTCGCATGGCGATCGACCGAGC
CTTTAGCGTTAAAGGTGCAGGCCTTGTCGTCACCGGCACCGTGATTAGTGGGCAGGTGAGTCAGGGGCAAAGTCTATATC
TTTCAGGGCAGCGTAAAGCGGTAAAAGTCAGAAGCCTACATAGCCAAGGTCGTGTCACTGATAAGGCGCATCATTGTCAG
CGCGTGGCGCTTAACTTAACCGGAGTAGACCAACATCGGGGCGCCCAGCGCGGCGATTGGCTAACGGCACTTGAGCCTGC
TGTTGCAGTTATTGAAGCGCCTAAGGTGATTTGCGGTGTGTTCGAATCCAGCTCTTCATTTAAGCACTGGCAAGCTGTGC
AAGTGCACTTAGGTAATAGCCACACCACGGCTCGTCTTGGGTTATTGCAGAGCCTTGCCGACGGCAAAGCCTTGGTGGAA
CTTCAGTGTGAGCAGTCACTTCATTGCGTGGAACAAGACCGAATCATTGTGCGTGATAGTGCGGCTAAGACCACTCTAGG
TGCGCTGCGAGTGTTAGATATTAATCCGCCAAAACGAGGCAAGCGTAGTCCTGAACGTTTGGCTTATATAGAGGCACTAA
AAGAGTGCAGCTCAGTTAAGCGCAGCTTGCAAGTTCAAACACAAGATCACTGCGTGAAGAAGTCTGACTTCATGTGGGCC
AATCAGCTAACGGATCAGGCTCGGCTATTAGCCGATGAACAGCTACTAGAGCTTGATGGCTACCTGCTATCTCACACATT
AAAGCAGCAGATTGAGACTCAGCTATTAACCCTAGTGGAAGACTACCATCAGGCATCTCCAGAACTGCTTGGACTAAGCA
TTAACCGCCTACAGCGCATGACTCATGGAAAATATCCTTTGGCTGTACTGCTCAAGCTTACGGATAGTCTGCGTGAGCAG
CAACTGCTGCAGAGCACCCGCGGCCTGTTGCACCTACCGAGGCACAGCTTAAGCTTATCGGAGCAAGAGCAACAGCAGTG
GCTCAGCATTAAACAGTTGATGTTGGCAGCAAATGGTCCTTTGTGGTCATCTGATCTGGCTAAGGAACTTAACCTTGAGC
TAACTGTTGTGCGGTTACTTTGCCGTAAGTTGATTCAATTAGGTTACTTATCCGCCATTATTAAAGACCGCTTTATGTTA
ACCGAAAGTCTTTATTTTTACGCCGATGTTATCAGACAACAAATTAATGTTTGTGGCGAAATAAAAACCGCCGATTTTAA
TTCGATTATTAAGCTAGGCAGAAAAGCCAGTATTCAACTTTTAGAGTTTTATGACCGCAGTGGATTAACGTGGCGAAAGC
GAAAGGATAATTCGAGGGTCATAAGAGACAGTAGCATCTTTATATCGAGTGATTTGGCGGAAGAACATAGGAGTTGA

Upstream 100 bases:

>100_bases
TTTGGCTCGATCTGCGTGGGAGTGATAACGATGAACAACTGGCTCAGGTATTAGTACAGATAGCCGCCAATATCGCTGCG
CAGTGCTCAGGAGTGAGCCA

Downstream 100 bases:

>100_bases
ACCTACCCGGGACTGCTGGCAGCCCCACCTGGATTTGAAATCCAGACGTTTCACCGGAAACGACGTTCTTCCGTATCACT
TGCGGGAATAATAGATAATT

Product: selenocysteine-specific translation elongation factor

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MIIVTSGHVDHGKTSLIQALTGTDADRLPEEKQRGMTIELGYAFMDLADDKRLAFVDVPGHSKFINTMLAGVSCAKHALL
IIACDDGVMPQTHEHLAILQLLNLEHLIVVLTKQDKVDSERVEIVKLEVSELLAHHHRQSVIYVVSAQTGFGITELSLAI
KLLAEAQTKTLNQLSVESSFRMAIDRAFSVKGAGLVVTGTVISGQVSQGQSLYLSGQRKAVKVRSLHSQGRVTDKAHHCQ
RVALNLTGVDQHRGAQRGDWLTALEPAVAVIEAPKVICGVFESSSSFKHWQAVQVHLGNSHTTARLGLLQSLADGKALVE
LQCEQSLHCVEQDRIIVRDSAAKTTLGALRVLDINPPKRGKRSPERLAYIEALKECSSVKRSLQVQTQDHCVKKSDFMWA
NQLTDQARLLADEQLLELDGYLLSHTLKQQIETQLLTLVEDYHQASPELLGLSINRLQRMTHGKYPLAVLLKLTDSLREQ
QLLQSTRGLLHLPRHSLSLSEQEQQQWLSIKQLMLAANGPLWSSDLAKELNLELTVVRLLCRKLIQLGYLSAIIKDRFML
TESLYFYADVIRQQINVCGEIKTADFNSIIKLGRKASIQLLEFYDRSGLTWRKRKDNSRVIRDSSIFISSDLAEEHRS

Sequences:

>Translated_638_residues
MIIVTSGHVDHGKTSLIQALTGTDADRLPEEKQRGMTIELGYAFMDLADDKRLAFVDVPGHSKFINTMLAGVSCAKHALL
IIACDDGVMPQTHEHLAILQLLNLEHLIVVLTKQDKVDSERVEIVKLEVSELLAHHHRQSVIYVVSAQTGFGITELSLAI
KLLAEAQTKTLNQLSVESSFRMAIDRAFSVKGAGLVVTGTVISGQVSQGQSLYLSGQRKAVKVRSLHSQGRVTDKAHHCQ
RVALNLTGVDQHRGAQRGDWLTALEPAVAVIEAPKVICGVFESSSSFKHWQAVQVHLGNSHTTARLGLLQSLADGKALVE
LQCEQSLHCVEQDRIIVRDSAAKTTLGALRVLDINPPKRGKRSPERLAYIEALKECSSVKRSLQVQTQDHCVKKSDFMWA
NQLTDQARLLADEQLLELDGYLLSHTLKQQIETQLLTLVEDYHQASPELLGLSINRLQRMTHGKYPLAVLLKLTDSLREQ
QLLQSTRGLLHLPRHSLSLSEQEQQQWLSIKQLMLAANGPLWSSDLAKELNLELTVVRLLCRKLIQLGYLSAIIKDRFML
TESLYFYADVIRQQINVCGEIKTADFNSIIKLGRKASIQLLEFYDRSGLTWRKRKDNSRVIRDSSIFISSDLAEEHRS
>Mature_638_residues
MIIVTSGHVDHGKTSLIQALTGTDADRLPEEKQRGMTIELGYAFMDLADDKRLAFVDVPGHSKFINTMLAGVSCAKHALL
IIACDDGVMPQTHEHLAILQLLNLEHLIVVLTKQDKVDSERVEIVKLEVSELLAHHHRQSVIYVVSAQTGFGITELSLAI
KLLAEAQTKTLNQLSVESSFRMAIDRAFSVKGAGLVVTGTVISGQVSQGQSLYLSGQRKAVKVRSLHSQGRVTDKAHHCQ
RVALNLTGVDQHRGAQRGDWLTALEPAVAVIEAPKVICGVFESSSSFKHWQAVQVHLGNSHTTARLGLLQSLADGKALVE
LQCEQSLHCVEQDRIIVRDSAAKTTLGALRVLDINPPKRGKRSPERLAYIEALKECSSVKRSLQVQTQDHCVKKSDFMWA
NQLTDQARLLADEQLLELDGYLLSHTLKQQIETQLLTLVEDYHQASPELLGLSINRLQRMTHGKYPLAVLLKLTDSLREQ
QLLQSTRGLLHLPRHSLSLSEQEQQQWLSIKQLMLAANGPLWSSDLAKELNLELTVVRLLCRKLIQLGYLSAIIKDRFML
TESLYFYADVIRQQINVCGEIKTADFNSIIKLGRKASIQLLEFYDRSGLTWRKRKDNSRVIRDSSIFISSDLAEEHRS

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=242, Percent_Identity=33.8842975206612, Blast_Score=123, Evalue=7e-28,
Organism=Homo sapiens, GI54607086, Length=282, Percent_Identity=26.9503546099291, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI53729339, Length=248, Percent_Identity=28.6290322580645, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI53729337, Length=248, Percent_Identity=28.6290322580645, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI194097354, Length=298, Percent_Identity=24.8322147651007, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI194018520, Length=298, Percent_Identity=24.8322147651007, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI194018522, Length=298, Percent_Identity=24.8322147651007, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI5729864, Length=252, Percent_Identity=24.6031746031746, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI223555963, Length=252, Percent_Identity=24.6031746031746, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI46094014, Length=299, Percent_Identity=24.7491638795987, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI2367247, Length=634, Percent_Identity=40.2208201892744, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1790412, Length=258, Percent_Identity=31.3953488372093, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1789737, Length=258, Percent_Identity=31.3953488372093, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1789559, Length=211, Percent_Identity=31.7535545023697, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1789108, Length=93, Percent_Identity=34.4086021505376, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25141371, Length=283, Percent_Identity=28.2685512367491, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17556456, Length=284, Percent_Identity=29.5774647887324, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17506081, Length=263, Percent_Identity=29.277566539924, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17552884, Length=316, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17569207, Length=316, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115532067, Length=275, Percent_Identity=26.5454545454545, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI115532065, Length=275, Percent_Identity=26.5454545454545, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71994658, Length=119, Percent_Identity=31.9327731092437, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32566629, Length=252, Percent_Identity=21.8253968253968, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324761, Length=242, Percent_Identity=33.0578512396694, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI19921738, Length=245, Percent_Identity=33.8775510204082, Blast_Score=126, Evalue=5e-29,
Organism=Drosophila melanogaster, GI281363316, Length=241, Percent_Identity=31.1203319502075, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17864358, Length=241, Percent_Identity=31.1203319502075, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI19922690, Length=259, Percent_Identity=30.5019305019305, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28572034, Length=162, Percent_Identity=30.2469135802469, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45553807, Length=321, Percent_Identity=25.2336448598131, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45553816, Length=321, Percent_Identity=25.2336448598131, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24651721, Length=321, Percent_Identity=25.2336448598131, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17864154, Length=321, Percent_Identity=25.2336448598131, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24652838, Length=320, Percent_Identity=24.6875, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137572, Length=320, Percent_Identity=24.6875, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 71248; Mature: 71248

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIVTSGHVDHGKTSLIQALTGTDADRLPEEKQRGMTIELGYAFMDLADDKRLAFVDVPG
CEEEECCCCCCCHHHHHHHHHCCCHHCCCHHHHCCCEEEECEEEEECCCCCEEEEEECCC
HSKFINTMLAGVSCAKHALLIIACDDGVMPQTHEHLAILQLLNLEHLIVVLTKQDKVDSE
CHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCC
RVEIVKLEVSELLAHHHRQSVIYVVSAQTGFGITELSLAIKLLAEAQTKTLNQLSVESSF
CEEEEEEEHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMAIDRAFSVKGAGLVVTGTVISGQVSQGQSLYLSGQRKAVKVRSLHSQGRVTDKAHHCQ
HHHHHHHHEECCCCEEEEEEEEECCCCCCCEEEEECCCCEEHHHHHHHCCCCCHHHHHHH
RVALNLTGVDQHRGAQRGDWLTALEPAVAVIEAPKVICGVFESSSSFKHWQAVQVHLGNS
EEEEEECCCHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEEEEECCC
HTTARLGLLQSLADGKALVELQCEQSLHCVEQDRIIVRDSAAKTTLGALRVLDINPPKRG
CCHHHHHHHHHHCCCCEEEEEEHHHHHHHHCCCCEEEECCCCHHHHCEEEEEECCCCCCC
KRSPERLAYIEALKECSSVKRSLQVQTQDHCVKKSDFMWANQLTDQARLLADEQLLELDG
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YLLSHTLKQQIETQLLTLVEDYHQASPELLGLSINRLQRMTHGKYPLAVLLKLTDSLREQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
QLLQSTRGLLHLPRHSLSLSEQEQQQWLSIKQLMLAANGPLWSSDLAKELNLELTVVRLL
HHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHH
CRKLIQLGYLSAIIKDRFMLTESLYFYADVIRQQINVCGEIKTADFNSIIKLGRKASIQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHH
LEFYDRSGLTWRKRKDNSRVIRDSSIFISSDLAEEHRS
HHHHCCCCCEEEECCCCCCEEECCCEEEECCHHHHHCC
>Mature Secondary Structure
MIIVTSGHVDHGKTSLIQALTGTDADRLPEEKQRGMTIELGYAFMDLADDKRLAFVDVPG
CEEEECCCCCCCHHHHHHHHHCCCHHCCCHHHHCCCEEEECEEEEECCCCCEEEEEECCC
HSKFINTMLAGVSCAKHALLIIACDDGVMPQTHEHLAILQLLNLEHLIVVLTKQDKVDSE
CHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCC
RVEIVKLEVSELLAHHHRQSVIYVVSAQTGFGITELSLAIKLLAEAQTKTLNQLSVESSF
CEEEEEEEHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMAIDRAFSVKGAGLVVTGTVISGQVSQGQSLYLSGQRKAVKVRSLHSQGRVTDKAHHCQ
HHHHHHHHEECCCCEEEEEEEEECCCCCCCEEEEECCCCEEHHHHHHHCCCCCHHHHHHH
RVALNLTGVDQHRGAQRGDWLTALEPAVAVIEAPKVICGVFESSSSFKHWQAVQVHLGNS
EEEEEECCCHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEEEEECCC
HTTARLGLLQSLADGKALVELQCEQSLHCVEQDRIIVRDSAAKTTLGALRVLDINPPKRG
CCHHHHHHHHHHCCCCEEEEEEHHHHHHHHCCCCEEEECCCCHHHHCEEEEEECCCCCCC
KRSPERLAYIEALKECSSVKRSLQVQTQDHCVKKSDFMWANQLTDQARLLADEQLLELDG
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YLLSHTLKQQIETQLLTLVEDYHQASPELLGLSINRLQRMTHGKYPLAVLLKLTDSLREQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
QLLQSTRGLLHLPRHSLSLSEQEQQQWLSIKQLMLAANGPLWSSDLAKELNLELTVVRLL
HHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHH
CRKLIQLGYLSAIIKDRFMLTESLYFYADVIRQQINVCGEIKTADFNSIIKLGRKASIQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHH
LEFYDRSGLTWRKRKDNSRVIRDSSIFISSDLAEEHRS
HHHHCCCCCEEEECCCCCCEEECCCEEEECCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2531290; 8041620; 9278503; 2140572 [H]