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The map label for this gene is ykoW [H]

Identifier: 167622255

GI number: 167622255

Start: 372829

End: 374976

Strand: Reverse

Name: ykoW [H]

Synonym: Shal_0314

Alternate gene names: 167622255

Gene position: 374976-372829 (Counterclockwise)

Preceding gene: 167622259

Following gene: 167622252

Centisome position: 7.17

GC content: 46.14

Gene sequence:

>2148_bases
ATGAGTGTGTTAATCTGGTCTAAGTTGTACCCGCGTGTATCTTCTTCTGATCCAGCACTATCTGAACAACTCTCGCTCTG
GCAACATGAATCAGAATCGACAGCTCTAGCTATAATGCAGGGACATCACTTTCTTGCTGCCAGTCCTGCAGCTCTCAGTT
ATTTTGAAAGCCTAGAGCAGAATTTTATTCACGCAACCCCCTTCGACTTCTCTCCCCGCTTGCAATCATCGGGTAGAAAC
AGCGTAGAGTATGGTCTGCAGATGATAAAGAAGGCGGCTAAGGGTGAGGTTGTCTCATTCAATTGGCTGCATATGAGCCA
GCAAGGCAAAGAGCTGCCTACAGTTGTGACCCTTCATCCGGCGCAACTTGACGACAGCCGAGTAATACTGGTTTCGTTCA
GACCTATAGATAGGCGTAAACGTAGTCGGATGAGTATTAGTAATGGCTTTGAAAAACTGCCAAAAGAGCTAATGTCGATA
ACCTTAGAAGACAGCGCCGAAGCCGTTTATATCACTAATGAAGACAATCTAATATTGGCCGTCAATAAGGCGATGTGCCG
GATCTGCGGTTATAGCGCAGAGCACTTGTTAGGTAAAACGCCACAGAACCTTAAGCTCGAATTACAACTAGAAGATCAAG
CCCACGATACTCCCCTAAAAGGCAGAGGAAGCTGGCAAGGGGAAGTCTGGAAATGCCGCTCTGATGGTTCAACCTTCCCA
GCATGGCAAAGCTGCCGCCGGATCTACGCAGATAATACGGTTTTTTTCGTCAACTTATTCAGTGACATTAGTGAGAAAAA
AACGCTTGAAGCCAAACTGACTCAGCAGGCCATGTATGACAAGCTGACGGGTCTACCCAATCGTTTTCATCTGATCCAAA
TCCTCAGTAAAGCGATAAACAATATCAAACGCTCTCCCGAAATGATTGGGGCCTTGATGTTCTTAGATCTCAACGGCTTT
AAGAATGTTAATGACAGCTTTGGCCACTCAACTGGTGATAAAGTCCTGCAGCTTGTTGCGGCTCGTCTCGAAGCGTGCTG
TATCGAAAATGCCGAAATCGCCCGTCTCGGTGGCGATGAGTTCACCTTAGTATTGCCTGAGTGCCATAATAGGCAAGAGA
TAGAAACATTTTCTGAACTGATTTTGTCTCTATTTGAGGCACCATTCGAAATTAACGGCCAGAAATTCTATCTCGGTACC
AGTATCGGGATCTCACTCTTTCCCCAACAAAGTGACGATCCCAATCAGCTGTTAAGCATGGCCGATACCGCTATGTATTC
AGCGAAGAGGAGCCCCAACCATGTTCGTTTTTATAACGCGACTATTCGTGAGGCCGCCGAGAAGAAACTGCACACCTTAA
ATGACCTACGCCATGCCCAAGGGCTTGGACAGTTTAGCTTGGCCTATCAAAGTATTGTCGATTTAGAGTCTAATGACATC
GTAGCGGTTGAAGCGTTATTACGCTGGACTCAAAGCCATGGCGAGATCATTGAAGCACAAGACTTCATTCCACTGCTCGA
AGAGGCTGGCCTGATGGTCAATGTTGGCCAATGGGCATTAGAGCAAGCCTGCACGCAGATGCTGAAGTGGCATCAAGAGT
TCGACTCCAGCCTTAAGATCAGCGTCAACATTTCAAGATCACAGCTCGAACACCCAGACTTTATTCCTATGCTTAAAGGA
CTACTCACACGAACTCAGCTCCCCGCTAACGCATTAATTATTGAGATCACCGAACGTACTTTTATACGTCGGCCTAAATT
AATGACAAAAGTCTTAGTTCAGCTAAAAGAGATGAATGTCGCTATCGCAATAGATGACTTTGGTGCAGAGTTATCCTCTC
TAGCTCGACTCAGTAGCTTGCCTATCGATAGCCTAAAAATTGATGCAGGCTTTGCCCAACGCGTAGACAACAAGCAAGGT
CAAAAGCTCTGCAAAGCAATTATGCAGTTAGCGCAAACTCTAGAGATTGATTTTGTTGTCGAGGGAGTCGAGACTCAAGC
TCAAAGAGACCTGTTATTAAGCTTAGGAAAGGGTATGGGCCAGGGTTATTTCTTCGATAGACCCGTGATAGCCGAGAGCT
TTACCCTTGAGCTACTTAGTCCAATTTATGCTACACCGCAGACCCGTTATCGGGTGTTAGGAAGGTAG

Upstream 100 bases:

>100_bases
TTTGACGCTAAACCGACTAAGCTATATCAAAACAATTATTTTAATCGCTGAAGTAAGAGTCATTTACGTATAAAAATGTC
ATGCCAAAAGGGAAGAGTGT

Downstream 100 bases:

>100_bases
CTACGCCAGCACTCTGAATAAGTTATTCAGTGTCGCCCCCTGCAAAAGCTGTTGCCGGCGTAGCCCCCATCATCACCATA
AGATGATGGACTCATTAAAC

Product: PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 715; Mature: 714

Protein sequence:

>715_residues
MSVLIWSKLYPRVSSSDPALSEQLSLWQHESESTALAIMQGHHFLAASPAALSYFESLEQNFIHATPFDFSPRLQSSGRN
SVEYGLQMIKKAAKGEVVSFNWLHMSQQGKELPTVVTLHPAQLDDSRVILVSFRPIDRRKRSRMSISNGFEKLPKELMSI
TLEDSAEAVYITNEDNLILAVNKAMCRICGYSAEHLLGKTPQNLKLELQLEDQAHDTPLKGRGSWQGEVWKCRSDGSTFP
AWQSCRRIYADNTVFFVNLFSDISEKKTLEAKLTQQAMYDKLTGLPNRFHLIQILSKAINNIKRSPEMIGALMFLDLNGF
KNVNDSFGHSTGDKVLQLVAARLEACCIENAEIARLGGDEFTLVLPECHNRQEIETFSELILSLFEAPFEINGQKFYLGT
SIGISLFPQQSDDPNQLLSMADTAMYSAKRSPNHVRFYNATIREAAEKKLHTLNDLRHAQGLGQFSLAYQSIVDLESNDI
VAVEALLRWTQSHGEIIEAQDFIPLLEEAGLMVNVGQWALEQACTQMLKWHQEFDSSLKISVNISRSQLEHPDFIPMLKG
LLTRTQLPANALIIEITERTFIRRPKLMTKVLVQLKEMNVAIAIDDFGAELSSLARLSSLPIDSLKIDAGFAQRVDNKQG
QKLCKAIMQLAQTLEIDFVVEGVETQAQRDLLLSLGKGMGQGYFFDRPVIAESFTLELLSPIYATPQTRYRVLGR

Sequences:

>Translated_715_residues
MSVLIWSKLYPRVSSSDPALSEQLSLWQHESESTALAIMQGHHFLAASPAALSYFESLEQNFIHATPFDFSPRLQSSGRN
SVEYGLQMIKKAAKGEVVSFNWLHMSQQGKELPTVVTLHPAQLDDSRVILVSFRPIDRRKRSRMSISNGFEKLPKELMSI
TLEDSAEAVYITNEDNLILAVNKAMCRICGYSAEHLLGKTPQNLKLELQLEDQAHDTPLKGRGSWQGEVWKCRSDGSTFP
AWQSCRRIYADNTVFFVNLFSDISEKKTLEAKLTQQAMYDKLTGLPNRFHLIQILSKAINNIKRSPEMIGALMFLDLNGF
KNVNDSFGHSTGDKVLQLVAARLEACCIENAEIARLGGDEFTLVLPECHNRQEIETFSELILSLFEAPFEINGQKFYLGT
SIGISLFPQQSDDPNQLLSMADTAMYSAKRSPNHVRFYNATIREAAEKKLHTLNDLRHAQGLGQFSLAYQSIVDLESNDI
VAVEALLRWTQSHGEIIEAQDFIPLLEEAGLMVNVGQWALEQACTQMLKWHQEFDSSLKISVNISRSQLEHPDFIPMLKG
LLTRTQLPANALIIEITERTFIRRPKLMTKVLVQLKEMNVAIAIDDFGAELSSLARLSSLPIDSLKIDAGFAQRVDNKQG
QKLCKAIMQLAQTLEIDFVVEGVETQAQRDLLLSLGKGMGQGYFFDRPVIAESFTLELLSPIYATPQTRYRVLGR
>Mature_714_residues
SVLIWSKLYPRVSSSDPALSEQLSLWQHESESTALAIMQGHHFLAASPAALSYFESLEQNFIHATPFDFSPRLQSSGRNS
VEYGLQMIKKAAKGEVVSFNWLHMSQQGKELPTVVTLHPAQLDDSRVILVSFRPIDRRKRSRMSISNGFEKLPKELMSIT
LEDSAEAVYITNEDNLILAVNKAMCRICGYSAEHLLGKTPQNLKLELQLEDQAHDTPLKGRGSWQGEVWKCRSDGSTFPA
WQSCRRIYADNTVFFVNLFSDISEKKTLEAKLTQQAMYDKLTGLPNRFHLIQILSKAINNIKRSPEMIGALMFLDLNGFK
NVNDSFGHSTGDKVLQLVAARLEACCIENAEIARLGGDEFTLVLPECHNRQEIETFSELILSLFEAPFEINGQKFYLGTS
IGISLFPQQSDDPNQLLSMADTAMYSAKRSPNHVRFYNATIREAAEKKLHTLNDLRHAQGLGQFSLAYQSIVDLESNDIV
AVEALLRWTQSHGEIIEAQDFIPLLEEAGLMVNVGQWALEQACTQMLKWHQEFDSSLKISVNISRSQLEHPDFIPMLKGL
LTRTQLPANALIIEITERTFIRRPKLMTKVLVQLKEMNVAIAIDDFGAELSSLARLSSLPIDSLKIDAGFAQRVDNKQGQ
KLCKAIMQLAQTLEIDFVVEGVETQAQRDLLLSLGKGMGQGYFFDRPVIAESFTLELLSPIYATPQTRYRVLGR

Specific function: Probable signaling protein whose physiological role is not yet known [H]

COG id: COG5001

COG function: function code T; Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=446, Percent_Identity=31.8385650224215, Blast_Score=226, Evalue=5e-60,
Organism=Escherichia coli, GI226510982, Length=424, Percent_Identity=30.6603773584906, Blast_Score=189, Evalue=6e-49,
Organism=Escherichia coli, GI87081921, Length=451, Percent_Identity=29.9334811529933, Blast_Score=185, Evalue=7e-48,
Organism=Escherichia coli, GI1787055, Length=389, Percent_Identity=27.2493573264781, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI87081845, Length=261, Percent_Identity=32.9501915708812, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI87081743, Length=226, Percent_Identity=31.4159292035398, Blast_Score=114, Evalue=3e-26,
Organism=Escherichia coli, GI1790496, Length=232, Percent_Identity=28.8793103448276, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI1788502, Length=247, Percent_Identity=31.9838056680162, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1788381, Length=285, Percent_Identity=28.7719298245614, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1786507, Length=236, Percent_Identity=28.3898305084746, Blast_Score=103, Evalue=5e-23,
Organism=Escherichia coli, GI1788849, Length=442, Percent_Identity=25.1131221719457, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI87081980, Length=237, Percent_Identity=31.2236286919831, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788956, Length=160, Percent_Identity=35, Blast_Score=96, Evalue=9e-21,
Organism=Escherichia coli, GI87082096, Length=426, Percent_Identity=25.8215962441315, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87081977, Length=176, Percent_Identity=31.8181818181818, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI87081881, Length=201, Percent_Identity=30.8457711442786, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI145693134, Length=166, Percent_Identity=33.7349397590361, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1787802, Length=203, Percent_Identity=27.0935960591133, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI87082007, Length=171, Percent_Identity=29.8245614035088, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1786584, Length=185, Percent_Identity=27.5675675675676, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1787816, Length=161, Percent_Identity=27.9503105590062, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787262, Length=189, Percent_Identity=24.8677248677249, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR005330
- InterPro:   IPR000014 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF03707 MHYT [H]

EC number: NA

Molecular weight: Translated: 80406; Mature: 80275

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS50112 PAS ; PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLIWSKLYPRVSSSDPALSEQLSLWQHESESTALAIMQGHHFLAASPAALSYFESLEQ
CCEEEEHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCEEEECCHHHHHHHHHHHH
NFIHATPFDFSPRLQSSGRNSVEYGLQMIKKAAKGEVVSFNWLHMSQQGKELPTVVTLHP
CCEECCCCCCCCCHHCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCEEEEEEC
AQLDDSRVILVSFRPIDRRKRSRMSISNGFEKLPKELMSITLEDSAEAVYITNEDNLILA
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCEEEE
VNKAMCRICGYSAEHLLGKTPQNLKLELQLEDQAHDTPLKGRGSWQGEVWKCRSDGSTFP
ECHHHHHHHCCCHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCH
AWQSCRRIYADNTVFFVNLFSDISEKKTLEAKLTQQAMYDKLTGLPNRFHLIQILSKAIN
HHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
NIKRSPEMIGALMFLDLNGFKNVNDSFGHSTGDKVLQLVAARLEACCIENAEIARLGGDE
HHHCCHHHHHEEHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCE
FTLVLPECHNRQEIETFSELILSLFEAPFEINGQKFYLGTSIGISLFPQQSDDPNQLLSM
EEEECCCCCCCHHHHHHHHHHHHHHCCCCEECCCEEEEEEECCEEECCCCCCCHHHHHHH
ADTAMYSAKRSPNHVRFYNATIREAAEKKLHTLNDLRHAQGLGQFSLAYQSIVDLESNDI
HHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCC
VAVEALLRWTQSHGEIIEAQDFIPLLEEAGLMVNVGQWALEQACTQMLKWHQEFDSSLKI
HHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHCCCCEEE
SVNISRSQLEHPDFIPMLKGLLTRTQLPANALIIEITERTFIRRPKLMTKVLVQLKEMNV
EEEECHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEECHHHHHCHHHHHHHHHHHHHCCE
AIAIDDFGAELSSLARLSSLPIDSLKIDAGFAQRVDNKQGQKLCKAIMQLAQTLEIDFVV
EEEEECCCHHHHHHHHHHCCCCCCEEECCHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEE
EGVETQAQRDLLLSLGKGMGQGYFFDRPVIAESFTLELLSPIYATPQTRYRVLGR
ECHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure 
SVLIWSKLYPRVSSSDPALSEQLSLWQHESESTALAIMQGHHFLAASPAALSYFESLEQ
CEEEEHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCEEEECCHHHHHHHHHHHH
NFIHATPFDFSPRLQSSGRNSVEYGLQMIKKAAKGEVVSFNWLHMSQQGKELPTVVTLHP
CCEECCCCCCCCCHHCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCEEEEEEC
AQLDDSRVILVSFRPIDRRKRSRMSISNGFEKLPKELMSITLEDSAEAVYITNEDNLILA
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCEEEE
VNKAMCRICGYSAEHLLGKTPQNLKLELQLEDQAHDTPLKGRGSWQGEVWKCRSDGSTFP
ECHHHHHHHCCCHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCH
AWQSCRRIYADNTVFFVNLFSDISEKKTLEAKLTQQAMYDKLTGLPNRFHLIQILSKAIN
HHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
NIKRSPEMIGALMFLDLNGFKNVNDSFGHSTGDKVLQLVAARLEACCIENAEIARLGGDE
HHHCCHHHHHEEHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCE
FTLVLPECHNRQEIETFSELILSLFEAPFEINGQKFYLGTSIGISLFPQQSDDPNQLLSM
EEEECCCCCCCHHHHHHHHHHHHHHCCCCEECCCEEEEEEECCEEECCCCCCCHHHHHHH
ADTAMYSAKRSPNHVRFYNATIREAAEKKLHTLNDLRHAQGLGQFSLAYQSIVDLESNDI
HHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCC
VAVEALLRWTQSHGEIIEAQDFIPLLEEAGLMVNVGQWALEQACTQMLKWHQEFDSSLKI
HHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHCCCCEEE
SVNISRSQLEHPDFIPMLKGLLTRTQLPANALIIEITERTFIRRPKLMTKVLVQLKEMNV
EEEECHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEECHHHHHCHHHHHHHHHHHHHCCE
AIAIDDFGAELSSLARLSSLPIDSLKIDAGFAQRVDNKQGQKLCKAIMQLAQTLEIDFVV
EEEEECCCHHHHHHHHHHCCCCCCEEECCHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEE
EGVETQAQRDLLLSLGKGMGQGYFFDRPVIAESFTLELLSPIYATPQTRYRVLGR
ECHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 11728710 [H]