Click here to switch to the map view.

The map label for this gene is mtr [H]

Identifier: 167622213

GI number: 167622213

Start: 327024

End: 328280

Strand: Direct

Name: mtr [H]

Synonym: Shal_0272

Alternate gene names: 167622213

Gene position: 327024-328280 (Clockwise)

Preceding gene: 167622212

Following gene: 167622215

Centisome position: 6.26

GC content: 49.09

Gene sequence:

>1257_bases
ATGGCTAATCATATGAATGCCGCGGGTCATGAGACCAGCGGCAAGTCTCTGCTGGGCGGAGCAATGATCATCGCGGGCAC
GGCTGTCGGCGCGGGTATGTTTTCTTTGCCTGTCGTTGGTGCTGGTATGTGGTTCGGTTACTCGCTATTGATGATGGCGG
GTGTGTGGTTTTGCATGTTGGTTTCAGGCCTGTTGCTGCTCGAAACCAATCTACATTTTAAGCCTGGCGACAGTTTCGAT
ACTCTGACTCGTACCACCTTAGGTAACTTTTGGCGGATAGTAAACGGCCTGTCTATCGCATTTGTACTCTACATTCTTGC
CTATGCTTATATCAGTGGCGGTGGATCGATTGTTAACTATAACTTAGCGTCTGCGGGGATCGAATTACCTCAGGGGATCG
CCGGTCTTATTTTCGCCCTTGGTCTGGCCTTTATCGTATTTATTAGCACCAAGGCGGTCGATAGGATCACCACCATCATG
CTCGGTGGCATGCTTATCACCTTCTTCCTCGCCGTGGGTAATCTGTTACTCGATGTCGAGTCGGTGAAGCTGTTTAGCCC
TGATGGTGAGAACAAGTATCTGCCCTATATGTTGGCTGCACTGCCTTTTGGCCTAGTGAGTTTTGGCTACCATGGTAATG
TACCCAGCCTAGTTAAATATTACGGTAAAGATCACCGCACCATCATCAAAGCCATAGTGATCGGTACTGGTATCGCACTG
GTTATCTATATCTGCTGGCTTGTTGCAACCATGGGAAATATCTCTAGAACGGATTTCATTGGCATCATAGAGCAGGGCGG
TAACATGGGCGTGCTAGTGAATGCCTTGTCCGGCGTGATGACTAGTGATTGGCTAACGACCATGCTAACCCTGTTTGCCA
ACCTTGCCGTAGCGTCATCTTTCTTAGGGGTCACCTTAGGTCTGTTTGATTATCTGGCGGATCTATTTGGCTTTGATGAG
TCACGTTCTGGCCGATTTAAGACCGCAGCGGTGACCTTTCTACCTCCAACAGTGTTGGGTCTTTTGTTTCCGGATGGCTT
TCTCGTCGCTATCGGTTTTGCTGCTCTGGCTGCCACCATTTGGGCAGCAATTGTACCTGCTATGATGGCCTATAAAGTCA
GGGTTATGTATCCAGATAGCGCTAGCTATAAAGTGCCTGGTGGCAACGCGGTGATTGTTATCGTGATCCTATTTGGCGTT
ATTACTGCAGCATGTCACCTGTTGGCGATGGCAGGTATGTTGCCGCTATACGGTTAA

Upstream 100 bases:

>100_bases
GTAGCGATATCAAACGTATTAAAGAAAGAGCGAACTTGTTGTTACGTTCATCAGTGAAGCAGACCATTGTCGATAGTGTT
CACGCGGAGCACATCGCTTA

Downstream 100 bases:

>100_bases
ACGTTACCTGCGAGTCAATCAAAAAAAGCCTCTTTAAAGAGGCTTTTTGTTTTCTAGCTTGAGTTGACTTAAATACTGAG
TCGGCGTTTGGCGGCGAAAA

Product: aromatic amino acid transporter

Products: Indole [Cytoplasm]; L-tryptophan [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Tryptophan permease [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MANHMNAAGHETSGKSLLGGAMIIAGTAVGAGMFSLPVVGAGMWFGYSLLMMAGVWFCMLVSGLLLLETNLHFKPGDSFD
TLTRTTLGNFWRIVNGLSIAFVLYILAYAYISGGGSIVNYNLASAGIELPQGIAGLIFALGLAFIVFISTKAVDRITTIM
LGGMLITFFLAVGNLLLDVESVKLFSPDGENKYLPYMLAALPFGLVSFGYHGNVPSLVKYYGKDHRTIIKAIVIGTGIAL
VIYICWLVATMGNISRTDFIGIIEQGGNMGVLVNALSGVMTSDWLTTMLTLFANLAVASSFLGVTLGLFDYLADLFGFDE
SRSGRFKTAAVTFLPPTVLGLLFPDGFLVAIGFAALAATIWAAIVPAMMAYKVRVMYPDSASYKVPGGNAVIVIVILFGV
ITAACHLLAMAGMLPLYG

Sequences:

>Translated_418_residues
MANHMNAAGHETSGKSLLGGAMIIAGTAVGAGMFSLPVVGAGMWFGYSLLMMAGVWFCMLVSGLLLLETNLHFKPGDSFD
TLTRTTLGNFWRIVNGLSIAFVLYILAYAYISGGGSIVNYNLASAGIELPQGIAGLIFALGLAFIVFISTKAVDRITTIM
LGGMLITFFLAVGNLLLDVESVKLFSPDGENKYLPYMLAALPFGLVSFGYHGNVPSLVKYYGKDHRTIIKAIVIGTGIAL
VIYICWLVATMGNISRTDFIGIIEQGGNMGVLVNALSGVMTSDWLTTMLTLFANLAVASSFLGVTLGLFDYLADLFGFDE
SRSGRFKTAAVTFLPPTVLGLLFPDGFLVAIGFAALAATIWAAIVPAMMAYKVRVMYPDSASYKVPGGNAVIVIVILFGV
ITAACHLLAMAGMLPLYG
>Mature_417_residues
ANHMNAAGHETSGKSLLGGAMIIAGTAVGAGMFSLPVVGAGMWFGYSLLMMAGVWFCMLVSGLLLLETNLHFKPGDSFDT
LTRTTLGNFWRIVNGLSIAFVLYILAYAYISGGGSIVNYNLASAGIELPQGIAGLIFALGLAFIVFISTKAVDRITTIML
GGMLITFFLAVGNLLLDVESVKLFSPDGENKYLPYMLAALPFGLVSFGYHGNVPSLVKYYGKDHRTIIKAIVIGTGIALV
IYICWLVATMGNISRTDFIGIIEQGGNMGVLVNALSGVMTSDWLTTMLTLFANLAVASSFLGVTLGLFDYLADLFGFDES
RSGRFKTAAVTFLPPTVLGLLFPDGFLVAIGFAALAATIWAAIVPAMMAYKVRVMYPDSASYKVPGGNAVIVIVILFGVI
TAACHLLAMAGMLPLYG

Specific function: Involved in transporting tryptophan across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789552, Length=386, Percent_Identity=57.7720207253886, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1790145, Length=413, Percent_Identity=46.0048426150121, Blast_Score=343, Evalue=1e-95,
Organism=Escherichia coli, GI1788218, Length=402, Percent_Identity=36.0696517412935, Blast_Score=239, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44257; Mature: 44126

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00059 ADH_ZINC ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANHMNAAGHETSGKSLLGGAMIIAGTAVGAGMFSLPVVGAGMWFGYSLLMMAGVWFCML
CCCCCCCCCCCCCCCHHHCCHHHEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSGLLLLETNLHFKPGDSFDTLTRTTLGNFWRIVNGLSIAFVLYILAYAYISGGGSIVNY
HHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
NLASAGIELPQGIAGLIFALGLAFIVFISTKAVDRITTIMLGGMLITFFLAVGNLLLDVE
EHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHH
SVKLFSPDGENKYLPYMLAALPFGLVSFGYHGNVPSLVKYYGKDHRTIIKAIVIGTGIAL
HEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
VIYICWLVATMGNISRTDFIGIIEQGGNMGVLVNALSGVMTSDWLTTMLTLFANLAVASS
HHHHHHHHHHHCCCCHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGVTLGLFDYLADLFGFDESRSGRFKTAAVTFLPPTVLGLLFPDGFLVAIGFAALAATI
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHH
WAAIVPAMMAYKVRVMYPDSASYKVPGGNAVIVIVILFGVITAACHLLAMAGMLPLYG
HHHHHHHHHHHEEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ANHMNAAGHETSGKSLLGGAMIIAGTAVGAGMFSLPVVGAGMWFGYSLLMMAGVWFCML
CCCCCCCCCCCCCCHHHCCHHHEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSGLLLLETNLHFKPGDSFDTLTRTTLGNFWRIVNGLSIAFVLYILAYAYISGGGSIVNY
HHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
NLASAGIELPQGIAGLIFALGLAFIVFISTKAVDRITTIMLGGMLITFFLAVGNLLLDVE
EHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHH
SVKLFSPDGENKYLPYMLAALPFGLVSFGYHGNVPSLVKYYGKDHRTIIKAIVIGTGIAL
HEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
VIYICWLVATMGNISRTDFIGIIEQGGNMGVLVNALSGVMTSDWLTTMLTLFANLAVASS
HHHHHHHHHHHCCCCHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGVTLGLFDYLADLFGFDESRSGRFKTAAVTFLPPTVLGLLFPDGFLVAIGFAALAATI
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHH
WAAIVPAMMAYKVRVMYPDSASYKVPGGNAVIVIVILFGVITAACHLLAMAGMLPLYG
HHHHHHHHHHHEEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Indole [Periplasm]; L-tryptophan [Periplasm]; Proton [Periplasm] [C]

Specific reaction: Proton [Periplasm] + indole [Periplasm] = Proton [Cytoplasm] + indole [Cytoplasm] L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1987112; 2061290; 9278503; 1904443; 7814318 [H]