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The map label for this gene is atoC [H]

Identifier: 167622091

GI number: 167622091

Start: 168374

End: 169744

Strand: Direct

Name: atoC [H]

Synonym: Shal_0150

Alternate gene names: 167622091

Gene position: 168374-169744 (Clockwise)

Preceding gene: 167622084

Following gene: 167622092

Centisome position: 3.22

GC content: 48.58

Gene sequence:

>1371_bases
ATGAATAATATGAAGCCACTTCCTTCTGCTGTATCTGTATTGATCGTCGATGATGAACCGGGCATGCGCAGCTTTCTAAA
GAAAGCGTTAGCGAAGAAATTTGCCTTAGTTGAAACCGCTTCGAGTGTTGAAGATGCGGAGCAACTGCGTTCACGCTGCC
ATTTTGATCTGCTAATTGTCGATATTCGTCTGCCTGGACGCTCGGGGATCGAGTGGCATGAGGCGCTTAACGATCAAGAG
AGACGCTCTGATATTATCTTTATGACCGGCTATGCCGATATGGATGTGGCGATAAAGGCATTACGTGCTGGCGCATCTGA
TTTCATTATGAAGCCGTTCCACCTTGAACAGATGATGAAGGCCGTTGACCGCTGTATCGAACGCCGCTTACTCAAGCGTG
AGAACTTGATGCTGCGCAGAGAAGTGTCTTTCAATCAGTCTTCGACCATTATTGGTCAAAGCGATGCGATGACAGAAGTG
AAGCATGTTATCGAACGTGTGGCGCCGACCAATGCAGTGGTCTTGATCGAGGGTGAATCAGGCACTGGTAAAGAGTTGGT
GGCCAGACAGCTGCATATTCTCAGTGGCCGCCAAGGTCCATTTGTCCCGGTTAACTGTGGCGCTATTGCCCCTGAACTGT
TAGAGAGTGAGCTATTTGGGCACTCTGCAGGCGCTTTTACTGGTGCGAAAGGTAACAGAGAAGGCTTATTTAGCTTTGCC
TCTGGCGGGACTATCTTCCTCGACGAAATTGGTGAAATGCCGCTTAAGATGCAAACGGCATTATTGCGTGTGCTCGAGCA
GCGTACTATTCGCCCTGTCGGCAGTGAGAAAGAGATTAACATCGATGTGCGCGTATTAGCGGCAACCAATCGTAAGCTTT
CAGAAGAAGTGGAAGCGGGTAACTTCAGACGTGACTTGTATTATCGCCTCAACGTGCTCGATATCGTGATCCCGCCTCTG
CGTGAGCGCCCAGAAGATATTGTAGAGCTAACTCATCACTTTACCTGCCAGTTAGCTGCCGAATTGGGTGTAAAAGAGGT
GGTTTGGAGTCATGAAGATCTATTAAAGCTGCAACAACACGAATGGCCAGGTAATATTCGTGAGCTGCGAAATATGATTG
AACGCTGTATCCTACTGGGAAAACCACCTGCCGAGTATTGGAAAGCACAACCTAAGGCTGAAACGTTGGGCGAATCGGGT
TACCCACTGCAATGGGCGCTTAAAGATGTTGAGCGTGACCATGTGACTCGCGTTGTTGACGTGCATGGTGGTAATAAATC
TGCGGCGGCAAGGGATCTAGGAGTATCACGTAAAACCCTAGATCGTAAGTATAAAGAGTGGTTTGGCGGCGAAGCCGACA
AAGAAGAATAA

Upstream 100 bases:

>100_bases
CGATTACATGGTTCATAGTGACCTATTGGGACTGGTTCGATGATAGACTCGGTTCATAATGAGTCAAAATGTCCCTCCAT
AAGACAGGGTGGGACAGAGA

Downstream 100 bases:

>100_bases
TAAAGAGATCGCTCTAGGAGGAGTATCGGTGTCGTTTTTTTCCAATATGTTTGGTGTGAGTTGGCAGCAGATGCAGGCGA
AGGTGCGTTATCGTATCTTG

Product: Fis family two component sigma54 specific transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MNNMKPLPSAVSVLIVDDEPGMRSFLKKALAKKFALVETASSVEDAEQLRSRCHFDLLIVDIRLPGRSGIEWHEALNDQE
RRSDIIFMTGYADMDVAIKALRAGASDFIMKPFHLEQMMKAVDRCIERRLLKRENLMLRREVSFNQSSTIIGQSDAMTEV
KHVIERVAPTNAVVLIEGESGTGKELVARQLHILSGRQGPFVPVNCGAIAPELLESELFGHSAGAFTGAKGNREGLFSFA
SGGTIFLDEIGEMPLKMQTALLRVLEQRTIRPVGSEKEINIDVRVLAATNRKLSEEVEAGNFRRDLYYRLNVLDIVIPPL
RERPEDIVELTHHFTCQLAAELGVKEVVWSHEDLLKLQQHEWPGNIRELRNMIERCILLGKPPAEYWKAQPKAETLGESG
YPLQWALKDVERDHVTRVVDVHGGNKSAAARDLGVSRKTLDRKYKEWFGGEADKEE

Sequences:

>Translated_456_residues
MNNMKPLPSAVSVLIVDDEPGMRSFLKKALAKKFALVETASSVEDAEQLRSRCHFDLLIVDIRLPGRSGIEWHEALNDQE
RRSDIIFMTGYADMDVAIKALRAGASDFIMKPFHLEQMMKAVDRCIERRLLKRENLMLRREVSFNQSSTIIGQSDAMTEV
KHVIERVAPTNAVVLIEGESGTGKELVARQLHILSGRQGPFVPVNCGAIAPELLESELFGHSAGAFTGAKGNREGLFSFA
SGGTIFLDEIGEMPLKMQTALLRVLEQRTIRPVGSEKEINIDVRVLAATNRKLSEEVEAGNFRRDLYYRLNVLDIVIPPL
RERPEDIVELTHHFTCQLAAELGVKEVVWSHEDLLKLQQHEWPGNIRELRNMIERCILLGKPPAEYWKAQPKAETLGESG
YPLQWALKDVERDHVTRVVDVHGGNKSAAARDLGVSRKTLDRKYKEWFGGEADKEE
>Mature_456_residues
MNNMKPLPSAVSVLIVDDEPGMRSFLKKALAKKFALVETASSVEDAEQLRSRCHFDLLIVDIRLPGRSGIEWHEALNDQE
RRSDIIFMTGYADMDVAIKALRAGASDFIMKPFHLEQMMKAVDRCIERRLLKRENLMLRREVSFNQSSTIIGQSDAMTEV
KHVIERVAPTNAVVLIEGESGTGKELVARQLHILSGRQGPFVPVNCGAIAPELLESELFGHSAGAFTGAKGNREGLFSFA
SGGTIFLDEIGEMPLKMQTALLRVLEQRTIRPVGSEKEINIDVRVLAATNRKLSEEVEAGNFRRDLYYRLNVLDIVIPPL
RERPEDIVELTHHFTCQLAAELGVKEVVWSHEDLLKLQQHEWPGNIRELRNMIERCILLGKPPAEYWKAQPKAETLGESG
YPLQWALKDVERDHVTRVVDVHGGNKSAAARDLGVSRKTLDRKYKEWFGGEADKEE

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=456, Percent_Identity=39.6929824561403, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1790437, Length=438, Percent_Identity=39.7260273972603, Blast_Score=285, Evalue=6e-78,
Organism=Escherichia coli, GI1790299, Length=465, Percent_Identity=38.9247311827957, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1788905, Length=427, Percent_Identity=36.2997658079625, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=40.7523510971787, Blast_Score=234, Evalue=8e-63,
Organism=Escherichia coli, GI1786524, Length=322, Percent_Identity=43.167701863354, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1789087, Length=332, Percent_Identity=44.578313253012, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI87082117, Length=253, Percent_Identity=49.0118577075099, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI87082152, Length=237, Percent_Identity=48.9451476793249, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI87081872, Length=231, Percent_Identity=43.2900432900433, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1787583, Length=318, Percent_Identity=37.4213836477987, Blast_Score=191, Evalue=8e-50,
Organism=Escherichia coli, GI1789828, Length=223, Percent_Identity=39.0134529147982, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI87081858, Length=294, Percent_Identity=30.6122448979592, Blast_Score=123, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51323; Mature: 51323

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNMKPLPSAVSVLIVDDEPGMRSFLKKALAKKFALVETASSVEDAEQLRSRCHFDLLIV
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
DIRLPGRSGIEWHEALNDQERRSDIIFMTGYADMDVAIKALRAGASDFIMKPFHLEQMMK
EEECCCCCCCCHHHHCCCHHHCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCHHHHHHHH
AVDRCIERRLLKRENLMLRREVSFNQSSTIIGQSDAMTEVKHVIERVAPTNAVVLIEGES
HHHHHHHHHHHHHHCHHEEEECCCCCCCEEECCCHHHHHHHHHHHHHCCCCEEEEEECCC
GTGKELVARQLHILSGRQGPFVPVNCGAIAPELLESELFGHSAGAFTGAKGNREGLFSFA
CCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEC
SGGTIFLDEIGEMPLKMQTALLRVLEQRTIRPVGSEKEINIDVRVLAATNRKLSEEVEAG
CCCEEEEEHHCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCHHHHHHHCC
NFRRDLYYRLNVLDIVIPPLRERPEDIVELTHHFTCQLAAELGVKEVVWSHEDLLKLQQH
CCHHHHHHEEEHHEEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHC
EWPGNIRELRNMIERCILLGKPPAEYWKAQPKAETLGESGYPLQWALKDVERDHVTRVVD
CCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHEEEEE
VHGGNKSAAARDLGVSRKTLDRKYKEWFGGEADKEE
ECCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNNMKPLPSAVSVLIVDDEPGMRSFLKKALAKKFALVETASSVEDAEQLRSRCHFDLLIV
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
DIRLPGRSGIEWHEALNDQERRSDIIFMTGYADMDVAIKALRAGASDFIMKPFHLEQMMK
EEECCCCCCCCHHHHCCCHHHCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCHHHHHHHH
AVDRCIERRLLKRENLMLRREVSFNQSSTIIGQSDAMTEVKHVIERVAPTNAVVLIEGES
HHHHHHHHHHHHHHCHHEEEECCCCCCCEEECCCHHHHHHHHHHHHHCCCCEEEEEECCC
GTGKELVARQLHILSGRQGPFVPVNCGAIAPELLESELFGHSAGAFTGAKGNREGLFSFA
CCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEC
SGGTIFLDEIGEMPLKMQTALLRVLEQRTIRPVGSEKEINIDVRVLAATNRKLSEEVEAG
CCCEEEEEHHCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCHHHHHHHCC
NFRRDLYYRLNVLDIVIPPLRERPEDIVELTHHFTCQLAAELGVKEVVWSHEDLLKLQQH
CCHHHHHHEEEHHEEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHC
EWPGNIRELRNMIERCILLGKPPAEYWKAQPKAETLGESGYPLQWALKDVERDHVTRVVD
CCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHEEEEE
VHGGNKSAAARDLGVSRKTLDRKYKEWFGGEADKEE
ECCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]