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The map label for this gene is cusR [H]

Identifier: 167622073

GI number: 167622073

Start: 146245

End: 146922

Strand: Direct

Name: cusR [H]

Synonym: Shal_0132

Alternate gene names: 167622073

Gene position: 146245-146922 (Clockwise)

Preceding gene: 167622072

Following gene: 167622074

Centisome position: 2.8

GC content: 46.31

Gene sequence:

>678_bases
ATGAAAATACTCATGGTTGAAGATGATGCGACTACCATCGAATATGTCGTAAAGGGATTTGTTGAGCAAGGGCACAATAT
AGAAACGGCAACAGACGGTCATCAAGGCTTATTGCTGGCTACCAGCATGAAGTACGACTTGATCATTTTGGATCGTATGT
TGCCACAGCTAGACGGGCTAAAACTGTTAGCGGCGCTACGCGCCACGGGTAGTCAAACACCAGTATTGATCTTGTCTGCA
CTCAGTCACGTTGACGAGCGAGTCAAAGGTTTGCGTGCTGGTGGCGATGACTATATGACAAAGCCTTTCGCTTTCTCTGA
ATTGTTGGTTCGCGCCGAAAAGTTAATGCAACGTGGTGAATCGCTGCCCACTATTACCGACTTGAATGTCGGTCCGCTCA
CTATTGAACTGCTGACACGTAAAGTGACCTTAGATGGGCAAGAGATCTTGCTGCAGCCGAAAGAGTTCCAGTTACTTAAG
TACCTGATGGAACATGTGAATCAAGTTATCAGTCGCACGCTACTGTTTGAAGCTGTGTGGGATTATCATTTCGATCCGCG
TACTAATGTTATCGATGTGCATATCGCTAAGCTAAGACGTAAGTTTGAAGAGCTAGGCCATGGCGAATTAATCGAAACGG
TTCGAGGTGCTGGATATCGGTTACGCCAAGGGCATTAA

Upstream 100 bases:

>100_bases
CTATATAGAATTAGAAATACTTGATATTGATGGTAAACGTCAGTTAGCCTTCGATATTGAAAATAAACAATTATTACCAC
TGCTCAAATGGAACTAAAAC

Downstream 100 bases:

>100_bases
GCCCTATCAGAGTAGTGCTTGGCGCATTACCATCATATTTTCAGCCCTAGTAACCGTCATTATTGGCACCTTGTTACTGG
GGATGTATCGTCAGCTGATC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKILMVEDDATTIEYVVKGFVEQGHNIETATDGHQGLLLATSMKYDLIILDRMLPQLDGLKLLAALRATGSQTPVLILSA
LSHVDERVKGLRAGGDDYMTKPFAFSELLVRAEKLMQRGESLPTITDLNVGPLTIELLTRKVTLDGQEILLQPKEFQLLK
YLMEHVNQVISRTLLFEAVWDYHFDPRTNVIDVHIAKLRRKFEELGHGELIETVRGAGYRLRQGH

Sequences:

>Translated_225_residues
MKILMVEDDATTIEYVVKGFVEQGHNIETATDGHQGLLLATSMKYDLIILDRMLPQLDGLKLLAALRATGSQTPVLILSA
LSHVDERVKGLRAGGDDYMTKPFAFSELLVRAEKLMQRGESLPTITDLNVGPLTIELLTRKVTLDGQEILLQPKEFQLLK
YLMEHVNQVISRTLLFEAVWDYHFDPRTNVIDVHIAKLRRKFEELGHGELIETVRGAGYRLRQGH
>Mature_225_residues
MKILMVEDDATTIEYVVKGFVEQGHNIETATDGHQGLLLATSMKYDLIILDRMLPQLDGLKLLAALRATGSQTPVLILSA
LSHVDERVKGLRAGGDDYMTKPFAFSELLVRAEKLMQRGESLPTITDLNVGPLTIELLTRKVTLDGQEILLQPKEFQLLK
YLMEHVNQVISRTLLFEAVWDYHFDPRTNVIDVHIAKLRRKFEELGHGELIETVRGAGYRLRQGH

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=44.3438914027149, Blast_Score=193, Evalue=7e-51,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=42.4657534246575, Blast_Score=175, Evalue=3e-45,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=38.4615384615385, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=36.8888888888889, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=32.8828828828829, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=29.6803652968037, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=32, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=34.5132743362832, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=31.390134529148, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=31.2217194570136, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=31.0810810810811, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=28.9473684210526, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=29.004329004329, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=29.2576419213974, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=31.0344827586207, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1790437, Length=138, Percent_Identity=30.4347826086957, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1788713, Length=133, Percent_Identity=30.0751879699248, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=37.6237623762376, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788191, Length=119, Percent_Identity=29.4117647058824, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25430; Mature: 25430

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILMVEDDATTIEYVVKGFVEQGHNIETATDGHQGLLLATSMKYDLIILDRMLPQLDGL
CEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCHHCHH
KLLAALRATGSQTPVLILSALSHVDERVKGLRAGGDDYMTKPFAFSELLVRAEKLMQRGE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
SLPTITDLNVGPLTIELLTRKVTLDGQEILLQPKEFQLLKYLMEHVNQVISRTLLFEAVW
CCCCEECCCCCCEEHEEHHHHHCCCCHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYHFDPRTNVIDVHIAKLRRKFEELGHGELIETVRGAGYRLRQGH
HCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKILMVEDDATTIEYVVKGFVEQGHNIETATDGHQGLLLATSMKYDLIILDRMLPQLDGL
CEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCHHCHH
KLLAALRATGSQTPVLILSALSHVDERVKGLRAGGDDYMTKPFAFSELLVRAEKLMQRGE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
SLPTITDLNVGPLTIELLTRKVTLDGQEILLQPKEFQLLKYLMEHVNQVISRTLLFEAVW
CCCCEECCCCCCEEHEEHHHHHCCCCHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYHFDPRTNVIDVHIAKLRRKFEELGHGELIETVRGAGYRLRQGH
HCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]