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The map label for this gene is moaB [H]

Identifier: 167622064

GI number: 167622064

Start: 140829

End: 141353

Strand: Direct

Name: moaB [H]

Synonym: Shal_0123

Alternate gene names: 167622064

Gene position: 140829-141353 (Clockwise)

Preceding gene: 167622063

Following gene: 167622065

Centisome position: 2.69

GC content: 46.29

Gene sequence:

>525_bases
ATGGGACACTGCACTCAAAGCCAGTTTTCGGCGCTAAACATTGCTGTTTTAACCTTATCTGACACCCGCGATTTTGATTC
GGATACATCGGGTGCTTTTCTTGAGAGCGCATTGCTTGAGGCTGGGCATAAGCTTGCCGAACGTCAGATTATCAAAGATG
ATAAATACCAGATCCGTTCGGTACTATCCCAATGGATCGCCTCCGATGATGTGCAGGTGATCATTACCACTGGCGGAACA
GGTTTTACCGATAGGGACAATACCCCTGAAGCGGTTAAGCCATTGTTCGATAGAGATATCGAAGGCTTTGGAGAGCTTTT
CCGTCATATCACTTATACCGAGCTTGGTACTTCGACGGTGCAGTCGCGTGCCTTAGGTGGTATCGCCAATAAAACCGCTA
TCTTCTGTCTTCCAGGCTCCACAGGTGCTTGCAAGACTGGCTGGAATAAGCTGATTAAAGAACAACTTGATGCAACACAT
CGTCCTTGTAACTTTGTGATGCATGTAAAAAAAATCACCGAATAG

Upstream 100 bases:

>100_bases
GCTTCTATCGGCGGCTAATTAAACTCTGATCTGACGCAACTTAGTTGCGTCAGAAGCTAGGTATAATTATCGCTATGACT
CGAATAAATAAGAGACCATA

Downstream 100 bases:

>100_bases
GTCTCATCGAGACAAGTTTTACGGTGCTGTTTTTAGGTACCTTGACCCAAATTTATTAGAAGGCGTAAACCCAATGACCC
ATGCTTTTACCCATATTAAT

Product: molybdenum cofactor biosynthesis protein B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MGHCTQSQFSALNIAVLTLSDTRDFDSDTSGAFLESALLEAGHKLAERQIIKDDKYQIRSVLSQWIASDDVQVIITTGGT
GFTDRDNTPEAVKPLFDRDIEGFGELFRHITYTELGTSTVQSRALGGIANKTAIFCLPGSTGACKTGWNKLIKEQLDATH
RPCNFVMHVKKITE

Sequences:

>Translated_174_residues
MGHCTQSQFSALNIAVLTLSDTRDFDSDTSGAFLESALLEAGHKLAERQIIKDDKYQIRSVLSQWIASDDVQVIITTGGT
GFTDRDNTPEAVKPLFDRDIEGFGELFRHITYTELGTSTVQSRALGGIANKTAIFCLPGSTGACKTGWNKLIKEQLDATH
RPCNFVMHVKKITE
>Mature_173_residues
GHCTQSQFSALNIAVLTLSDTRDFDSDTSGAFLESALLEAGHKLAERQIIKDDKYQIRSVLSQWIASDDVQVIITTGGTG
FTDRDNTPEAVKPLFDRDIEGFGELFRHITYTELGTSTVQSRALGGIANKTAIFCLPGSTGACKTGWNKLIKEQLDATHR
PCNFVMHVKKITE

Specific function: Maybe involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity [H]

COG id: COG0521

COG function: function code H; Molybdopterin biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=136, Percent_Identity=35.2941176470588, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI66932975, Length=136, Percent_Identity=35.2941176470588, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI1787000, Length=165, Percent_Identity=54.5454545454545, Blast_Score=204, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17564954, Length=147, Percent_Identity=34.6938775510204, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17136978, Length=143, Percent_Identity=37.7622377622378, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24638841, Length=143, Percent_Identity=37.7622377622378, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR012245
- InterPro:   IPR013484
- InterPro:   IPR008284
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 19125; Mature: 18994

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS01078 MOCF_BIOSYNTHESIS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHCTQSQFSALNIAVLTLSDTRDFDSDTSGAFLESALLEAGHKLAERQIIKDDKYQIRS
CCCCCCHHHCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VLSQWIASDDVQVIITTGGTGFTDRDNTPEAVKPLFDRDIEGFGELFRHITYTELGTSTV
HHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
QSRALGGIANKTAIFCLPGSTGACKTGWNKLIKEQLDATHRPCNFVMHVKKITE
HHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
GHCTQSQFSALNIAVLTLSDTRDFDSDTSGAFLESALLEAGHKLAERQIIKDDKYQIRS
CCCCCHHHCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VLSQWIASDDVQVIITTGGTGFTDRDNTPEAVKPLFDRDIEGFGELFRHITYTELGTSTV
HHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
QSRALGGIANKTAIFCLPGSTGACKTGWNKLIKEQLDATHRPCNFVMHVKKITE
HHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin precursor biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]