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The map label for this gene is moaA [H]

Identifier: 167622063

GI number: 167622063

Start: 139766

End: 140746

Strand: Direct

Name: moaA [H]

Synonym: Shal_0122

Alternate gene names: 167622063

Gene position: 139766-140746 (Clockwise)

Preceding gene: 167622061

Following gene: 167622064

Centisome position: 2.67

GC content: 48.83

Gene sequence:

>981_bases
ATGTCCCAACTACAAGACAATTTTGGTCGACGGTTTCATTACCTGCGTATGTCAGTCACTGACGTATGTAACTTTAAGTG
TACGTATTGCCTCCCCGATGGCTACCGCCCTGACGGTAAGCCCAAGTTTCTCGATCTCAATGAAATCGAGCACCTCGTTT
CGGCATTCTCGCAAGTCGGCACCCAAAAAATCCGCATCACAGGTGGTGAGCCCTCCCTACGTAAAGACTTCACCGATATT
ATTCGTATCGTTAATGACAACGATAAGATTAAAACCATTGCCACCACGACCAACGGTTACCGTTTAGCTAAGCATGCCCA
AGAGTGGTATGACGCTGGGCTTAGACGTATCAACATCTCGGTCGATAGCTTAGATCCAAAGATGTTTTACCAGATCACTG
GTGAGAATAAATTTGATGAGGTGATGCGTGGCGTGGATGCGGCGCTAGAAGCAGGCTTCGAGCGCGTTAAAATCAATGCC
GTGCTGCTAAAAGGCCTCAACGATAAAGATCTGCCACGTTTTCTGCACTGGATTAAAAACACCCCCATTGATTTACGCTT
TATTGAGCTGATGGAAACGGGTTTAGGCCATGATTATTTCAAGGCGCACCATCTAGCGGGTAACGACATCAAGTCGCAGC
TAGAACAGGCGGGATGGCAATTCGATACGCCTGCGGCTGATGATGGTCCAGCGCAAAACTTCAGTCATCAAGACTACCAA
GGTCGCATCGGGCTTATCATGCCTTACGCGAAGAATTTCTGTGCCAGTTGTAATCGCCTACGTGTGTCGGCAAATGGAAA
GCTTCATCTTTGCCTGTTCACCGAAAATGGCGTTGACCTGCGCGATCTACTGCAAACGAGCGATCAGCAAGCGGAGTTAG
TTGAACGCTTGCATGGCCAGCTCGCGCAGAAGAAGCAAACGCACTTCTTACACGATGGCATTACAGGTGTTACGCAGCAC
CTCGCTTCTATCGGCGGCTAA

Upstream 100 bases:

>100_bases
TACCCTACGTCGAGACAGATACGGGTTTTTAGCCGTGGCAATAACGCCACCGGGGTGAGAAAAGAAATGATCTCACCTCC
CCTTACTTGGAAAGGTGATC

Downstream 100 bases:

>100_bases
TTAAACTCTGATCTGACGCAACTTAGTTGCGTCAGAAGCTAGGTATAATTATCGCTATGACTCGAATAAATAAGAGACCA
TAATGGGACACTGCACTCAA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MSQLQDNFGRRFHYLRMSVTDVCNFKCTYCLPDGYRPDGKPKFLDLNEIEHLVSAFSQVGTQKIRITGGEPSLRKDFTDI
IRIVNDNDKIKTIATTTNGYRLAKHAQEWYDAGLRRINISVDSLDPKMFYQITGENKFDEVMRGVDAALEAGFERVKINA
VLLKGLNDKDLPRFLHWIKNTPIDLRFIELMETGLGHDYFKAHHLAGNDIKSQLEQAGWQFDTPAADDGPAQNFSHQDYQ
GRIGLIMPYAKNFCASCNRLRVSANGKLHLCLFTENGVDLRDLLQTSDQQAELVERLHGQLAQKKQTHFLHDGITGVTQH
LASIGG

Sequences:

>Translated_326_residues
MSQLQDNFGRRFHYLRMSVTDVCNFKCTYCLPDGYRPDGKPKFLDLNEIEHLVSAFSQVGTQKIRITGGEPSLRKDFTDI
IRIVNDNDKIKTIATTTNGYRLAKHAQEWYDAGLRRINISVDSLDPKMFYQITGENKFDEVMRGVDAALEAGFERVKINA
VLLKGLNDKDLPRFLHWIKNTPIDLRFIELMETGLGHDYFKAHHLAGNDIKSQLEQAGWQFDTPAADDGPAQNFSHQDYQ
GRIGLIMPYAKNFCASCNRLRVSANGKLHLCLFTENGVDLRDLLQTSDQQAELVERLHGQLAQKKQTHFLHDGITGVTQH
LASIGG
>Mature_325_residues
SQLQDNFGRRFHYLRMSVTDVCNFKCTYCLPDGYRPDGKPKFLDLNEIEHLVSAFSQVGTQKIRITGGEPSLRKDFTDII
RIVNDNDKIKTIATTTNGYRLAKHAQEWYDAGLRRINISVDSLDPKMFYQITGENKFDEVMRGVDAALEAGFERVKINAV
LLKGLNDKDLPRFLHWIKNTPIDLRFIELMETGLGHDYFKAHHLAGNDIKSQLEQAGWQFDTPAADDGPAQNFSHQDYQG
RIGLIMPYAKNFCASCNRLRVSANGKLHLCLFTENGVDLRDLLQTSDQQAELVERLHGQLAQKKQTHFLHDGITGVTQHL
ASIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=307, Percent_Identity=36.1563517915309, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI22027536, Length=307, Percent_Identity=36.1563517915309, Blast_Score=207, Evalue=7e-54,
Organism=Escherichia coli, GI1786999, Length=327, Percent_Identity=58.4097859327217, Blast_Score=410, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17561210, Length=326, Percent_Identity=34.9693251533742, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI32566329, Length=326, Percent_Identity=34.3558282208589, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI32566331, Length=307, Percent_Identity=35.1791530944625, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI28574488, Length=322, Percent_Identity=33.5403726708075, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI28574490, Length=312, Percent_Identity=33.974358974359, Blast_Score=189, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36954; Mature: 36823

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLQDNFGRRFHYLRMSVTDVCNFKCTYCLPDGYRPDGKPKFLDLNEIEHLVSAFSQVG
CCCHHHHHHHHEEHHEEEHHHHHCCEEEEECCCCCCCCCCCCEECHHHHHHHHHHHHHCC
TQKIRITGGEPSLRKDFTDIIRIVNDNDKIKTIATTTNGYRLAKHAQEWYDAGLRRINIS
CEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
VDSLDPKMFYQITGENKFDEVMRGVDAALEAGFERVKINAVLLKGLNDKDLPRFLHWIKN
EECCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHEEEEEEEEECCCCCCHHHHHHHHHC
TPIDLRFIELMETGLGHDYFKAHHLAGNDIKSQLEQAGWQFDTPAADDGPAQNFSHQDYQ
CCCCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
GRIGLIMPYAKNFCASCNRLRVSANGKLHLCLFTENGVDLRDLLQTSDQQAELVERLHGQ
CCEEEEEHHHHHHHCCCCEEEEECCCEEEEEEEECCCCCHHHHHHCCCHHHHHHHHHHHH
LAQKKQTHFLHDGITGVTQHLASIGG
HHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SQLQDNFGRRFHYLRMSVTDVCNFKCTYCLPDGYRPDGKPKFLDLNEIEHLVSAFSQVG
CCHHHHHHHHEEHHEEEHHHHHCCEEEEECCCCCCCCCCCCEECHHHHHHHHHHHHHCC
TQKIRITGGEPSLRKDFTDIIRIVNDNDKIKTIATTTNGYRLAKHAQEWYDAGLRRINIS
CEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
VDSLDPKMFYQITGENKFDEVMRGVDAALEAGFERVKINAVLLKGLNDKDLPRFLHWIKN
EECCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHEEEEEEEEECCCCCCHHHHHHHHHC
TPIDLRFIELMETGLGHDYFKAHHLAGNDIKSQLEQAGWQFDTPAADDGPAQNFSHQDYQ
CCCCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
GRIGLIMPYAKNFCASCNRLRVSANGKLHLCLFTENGVDLRDLLQTSDQQAELVERLHGQ
CCEEEEEHHHHHHHCCCCEEEEECCCEEEEEEEECCCCCHHHHHHCCCHHHHHHHHHHHH
LAQKKQTHFLHDGITGVTQHLASIGG
HHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA