Click here to switch to the map view.

The map label for this gene is hemN [H]

Identifier: 167040705

GI number: 167040705

Start: 2093144

End: 2094271

Strand: Reverse

Name: hemN [H]

Synonym: Teth514_2082

Alternate gene names: 167040705

Gene position: 2094271-2093144 (Counterclockwise)

Preceding gene: 167040706

Following gene: 167040704

Centisome position: 85.23

GC content: 30.94

Gene sequence:

>1128_bases
ATGAGGGAGATAGGATTATACATTCACATTCCTTTTTGTAAAAGAAAATGCTATTATTGTGATTTTAATTCTTATGCAGG
CTATGATTATCTTTTTGACGACTATATTCGGGCACTACTTATGGAAATAGAATCAAATTCTACAAAAGATTATAATGTGG
TTTCGGTTTATATAGGAGGAGGTACCCCTAACCTTTTGCCTCCTTCTTATATAGAGAAGATATTGAAATCTGTATTTAAA
AATTATAAAATACTTGATGGTTGCGAAATTACTATTGAAATGAATCCCGGCCTTATAACTGAAGAAAAACTAAAAATTTA
TAAAGACAACGGGATAAACCGAGTAAGTATTGGACTTCAAGCTTTTCAAAATAGGCTTTTAAAATATATAGGTAGAATTC
ATACAGTAGAAGAATTTTTTGGAAATTATGAGTTAGTGAAAAAGTTCTTTGACAATATAAATATAGACCTTATGTATGCT
CTTCCTACTCAAACCTTTAAAGAGTGGCAAGAAACTTTAAAAGAAGTAGTAAAATTACAGCCGACGCATGTTTCTACTTA
TAGCTTGATTTTAGAACCTAACACCTCCTTTTACAGACTTTATGAAAAGGGTCAGTTGCCTATAGTTGATGAGGAAGAAG
AGCTTAAAATGTATCATTGGGGTATAGAGTTTTTAAAAGAAAAAGGCTATCACCATTACGAAATATCTAATTTTGCATTG
CCCACATTTGAATGTCGCCACAATATTTTATACTGGGAATGCAAAAATTATTTGGGATTTGGTGCAGGAGCCCATTCTTA
TATGGCGGATGTGAGATATAGTAATATTGAAAATATAAAAGACTATATTAAGAGCATTTTAGAAAGAAAAAGTGCAGTTA
AGGAAAAGATAAAGTTGACAAAACAAGATAGAATGGCTGAGTTTATGTTTTTAGGAATGAGAATGACAAAAGGAGTGTGT
GACAAGGATTTTAAGAAAAGATTTGGTATCAGTTTGTTTGAAATTTACAAAAAAGTAATACAAAAATACTTAAAAGAAGG
TCTAATTGAGATTGATAATGAGTGTGTAAAACTTACCGAGAGGGGTATTGATGTCTCTAACGTCATTTTTGAAGAATTTC
TGCCCTAA

Upstream 100 bases:

>100_bases
TGGAGAAGCAAAAAGAAGGCAAAAAGCGCATGAGACAGGTGGGAAGTGTCGAAATACCTCAAGAGGCTTTTATGTCAATA
TTGAAGCTAGATGATGAAAA

Downstream 100 bases:

>100_bases
ATGAGTATTGACAAAAAATTATAAGAGTGGTATTTTAAAAACATGAATTAGCACTCAATCGAGTAGAGTGCTAATAATAC
ATGGGGTGGTGAAAATGCCG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MREIGLYIHIPFCKRKCYYCDFNSYAGYDYLFDDYIRALLMEIESNSTKDYNVVSVYIGGGTPNLLPPSYIEKILKSVFK
NYKILDGCEITIEMNPGLITEEKLKIYKDNGINRVSIGLQAFQNRLLKYIGRIHTVEEFFGNYELVKKFFDNINIDLMYA
LPTQTFKEWQETLKEVVKLQPTHVSTYSLILEPNTSFYRLYEKGQLPIVDEEEELKMYHWGIEFLKEKGYHHYEISNFAL
PTFECRHNILYWECKNYLGFGAGAHSYMADVRYSNIENIKDYIKSILERKSAVKEKIKLTKQDRMAEFMFLGMRMTKGVC
DKDFKKRFGISLFEIYKKVIQKYLKEGLIEIDNECVKLTERGIDVSNVIFEEFLP

Sequences:

>Translated_375_residues
MREIGLYIHIPFCKRKCYYCDFNSYAGYDYLFDDYIRALLMEIESNSTKDYNVVSVYIGGGTPNLLPPSYIEKILKSVFK
NYKILDGCEITIEMNPGLITEEKLKIYKDNGINRVSIGLQAFQNRLLKYIGRIHTVEEFFGNYELVKKFFDNINIDLMYA
LPTQTFKEWQETLKEVVKLQPTHVSTYSLILEPNTSFYRLYEKGQLPIVDEEEELKMYHWGIEFLKEKGYHHYEISNFAL
PTFECRHNILYWECKNYLGFGAGAHSYMADVRYSNIENIKDYIKSILERKSAVKEKIKLTKQDRMAEFMFLGMRMTKGVC
DKDFKKRFGISLFEIYKKVIQKYLKEGLIEIDNECVKLTERGIDVSNVIFEEFLP
>Mature_375_residues
MREIGLYIHIPFCKRKCYYCDFNSYAGYDYLFDDYIRALLMEIESNSTKDYNVVSVYIGGGTPNLLPPSYIEKILKSVFK
NYKILDGCEITIEMNPGLITEEKLKIYKDNGINRVSIGLQAFQNRLLKYIGRIHTVEEFFGNYELVKKFFDNINIDLMYA
LPTQTFKEWQETLKEVVKLQPTHVSTYSLILEPNTSFYRLYEKGQLPIVDEEEELKMYHWGIEFLKEKGYHHYEISNFAL
PTFECRHNILYWECKNYLGFGAGAHSYMADVRYSNIENIKDYIKSILERKSAVKEKIKLTKQDRMAEFMFLGMRMTKGVC
DKDFKKRFGISLFEIYKKVIQKYLKEGLIEIDNECVKLTERGIDVSNVIFEEFLP

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=378, Percent_Identity=28.8359788359788, Blast_Score=198, Evalue=6e-51,
Organism=Escherichia coli, GI1789325, Length=383, Percent_Identity=30.8093994778068, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI87082341, Length=382, Percent_Identity=27.4869109947644, Blast_Score=145, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 44309; Mature: 44309

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREIGLYIHIPFCKRKCYYCDFNSYAGYDYLFDDYIRALLMEIESNSTKDYNVVSVYIGG
CCCEEEEEEEEHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECC
GTPNLLPPSYIEKILKSVFKNYKILDGCEITIEMNPGLITEEKLKIYKDNGINRVSIGLQ
CCCCCCCHHHHHHHHHHHHHCCEEECCEEEEEEECCCCCCHHHHHEEECCCCCEEHHHHH
AFQNRLLKYIGRIHTVEEFFGNYELVKKFFDNINIDLMYALPTQTFKEWQETLKEVVKLQ
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCC
PTHVSTYSLILEPNTSFYRLYEKGQLPIVDEEEELKMYHWGIEFLKEKGYHHYEISNFAL
CCEEEEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCC
PTFECRHNILYWECKNYLGFGAGAHSYMADVRYSNIENIKDYIKSILERKSAVKEKIKLT
CCHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
KQDRMAEFMFLGMRMTKGVCDKDFKKRFGISLFEIYKKVIQKYLKEGLIEIDNECVKLTE
HHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
RGIDVSNVIFEEFLP
CCCCHHHHHHHHHCC
>Mature Secondary Structure
MREIGLYIHIPFCKRKCYYCDFNSYAGYDYLFDDYIRALLMEIESNSTKDYNVVSVYIGG
CCCEEEEEEEEHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECC
GTPNLLPPSYIEKILKSVFKNYKILDGCEITIEMNPGLITEEKLKIYKDNGINRVSIGLQ
CCCCCCCHHHHHHHHHHHHHCCEEECCEEEEEEECCCCCCHHHHHEEECCCCCEEHHHHH
AFQNRLLKYIGRIHTVEEFFGNYELVKKFFDNINIDLMYALPTQTFKEWQETLKEVVKLQ
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCC
PTHVSTYSLILEPNTSFYRLYEKGQLPIVDEEEELKMYHWGIEFLKEKGYHHYEISNFAL
CCEEEEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCC
PTFECRHNILYWECKNYLGFGAGAHSYMADVRYSNIENIKDYIKSILERKSAVKEKIKLT
CCHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
KQDRMAEFMFLGMRMTKGVCDKDFKKRFGISLFEIYKKVIQKYLKEGLIEIDNECVKLTE
HHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
RGIDVSNVIFEEFLP
CCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]