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The map label for this gene is lipB [H]

Identifier: 167040660

GI number: 167040660

Start: 2047008

End: 2047694

Strand: Reverse

Name: lipB [H]

Synonym: Teth514_2037

Alternate gene names: 167040660

Gene position: 2047694-2047008 (Counterclockwise)

Preceding gene: 167040661

Following gene: 167040659

Centisome position: 83.33

GC content: 36.68

Gene sequence:

>687_bases
TTGAGAAAAGGAGAAGTGTTAAAACTGGGAATTGTACCTTATATGGAAGGAAAAGAGATACAGCTTAAAGCCTTTGAAAG
AGTTAAAAAGGGCGAGACGGACGGGATTCTTATATTGCTTCAACATCCACCAGTATATACTATAGGAGTTTCAGGTGGTT
TTGACGAAAACATCCTTGTGCCTTTAGCGGAACTTAAGAAAAAAGCGGAGCTTTATAAAGTAGAAAGGGGAGGTAAAATA
ACTTTTCACGGACCAGGACAAATAGTTGCCTATCCTATATTTAATTTGGCAAAGTGGCAAAAAGATGTTCATCTTTTTGT
TTATAAATTAGAAGAGACGATTATAAAACTCCTGGAGGAGTATGGTATAAAAGCGGGAAGGAAGCCTAAATACACCGGAG
TATGGGTAGGAGATGAAAAGATATGCGCCATAGGTATCGCTGTTAGGCGCTGGATTACTTGGCATGGAATAGCCTTTAAT
GTAAATACTGACCTTTCATATTTTGGCTTAATAAATGCCTGCGGCATCACTGAGTTTGGAGTTACTTCTATGCAAAAACT
TGGAATAAATGAAGACATAGAAAAAGTAAAAGAAAAAATGGTTGATAAATTTAGCGAAGTATTTGGTATACACTTTAGTG
AGATAACTTTAGATAGATTGGCGGTGATTGATAATGCAAAAGCCTGA

Upstream 100 bases:

>100_bases
AATTCATGCTCATCCTACGCTTTCAGAAAGCGTAAAAGAGGCAGCAGAAGACGCATTAGGAATGCCTATAAATAAAGGAT
AAGTTAAAGGAGAGATTCAC

Downstream 100 bases:

>100_bases
ATGGCTCAAAGTGAGGCTATTAAACGAAGATTTAAACAGGATGGAAGCTTTTTTAAAAAGTATGTCTTTAAACACAGTTT
GTCAAAGTGCCAATTGTCCC

Product: lipoate-protein ligase B

Products: NA

Alternate protein names: Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MRKGEVLKLGIVPYMEGKEIQLKAFERVKKGETDGILILLQHPPVYTIGVSGGFDENILVPLAELKKKAELYKVERGGKI
TFHGPGQIVAYPIFNLAKWQKDVHLFVYKLEETIIKLLEEYGIKAGRKPKYTGVWVGDEKICAIGIAVRRWITWHGIAFN
VNTDLSYFGLINACGITEFGVTSMQKLGINEDIEKVKEKMVDKFSEVFGIHFSEITLDRLAVIDNAKA

Sequences:

>Translated_228_residues
MRKGEVLKLGIVPYMEGKEIQLKAFERVKKGETDGILILLQHPPVYTIGVSGGFDENILVPLAELKKKAELYKVERGGKI
TFHGPGQIVAYPIFNLAKWQKDVHLFVYKLEETIIKLLEEYGIKAGRKPKYTGVWVGDEKICAIGIAVRRWITWHGIAFN
VNTDLSYFGLINACGITEFGVTSMQKLGINEDIEKVKEKMVDKFSEVFGIHFSEITLDRLAVIDNAKA
>Mature_228_residues
MRKGEVLKLGIVPYMEGKEIQLKAFERVKKGETDGILILLQHPPVYTIGVSGGFDENILVPLAELKKKAELYKVERGGKI
TFHGPGQIVAYPIFNLAKWQKDVHLFVYKLEETIIKLLEEYGIKAGRKPKYTGVWVGDEKICAIGIAVRRWITWHGIAFN
VNTDLSYFGLINACGITEFGVTSMQKLGINEDIEKVKEKMVDKFSEVFGIHFSEITLDRLAVIDNAKA

Specific function: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate

COG id: COG0321

COG function: function code H; Lipoate-protein ligase B

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lipB family [H]

Homologues:

Organism=Homo sapiens, GI221554520, Length=222, Percent_Identity=36.9369369369369, Blast_Score=128, Evalue=5e-30,
Organism=Escherichia coli, GI87081767, Length=170, Percent_Identity=38.8235294117647, Blast_Score=117, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323268, Length=171, Percent_Identity=36.8421052631579, Blast_Score=100, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21355483, Length=218, Percent_Identity=36.697247706422, Blast_Score=141, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR000544
- InterPro:   IPR020605 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB [H]

EC number: =2.3.1.181 [H]

Molecular weight: Translated: 25684; Mature: 25684

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS01313 LIPB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKGEVLKLGIVPYMEGKEIQLKAFERVKKGETDGILILLQHPPVYTIGVSGGFDENILV
CCCCCEEEEEEEECCCCCEEHHHHHHHHHCCCCCCEEEEEECCCEEEEECCCCCCCCEEE
PLAELKKKAELYKVERGGKITFHGPGQIVAYPIFNLAKWQKDVHLFVYKLEETIIKLLEE
EHHHHHHHHHHEEECCCCEEEEECCCCEEEEEHHHHHHHHCCCEEEEEHHHHHHHHHHHH
YGIKAGRKPKYTGVWVGDEKICAIGIAVRRWITWHGIAFNVNTDLSYFGLINACGITEFG
HCCCCCCCCCEEEEEECCCCEEEHHHHHHHEEEECCEEEEECCCCHHHHHHHHCCCCHHC
VTSMQKLGINEDIEKVKEKMVDKFSEVFGIHFSEITLDRLAVIDNAKA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEECCCCC
>Mature Secondary Structure
MRKGEVLKLGIVPYMEGKEIQLKAFERVKKGETDGILILLQHPPVYTIGVSGGFDENILV
CCCCCEEEEEEEECCCCCEEHHHHHHHHHCCCCCCEEEEEECCCEEEEECCCCCCCCEEE
PLAELKKKAELYKVERGGKITFHGPGQIVAYPIFNLAKWQKDVHLFVYKLEETIIKLLEE
EHHHHHHHHHHEEECCCCEEEEECCCCEEEEEHHHHHHHHCCCEEEEEHHHHHHHHHHHH
YGIKAGRKPKYTGVWVGDEKICAIGIAVRRWITWHGIAFNVNTDLSYFGLINACGITEFG
HCCCCCCCCCEEEEEECCCCEEEHHHHHHHEEEECCEEEEECCCCHHHHHHHHCCCCHHC
VTSMQKLGINEDIEKVKEKMVDKFSEVFGIHFSEITLDRLAVIDNAKA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA