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The map label for this gene is acoB [H]

Identifier: 167040655

GI number: 167040655

Start: 2041665

End: 2042627

Strand: Reverse

Name: acoB [H]

Synonym: Teth514_2032

Alternate gene names: 167040655

Gene position: 2042627-2041665 (Counterclockwise)

Preceding gene: 167040656

Following gene: 167040654

Centisome position: 83.13

GC content: 40.71

Gene sequence:

>963_bases
ATGACGTATGCAGAGGCTTTAAGAGAAGCTATTTTAAATGAGATGAGAAGAGACCCGGCAGTGTTTTTATTAGGAGAAGA
TATTGGGAGATTTGGAGGGACTTTTGGCGTAACTCGCGGCTTGATAGATGAATTTGGAGAGGACAGAGTAAGAGATACTC
CTATTTCAGAAACAGCAATTACAGGTGTTTCGATAGGAGCTGCAGCTACTGGCATGCGACCTGTTGCTGAGCTTATGTTT
ATGGATTTTGTAACAGTGGCAATGGACCAGCTTGTCAATCAGGCTGCAAAAATGAGGTATATGTTTGGCGGGAAAATCAC
AATACCTATGGTTTTAAGAATGCCAGCAGGTGCAGGAATACAAGCAGCAGCTCAGCATTCACAAAGCCTTGAAGCGTGGT
TTACTCATGTGCCGGGATTAAAGGTGGTTTATCCTTCTACTCCTAAAGATGCTTTAGGTCTAATGATATCTGCAATACGT
GATGACAACCCGGTGGTTTTTGTGGAACATAAAGTTTTGTACAGTATGAAAGGGGATGTTCCTGATATTAATGAACCCAT
ACCTCTTGGAGTAGCAGATATCAAAAGAGAAGGCAGCGACGTTACCGTAGTTGCAACAGGTCTCATGGTCCATAAAGCGT
TAAAAGCAGCAGAAATATTGTCAAAAGAGGGTATAGAAGTGGAAGTAATAGACCCGAGGACTTTGTTCCCTCTTGACAAA
GAAAAAATTTTTAATTCCCTAAAAAAGACTCACAAGATAGTAATAGTTACAGAAGAAGTTAAGAGGGGTAGCTGGGGCGG
TGAGTTAGCAGCATTGATAGCTGAAGAAATGTTTGATTATCTAGATGCACAGATAGTACGCATTGGAGCTTTAAATACAC
CAATTCCATTTACGACGGTTCTTGAGAATGCTGTAATCCCTAATGAAGAAGATATAATAAAGGCGGTAAAATCAATAGCA
TAG

Upstream 100 bases:

>100_bases
CGGTAAGGTTTGCTGAAGAAAGCCCATATCCAAAAGAAGAGGCAGCGGTAGAGGATGTTTATACAGATATAGTAGAGGAG
GTAAGGGTAAGATGAGGAAT

Downstream 100 bases:

>100_bases
GACGTAAAGCATTTTGTTTGATAAATATAAGGAGGCAGACATGAAAACCATAGGGATAATTGCAAATCCGTCATCGGGGA
AAGATATAAGGCGATTGGTT

Product: transketolase, central region

Products: [dihydrolipoyllysine-residue acetyltransferase] ; $S-acetyldihydrolipoyllysine; CO2

Alternate protein names: Acetoin:DCPIP oxidoreductase-beta; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit beta [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MTYAEALREAILNEMRRDPAVFLLGEDIGRFGGTFGVTRGLIDEFGEDRVRDTPISETAITGVSIGAAATGMRPVAELMF
MDFVTVAMDQLVNQAAKMRYMFGGKITIPMVLRMPAGAGIQAAAQHSQSLEAWFTHVPGLKVVYPSTPKDALGLMISAIR
DDNPVVFVEHKVLYSMKGDVPDINEPIPLGVADIKREGSDVTVVATGLMVHKALKAAEILSKEGIEVEVIDPRTLFPLDK
EKIFNSLKKTHKIVIVTEEVKRGSWGGELAALIAEEMFDYLDAQIVRIGALNTPIPFTTVLENAVIPNEEDIIKAVKSIA

Sequences:

>Translated_320_residues
MTYAEALREAILNEMRRDPAVFLLGEDIGRFGGTFGVTRGLIDEFGEDRVRDTPISETAITGVSIGAAATGMRPVAELMF
MDFVTVAMDQLVNQAAKMRYMFGGKITIPMVLRMPAGAGIQAAAQHSQSLEAWFTHVPGLKVVYPSTPKDALGLMISAIR
DDNPVVFVEHKVLYSMKGDVPDINEPIPLGVADIKREGSDVTVVATGLMVHKALKAAEILSKEGIEVEVIDPRTLFPLDK
EKIFNSLKKTHKIVIVTEEVKRGSWGGELAALIAEEMFDYLDAQIVRIGALNTPIPFTTVLENAVIPNEEDIIKAVKSIA
>Mature_319_residues
TYAEALREAILNEMRRDPAVFLLGEDIGRFGGTFGVTRGLIDEFGEDRVRDTPISETAITGVSIGAAATGMRPVAELMFM
DFVTVAMDQLVNQAAKMRYMFGGKITIPMVLRMPAGAGIQAAAQHSQSLEAWFTHVPGLKVVYPSTPKDALGLMISAIRD
DNPVVFVEHKVLYSMKGDVPDINEPIPLGVADIKREGSDVTVVATGLMVHKALKAAEILSKEGIEVEVIDPRTLFPLDKE
KIFNSLKKTHKIVIVTEEVKRGSWGGELAALIAEEMFDYLDAQIVRIGALNTPIPFTTVLENAVIPNEEDIIKAVKSIA

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde [H]

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=327, Percent_Identity=43.1192660550459, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI291084858, Length=327, Percent_Identity=40.9785932721713, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI4557353, Length=322, Percent_Identity=39.4409937888199, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI34101272, Length=322, Percent_Identity=39.4409937888199, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI133778974, Length=156, Percent_Identity=32.6923076923077, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI205277463, Length=242, Percent_Identity=28.099173553719, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4507521, Length=242, Percent_Identity=28.099173553719, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538422, Length=322, Percent_Identity=42.8571428571429, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17506935, Length=321, Percent_Identity=40.4984423676012, Blast_Score=204, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6319698, Length=327, Percent_Identity=42.2018348623853, Blast_Score=263, Evalue=3e-71,
Organism=Drosophila melanogaster, GI21358145, Length=320, Percent_Identity=41.875, Blast_Score=264, Evalue=7e-71,
Organism=Drosophila melanogaster, GI24650940, Length=320, Percent_Identity=41.875, Blast_Score=264, Evalue=7e-71,
Organism=Drosophila melanogaster, GI160714832, Length=322, Percent_Identity=39.1304347826087, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI160714828, Length=322, Percent_Identity=39.1304347826087, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24650943, Length=90, Percent_Identity=43.3333333333333, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24650945, Length=90, Percent_Identity=43.3333333333333, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: 1.2.4.1

Molecular weight: Translated: 34848; Mature: 34717

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYAEALREAILNEMRRDPAVFLLGEDIGRFGGTFGVTRGLIDEFGEDRVRDTPISETAI
CCHHHHHHHHHHHHHCCCCEEEEECCHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHC
TGVSIGAAATGMRPVAELMFMDFVTVAMDQLVNQAAKMRYMFGGKITIPMVLRMPAGAGI
CCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCH
QAAAQHSQSLEAWFTHVPGLKVVYPSTPKDALGLMISAIRDDNPVVFVEHKVLYSMKGDV
HHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEEHEEEECCCCC
PDINEPIPLGVADIKREGSDVTVVATGLMVHKALKAAEILSKEGIEVEVIDPRTLFPLDK
CCCCCCCCCCHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCH
EKIFNSLKKTHKIVIVTEEVKRGSWGGELAALIAEEMFDYLDAQIVRIGALNTPIPFTTV
HHHHHHHHHHCEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHH
LENAVIPNEEDIIKAVKSIA
HHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TYAEALREAILNEMRRDPAVFLLGEDIGRFGGTFGVTRGLIDEFGEDRVRDTPISETAI
CHHHHHHHHHHHHHCCCCEEEEECCHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHC
TGVSIGAAATGMRPVAELMFMDFVTVAMDQLVNQAAKMRYMFGGKITIPMVLRMPAGAGI
CCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCH
QAAAQHSQSLEAWFTHVPGLKVVYPSTPKDALGLMISAIRDDNPVVFVEHKVLYSMKGDV
HHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEEHEEEECCCCC
PDINEPIPLGVADIKREGSDVTVVATGLMVHKALKAAEILSKEGIEVEVIDPRTLFPLDK
CCCCCCCCCCHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCH
EKIFNSLKKTHKIVIVTEEVKRGSWGGELAALIAEEMFDYLDAQIVRIGALNTPIPFTTV
HHHHHHHHHHCEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHH
LENAVIPNEEDIIKAVKSIA
HHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pyruvate; [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

Specific reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S- $acetyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10368162; 8969503; 9384377 [H]