Click here to switch to the map view.

The map label for this gene is ppnK

Identifier: 167040180

GI number: 167040180

Start: 1565178

End: 1566029

Strand: Direct

Name: ppnK

Synonym: Teth514_1542

Alternate gene names: 167040180

Gene position: 1565178-1566029 (Clockwise)

Preceding gene: 167040179

Following gene: 167040181

Centisome position: 63.7

GC content: 30.75

Gene sequence:

>852_bases
ATGAAAAAAGTCGGAGTAATTCCAAATATCAATAAAGATAAAGACTTAGAAGTGACAAAATCTGTAGTAAAATGGCTATT
GGAACATGATTCTGAACCATATCTTAATGAAATAGTTGCCTCTAAAATGGGTTATGATGAATATGGTAAAAAATCCACAG
ATATATATAGTAAATCTGATTTCATAATTGCTTTAGGTGGAGATGGTACTATTTTAAATGTTGCAAGGCTTTGTGCACCT
TTTGGGACGCCTATTTTTGCTGTGAATTTAGGTCATCTTGGATTTCTTACAGAAGTAGATATGAATGAGGTGTTTGTTTC
TTTAGATAAAATATATAAAGGAGAATATACAGTAGAAAAAAGGATGATGCTAGAGGCAAATGTAGTTAAAAATGATATGG
AGATTATTAATTTTAGAGCTTTGAATGACATTGTCATTACAAGAGGAGCTTTTTCAAGAATGGCTCGTATAAATGCCTAT
GTCAATAATAATTATGTAGATACTTATTTAGCAGATGGAGTAATAATTGCAACTCCTACTGGTTCAACTGCTTATTCACT
TTCAGCAGGAGGACCTATTGTATATCCTACAGTAGAAGTTATAATAATAACACCTATCTGTCCTCATACTTTATATTCGA
GGTCTATAATAGTTTCACCAGATGATGTAATTAGGTTGGAAATAAGCGAAGAAAATCAAGATTTAATGATAACAACAGAT
GGGCAACAGGGATATAAACTTGATTATAGAGACATAATTTACATTAAAAAGAGCAATGAATATACCAATCTCATAAGAGT
AAAAAATACCAATTTTTTTGACTTGTTGAGGGACAAACTTACAGAAAGATAA

Upstream 100 bases:

>100_bases
TACAAAAATTGTAGAAGAGGCATTTAAAAATTTGAACAAATAAAATATTAGCAGGAAAATTTGTTTTTTTGTAGAATATG
ATAAATGTGGTGAGATTGTA

Downstream 100 bases:

>100_bases
AAAGTAAAAAGAGGTGAAGACTAATATGATGAAAATAGCTCGACACGCTAAAATTCTTGAAATAATCTCTGAAAAAGAAA
TTGAAACACAGGAAGAGTTA

Product: ATP-NAD/AcoX kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MKKVGVIPNINKDKDLEVTKSVVKWLLEHDSEPYLNEIVASKMGYDEYGKKSTDIYSKSDFIIALGGDGTILNVARLCAP
FGTPIFAVNLGHLGFLTEVDMNEVFVSLDKIYKGEYTVEKRMMLEANVVKNDMEIINFRALNDIVITRGAFSRMARINAY
VNNNYVDTYLADGVIIATPTGSTAYSLSAGGPIVYPTVEVIIITPICPHTLYSRSIIVSPDDVIRLEISEENQDLMITTD
GQQGYKLDYRDIIYIKKSNEYTNLIRVKNTNFFDLLRDKLTER

Sequences:

>Translated_283_residues
MKKVGVIPNINKDKDLEVTKSVVKWLLEHDSEPYLNEIVASKMGYDEYGKKSTDIYSKSDFIIALGGDGTILNVARLCAP
FGTPIFAVNLGHLGFLTEVDMNEVFVSLDKIYKGEYTVEKRMMLEANVVKNDMEIINFRALNDIVITRGAFSRMARINAY
VNNNYVDTYLADGVIIATPTGSTAYSLSAGGPIVYPTVEVIIITPICPHTLYSRSIIVSPDDVIRLEISEENQDLMITTD
GQQGYKLDYRDIIYIKKSNEYTNLIRVKNTNFFDLLRDKLTER
>Mature_283_residues
MKKVGVIPNINKDKDLEVTKSVVKWLLEHDSEPYLNEIVASKMGYDEYGKKSTDIYSKSDFIIALGGDGTILNVARLCAP
FGTPIFAVNLGHLGFLTEVDMNEVFVSLDKIYKGEYTVEKRMMLEANVVKNDMEIINFRALNDIVITRGAFSRMARINAY
VNNNYVDTYLADGVIIATPTGSTAYSLSAGGPIVYPTVEVIIITPICPHTLYSRSIIVSPDDVIRLEISEENQDLMITTD
GQQGYKLDYRDIIYIKKSNEYTNLIRVKNTNFFDLLRDKLTER

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family

Homologues:

Organism=Homo sapiens, GI55743112, Length=256, Percent_Identity=32.03125, Blast_Score=111, Evalue=8e-25,
Organism=Escherichia coli, GI1788968, Length=281, Percent_Identity=31.3167259786477, Blast_Score=170, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6325068, Length=219, Percent_Identity=36.0730593607306, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6320794, Length=312, Percent_Identity=30.4487179487179, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322509, Length=276, Percent_Identity=30.4347826086957, Blast_Score=119, Evalue=6e-28,
Organism=Drosophila melanogaster, GI28573830, Length=246, Percent_Identity=30.4878048780488, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28573828, Length=248, Percent_Identity=29.8387096774194, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI161077047, Length=246, Percent_Identity=30.4878048780488, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28573832, Length=246, Percent_Identity=30.4878048780488, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28573826, Length=246, Percent_Identity=30.4878048780488, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI20129957, Length=249, Percent_Identity=27.3092369477912, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281363323, Length=249, Percent_Identity=27.3092369477912, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281363321, Length=249, Percent_Identity=27.3092369477912, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24653424, Length=249, Percent_Identity=27.3092369477912, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24653422, Length=249, Percent_Identity=27.3092369477912, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPNK_THEP3 (B0K9E7)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001665096.1
- ProteinModelPortal:   B0K9E7
- SMR:   B0K9E7
- GeneID:   5875352
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_1105
- HOGENOM:   HBG713904
- OMA:   FESFMID
- ProtClustDB:   CLSK901156
- BioCyc:   TPSE340099:TETH39_1105-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00361
- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504
- Gene3D:   G3DSA:2.60.200.30
- Gene3D:   G3DSA:3.40.50.10330
- PANTHER:   PTHR20275

Pfam domain/function: PF01513 NAD_kinase; SSF111331 ATP-NAD_kinase_PpnK-typ

EC number: =2.7.1.23

Molecular weight: Translated: 31908; Mature: 31908

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVGVIPNINKDKDLEVTKSVVKWLLEHDSEPYLNEIVASKMGYDEYGKKSTDIYSKSD
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHCCCCCCEECCCC
FIIALGGDGTILNVARLCAPFGTPIFAVNLGHLGFLTEVDMNEVFVSLDKIYKGEYTVEK
EEEEECCCCCHHHHHHHHHCCCCCEEEEEECCEEEEEECCHHHHHHHHHHHHCCCEEEHH
RMMLEANVVKNDMEIINFRALNDIVITRGAFSRMARINAYVNNNYVDTYLADGVIIATPT
HHEEHHHHHHCCHHEEEEEEECEEEEECHHHHHHHHEEEEECCCEEEEEECCCEEEECCC
GSTAYSLSAGGPIVYPTVEVIIITPICPHTLYSRSIIVSPDDVIRLEISEENQDLMITTD
CCCEEEECCCCCEEECEEEEEEECCCCCCHHHCCEEEECCCCEEEEEECCCCCEEEEEEC
GQQGYKLDYRDIIYIKKSNEYTNLIRVKNTNFFDLLRDKLTER
CCCCCEECCEEEEEEEECCCCEEEEEEECCCHHHHHHHHHCCC
>Mature Secondary Structure
MKKVGVIPNINKDKDLEVTKSVVKWLLEHDSEPYLNEIVASKMGYDEYGKKSTDIYSKSD
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHCCCCCCEECCCC
FIIALGGDGTILNVARLCAPFGTPIFAVNLGHLGFLTEVDMNEVFVSLDKIYKGEYTVEK
EEEEECCCCCHHHHHHHHHCCCCCEEEEEECCEEEEEECCHHHHHHHHHHHHCCCEEEHH
RMMLEANVVKNDMEIINFRALNDIVITRGAFSRMARINAYVNNNYVDTYLADGVIIATPT
HHEEHHHHHHCCHHEEEEEEECEEEEECHHHHHHHHEEEEECCCEEEEEECCCEEEECCC
GSTAYSLSAGGPIVYPTVEVIIITPICPHTLYSRSIIVSPDDVIRLEISEENQDLMITTD
CCCEEEECCCCCEEECEEEEEEECCCCCCHHHCCEEEECCCCEEEEEECCCCCEEEEEEC
GQQGYKLDYRDIIYIKKSNEYTNLIRVKNTNFFDLLRDKLTER
CCCCCEECCEEEEEEEECCCCEEEEEEECCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA