Click here to switch to the map view.

The map label for this gene is trxA [H]

Identifier: 167040114

GI number: 167040114

Start: 1509452

End: 1510123

Strand: Direct

Name: trxA [H]

Synonym: Teth514_1476

Alternate gene names: 167040114

Gene position: 1509452-1510123 (Clockwise)

Preceding gene: 167040113

Following gene: 167040115

Centisome position: 61.43

GC content: 33.04

Gene sequence:

>672_bases
ATGGCAGAATTAGTTATTACACTTGAAAATTTCGAACAAGAAGTTGTAAATTCGGACGTACCAGTCTTGATAGATTTTTG
GGCTGAATGGTGTATGCCTTGTAGAATGGTGGCTCCAATAATTGACGAATTAGCGAAAGAATATGAAGGAAAAATCAAAG
TAGGTAAAATTAATGTTGATGAAGAAAATGAATTGGCAATGAAATTTAGAATAATGAGTATACCTACAATTGGGCTTTTC
AAAAATGGTAAAATGGTAGATAAGATAATAGGAGCAAGACCTAAAGCAGATTTTGTAAGATTTATAGAAAAACATCTCAA
TGGTGGTGCTACACAATCAGAAGAGTCTGACGAGGTAGAAATTACATACGATAATTTCGAAGAAGAAGTTGTAAACTCTG
ATGTACCAGTATTGATAGACTTTTGGGCTGAATGGTGTGCACCTTGTAGATTAGTTGCTCCCATAATAGATGAACTAGCA
AAAGAGTATAAAGGAAAGATTAAAGTAGGAAAAGTTAATGTAGACGAAGAAAATGAGCTGGCAATGCAATTTAGGATAAT
GAGCATACCTACAATAGGACTTTTCAAAAATGGCAAGATGGTAGATAAAATAATAGGAGCAAGACCTAAAGCAGACTTTG
TAAAGTTTATAGAAAAGCATTTAAACAATTAA

Upstream 100 bases:

>100_bases
TTAAAAGTTAGGTTTTGTGAGCAATTTGTTTTATAATAAATGTATAAAGCAATTGCTTTGTATAAAAATAAAAATGAAAT
AAGAGTATAGGAGTGGTTTT

Downstream 100 bases:

>100_bases
AAATCCTGCATTATGCAGGATTTTTAATTTTATTCCTTGAATAAATATAAAAAGAATTGTTTAATTTTCCAAAAAATTAC
GAAAATCGAAACATACTAAG

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MAELVITLENFEQEVVNSDVPVLIDFWAEWCMPCRMVAPIIDELAKEYEGKIKVGKINVDEENELAMKFRIMSIPTIGLF
KNGKMVDKIIGARPKADFVRFIEKHLNGGATQSEESDEVEITYDNFEEEVVNSDVPVLIDFWAEWCAPCRLVAPIIDELA
KEYKGKIKVGKVNVDEENELAMQFRIMSIPTIGLFKNGKMVDKIIGARPKADFVKFIEKHLNN

Sequences:

>Translated_223_residues
MAELVITLENFEQEVVNSDVPVLIDFWAEWCMPCRMVAPIIDELAKEYEGKIKVGKINVDEENELAMKFRIMSIPTIGLF
KNGKMVDKIIGARPKADFVRFIEKHLNGGATQSEESDEVEITYDNFEEEVVNSDVPVLIDFWAEWCAPCRLVAPIIDELA
KEYKGKIKVGKVNVDEENELAMQFRIMSIPTIGLFKNGKMVDKIIGARPKADFVKFIEKHLNN
>Mature_222_residues
AELVITLENFEQEVVNSDVPVLIDFWAEWCMPCRMVAPIIDELAKEYEGKIKVGKINVDEENELAMKFRIMSIPTIGLFK
NGKMVDKIIGARPKADFVRFIEKHLNGGATQSEESDEVEITYDNFEEEVVNSDVPVLIDFWAEWCAPCRLVAPIIDELAK
EYKGKIKVGKVNVDEENELAMQFRIMSIPTIGLFKNGKMVDKIIGARPKADFVKFIEKHLNN

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI42794771, Length=235, Percent_Identity=28.0851063829787, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI224493972, Length=235, Percent_Identity=28.0851063829787, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI4758304, Length=220, Percent_Identity=31.8181818181818, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI5031973, Length=235, Percent_Identity=26.3829787234043, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI21361403, Length=95, Percent_Identity=34.7368421052632, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI24308127, Length=201, Percent_Identity=25.8706467661692, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI5803121, Length=224, Percent_Identity=24.5535714285714, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=42.7184466019417, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1788936, Length=110, Percent_Identity=46.3636363636364, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87081747, Length=134, Percent_Identity=30.5970149253731, Blast_Score=74, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI25144092, Length=217, Percent_Identity=29.0322580645161, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17556044, Length=237, Percent_Identity=25.7383966244726, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17549970, Length=239, Percent_Identity=26.3598326359833, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI115532380, Length=231, Percent_Identity=27.2727272727273, Blast_Score=90, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=39.1752577319588, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115532378, Length=228, Percent_Identity=27.6315789473684, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17554386, Length=120, Percent_Identity=38.3333333333333, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17507705, Length=123, Percent_Identity=30.0813008130081, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17569137, Length=89, Percent_Identity=37.0786516853933, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=89, Percent_Identity=37.0786516853933, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=89, Percent_Identity=37.0786516853933, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=90, Percent_Identity=40, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=90, Percent_Identity=35.5555555555556, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=113, Percent_Identity=29.2035398230088, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19921434, Length=239, Percent_Identity=30.9623430962343, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=36, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18859803, Length=229, Percent_Identity=24.8908296943231, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24639826, Length=98, Percent_Identity=35.7142857142857, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21358065, Length=87, Percent_Identity=37.9310344827586, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24639068, Length=118, Percent_Identity=33.0508474576271, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=40.5405405405405, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=40.5405405405405, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17647799, Length=200, Percent_Identity=29.5, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24664269, Length=71, Percent_Identity=38.0281690140845, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24584105, Length=207, Percent_Identity=24.6376811594203, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664525, Length=163, Percent_Identity=29.4478527607362, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI18860011, Length=112, Percent_Identity=32.1428571428571, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642439, Length=112, Percent_Identity=32.1428571428571, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642441, Length=112, Percent_Identity=32.1428571428571, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642443, Length=110, Percent_Identity=31.8181818181818, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24644807, Length=115, Percent_Identity=32.1739130434783, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 25413; Mature: 25282

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELVITLENFEQEVVNSDVPVLIDFWAEWCMPCRMVAPIIDELAKEYEGKIKVGKINVD
CCEEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
EENELAMKFRIMSIPTIGLFKNGKMVDKIIGARPKADFVRFIEKHLNGGATQSEESDEVE
CCCCEEEEEEEEECCEEEEECCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEE
ITYDNFEEEVVNSDVPVLIDFWAEWCAPCRLVAPIIDELAKEYKGKIKVGKVNVDEENEL
EEECCHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHH
AMQFRIMSIPTIGLFKNGKMVDKIIGARPKADFVKFIEKHLNN
EEEEEEEECCEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AELVITLENFEQEVVNSDVPVLIDFWAEWCMPCRMVAPIIDELAKEYEGKIKVGKINVD
CEEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
EENELAMKFRIMSIPTIGLFKNGKMVDKIIGARPKADFVRFIEKHLNGGATQSEESDEVE
CCCCEEEEEEEEECCEEEEECCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEE
ITYDNFEEEVVNSDVPVLIDFWAEWCAPCRLVAPIIDELAKEYKGKIKVGKVNVDEENEL
EEECCHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHH
AMQFRIMSIPTIGLFKNGKMVDKIIGARPKADFVKFIEKHLNN
EEEEEEEECCEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]