Click here to switch to the map view.

The map label for this gene is cobD [H]

Identifier: 167038971

GI number: 167038971

Start: 322438

End: 323523

Strand: Direct

Name: cobD [H]

Synonym: Teth514_0304

Alternate gene names: 167038971

Gene position: 322438-323523 (Clockwise)

Preceding gene: 167038970

Following gene: 167038972

Centisome position: 13.12

GC content: 32.23

Gene sequence:

>1086_bases
ATGAAGCCTTATGAGCATGGTGGAAATGTTTATGATTATGAAGGAGAAATAATTGATTTTAGTTCAAATATAAATCCTCT
TGGGGTTCCGGAATGGATTTTTGATATTATCAAAAAAGTTGATTTAACGAAATATCCGGATATAAAATATCGAAAACTAA
AAGAGGCTATTTCACAGTATGTGGGGTATTCACAAGAAAATATAATTGTTGGAAATGGTGCGACAGAGCTCATACATCTT
TTTGTGAGAGCATTTAAGGTGAAAAGACCCCTCATTCCGTCTCCTGCTTTTTTGGAATATGAAAGGGCAGTCCACATAAA
CGGTGGTGAACCGATATATTTCAGGCTGGAAGAAGACTATGGGTTTAAAGTAAATCTCGCAAAGCTTATTTCACAAATGG
AAGAGGCGGATTCTTTAATCATTGGGAATCCTAACAATCCTACAGGACAAGCCATAATTAGAGAGGAAATAGGAATTTTA
TTAAAAAAAGCGGAGATTTTGAACATGCCTGTCATGATAGATGAAGCTTTTATTGAATTTATGAAAGACTATAAAAATTA
TGAAGCTTTACCTCTTATAAAAAAGCATGATAAATTGTTTGTTGTAAGAGCGGCAACGAAATTTTTTGGTATGCCGGGGT
TGAGGCTGGGATATGGGATTGGGAGCTCTTCTTTAATACAAAAACTGGAAGAGTATAAAGAGCCTTGGACAGTAAATGCT
CTTGCAGATGCTGTGGGGAGAGAAATATTTAAAGATGAAGCTTATATAGAAAAAACAAGGGAATATGTAAATAAAGAAAT
AGAGTATATGCTTTATACTTTAAGAGAAATTGATTATTTAGTTGCTTTTGATACAAAAGTAAATTTTATATTGTTAAAGT
TAAGAACAGGAAGGGTAAATAACCTTAAACAAATACTTCTAAAAAAAGGAATTCTCATAAGAGATGCTTCTAATTTTAGA
TATCTGGACAAAAGCTTTTTTAGAGTTGCTATAAAAAGACATGAAGACAATGAAAAATTGATACAGGCTTTGAAAGAAAT
AGATATAAAAGACTTGGTAGAAGATAAAGAAAGGGTTGTAATATAA

Upstream 100 bases:

>100_bases
TGCACAACGAAGAAGATACAGTATCTATTAAAGGACTGACAGATAAACCCTTAACATATGTCGGGGTGCTGATTTAGAGT
AAACGAAAGAAGGTGTTTCA

Downstream 100 bases:

>100_bases
ATGAGCCTTGTTATGATCACAGGCGGTGCAAGGTCTGGCAAAAGTGAATTTGCTGAAAAATTGGCTTTAGAAAAAGGAGG
AAACAGTGTCCTTTATATAG

Product: putative L-threonine-O-3-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MKPYEHGGNVYDYEGEIIDFSSNINPLGVPEWIFDIIKKVDLTKYPDIKYRKLKEAISQYVGYSQENIIVGNGATELIHL
FVRAFKVKRPLIPSPAFLEYERAVHINGGEPIYFRLEEDYGFKVNLAKLISQMEEADSLIIGNPNNPTGQAIIREEIGIL
LKKAEILNMPVMIDEAFIEFMKDYKNYEALPLIKKHDKLFVVRAATKFFGMPGLRLGYGIGSSSLIQKLEEYKEPWTVNA
LADAVGREIFKDEAYIEKTREYVNKEIEYMLYTLREIDYLVAFDTKVNFILLKLRTGRVNNLKQILLKKGILIRDASNFR
YLDKSFFRVAIKRHEDNEKLIQALKEIDIKDLVEDKERVVI

Sequences:

>Translated_361_residues
MKPYEHGGNVYDYEGEIIDFSSNINPLGVPEWIFDIIKKVDLTKYPDIKYRKLKEAISQYVGYSQENIIVGNGATELIHL
FVRAFKVKRPLIPSPAFLEYERAVHINGGEPIYFRLEEDYGFKVNLAKLISQMEEADSLIIGNPNNPTGQAIIREEIGIL
LKKAEILNMPVMIDEAFIEFMKDYKNYEALPLIKKHDKLFVVRAATKFFGMPGLRLGYGIGSSSLIQKLEEYKEPWTVNA
LADAVGREIFKDEAYIEKTREYVNKEIEYMLYTLREIDYLVAFDTKVNFILLKLRTGRVNNLKQILLKKGILIRDASNFR
YLDKSFFRVAIKRHEDNEKLIQALKEIDIKDLVEDKERVVI
>Mature_361_residues
MKPYEHGGNVYDYEGEIIDFSSNINPLGVPEWIFDIIKKVDLTKYPDIKYRKLKEAISQYVGYSQENIIVGNGATELIHL
FVRAFKVKRPLIPSPAFLEYERAVHINGGEPIYFRLEEDYGFKVNLAKLISQMEEADSLIIGNPNNPTGQAIIREEIGIL
LKKAEILNMPVMIDEAFIEFMKDYKNYEALPLIKKHDKLFVVRAATKFFGMPGLRLGYGIGSSSLIQKLEEYKEPWTVNA
LADAVGREIFKDEAYIEKTREYVNKEIEYMLYTLREIDYLVAFDTKVNFILLKLRTGRVNNLKQILLKKGILIRDASNFR
YLDKSFFRVAIKRHEDNEKLIQALKEIDIKDLVEDKERVVI

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=318, Percent_Identity=24.5283018867925, Blast_Score=96, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6322075, Length=341, Percent_Identity=25.5131964809384, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 41877; Mature: 41877

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPYEHGGNVYDYEGEIIDFSSNINPLGVPEWIFDIIKKVDLTKYPDIKYRKLKEAISQY
CCCCCCCCCEEECCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
VGYSQENIIVGNGATELIHLFVRAFKVKRPLIPSPAFLEYERAVHINGGEPIYFRLEEDY
HCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCC
GFKVNLAKLISQMEEADSLIIGNPNNPTGQAIIREEIGILLKKAEILNMPVMIDEAFIEF
CCEEEHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MKDYKNYEALPLIKKHDKLFVVRAATKFFGMPGLRLGYGIGSSSLIQKLEEYKEPWTVNA
HHHHCCCCCCCEEECCCCEEEEEEHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCCCHHH
LADAVGREIFKDEAYIEKTREYVNKEIEYMLYTLREIDYLVAFDTKVNFILLKLRTGRVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEEEEECCCCH
NLKQILLKKGILIRDASNFRYLDKSFFRVAIKRHEDNEKLIQALKEIDIKDLVEDKERVV
HHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHCCHHCCC
I
C
>Mature Secondary Structure
MKPYEHGGNVYDYEGEIIDFSSNINPLGVPEWIFDIIKKVDLTKYPDIKYRKLKEAISQY
CCCCCCCCCEEECCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
VGYSQENIIVGNGATELIHLFVRAFKVKRPLIPSPAFLEYERAVHINGGEPIYFRLEEDY
HCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCC
GFKVNLAKLISQMEEADSLIIGNPNNPTGQAIIREEIGILLKKAEILNMPVMIDEAFIEF
CCEEEHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MKDYKNYEALPLIKKHDKLFVVRAATKFFGMPGLRLGYGIGSSSLIQKLEEYKEPWTVNA
HHHHCCCCCCCEEECCCCEEEEEEHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCCCHHH
LADAVGREIFKDEAYIEKTREYVNKEIEYMLYTLREIDYLVAFDTKVNFILLKLRTGRVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEEEEECCCCH
NLKQILLKKGILIRDASNFRYLDKSFFRVAIKRHEDNEKLIQALKEIDIKDLVEDKERVV
HHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHCCHHCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]