Click here to switch to the map view.

The map label for this gene is cobB [H]

Identifier: 167038966

GI number: 167038966

Start: 317274

End: 318656

Strand: Direct

Name: cobB [H]

Synonym: Teth514_0299

Alternate gene names: 167038966

Gene position: 317274-318656 (Clockwise)

Preceding gene: 167038965

Following gene: 167038967

Centisome position: 12.91

GC content: 35.57

Gene sequence:

>1383_bases
TTGTGTAAAGCTGTAATGATTGCAGGTCCTCATTCAGGGGCAGGTAAAACTACTGTAAGCCTTGGGCTTATGGGAGTGCT
GTCAAAAAGGTATAAAGTTCAGCCTTTTAAAGTAGGTCCAGATTATATAGATGCTGCTTATCACCGATATGTCACAGGGA
ATTTTTCCTGCAATCTTGACTTATACATGTTGGGGGAACAAAACCTTAAATCGCTTTTTTACAAAAATGCCTGCAATGCT
GACATTTCTATAATTGAAGGTGTTATGGGAATGTACGATGGGATTGATACTACAAAAAAGGGAAGCAGTGCCCATATTGC
GAAAATTTTAGATATTCCTGTGATTTTAGTTGTAGATGCTTCTTCTATGGCGACAAGTGTATCAGCTTTAATAATGGGTT
ATATGCACTATGACAGGGAAGTAAAAATTAAAGGGGTGATATTAAATAAAGTTGGAAGTGAAAAACACTATGCCCTTTTG
AAAGAATGCATAACAAGAGATTTAGGTATTGAGGTTTTTGGCTATCTTCCAAAGGATCCAAAATTAGATTTGCCAGAAAG
ACACTTAGGCCTTGTGCCGATATATGAGATGCCAGAAATTAAACACAAGTTTGATACCTTATATGATTATATTGAAAAAT
ACATTGATATAGAAAAAATTCTTAATGTAGGTGTAATTGACTGTTCAAATACATTTAGAAACACGATTGCTGAGGGCCAT
GATTTAAAAAGGGTAAAAATAGGGTATGCGTTTGATGAGGCTTTTAACTTTTATTACAAAGAGAGTTTGGAACTTTTTGA
AGAAATAGGAGCAGAGCTTGTACCCTTTAGCCCTCTTAAGGATTATAAGCTGCCAGATGGAATATCGGGTTTGTACATAG
GGGGAGGATTTCCAGAGGTTTTTGCAGAAAAACTAAGTAAAAACAAAAAAATATTAAAATCGGTTAAAGATGCGATAGAT
TCTGGTATGCCTGCATATGCAGAGTGTGGCGGATTTATGTATCTTACAAAAAGCATAACAGATTTACAAGGAGATACTTT
TGAAATGGCAGGAATTTACGATTTTGAAACTGTCATGACTAAAAGGCTTCAGAGATTTGGCTATGTTGAAGCAGAAGTTA
TTGAAGATAACGCCCTTTTTAGAAAAGGGGATAAAATAAAAGGACATGAGTTTCACCACTCAATAATAAAAGGTTTTTCA
CAGAAAGCCTCATACGTTGTGTATAAACCGGGAAAAGAAGAGGCTTGGGAATGTGGATTTGTGCATAAAAATTGCCTGGC
GACGTATGTTCACATAAATTTGTACACATATAAAGAGGCTGTCAAGAGGTTTGTTGACAAATGTATTCAATACCGAAACT
CAAATGCTTTTCAGGAGGATTAA

Upstream 100 bases:

>100_bases
ATAAAATCAGCCTTTTCAATAGATGTGGAAGTGTTTGAAAATCCCATCACACATACTCCTTACGTCATTCCTTCATTAAA
TGGAAAGGAGCAACTCAAAG

Downstream 100 bases:

>100_bases
TATGGCACTTAAATTGATGATACAAGGGACTGCATCATCTGTTGGCAAAAGCTTGTTGGTTGCCGCTTTTTGCAGGATTT
TCAAGCAAGATGGTTACAGA

Product: cobyrinic acid a,c-diamide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MCKAVMIAGPHSGAGKTTVSLGLMGVLSKRYKVQPFKVGPDYIDAAYHRYVTGNFSCNLDLYMLGEQNLKSLFYKNACNA
DISIIEGVMGMYDGIDTTKKGSSAHIAKILDIPVILVVDASSMATSVSALIMGYMHYDREVKIKGVILNKVGSEKHYALL
KECITRDLGIEVFGYLPKDPKLDLPERHLGLVPIYEMPEIKHKFDTLYDYIEKYIDIEKILNVGVIDCSNTFRNTIAEGH
DLKRVKIGYAFDEAFNFYYKESLELFEEIGAELVPFSPLKDYKLPDGISGLYIGGGFPEVFAEKLSKNKKILKSVKDAID
SGMPAYAECGGFMYLTKSITDLQGDTFEMAGIYDFETVMTKRLQRFGYVEAEVIEDNALFRKGDKIKGHEFHHSIIKGFS
QKASYVVYKPGKEEAWECGFVHKNCLATYVHINLYTYKEAVKRFVDKCIQYRNSNAFQED

Sequences:

>Translated_460_residues
MCKAVMIAGPHSGAGKTTVSLGLMGVLSKRYKVQPFKVGPDYIDAAYHRYVTGNFSCNLDLYMLGEQNLKSLFYKNACNA
DISIIEGVMGMYDGIDTTKKGSSAHIAKILDIPVILVVDASSMATSVSALIMGYMHYDREVKIKGVILNKVGSEKHYALL
KECITRDLGIEVFGYLPKDPKLDLPERHLGLVPIYEMPEIKHKFDTLYDYIEKYIDIEKILNVGVIDCSNTFRNTIAEGH
DLKRVKIGYAFDEAFNFYYKESLELFEEIGAELVPFSPLKDYKLPDGISGLYIGGGFPEVFAEKLSKNKKILKSVKDAID
SGMPAYAECGGFMYLTKSITDLQGDTFEMAGIYDFETVMTKRLQRFGYVEAEVIEDNALFRKGDKIKGHEFHHSIIKGFS
QKASYVVYKPGKEEAWECGFVHKNCLATYVHINLYTYKEAVKRFVDKCIQYRNSNAFQED
>Mature_460_residues
MCKAVMIAGPHSGAGKTTVSLGLMGVLSKRYKVQPFKVGPDYIDAAYHRYVTGNFSCNLDLYMLGEQNLKSLFYKNACNA
DISIIEGVMGMYDGIDTTKKGSSAHIAKILDIPVILVVDASSMATSVSALIMGYMHYDREVKIKGVILNKVGSEKHYALL
KECITRDLGIEVFGYLPKDPKLDLPERHLGLVPIYEMPEIKHKFDTLYDYIEKYIDIEKILNVGVIDCSNTFRNTIAEGH
DLKRVKIGYAFDEAFNFYYKESLELFEEIGAELVPFSPLKDYKLPDGISGLYIGGGFPEVFAEKLSKNKKILKSVKDAID
SGMPAYAECGGFMYLTKSITDLQGDTFEMAGIYDFETVMTKRLQRFGYVEAEVIEDNALFRKGDKIKGHEFHHSIIKGFS
QKASYVVYKPGKEEAWECGFVHKNCLATYVHINLYTYKEAVKRFVDKCIQYRNSNAFQED

Specific function: Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1797

COG function: function code H; Cobyrinic acid a,c-diamide synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR004484
- InterPro:   IPR017929
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: NA

Molecular weight: Translated: 51895; Mature: 51895

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCKAVMIAGPHSGAGKTTVSLGLMGVLSKRYKVQPFKVGPDYIDAAYHRYVTGNFSCNLD
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHEEECCEEECEE
LYMLGEQNLKSLFYKNACNADISIIEGVMGMYDGIDTTKKGSSAHIAKILDIPVILVVDA
EEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEEECC
SSMATSVSALIMGYMHYDREVKIKGVILNKVGSEKHYALLKECITRDLGIEVFGYLPKDP
HHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCC
KLDLPERHLGLVPIYEMPEIKHKFDTLYDYIEKYIDIEKILNVGVIDCSNTFRNTIAEGH
CCCCCHHHCCCEECCCCCHHHHHHHHHHHHHHHHHCHHHHHCCCEEECCHHHHHHHHCCC
DLKRVKIGYAFDEAFNFYYKESLELFEEIGAELVPFSPLKDYKLPDGISGLYIGGGFPEV
CCEEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHH
FAEKLSKNKKILKSVKDAIDSGMPAYAECGGFMYLTKSITDLQGDTFEMAGIYDFETVMT
HHHHHHCCHHHHHHHHHHHHCCCCCHHHCCCEEEEEHHHHHCCCCCEEECCCCHHHHHHH
KRLQRFGYVEAEVIEDNALFRKGDKIKGHEFHHSIIKGFSQKASYVVYKPGKEEAWECGF
HHHHHCCCCEEEEECCCHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCC
VHKNCLATYVHINLYTYKEAVKRFVDKCIQYRNSNAFQED
HHHHHEEEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MCKAVMIAGPHSGAGKTTVSLGLMGVLSKRYKVQPFKVGPDYIDAAYHRYVTGNFSCNLD
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHEEECCEEECEE
LYMLGEQNLKSLFYKNACNADISIIEGVMGMYDGIDTTKKGSSAHIAKILDIPVILVVDA
EEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEEECC
SSMATSVSALIMGYMHYDREVKIKGVILNKVGSEKHYALLKECITRDLGIEVFGYLPKDP
HHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCC
KLDLPERHLGLVPIYEMPEIKHKFDTLYDYIEKYIDIEKILNVGVIDCSNTFRNTIAEGH
CCCCCHHHCCCEECCCCCHHHHHHHHHHHHHHHHHCHHHHHCCCEEECCHHHHHHHHCCC
DLKRVKIGYAFDEAFNFYYKESLELFEEIGAELVPFSPLKDYKLPDGISGLYIGGGFPEV
CCEEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHH
FAEKLSKNKKILKSVKDAIDSGMPAYAECGGFMYLTKSITDLQGDTFEMAGIYDFETVMT
HHHHHHCCHHHHHHHHHHHHCCCCCHHHCCCEEEEEHHHHHCCCCCEEECCCCHHHHHHH
KRLQRFGYVEAEVIEDNALFRKGDKIKGHEFHHSIIKGFSQKASYVVYKPGKEEAWECGF
HHHHHCCCCEEEEECCCHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCC
VHKNCLATYVHINLYTYKEAVKRFVDKCIQYRNSNAFQED
HHHHHEEEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]