Click here to switch to the map view.

The map label for this gene is cobQ [H]

Identifier: 167038967

GI number: 167038967

Start: 318658

End: 320181

Strand: Direct

Name: cobQ [H]

Synonym: Teth514_0300

Alternate gene names: 167038967

Gene position: 318658-320181 (Clockwise)

Preceding gene: 167038966

Following gene: 167038968

Centisome position: 12.97

GC content: 35.7

Gene sequence:

>1524_bases
ATGGCACTTAAATTGATGATACAAGGGACTGCATCATCTGTTGGCAAAAGCTTGTTGGTTGCCGCTTTTTGCAGGATTTT
CAAGCAAGATGGTTACAGAGTAGCCCCTTTTAAGTCTCAAAACATGGCTTTAAATTCCTATATAACCGATGAAGGATTAG
AAATAGGAAGAGCACAAGCTATGCAGGCGGAAGCGGCAGGAGTTAAGCCTTCTTATCACATGAATCCAATACTTCTAAAG
CCCAGTTCTGATAAAAAAAGCCAAGTTGTTTTAAGAGGCAAAGTTTATAAAAACATGTCTGCAGCCGAATACCACCAATT
TAAACCCCAGCTTTTAAAGTTTATTAAAGAGGACTTTGATTTTCTTGCAAGTCAAAATGACATTGTAGTAATAGAAGGTG
CTGGAAGCCCTGCAGAAATAAATTTAAGAGATAGAGATGTCGTAAACATGGGTATGGCAGAGATGGTAAATGCACCAGTA
CTTCTTGTAGGAGATATTGATAAAGGAGGTGTATTTGCTTCAATAGCTGGCACTTTGCTCCTTTTAAAAGAAAATGAGAG
AAATCGCATTGAAGGTGTACTTATAAATAAGTTTAGAGGAGACATTGAAATATTAAAGCCAGGTTTGGAGATGTTAGAAA
ACATTGTACACAAAAAGGTTTTAGGTGTTGTCCCTTATATGGATGTGCACATTGATGAAGAGGATGGGGCGACGGAGAGA
TTTTATCGCAGGAGTACAGAAGGAGATATAGAGATTGCAGTTATAAATCTTCCCCACATATCGAATTTTACGGATTTTGA
ACCTCTTGCTAAAGTTCCCGGAGTAAAGCTTCGCTATGTGAATAAAGGGGAAAGGATTGGAGATTGTGATGTTGTTATAA
TTCCGGGAACAAAAAACACAATTGGAGATTTGCAAGCATTAAAAGGATATAGGCTTGATAAGGAAATTTTTGAAATGAGA
AAAAAAGGGAAATTTATAGTCGGCATTTGTGGAGGATACCAAATACTGGGAAAAGTCATTAAAGACCCAGGAAGAATTGA
AAGTACAACTTCAGAAATTGAGGGACTGGGACTTTTGGATGTAGAGACTGTAATTGAAAATGAAAAGACAACAACCCAAA
TTAAGGCGGTTATTCGCAATAATTTACCATCAATATTATCACCTCTTAGAAATATTGCTGTAGAGGGATATGAAATACAC
ATGGGGAAAAGTCGAATTTTGGGAGATTGTCAGCCTTTTTCAGTAATAACTCATAGAAATGGAGAAAAAATCGAAGTCTA
TGACGGTTGTATAAGCGATGATGGAAAAGTGTTTGGAACTTACATACACGGAATTTTTGAAAATAGAGAGTTTGTCAGGG
AATTTATAAATATTGTGAGAAAATCAAAAGGACTTTCTCCTATAGAGGAAATTATTGATTACAAAGAATTTAAAGAAAGA
GAATATGATAAGCTTGCAGATATTGTGAGAAAAAGTATCGACATGAAAAAAGTCTATGAAATTATGGAGAGGTATAAAGA
TTAA

Upstream 100 bases:

>100_bases
TATGTTCACATAAATTTGTACACATATAAAGAGGCTGTCAAGAGGTTTGTTGACAAATGTATTCAATACCGAAACTCAAA
TGCTTTTCAGGAGGATTAAT

Downstream 100 bases:

>100_bases
TGGAAGTGGTATTAGCCTACTTATTAGATTTGTTGATAGGAGACCCTGAAGGATATCCTCATCCTGTAAGAATTATAGGG
AGAGTGGTATCACATTTAGA

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MALKLMIQGTASSVGKSLLVAAFCRIFKQDGYRVAPFKSQNMALNSYITDEGLEIGRAQAMQAEAAGVKPSYHMNPILLK
PSSDKKSQVVLRGKVYKNMSAAEYHQFKPQLLKFIKEDFDFLASQNDIVVIEGAGSPAEINLRDRDVVNMGMAEMVNAPV
LLVGDIDKGGVFASIAGTLLLLKENERNRIEGVLINKFRGDIEILKPGLEMLENIVHKKVLGVVPYMDVHIDEEDGATER
FYRRSTEGDIEIAVINLPHISNFTDFEPLAKVPGVKLRYVNKGERIGDCDVVIIPGTKNTIGDLQALKGYRLDKEIFEMR
KKGKFIVGICGGYQILGKVIKDPGRIESTTSEIEGLGLLDVETVIENEKTTTQIKAVIRNNLPSILSPLRNIAVEGYEIH
MGKSRILGDCQPFSVITHRNGEKIEVYDGCISDDGKVFGTYIHGIFENREFVREFINIVRKSKGLSPIEEIIDYKEFKER
EYDKLADIVRKSIDMKKVYEIMERYKD

Sequences:

>Translated_507_residues
MALKLMIQGTASSVGKSLLVAAFCRIFKQDGYRVAPFKSQNMALNSYITDEGLEIGRAQAMQAEAAGVKPSYHMNPILLK
PSSDKKSQVVLRGKVYKNMSAAEYHQFKPQLLKFIKEDFDFLASQNDIVVIEGAGSPAEINLRDRDVVNMGMAEMVNAPV
LLVGDIDKGGVFASIAGTLLLLKENERNRIEGVLINKFRGDIEILKPGLEMLENIVHKKVLGVVPYMDVHIDEEDGATER
FYRRSTEGDIEIAVINLPHISNFTDFEPLAKVPGVKLRYVNKGERIGDCDVVIIPGTKNTIGDLQALKGYRLDKEIFEMR
KKGKFIVGICGGYQILGKVIKDPGRIESTTSEIEGLGLLDVETVIENEKTTTQIKAVIRNNLPSILSPLRNIAVEGYEIH
MGKSRILGDCQPFSVITHRNGEKIEVYDGCISDDGKVFGTYIHGIFENREFVREFINIVRKSKGLSPIEEIIDYKEFKER
EYDKLADIVRKSIDMKKVYEIMERYKD
>Mature_506_residues
ALKLMIQGTASSVGKSLLVAAFCRIFKQDGYRVAPFKSQNMALNSYITDEGLEIGRAQAMQAEAAGVKPSYHMNPILLKP
SSDKKSQVVLRGKVYKNMSAAEYHQFKPQLLKFIKEDFDFLASQNDIVVIEGAGSPAEINLRDRDVVNMGMAEMVNAPVL
LVGDIDKGGVFASIAGTLLLLKENERNRIEGVLINKFRGDIEILKPGLEMLENIVHKKVLGVVPYMDVHIDEEDGATERF
YRRSTEGDIEIAVINLPHISNFTDFEPLAKVPGVKLRYVNKGERIGDCDVVIIPGTKNTIGDLQALKGYRLDKEIFEMRK
KGKFIVGICGGYQILGKVIKDPGRIESTTSEIEGLGLLDVETVIENEKTTTQIKAVIRNNLPSILSPLRNIAVEGYEIHM
GKSRILGDCQPFSVITHRNGEKIEVYDGCISDDGKVFGTYIHGIFENREFVREFINIVRKSKGLSPIEEIIDYKEFKERE
YDKLADIVRKSIDMKKVYEIMERYKD

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 56875; Mature: 56744

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKLMIQGTASSVGKSLLVAAFCRIFKQDGYRVAPFKSQNMALNSYITDEGLEIGRAQA
CEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCEEEEEEECCCCCHHCHHHH
MQAEAAGVKPSYHMNPILLKPSSDKKSQVVLRGKVYKNMSAAEYHQFKPQLLKFIKEDFD
HHHHHCCCCCCCCCCEEEECCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHH
FLASQNDIVVIEGAGSPAEINLRDRDVVNMGMAEMVNAPVLLVGDIDKGGVFASIAGTLL
HHCCCCCEEEEECCCCCCEEEECCCHHHHCCHHHHCCCCEEEEECCCCCCEEHEECCEEE
LLKENERNRIEGVLINKFRGDIEILKPGLEMLENIVHKKVLGVVPYMDVHIDEEDGATER
EEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHH
FYRRSTEGDIEIAVINLPHISNFTDFEPLAKVPGVKLRYVNKGERIGDCDVVIIPGTKNT
HHHCCCCCCEEEEEEECCCCCCCCCCCHHHHCCCCEEEEECCCCCCCCCCEEEECCCCCC
IGDLQALKGYRLDKEIFEMRKKGKFIVGICGGYQILGKVIKDPGRIESTTSEIEGLGLLD
HHHHHHHCCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCCCHHHHCCCCEEE
VETVIENEKTTTQIKAVIRNNLPSILSPLRNIAVEGYEIHMGKSRILGDCQPFSVITHRN
HHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCHHHCCCCCCEEEEEECC
GEKIEVYDGCISDDGKVFGTYIHGIFENREFVREFINIVRKSKGLSPIEEIIDYKEFKER
CCEEEEEECCCCCCCCEEHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
EYDKLADIVRKSIDMKKVYEIMERYKD
HHHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure 
ALKLMIQGTASSVGKSLLVAAFCRIFKQDGYRVAPFKSQNMALNSYITDEGLEIGRAQA
EEEEEEECCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCEEEEEEECCCCCHHCHHHH
MQAEAAGVKPSYHMNPILLKPSSDKKSQVVLRGKVYKNMSAAEYHQFKPQLLKFIKEDFD
HHHHHCCCCCCCCCCEEEECCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHH
FLASQNDIVVIEGAGSPAEINLRDRDVVNMGMAEMVNAPVLLVGDIDKGGVFASIAGTLL
HHCCCCCEEEEECCCCCCEEEECCCHHHHCCHHHHCCCCEEEEECCCCCCEEHEECCEEE
LLKENERNRIEGVLINKFRGDIEILKPGLEMLENIVHKKVLGVVPYMDVHIDEEDGATER
EEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHH
FYRRSTEGDIEIAVINLPHISNFTDFEPLAKVPGVKLRYVNKGERIGDCDVVIIPGTKNT
HHHCCCCCCEEEEEEECCCCCCCCCCCHHHHCCCCEEEEECCCCCCCCCCEEEECCCCCC
IGDLQALKGYRLDKEIFEMRKKGKFIVGICGGYQILGKVIKDPGRIESTTSEIEGLGLLD
HHHHHHHCCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCCCHHHHCCCCEEE
VETVIENEKTTTQIKAVIRNNLPSILSPLRNIAVEGYEIHMGKSRILGDCQPFSVITHRN
HHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCHHHCCCCCCEEEEEECC
GEKIEVYDGCISDDGKVFGTYIHGIFENREFVREFINIVRKSKGLSPIEEIIDYKEFKER
CCEEEEEECCCCCCCCEEHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
EYDKLADIVRKSIDMKKVYEIMERYKD
HHHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA