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The map label for this gene is mtlD [H]

Identifier: 167038939

GI number: 167038939

Start: 287922

End: 289088

Strand: Direct

Name: mtlD [H]

Synonym: Teth514_0271

Alternate gene names: 167038939

Gene position: 287922-289088 (Clockwise)

Preceding gene: 167038938

Following gene: 167038940

Centisome position: 11.72

GC content: 30.33

Gene sequence:

>1167_bases
ATGTTAAAAGCGGTTCATTTTGGAGCAGGGAATATAGGCAGAGGATTTATAGGGTATTTGCTTTATAAATCTGGATATGA
AATAACTTTTGTTGATATATCAAAAGAATTAGTAGAAAGCATAAATAATTATAAAAGATATAATGTGATTATTTTAAAAG
ATAATGTGGAAAAAGAAGAAGTAAAAAATATCAAAGCTATTCATATCGAGGATGAAGAAAATCTATCCAAGGCTATTGTA
GATGCAGATATAGTTACGACTTCAGTAGGAGCTAATAATCTTAAGAGCATAGGGGAAAAGTTGATAAATTATTTAAAGAT
AAGAAAAGCTAACATTGATAAACCTTTGAATATAATGGCATGTGAAAATGCACTGTTTGCAACAAATATACTAAAAAATA
GTATATTGGAAAAAGGTGATAGAGATTTTATTGAGTACGTAAATCAAAAAATTGGTTTTCCTAATACGGCTGTGGACAGA
ATAGTACCGAATGTAGATATAAAGAAAGAACTGCCAATAGATGTAGCAGTGGAAGATTTTTATGAATGGGATATTGAGAA
AAAAGCAATTATTGGGGATTTAAATATCAGAGGGGCGGAACTTGTCGATGACCTTGAACCTTATATAGAAAGAAAATTAT
TTTTATTAAATGGAGCCCATGCTACCACTGCATATTTAGGATATTTAAAAGGGTATAAATATATACATGAAGCGATTGAG
GACGATTTTATAAGAAATATAGTGTCTAGGATGCAAGAAGAAGCTTCTCTTGCGCTTTCTAGAAAGCACAATATAAAAAA
AGATGATTTAGAGAGGTATGCAAGTAAGGTAATAAAAAGGTTTAAAAACCCCTATTTAAAAGACGAAGTTGTAAGAGTAG
GAAGAGAGCCTACAAGGAAATTGTCTGTAAATGACCGGTTAATGATGCCTGCCAAACTTTGTTATGAAATTGGAATTACG
CCTGAATTTATACTATATGGTATAGCTGCAGGGTTTTTGTTTGATTATAAGGAAGACCCTCAAGCTTGTAAAATTCAAGA
TGACATTAAAAATTTCGGCTTAGAAAAAACAATAAGCAAAGTTACAGGTTTAGAAGAAAATAGTGATTTATTGCAAGAAA
TTGTAAAGAAGTATAAAGAATTGAAAGAAACTTTTAGAAAAAGATGA

Upstream 100 bases:

>100_bases
ATAGCTCTTACCTGCCAGTATGAAGAAAATGTCGAGAAATTGAAAAAGGCAAGGACAAAACAAGAAATAATAGAAATACT
TCAAAAAGGTGATGAATAAT

Downstream 100 bases:

>100_bases
TATAGATTGAATTCTATATCATCTTTTTTTTAATGGAAGATTATTATAATAAATTTAAAAATGTTTACAATACTAAGTAA
ACGTATAAAAGAAAAAGCAA

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MLKAVHFGAGNIGRGFIGYLLYKSGYEITFVDISKELVESINNYKRYNVIILKDNVEKEEVKNIKAIHIEDEENLSKAIV
DADIVTTSVGANNLKSIGEKLINYLKIRKANIDKPLNIMACENALFATNILKNSILEKGDRDFIEYVNQKIGFPNTAVDR
IVPNVDIKKELPIDVAVEDFYEWDIEKKAIIGDLNIRGAELVDDLEPYIERKLFLLNGAHATTAYLGYLKGYKYIHEAIE
DDFIRNIVSRMQEEASLALSRKHNIKKDDLERYASKVIKRFKNPYLKDEVVRVGREPTRKLSVNDRLMMPAKLCYEIGIT
PEFILYGIAAGFLFDYKEDPQACKIQDDIKNFGLEKTISKVTGLEENSDLLQEIVKKYKELKETFRKR

Sequences:

>Translated_388_residues
MLKAVHFGAGNIGRGFIGYLLYKSGYEITFVDISKELVESINNYKRYNVIILKDNVEKEEVKNIKAIHIEDEENLSKAIV
DADIVTTSVGANNLKSIGEKLINYLKIRKANIDKPLNIMACENALFATNILKNSILEKGDRDFIEYVNQKIGFPNTAVDR
IVPNVDIKKELPIDVAVEDFYEWDIEKKAIIGDLNIRGAELVDDLEPYIERKLFLLNGAHATTAYLGYLKGYKYIHEAIE
DDFIRNIVSRMQEEASLALSRKHNIKKDDLERYASKVIKRFKNPYLKDEVVRVGREPTRKLSVNDRLMMPAKLCYEIGIT
PEFILYGIAAGFLFDYKEDPQACKIQDDIKNFGLEKTISKVTGLEENSDLLQEIVKKYKELKETFRKR
>Mature_388_residues
MLKAVHFGAGNIGRGFIGYLLYKSGYEITFVDISKELVESINNYKRYNVIILKDNVEKEEVKNIKAIHIEDEENLSKAIV
DADIVTTSVGANNLKSIGEKLINYLKIRKANIDKPLNIMACENALFATNILKNSILEKGDRDFIEYVNQKIGFPNTAVDR
IVPNVDIKKELPIDVAVEDFYEWDIEKKAIIGDLNIRGAELVDDLEPYIERKLFLLNGAHATTAYLGYLKGYKYIHEAIE
DDFIRNIVSRMQEEASLALSRKHNIKKDDLERYASKVIKRFKNPYLKDEVVRVGREPTRKLSVNDRLMMPAKLCYEIGIT
PEFILYGIAAGFLFDYKEDPQACKIQDDIKNFGLEKTISKVTGLEENSDLLQEIVKKYKELKETFRKR

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790028, Length=383, Percent_Identity=38.3812010443864, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI1788497, Length=316, Percent_Identity=27.2151898734177, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1790779, Length=317, Percent_Identity=26.813880126183, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787823, Length=218, Percent_Identity=32.1100917431193, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI48994885, Length=261, Percent_Identity=28.3524904214559, Blast_Score=75, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324401, Length=197, Percent_Identity=31.9796954314721, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6320765, Length=197, Percent_Identity=31.9796954314721, Blast_Score=102, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.17 [H]

Molecular weight: Translated: 44547; Mature: 44547

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKAVHFGAGNIGRGFIGYLLYKSGYEITFVDISKELVESINNYKRYNVIILKDNVEKEE
CCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCEEEEEEEECCCCHHH
VKNIKAIHIEDEENLSKAIVDADIVTTSVGANNLKSIGEKLINYLKIRKANIDKPLNIMA
HCCEEEEEECCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
CENALFATNILKNSILEKGDRDFIEYVNQKIGFPNTAVDRIVPNVDIKKELPIDVAVEDF
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCHHHHHHH
YEWDIEKKAIIGDLNIRGAELVDDLEPYIERKLFLLNGAHATTAYLGYLKGYKYIHEAIE
HHHCCCCHHEEECCCCCHHHHHHHHHHHHHHEEHEEECCHHHHHHHHHHHHHHHHHHHHH
DDFIRNIVSRMQEEASLALSRKHNIKKDDLERYASKVIKRFKNPYLKDEVVRVGREPTRK
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCE
LSVNDRLMMPAKLCYEIGITPEFILYGIAAGFLFDYKEDPQACKIQDDIKNFGLEKTISK
ECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHH
VTGLEENSDLLQEIVKKYKELKETFRKR
HHCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLKAVHFGAGNIGRGFIGYLLYKSGYEITFVDISKELVESINNYKRYNVIILKDNVEKEE
CCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCEEEEEEEECCCCHHH
VKNIKAIHIEDEENLSKAIVDADIVTTSVGANNLKSIGEKLINYLKIRKANIDKPLNIMA
HCCEEEEEECCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
CENALFATNILKNSILEKGDRDFIEYVNQKIGFPNTAVDRIVPNVDIKKELPIDVAVEDF
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCHHHHHHH
YEWDIEKKAIIGDLNIRGAELVDDLEPYIERKLFLLNGAHATTAYLGYLKGYKYIHEAIE
HHHCCCCHHEEECCCCCHHHHHHHHHHHHHHEEHEEECCHHHHHHHHHHHHHHHHHHHHH
DDFIRNIVSRMQEEASLALSRKHNIKKDDLERYASKVIKRFKNPYLKDEVVRVGREPTRK
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCE
LSVNDRLMMPAKLCYEIGITPEFILYGIAAGFLFDYKEDPQACKIQDDIKNFGLEKTISK
ECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHH
VTGLEENSDLLQEIVKKYKELKETFRKR
HHCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA