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The map label for this gene is ilvD [H]

Identifier: 162149608

GI number: 162149608

Start: 3926972

End: 3928846

Strand: Direct

Name: ilvD [H]

Synonym: GDI_3847

Alternate gene names: 162149608

Gene position: 3926972-3928846 (Clockwise)

Preceding gene: 162149607

Following gene: 162149610

Centisome position: 99.56

GC content: 69.81

Gene sequence:

>1875_bases
TTGTCCGGAAAGGCACCAGAAATGCCCGCCTATCGTTCCCGCACCACCACCCATGGCCGCAACATGGCCGGCGCCCGCAG
CCTGTGGCGTGCCACGGGCATGCAGGAGTCCGATTTCGGCAAGCCGATCATCGCCGTCGCCAATTCCTTCACCCAGTTCG
TGCCCGGGCACGTGCATCTGAAGGACCTGGGTCAGCTCGTGGCCGGGGCGGTGGCCGAGGCGGGCGGAATCGCGCGGGAA
TTCAACACGATCGCGGTCGATGACGGCATCGCCATGGGCCATGGCGGCATGCTGTACAGCCTGCCGTCGCGCGAGCTGAT
CGCCGATGCGGTGGAATACATGGTCAACGCGCACTGCGCCGACGCGCTGGTGTGCATCAGCAATTGCGACAAGATCACCC
CCGGCATGCTGATGGCCGCGATGCGGCTGAACATCCCCACCATCTTCGTGTCCGGCGGCCCGATGGAGGCCGGACGGGTG
ATCCAGGACGGGGTGGAACGCCATGTGGACCTGGTGACGTCGATGGTCTCGGCCGCCGATCCGCGTGTCAGCGATGCCGA
GTCGGAGTCGATCGAACGTTCGGCCTGCCCGACCTGCGGATCGTGCTCGGGCATGTTCACCGCCAATTCCATGAACTGCC
TGACCGAGGCGCTGGGCCTGGCGCTGCCGGGCAATGGCAGCCTGGTCGCCACCCATGCCGACCGGCGCGAATTGTTCCTG
GAGGCCGGGCGGCGCATCGTCGGCCTGGCGCGGCGGTGGTACGAGCATGACGATGCCGGCGTGCTGCCGCGCGGGATCGC
GACGGCGCGGGCGTTCGAGAACGCGATGACGGTCGATATCGCCATGGGCGGGTCGACCAACACGGTGCTGCACCTGCTGG
CGGCGGCGCATGAGGGCGAGGTGCCCTTCACCATGGCCGATATCGACCGGCTGTCGCGCCGGGTGCCGCATCTGTGCAAG
GTCGCGCCGTCCAAGGCCGACGTGCATATGGAAGACGTGCATCGCGCCGGCGGCATCTTCGCCATCCTGGGCGAACTGGA
CCGGCTGGGCCTGCTGGATCGCGAGGTGTCGATGGTCCATGCGCCGTCGCTGGCCCAGGCGCTGGAACGTTGGGACGTGT
CGGCCCCAGGCGCGTCCGAGGCCGCGACGACCCTGTTCCGCGCCGCGCCGGGCGGCTTGCGGACCACGCAGGCGTTCTCG
CAGGCCAGCCGGTATCACGCGCTGGACCTGGACCGCGCGGCGGGGGCGATCCGCGACGGGGCGCATGCCTTCAGCCAGGA
TGGCGGGCTGGCGGTGCTGTACGGCAACATCGCCGAGGACGGGGCGATCGTGAAGACGGCGGGCGTCGCGGCCGGGCTGC
TGACCTTCACCGGGCCGGCGCGCATCTTCGAAAGCCAGGACGCGGCGGTGTCGGCCATCCTGGGCAACCGGATCGTGGCG
GGCGATGTCGTCGTCATCCGCTACGAGGGGCCGAAGGGCGGTCCGGGCATGCAGGAAATGCTGTACCCGACCAGCTACCT
GAAATCGAAGGGGCTGGCCGAACGCTGCGCCCTGATCACCGACGGGCGTTTCTCGGGCGGCAGCGCCGGGCTGTCGATCG
GCCATATCTCGCCCGAGGCCGCCGAGGGCGGGGCGATCGGCCTGCTGCGCGACGGCGACATCATCGAGATCGACATTCCC
AACCGCATCCTGCGTACCGCCGTGCCGGACGCGGAACTGGCCGCGCGGCGCCTGCGGATGGAGGAAGCCGGCGAGGACGC
CTGGCGGCCCGACCGCGACCGGACGGTGTCCGTCGCGTTGCAGGCCTATGCCGCGCTGACCACCAGCGCGGCGCGGGGCG
CCGTGCGCGACATCACGCAGATCAAGCGGCGCTGA

Upstream 100 bases:

>100_bases
CCGCTGACCGCGTCCTGACCCGCCGGGCCGGACAGTCGGTGCTTCACGGAAGGCCATTCCGTCCCATATAAGGGGCGCCC
ACCCGAACCGAAGCGCCTGA

Downstream 100 bases:

>100_bases
ACCTGCCCGCACAGGCGCGCCGGCGGCGGTCCGGCGCGCCTTTCGATGGTATTGTGCCCGTTTTGTGTTACGTTGCGCAA
TAATTCGTCGAACAATGGTG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MSGKAPEMPAYRSRTTTHGRNMAGARSLWRATGMQESDFGKPIIAVANSFTQFVPGHVHLKDLGQLVAGAVAEAGGIARE
FNTIAVDDGIAMGHGGMLYSLPSRELIADAVEYMVNAHCADALVCISNCDKITPGMLMAAMRLNIPTIFVSGGPMEAGRV
IQDGVERHVDLVTSMVSAADPRVSDAESESIERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSLVATHADRRELFL
EAGRRIVGLARRWYEHDDAGVLPRGIATARAFENAMTVDIAMGGSTNTVLHLLAAAHEGEVPFTMADIDRLSRRVPHLCK
VAPSKADVHMEDVHRAGGIFAILGELDRLGLLDREVSMVHAPSLAQALERWDVSAPGASEAATTLFRAAPGGLRTTQAFS
QASRYHALDLDRAAGAIRDGAHAFSQDGGLAVLYGNIAEDGAIVKTAGVAAGLLTFTGPARIFESQDAAVSAILGNRIVA
GDVVVIRYEGPKGGPGMQEMLYPTSYLKSKGLAERCALITDGRFSGGSAGLSIGHISPEAAEGGAIGLLRDGDIIEIDIP
NRILRTAVPDAELAARRLRMEEAGEDAWRPDRDRTVSVALQAYAALTTSAARGAVRDITQIKRR

Sequences:

>Translated_624_residues
MSGKAPEMPAYRSRTTTHGRNMAGARSLWRATGMQESDFGKPIIAVANSFTQFVPGHVHLKDLGQLVAGAVAEAGGIARE
FNTIAVDDGIAMGHGGMLYSLPSRELIADAVEYMVNAHCADALVCISNCDKITPGMLMAAMRLNIPTIFVSGGPMEAGRV
IQDGVERHVDLVTSMVSAADPRVSDAESESIERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSLVATHADRRELFL
EAGRRIVGLARRWYEHDDAGVLPRGIATARAFENAMTVDIAMGGSTNTVLHLLAAAHEGEVPFTMADIDRLSRRVPHLCK
VAPSKADVHMEDVHRAGGIFAILGELDRLGLLDREVSMVHAPSLAQALERWDVSAPGASEAATTLFRAAPGGLRTTQAFS
QASRYHALDLDRAAGAIRDGAHAFSQDGGLAVLYGNIAEDGAIVKTAGVAAGLLTFTGPARIFESQDAAVSAILGNRIVA
GDVVVIRYEGPKGGPGMQEMLYPTSYLKSKGLAERCALITDGRFSGGSAGLSIGHISPEAAEGGAIGLLRDGDIIEIDIP
NRILRTAVPDAELAARRLRMEEAGEDAWRPDRDRTVSVALQAYAALTTSAARGAVRDITQIKRR
>Mature_623_residues
SGKAPEMPAYRSRTTTHGRNMAGARSLWRATGMQESDFGKPIIAVANSFTQFVPGHVHLKDLGQLVAGAVAEAGGIAREF
NTIAVDDGIAMGHGGMLYSLPSRELIADAVEYMVNAHCADALVCISNCDKITPGMLMAAMRLNIPTIFVSGGPMEAGRVI
QDGVERHVDLVTSMVSAADPRVSDAESESIERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSLVATHADRRELFLE
AGRRIVGLARRWYEHDDAGVLPRGIATARAFENAMTVDIAMGGSTNTVLHLLAAAHEGEVPFTMADIDRLSRRVPHLCKV
APSKADVHMEDVHRAGGIFAILGELDRLGLLDREVSMVHAPSLAQALERWDVSAPGASEAATTLFRAAPGGLRTTQAFSQ
ASRYHALDLDRAAGAIRDGAHAFSQDGGLAVLYGNIAEDGAIVKTAGVAAGLLTFTGPARIFESQDAAVSAILGNRIVAG
DVVVIRYEGPKGGPGMQEMLYPTSYLKSKGLAERCALITDGRFSGGSAGLSIGHISPEAAEGGAIGLLRDGDIIEIDIPN
RILRTAVPDAELAARRLRMEEAGEDAWRPDRDRTVSVALQAYAALTTSAARGAVRDITQIKRR

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=615, Percent_Identity=71.0569105691057, Blast_Score=912, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=503, Percent_Identity=31.8091451292247, Blast_Score=188, Evalue=7e-49,
Organism=Escherichia coli, GI1786464, Length=549, Percent_Identity=31.6939890710383, Blast_Score=182, Evalue=7e-47,
Organism=Escherichia coli, GI1788157, Length=552, Percent_Identity=29.5289855072464, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6322476, Length=612, Percent_Identity=36.437908496732, Blast_Score=340, Evalue=3e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65825; Mature: 65694

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGKAPEMPAYRSRTTTHGRNMAGARSLWRATGMQESDFGKPIIAVANSFTQFVPGHVHL
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEH
KDLGQLVAGAVAEAGGIAREFNTIAVDDGIAMGHGGMLYSLPSRELIADAVEYMVNAHCA
HHHHHHHHHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHH
DALVCISNCDKITPGMLMAAMRLNIPTIFVSGGPMEAGRVIQDGVERHVDLVTSMVSAAD
HHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCC
PRVSDAESESIERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSLVATHADRRELFL
CCCCCCCHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCCEEEECCHHHHHHH
EAGRRIVGLARRWYEHDDAGVLPRGIATARAFENAMTVDIAMGGSTNTVLHLLAAAHEGE
HHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCC
VPFTMADIDRLSRRVPHLCKVAPSKADVHMEDVHRAGGIFAILGELDRLGLLDREVSMVH
CCEEHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHCCCCEEEEHHHHHCCCCHHHHHHHC
APSLAQALERWDVSAPGASEAATTLFRAAPGGLRTTQAFSQASRYHALDLDRAAGAIRDG
CCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHC
AHAFSQDGGLAVLYGNIAEDGAIVKTAGVAAGLLTFTGPARIFESQDAAVSAILGNRIVA
HHHHCCCCCEEEEECCCCCCCCEEEEHHHHHHHHHCCCHHHHHCCCHHHHHHHHCCEEEE
GDVVVIRYEGPKGGPGMQEMLYPTSYLKSKGLAERCALITDGRFSGGSAGLSIGHISPEA
CCEEEEEECCCCCCCCHHHHHCCHHHHHHCCHHHHHHEEECCCCCCCCCCEEEECCCCCC
AEGGAIGLLRDGDIIEIDIPNRILRTAVPDAELAARRLRMEEAGEDAWRPDRDRTVSVAL
CCCCEEEEEECCCEEEEECCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
QAYAALTTSAARGAVRDITQIKRR
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGKAPEMPAYRSRTTTHGRNMAGARSLWRATGMQESDFGKPIIAVANSFTQFVPGHVHL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEH
KDLGQLVAGAVAEAGGIAREFNTIAVDDGIAMGHGGMLYSLPSRELIADAVEYMVNAHCA
HHHHHHHHHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHH
DALVCISNCDKITPGMLMAAMRLNIPTIFVSGGPMEAGRVIQDGVERHVDLVTSMVSAAD
HHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCC
PRVSDAESESIERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSLVATHADRRELFL
CCCCCCCHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCCEEEECCHHHHHHH
EAGRRIVGLARRWYEHDDAGVLPRGIATARAFENAMTVDIAMGGSTNTVLHLLAAAHEGE
HHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCC
VPFTMADIDRLSRRVPHLCKVAPSKADVHMEDVHRAGGIFAILGELDRLGLLDREVSMVH
CCEEHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHCCCCEEEEHHHHHCCCCHHHHHHHC
APSLAQALERWDVSAPGASEAATTLFRAAPGGLRTTQAFSQASRYHALDLDRAAGAIRDG
CCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHC
AHAFSQDGGLAVLYGNIAEDGAIVKTAGVAAGLLTFTGPARIFESQDAAVSAILGNRIVA
HHHHCCCCCEEEEECCCCCCCCEEEEHHHHHHHHHCCCHHHHHCCCHHHHHHHHCCEEEE
GDVVVIRYEGPKGGPGMQEMLYPTSYLKSKGLAERCALITDGRFSGGSAGLSIGHISPEA
CCEEEEEECCCCCCCCHHHHHCCHHHHHHCCHHHHHHEEECCCCCCCCCCEEEECCCCCC
AEGGAIGLLRDGDIIEIDIPNRILRTAVPDAELAARRLRMEEAGEDAWRPDRDRTVSVAL
CCCCEEEEEECCCEEEEECCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
QAYAALTTSAARGAVRDITQIKRR
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA