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The map label for this gene is dctA2 [H]

Identifier: 162149607

GI number: 162149607

Start: 3925522

End: 3926889

Strand: Direct

Name: dctA2 [H]

Synonym: GDI_3846

Alternate gene names: 162149607

Gene position: 3925522-3926889 (Clockwise)

Preceding gene: 162149606

Following gene: 162149608

Centisome position: 99.53

GC content: 71.35

Gene sequence:

>1368_bases
GTGATCGCCGGATCGCCTCTTGGTCGTGGCGGGTACGTATCGTATGCGGTGGGCATGACGAAGGCGCCGCTTTATCAATC
GCTGTTCCTCCAGATCGTCGTCGCGACGGCGGGCGGGGTCGCGATCGGGCTGCTGGACCCGGCGCTGGGCATGGCGCTAC
GGCCGCTGAGCGACCTGTTCCTGCGGCTGATCGCCATGATCGTCTCGCCGCTGGTGTTCTGCGTCGTGGTGCAGGGCATT
GCCGGCGCGGGCAGCCTGCGCACGGTCGGGCGGGTCGGGATCAAGGCGCTAATCTATTTCGAGGCGATGACAACGCTGGC
CCTGAGCTTCGGCCTGCTGGCGGCGGGCCTGGCCGGGCCGGGTCGGGGCATGCATGTGCCCCTGGCCGGGCGGGCCGTGA
CGGACGGCGCCGTGGCGCTGGGGTCGGTCGGCGGGTCGGCGGCGGCGCTGCGCCAGGGCGGGATCGGCGCCTTCCTGCTG
AACATCGTCCCCACCAGCCCGGTGCGGGCCTTCGCCGGCAATGACGTGCTGCAGATCCTGTTCTTTGCGATCCTGTTCGG
CTGCGCCCTGACGCAGGTCGGGCCCGCCGGGCAGCCGGTGGCGCGGGTCATCGACGGGCTGACGGCGGTGATGTTCCGCA
TCATGGGGATCGTCACCTGGGTGGCACCGGTGGGCGTGCTGGGGGCAGTGGCCTGGACGGTGGGGCATTACGGCGCGGCC
GCGCTGGGGCAGCTTGGGCTGCTGGTGGTGCTGTATGTGGGCACCGTCGCGGCGTTCGTCACGCTGGCGCTGGGGCTGGT
GATGCGGCGCTGCGGGGTCGGGCTGTGGCGGCTGCTGGTCTATCTGCGGGCGGAACTGCTGATCGTGGCGGCCACCACGG
CGTCGGACGCCGTGCTGCCGCAGACGATGGACAAGCTGGAGCGGCTGGGCATACGGCGCGAGGTCGTGGGGCTGGTGATC
CCGGCGGGCTATTCGTTCAATCTGGATGCGCTGTCGATCTATCTGGGCATGGCGGTGCTGTTCCTGGCCCAGGCCACCGG
CACGGTGCTGGGGTGGGGGCAGATGGCGCTGGTCCTGGGCACCGCGCTGGTGACGTCGAAGGGGGCGCACGGGGTGCCGG
GGGTGGCCATCGTCATCCTGGCCGCCACGCTGGCGGTGGTGCCGCAGGTTCCGCCGATCGGGCTGGTGCTGGTGGTGTCG
GTGGACTGGTTCATCGGCATTGCCCGCGCGCTGGGCAATTTCGTCGGCAATTGCGTGGCCACCATCGCGGTCGCCGCGTG
GGAGGGCGAGATCGACCTGGCGCAGGCACGGCGCGTGCTGGCGGCGGGCGACGATGCGGCGGCCGAGGCGCCGCTGACCG
CGTCCTGA

Upstream 100 bases:

>100_bases
GGGCGCGGGGGATGCGGGTGGTGTCGCGTTGTTCGTTCGTGACGGCCTTCATCCGCCGCCATCCCGAATATGCCGACCTG
CTGGAGCGTCCGCCTGGCGG

Downstream 100 bases:

>100_bases
CCCGCCGGGCCGGACAGTCGGTGCTTCACGGAAGGCCATTCCGTCCCATATAAGGGGCGCCCACCCGAACCGAAGCGCCT
GATTGTCCGGAAAGGCACCA

Product: C4-dicarboxylate transport protein

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MIAGSPLGRGGYVSYAVGMTKAPLYQSLFLQIVVATAGGVAIGLLDPALGMALRPLSDLFLRLIAMIVSPLVFCVVVQGI
AGAGSLRTVGRVGIKALIYFEAMTTLALSFGLLAAGLAGPGRGMHVPLAGRAVTDGAVALGSVGGSAAALRQGGIGAFLL
NIVPTSPVRAFAGNDVLQILFFAILFGCALTQVGPAGQPVARVIDGLTAVMFRIMGIVTWVAPVGVLGAVAWTVGHYGAA
ALGQLGLLVVLYVGTVAAFVTLALGLVMRRCGVGLWRLLVYLRAELLIVAATTASDAVLPQTMDKLERLGIRREVVGLVI
PAGYSFNLDALSIYLGMAVLFLAQATGTVLGWGQMALVLGTALVTSKGAHGVPGVAIVILAATLAVVPQVPPIGLVLVVS
VDWFIGIARALGNFVGNCVATIAVAAWEGEIDLAQARRVLAAGDDAAAEAPLTAS

Sequences:

>Translated_455_residues
MIAGSPLGRGGYVSYAVGMTKAPLYQSLFLQIVVATAGGVAIGLLDPALGMALRPLSDLFLRLIAMIVSPLVFCVVVQGI
AGAGSLRTVGRVGIKALIYFEAMTTLALSFGLLAAGLAGPGRGMHVPLAGRAVTDGAVALGSVGGSAAALRQGGIGAFLL
NIVPTSPVRAFAGNDVLQILFFAILFGCALTQVGPAGQPVARVIDGLTAVMFRIMGIVTWVAPVGVLGAVAWTVGHYGAA
ALGQLGLLVVLYVGTVAAFVTLALGLVMRRCGVGLWRLLVYLRAELLIVAATTASDAVLPQTMDKLERLGIRREVVGLVI
PAGYSFNLDALSIYLGMAVLFLAQATGTVLGWGQMALVLGTALVTSKGAHGVPGVAIVILAATLAVVPQVPPIGLVLVVS
VDWFIGIARALGNFVGNCVATIAVAAWEGEIDLAQARRVLAAGDDAAAEAPLTAS
>Mature_455_residues
MIAGSPLGRGGYVSYAVGMTKAPLYQSLFLQIVVATAGGVAIGLLDPALGMALRPLSDLFLRLIAMIVSPLVFCVVVQGI
AGAGSLRTVGRVGIKALIYFEAMTTLALSFGLLAAGLAGPGRGMHVPLAGRAVTDGAVALGSVGGSAAALRQGGIGAFLL
NIVPTSPVRAFAGNDVLQILFFAILFGCALTQVGPAGQPVARVIDGLTAVMFRIMGIVTWVAPVGVLGAVAWTVGHYGAA
ALGQLGLLVVLYVGTVAAFVTLALGLVMRRCGVGLWRLLVYLRAELLIVAATTASDAVLPQTMDKLERLGIRREVVGLVI
PAGYSFNLDALSIYLGMAVLFLAQATGTVLGWGQMALVLGTALVTSKGAHGVPGVAIVILAATLAVVPQVPPIGLVLVVS
VDWFIGIARALGNFVGNCVATIAVAAWEGEIDLAQARRVLAAGDDAAAEAPLTAS

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI4827012, Length=494, Percent_Identity=25.7085020242915, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI169790839, Length=463, Percent_Identity=25.4859611231102, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI194239697, Length=431, Percent_Identity=24.3619489559165, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI21314632, Length=435, Percent_Identity=24.8275862068966, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI5032093, Length=291, Percent_Identity=25.085910652921, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI223468566, Length=291, Percent_Identity=25.085910652921, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI223468564, Length=285, Percent_Identity=25.2631578947368, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI262359914, Length=399, Percent_Identity=24.812030075188, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI66773030, Length=262, Percent_Identity=25.9541984732824, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI40254478, Length=275, Percent_Identity=27.2727272727273, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1789947, Length=420, Percent_Identity=43.8095238095238, Blast_Score=342, Evalue=3e-95,
Organism=Escherichia coli, GI1790514, Length=404, Percent_Identity=38.1188118811881, Blast_Score=244, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17537407, Length=413, Percent_Identity=25.6658595641646, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71996953, Length=467, Percent_Identity=24.8394004282655, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI193206505, Length=446, Percent_Identity=23.0941704035874, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71983099, Length=407, Percent_Identity=23.8329238329238, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71983106, Length=407, Percent_Identity=23.8329238329238, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193206654, Length=444, Percent_Identity=20.9459459459459, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17541374, Length=396, Percent_Identity=23.989898989899, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583025, Length=426, Percent_Identity=24.4131455399061, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137668, Length=426, Percent_Identity=24.4131455399061, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24583023, Length=426, Percent_Identity=24.4131455399061, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281360481, Length=454, Percent_Identity=25.1101321585903, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281360483, Length=454, Percent_Identity=25.1101321585903, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17137666, Length=454, Percent_Identity=25.1101321585903, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46206; Mature: 46206

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCCEEHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHCCCCEEHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]