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The map label for this gene is aapA [H]

Identifier: 162149549

GI number: 162149549

Start: 3870328

End: 3871737

Strand: Direct

Name: aapA [H]

Synonym: GDI_3787

Alternate gene names: 162149549

Gene position: 3870328-3871737 (Clockwise)

Preceding gene: 162149548

Following gene: 162149558

Centisome position: 98.13

GC content: 70.71

Gene sequence:

>1410_bases
ATGGTGCGCGTGGTTCGGGCGGCGCAACGATGTGGGGGCCCGGCGAGTCAAGGGAGCGGGTTCTTGGGTCTGAAGCAGCG
CCATATCCTGTTCATGGCATTGGGCGGGTCGGTCGGGGCGGGGTTGTTCCTGGGTTCGGGCGGGGCGATCCATCAGGCGG
GGTCGTCCGTGCTGGTGGCCTATGTGCTGTGCGGCATCATCGTGTTCTTCATCGGGCGGGCGGCGGCGGAACTGGCGCTG
AGCGATCCGGGGGGGCGGACGCTGAACGCGTTCGTCGGGCGCTATCTGGGCCCGCGCATGGAATTCCTGACCGGCTGGAG
CTACTGGCTGATCTGGACGCTGGTGTGCATTTCGGAAATCACCGCCGCCGGGATCTTCGTGCGCTACTGGTTTCCCGCCG
TGCCGCAATGGTCGGTCGCCGCCGTGCTGGGCGGGGTGCTGCTGGCCGTGGGGTCGCGCGCCGTCGCCACGTTCGGCGAG
ATGGAATTCTGGCTGGCCATCATCAAGATCTGGGCCATCGTGGCGCTGATCCTGTGCGGGCTGGCCACGATCGTCCTGCA
TGTGGGGCTGGCGGGGCCGGGCGCATCCTTCGCCCATATCTGGCAGGCGGGCACGATGCTGCCGCACGGGGCGGCGGGCT
TCGCCGCCATCCTGCCGATGGCGCTGTTCGCCTTCGGCGGCACCGAGGTCGTGGCCCTGACGGCGGCGGAAACCGAGGAC
GCCGTGCGCGTGCTGCCGCGCGCGGTCAACGGCATCGTGGGGCGCATCGTCGTGTTCTATGTCGGCAGCCTGGCGATCAT
CATGGCCATCGTGCCGTGGGGCGAGGCCGACGCGACGCACAGCCCGTTCGTGCTGGCGTTCACGCATATGGGCCTGCCGA
CGGCGGCCGCGTCCATCAACGCGGTCATGGCGCTGGCGGCGCTGTCATCGTGCAATACCGGGCTGTATGCCACCAGCCGG
ACCCTGGCGTCGCTGGCCGAGGGCGGCATGGCCTCGGCCCGGCTGCGCGACCGGGCCGCGAACGGCGTGCCGGCCCTGGC
GTTCGCGGCCTCGTTCGTTACCGTGCTGGCGGGGGTGGTGCTGAACTACTTCCTGCCCGACCGGCTGTTCGGCTACGCGA
TCCAGGGCGTGTCCTTCCTGCTGATCTTCGTCTGGGTCACGATCATGGCGGCGCACCTGGCCTATCGGCGCGGCGCCGAC
GGTGGGGCGGGGGCGGGCGCGGGCACGCGCCGGGTGGCGGCGCTGCCGTGGGCGCCGGCCAGCAACCTGGTCGCCATCGC
CTTCCTGCTGGCCATCGGGCTGGACATCGTGTGGGTCGGGCGGCTGTACGTGCCCTTCGCGCTGGACGCCGTGTGGCTGG
GCGGCCTGCTGCTGGCGCGGGAGCGTCTATTCCGCGTTCAGCGCCCGTGA

Upstream 100 bases:

>100_bases
GTGCTGATCAACGGCGGCTACACCACCAGGTAACCCGACCCGGCCGGGACGCGCGCGCCGGCGCCCGTGGGCCGCTTTGT
CGGATCCGCGGGCCGTGTCT

Downstream 100 bases:

>100_bases
CAGTTCGTCGGGCTTCATCCTGCTGCTCTGCGCCTCGGTCGGGAAGGTTCCGGACTGGACTTCACTGACGTAGGCGCGCA
GCGCGTCCTCGATCGCGGTG

Product: amino acid permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MVRVVRAAQRCGGPASQGSGFLGLKQRHILFMALGGSVGAGLFLGSGGAIHQAGSSVLVAYVLCGIIVFFIGRAAAELAL
SDPGGRTLNAFVGRYLGPRMEFLTGWSYWLIWTLVCISEITAAGIFVRYWFPAVPQWSVAAVLGGVLLAVGSRAVATFGE
MEFWLAIIKIWAIVALILCGLATIVLHVGLAGPGASFAHIWQAGTMLPHGAAGFAAILPMALFAFGGTEVVALTAAETED
AVRVLPRAVNGIVGRIVVFYVGSLAIIMAIVPWGEADATHSPFVLAFTHMGLPTAAASINAVMALAALSSCNTGLYATSR
TLASLAEGGMASARLRDRAANGVPALAFAASFVTVLAGVVLNYFLPDRLFGYAIQGVSFLLIFVWVTIMAAHLAYRRGAD
GGAGAGAGTRRVAALPWAPASNLVAIAFLLAIGLDIVWVGRLYVPFALDAVWLGGLLLARERLFRVQRP

Sequences:

>Translated_469_residues
MVRVVRAAQRCGGPASQGSGFLGLKQRHILFMALGGSVGAGLFLGSGGAIHQAGSSVLVAYVLCGIIVFFIGRAAAELAL
SDPGGRTLNAFVGRYLGPRMEFLTGWSYWLIWTLVCISEITAAGIFVRYWFPAVPQWSVAAVLGGVLLAVGSRAVATFGE
MEFWLAIIKIWAIVALILCGLATIVLHVGLAGPGASFAHIWQAGTMLPHGAAGFAAILPMALFAFGGTEVVALTAAETED
AVRVLPRAVNGIVGRIVVFYVGSLAIIMAIVPWGEADATHSPFVLAFTHMGLPTAAASINAVMALAALSSCNTGLYATSR
TLASLAEGGMASARLRDRAANGVPALAFAASFVTVLAGVVLNYFLPDRLFGYAIQGVSFLLIFVWVTIMAAHLAYRRGAD
GGAGAGAGTRRVAALPWAPASNLVAIAFLLAIGLDIVWVGRLYVPFALDAVWLGGLLLARERLFRVQRP
>Mature_469_residues
MVRVVRAAQRCGGPASQGSGFLGLKQRHILFMALGGSVGAGLFLGSGGAIHQAGSSVLVAYVLCGIIVFFIGRAAAELAL
SDPGGRTLNAFVGRYLGPRMEFLTGWSYWLIWTLVCISEITAAGIFVRYWFPAVPQWSVAAVLGGVLLAVGSRAVATFGE
MEFWLAIIKIWAIVALILCGLATIVLHVGLAGPGASFAHIWQAGTMLPHGAAGFAAILPMALFAFGGTEVVALTAAETED
AVRVLPRAVNGIVGRIVVFYVGSLAIIMAIVPWGEADATHSPFVLAFTHMGLPTAAASINAVMALAALSSCNTGLYATSR
TLASLAEGGMASARLRDRAANGVPALAFAASFVTVLAGVVLNYFLPDRLFGYAIQGVSFLLIFVWVTIMAAHLAYRRGAD
GGAGAGAGTRRVAALPWAPASNLVAIAFLLAIGLDIVWVGRLYVPFALDAVWLGGLLLARERLFRVQRP

Specific function: Probable amino-acid or metabolite transport protein [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1790653, Length=400, Percent_Identity=40.25, Blast_Score=286, Evalue=3e-78,
Organism=Escherichia coli, GI1786302, Length=431, Percent_Identity=36.8909512761021, Blast_Score=284, Evalue=7e-78,
Organism=Escherichia coli, GI1786789, Length=443, Percent_Identity=37.9232505643341, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI48994972, Length=412, Percent_Identity=36.4077669902913, Blast_Score=262, Evalue=4e-71,
Organism=Escherichia coli, GI1786602, Length=375, Percent_Identity=36.8, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI87081915, Length=421, Percent_Identity=33.729216152019, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI87081708, Length=435, Percent_Identity=31.264367816092, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1788480, Length=448, Percent_Identity=33.0357142857143, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1789017, Length=384, Percent_Identity=30.2083333333333, Blast_Score=189, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6324061, Length=343, Percent_Identity=32.0699708454811, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320772, Length=396, Percent_Identity=29.5454545454545, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324924, Length=361, Percent_Identity=32.6869806094183, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6324990, Length=412, Percent_Identity=27.1844660194175, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324553, Length=386, Percent_Identity=29.0155440414508, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322967, Length=348, Percent_Identity=31.8965517241379, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6321053, Length=421, Percent_Identity=28.0285035629454, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319543, Length=407, Percent_Identity=28.5012285012285, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320717, Length=409, Percent_Identity=28.8508557457213, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6324059, Length=362, Percent_Identity=29.2817679558011, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6322892, Length=390, Percent_Identity=27.1794871794872, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6321629, Length=399, Percent_Identity=26.5664160401003, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6319824, Length=396, Percent_Identity=28.5353535353535, Blast_Score=126, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6319542, Length=394, Percent_Identity=28.6802030456853, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320251, Length=392, Percent_Identity=27.5510204081633, Blast_Score=123, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6324981, Length=390, Percent_Identity=26.9230769230769, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319608, Length=354, Percent_Identity=25.7062146892655, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48938; Mature: 48938

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRVVRAAQRCGGPASQGSGFLGLKQRHILFMALGGSVGAGLFLGSGGAIHQAGSSVLVA
CCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEECCCCCHHHCCHHHHHH
YVLCGIIVFFIGRAAAELALSDPGGRTLNAFVGRYLGPRMEFLTGWSYWLIWTLVCISEI
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHH
TAAGIFVRYWFPAVPQWSVAAVLGGVLLAVGSRAVATFGEMEFWLAIIKIWAIVALILCG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATIVLHVGLAGPGASFAHIWQAGTMLPHGAAGFAAILPMALFAFGGTEVVALTAAETED
HHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHH
AVRVLPRAVNGIVGRIVVFYVGSLAIIMAIVPWGEADATHSPFVLAFTHMGLPTAAASIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHH
AVMALAALSSCNTGLYATSRTLASLAEGGMASARLRDRAANGVPALAFAASFVTVLAGVV
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LNYFLPDRLFGYAIQGVSFLLIFVWVTIMAAHLAYRRGADGGAGAGAGTRRVAALPWAPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCC
SNLVAIAFLLAIGLDIVWVGRLYVPFALDAVWLGGLLLARERLFRVQRP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVRVVRAAQRCGGPASQGSGFLGLKQRHILFMALGGSVGAGLFLGSGGAIHQAGSSVLVA
CCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEECCCCCHHHCCHHHHHH
YVLCGIIVFFIGRAAAELALSDPGGRTLNAFVGRYLGPRMEFLTGWSYWLIWTLVCISEI
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHH
TAAGIFVRYWFPAVPQWSVAAVLGGVLLAVGSRAVATFGEMEFWLAIIKIWAIVALILCG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATIVLHVGLAGPGASFAHIWQAGTMLPHGAAGFAAILPMALFAFGGTEVVALTAAETED
HHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHH
AVRVLPRAVNGIVGRIVVFYVGSLAIIMAIVPWGEADATHSPFVLAFTHMGLPTAAASIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHH
AVMALAALSSCNTGLYATSRTLASLAEGGMASARLRDRAANGVPALAFAASFVTVLAGVV
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LNYFLPDRLFGYAIQGVSFLLIFVWVTIMAAHLAYRRGADGGAGAGAGTRRVAALPWAPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCC
SNLVAIAFLLAIGLDIVWVGRLYVPFALDAVWLGGLLLARERLFRVQRP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]