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The map label for this gene is oprM [H]

Identifier: 162149558

GI number: 162149558

Start: 3880307

End: 3881983

Strand: Direct

Name: oprM [H]

Synonym: GDI_3796

Alternate gene names: 162149558

Gene position: 3880307-3881983 (Clockwise)

Preceding gene: 162149549

Following gene: 162149559

Centisome position: 98.38

GC content: 70.36

Gene sequence:

>1677_bases
TTGGTGGATGATGTCATACCGCCTCCTGTCCTGTCGATAGGGCGATGGCGGGATCGAAGCGTAACAGGGGGCCGTCTGGT
GCATAGGGGACATTCTTGGCGGGCGGCGATCGTCGGGCTGTCGGTCCTTGCGACCGGATGCGCGGTCGGGCCGGACTTCC
ACAAGCCCGTGGCCTGGGCGCCGCCGCACTGGGCGGGCCAGCATTGGGTGGGTTCAGCCCCCGGGTCGACCTCTGGGGCA
TCCAGGCCGCCTGTCAGCAGCGATATCTCGGATGCCGCCCCCGACCCCGCATGGTGGGACGTGTTCCATGATCCCGAACT
GTCGGCGCTGGAACGCCGGGTGGCCGGGCAGAACCTGTCCGTCGCCATCGCCACCGCCCGTCTGGCGCAGAGCCGGTCGC
AACTGCGGATTGCCGGGGCCGAGCGTTATCCGGGGCTGAGCGCCGCGGGGTCGTACACCCGGTCGCAATACAGCACCAAG
GAATTGCAGCGGATCGTCAGCGATGTCGGCAAGTCCGGCAACCTGCCGCTGGGCGGGGTCAACCTGGCGGACCAGTCCGG
GCAGTTCACCATTCCGCTGCTGGACCAGTGGCGCGACAGCATCGACGCGACGTGGGAGGTCGACCTGTGGGGCCGCGTGC
GCCGGCAGTACGAGGCGGCGGGCGCCGACCTGCAGGCCTCGGTCGAGGAACGGCGCGGCGTGCTGACCGCGCAGATGGCC
GAACTGGCCCGCGATTACGTGGCCCTGCGCGAGGCCCAGGCGCAACTGCGCATCCTGCTGGACAATCGCGACACCGCGTC
CCGCTCGCTGGACCTCAGCCGCCAGCGCAACCAGGCGGGCCTGGTCAGCGAACTGGACGTGCAGAGCGCGCAGTCGCAAC
TGGATTCCGTCACCGCGCGCATTCCGCAGATGGAACAGCAGATCGCGCTGCAGGTGAACGCGCTGAGCCTGCTGCTGGGG
GCGCCGCCGTCCGCCCTGGCCGGCGAACTGCTGACCGACCGTGACATTCCGCCCGTGCCGCCGCGCGTGCCGGCCGGCGT
GCCGTCCGAACTGGCCCGCCGCCGCCCAGACATCCGCCAGGCCGAGGCGCAGCTTCATGCCGCCACCGCGCAGGTGGGCG
AGGCAGTGGCCGAGTTCTATCCCCGCGTGACCATCGACGCCGGATTCGGCTTCCAGTCGCTGTCCTTCCGCGATTTCGGA
TTCTGGAATGCCCGGGCGTGGAATGTCGGCCCGTCGATCAGCCTGCCGATCTTCCAGGGCGGGCGGCTGCGCGGGCAGCT
TGAGTTGCGCCACGCGGCGGAGCAGGAGGCCGCGATCACCTATCGCCGGACCGTGCTGGGCGCCTGGCACGAGGTCGACA
ACGCCCTGACCGCGTATCGTGACGAACAGATGCGCCATGACAGTCTGGCGCGGCAGGTGGCCGACGACCAGCGGTCGCTG
GACCTGGCCCGCGACCAGTATCGCCACGGCATGGTGACGTTCCTGACGGTGCTGGATGCCGAACGCCGGGTGCTGGGGTC
GCAGACCGACCTGACCAGCAGCACGGCCAGCCTGTCGACCGATCTGGTGCAGCTCTATTCCGCGCTGGGCGGCGGGTGGG
AAAATACCTTCCCGGTCCAGATGGCGGCCCCGGCCCGCCTGGCCGGTGCCGCGCCCGGCGCGGCCCCCCCGGCATGA

Upstream 100 bases:

>100_bases
TCTCTCCGGTGGTCGGTGCGTTGCTTTCCCGGTCCGGACGGATTGACCCGCCGAGGAAAGCCGATAGGGTGGCGGTAATG
ACCGAACGGGTCGGTCAGTT

Downstream 100 bases:

>100_bases
GGCCGATTCGGGCCGGACGCGGCGTGCGGGGATGGTCCGGGCCGTTTTGCAAGTCTTCGGGCTTGGCGGATGGCGGTCGG
CAGCGTATAAGCCGCCCGTT

Product: outer membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MVDDVIPPPVLSIGRWRDRSVTGGRLVHRGHSWRAAIVGLSVLATGCAVGPDFHKPVAWAPPHWAGQHWVGSAPGSTSGA
SRPPVSSDISDAAPDPAWWDVFHDPELSALERRVAGQNLSVAIATARLAQSRSQLRIAGAERYPGLSAAGSYTRSQYSTK
ELQRIVSDVGKSGNLPLGGVNLADQSGQFTIPLLDQWRDSIDATWEVDLWGRVRRQYEAAGADLQASVEERRGVLTAQMA
ELARDYVALREAQAQLRILLDNRDTASRSLDLSRQRNQAGLVSELDVQSAQSQLDSVTARIPQMEQQIALQVNALSLLLG
APPSALAGELLTDRDIPPVPPRVPAGVPSELARRRPDIRQAEAQLHAATAQVGEAVAEFYPRVTIDAGFGFQSLSFRDFG
FWNARAWNVGPSISLPIFQGGRLRGQLELRHAAEQEAAITYRRTVLGAWHEVDNALTAYRDEQMRHDSLARQVADDQRSL
DLARDQYRHGMVTFLTVLDAERRVLGSQTDLTSSTASLSTDLVQLYSALGGGWENTFPVQMAAPARLAGAAPGAAPPA

Sequences:

>Translated_558_residues
MVDDVIPPPVLSIGRWRDRSVTGGRLVHRGHSWRAAIVGLSVLATGCAVGPDFHKPVAWAPPHWAGQHWVGSAPGSTSGA
SRPPVSSDISDAAPDPAWWDVFHDPELSALERRVAGQNLSVAIATARLAQSRSQLRIAGAERYPGLSAAGSYTRSQYSTK
ELQRIVSDVGKSGNLPLGGVNLADQSGQFTIPLLDQWRDSIDATWEVDLWGRVRRQYEAAGADLQASVEERRGVLTAQMA
ELARDYVALREAQAQLRILLDNRDTASRSLDLSRQRNQAGLVSELDVQSAQSQLDSVTARIPQMEQQIALQVNALSLLLG
APPSALAGELLTDRDIPPVPPRVPAGVPSELARRRPDIRQAEAQLHAATAQVGEAVAEFYPRVTIDAGFGFQSLSFRDFG
FWNARAWNVGPSISLPIFQGGRLRGQLELRHAAEQEAAITYRRTVLGAWHEVDNALTAYRDEQMRHDSLARQVADDQRSL
DLARDQYRHGMVTFLTVLDAERRVLGSQTDLTSSTASLSTDLVQLYSALGGGWENTFPVQMAAPARLAGAAPGAAPPA
>Mature_558_residues
MVDDVIPPPVLSIGRWRDRSVTGGRLVHRGHSWRAAIVGLSVLATGCAVGPDFHKPVAWAPPHWAGQHWVGSAPGSTSGA
SRPPVSSDISDAAPDPAWWDVFHDPELSALERRVAGQNLSVAIATARLAQSRSQLRIAGAERYPGLSAAGSYTRSQYSTK
ELQRIVSDVGKSGNLPLGGVNLADQSGQFTIPLLDQWRDSIDATWEVDLWGRVRRQYEAAGADLQASVEERRGVLTAQMA
ELARDYVALREAQAQLRILLDNRDTASRSLDLSRQRNQAGLVSELDVQSAQSQLDSVTARIPQMEQQIALQVNALSLLLG
APPSALAGELLTDRDIPPVPPRVPAGVPSELARRRPDIRQAEAQLHAATAQVGEAVAEFYPRVTIDAGFGFQSLSFRDFG
FWNARAWNVGPSISLPIFQGGRLRGQLELRHAAEQEAAITYRRTVLGAWHEVDNALTAYRDEQMRHDSLARQVADDQRSL
DLARDQYRHGMVTFLTVLDAERRVLGSQTDLTSSTASLSTDLVQLYSALGGGWENTFPVQMAAPARLAGAAPGAAPPA

Specific function: The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor. Note=Attached to the outer membrane by a lipid anchor and via the transmembrane beta-barrel. The membrane anchor is not necessary for antibiotic efflux. In one report (PubMed:10889211) the Cys-18- Gly mutant is reported

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=489, Percent_Identity=26.3803680981595, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI2367348, Length=512, Percent_Identity=25.5859375, Blast_Score=111, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 60492; Mature: 60492

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDDVIPPPVLSIGRWRDRSVTGGRLVHRGHSWRAAIVGLSVLATGCAVGPDFHKPVAWA
CCCCCCCCCCHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PPHWAGQHWVGSAPGSTSGASRPPVSSDISDAAPDPAWWDVFHDPELSALERRVAGQNLS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCE
VAIATARLAQSRSQLRIAGAERYPGLSAAGSYTRSQYSTKELQRIVSDVGKSGNLPLGGV
EEHHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHCCHHHHHHHHHHCCCCCCCCCCCC
NLADQSGQFTIPLLDQWRDSIDATWEVDLWGRVRRQYEAAGADLQASVEERRGVLTAQMA
CCCCCCCCEEECCHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHH
ELARDYVALREAQAQLRILLDNRDTASRSLDLSRQRNQAGLVSELDVQSAQSQLDSVTAR
HHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
IPQMEQQIALQVNALSLLLGAPPSALAGELLTDRDIPPVPPRVPAGVPSELARRRPDIRQ
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCHHH
AEAQLHAATAQVGEAVAEFYPRVTIDAGFGFQSLSFRDFGFWNARAWNVGPSISLPIFQG
HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCCEEECC
GRLRGQLELRHAAEQEAAITYRRTVLGAWHEVDNALTAYRDEQMRHDSLARQVADDQRSL
CCEECEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLARDQYRHGMVTFLTVLDAERRVLGSQTDLTSSTASLSTDLVQLYSALGGGWENTFPVQ
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEE
MAAPARLAGAAPGAAPPA
ECCCHHHCCCCCCCCCCC
>Mature Secondary Structure
MVDDVIPPPVLSIGRWRDRSVTGGRLVHRGHSWRAAIVGLSVLATGCAVGPDFHKPVAWA
CCCCCCCCCCHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PPHWAGQHWVGSAPGSTSGASRPPVSSDISDAAPDPAWWDVFHDPELSALERRVAGQNLS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCE
VAIATARLAQSRSQLRIAGAERYPGLSAAGSYTRSQYSTKELQRIVSDVGKSGNLPLGGV
EEHHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHCCHHHHHHHHHHCCCCCCCCCCCC
NLADQSGQFTIPLLDQWRDSIDATWEVDLWGRVRRQYEAAGADLQASVEERRGVLTAQMA
CCCCCCCCEEECCHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHH
ELARDYVALREAQAQLRILLDNRDTASRSLDLSRQRNQAGLVSELDVQSAQSQLDSVTAR
HHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
IPQMEQQIALQVNALSLLLGAPPSALAGELLTDRDIPPVPPRVPAGVPSELARRRPDIRQ
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCHHH
AEAQLHAATAQVGEAVAEFYPRVTIDAGFGFQSLSFRDFGFWNARAWNVGPSISLPIFQG
HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCCEEECC
GRLRGQLELRHAAEQEAAITYRRTVLGAWHEVDNALTAYRDEQMRHDSLARQVADDQRSL
CCEECEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLARDQYRHGMVTFLTVLDAERRVLGSQTDLTSSTASLSTDLVQLYSALGGGWENTFPVQ
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEE
MAAPARLAGAAPGAAPPA
ECCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8226684; 10889211; 10984043; 7968531; 8540696; 9401051; 9603892; 10952562 [H]