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The map label for this gene is pyrB [H]

Identifier: 161870950

GI number: 161870950

Start: 2086509

End: 2087429

Strand: Reverse

Name: pyrB [H]

Synonym: NMCC_2044

Alternate gene names: 161870950

Gene position: 2087429-2086509 (Counterclockwise)

Preceding gene: 161870956

Following gene: 161870949

Centisome position: 96.94

GC content: 57.98

Gene sequence:

>921_bases
ATGCCTAATCCGCTTTACAGACAGCATATCATCTCCATTTCGGATTTGTCGCGCGAACAGTTGGAATGCCTGCTTCAGAC
GGCATTGAAGCTGAAGGCGCATCCGCGCGGCGACCTGTTGGAAGGCAAACTTATCGGTTCGTGCTTTTTCGAGCCGTCCA
CGCGCACGAGGCTGTCGTTTGAAACGGCGGTGCAGTGTTTGGGCGGCAAGGTCATCGGCTTTTCGGACGGCGCGAATACC
AGTGCGAAAAAAGGCGAGACGCTTGCCGATACCGCCCGCATCATTTCCGGCTACACCGACGCTATCATCCAACGCCACCC
CAAAGACGGCGCGGCGCGCGTGGCAGCGGAGTTTTCGCGCGTCCCCGTTATCAACGCCGGCGACGGCACGAACCAGCACC
CCAGTCAGACCTTGTTGGATCTGGTAACGATTTATGAAACGCAGGGGCGTTTGGACAAGCTCAAAATCGCGATGGCGGGC
GACTTGAAATACGGGCGCACCGTGCATTCGCTTTGTCAGGCGTTGAAACGCTGGGGCTGCGAATTTGCCTTCGTCTCGCC
GCCCAGCCTCGCGATGCCCGACTACATTACCGAAGAGTTGGACGAAGCCGGCTGCCGATACCGTATCCTCGGCAGTTTGG
AAGAAGCGGCGGAATGGGCGGATATCCTGTATATGACCCGCGTCCAGCGCGAACGTTTCGACGAACAGGAATTTGCCAAA
ATCCAAGGCAAATTCAACCTCGAAGCGTCTATGCTCGCCCGCGCCAAACCGAACCTGCGCGTGCTGCACCCCCTGCCGCG
CGTGGACGAAATCCATCCCGATGTCGATGCCACGCCGCACGCCTATTATTTCGAGCAGGCGACCAACGGCGTTTATGCGC
GTATGGCGATATTGTCGCTGGTGTTGAACGAAGAAGTGTGA

Upstream 100 bases:

>100_bases
GCCGCTTTTGCGAAGCTGTTCCGCAAACATACGGGCGGCGTGGACGACGTATAACCGGATACCCGCCTGACGCGGGTTTT
TTACGGAAGGGGGGGCAAAA

Downstream 100 bases:

>100_bases
GGAACCGATATGGAAACCCCGAAACTCAGTGTCGAAGCCATTGAAAAAGGTACGGTTATCGACCATATTCCCGCCGGCAG
GGGGCTGACCATCCTGCGCC

Product: aspartate carbamoyltransferase catalytic subunit

Products: NA

Alternate protein names: Aspartate transcarbamylase; ATCase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MPNPLYRQHIISISDLSREQLECLLQTALKLKAHPRGDLLEGKLIGSCFFEPSTRTRLSFETAVQCLGGKVIGFSDGANT
SAKKGETLADTARIISGYTDAIIQRHPKDGAARVAAEFSRVPVINAGDGTNQHPSQTLLDLVTIYETQGRLDKLKIAMAG
DLKYGRTVHSLCQALKRWGCEFAFVSPPSLAMPDYITEELDEAGCRYRILGSLEEAAEWADILYMTRVQRERFDEQEFAK
IQGKFNLEASMLARAKPNLRVLHPLPRVDEIHPDVDATPHAYYFEQATNGVYARMAILSLVLNEEV

Sequences:

>Translated_306_residues
MPNPLYRQHIISISDLSREQLECLLQTALKLKAHPRGDLLEGKLIGSCFFEPSTRTRLSFETAVQCLGGKVIGFSDGANT
SAKKGETLADTARIISGYTDAIIQRHPKDGAARVAAEFSRVPVINAGDGTNQHPSQTLLDLVTIYETQGRLDKLKIAMAG
DLKYGRTVHSLCQALKRWGCEFAFVSPPSLAMPDYITEELDEAGCRYRILGSLEEAAEWADILYMTRVQRERFDEQEFAK
IQGKFNLEASMLARAKPNLRVLHPLPRVDEIHPDVDATPHAYYFEQATNGVYARMAILSLVLNEEV
>Mature_305_residues
PNPLYRQHIISISDLSREQLECLLQTALKLKAHPRGDLLEGKLIGSCFFEPSTRTRLSFETAVQCLGGKVIGFSDGANTS
AKKGETLADTARIISGYTDAIIQRHPKDGAARVAAEFSRVPVINAGDGTNQHPSQTLLDLVTIYETQGRLDKLKIAMAGD
LKYGRTVHSLCQALKRWGCEFAFVSPPSLAMPDYITEELDEAGCRYRILGSLEEAAEWADILYMTRVQRERFDEQEFAKI
QGKFNLEASMLARAKPNLRVLHPLPRVDEIHPDVDATPHAYYFEQATNGVYARMAILSLVLNEEV

Specific function: Pyrimidine biosynthesis; second step. [C]

COG id: COG0540

COG function: function code F; Aspartate carbamoyltransferase, catalytic chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=304, Percent_Identity=44.4078947368421, Blast_Score=260, Evalue=1e-69,
Organism=Homo sapiens, GI38788445, Length=309, Percent_Identity=26.2135922330097, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI2367364, Length=309, Percent_Identity=63.1067961165049, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1786469, Length=337, Percent_Identity=25.8160237388724, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790703, Length=337, Percent_Identity=25.5192878338279, Blast_Score=81, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI193204318, Length=328, Percent_Identity=38.4146341463415, Blast_Score=202, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6322331, Length=310, Percent_Identity=41.6129032258065, Blast_Score=243, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6322373, Length=328, Percent_Identity=28.9634146341463, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24642586, Length=304, Percent_Identity=43.421052631579, Blast_Score=248, Evalue=4e-66,

Paralogues:

None

Copy number: 2080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 14328 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002082 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.2 [H]

Molecular weight: Translated: 34095; Mature: 33964

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNPLYRQHIISISDLSREQLECLLQTALKLKAHPRGDLLEGKLIGSCFFEPSTRTRLSF
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHEEECCCCCCEECH
ETAVQCLGGKVIGFSDGANTSAKKGETLADTARIISGYTDAIIQRHPKDGAARVAAEFSR
HHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
VPVINAGDGTNQHPSQTLLDLVTIYETQGRLDKLKIAMAGDLKYGRTVHSLCQALKRWGC
CCEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHCCC
EFAFVSPPSLAMPDYITEELDEAGCRYRILGSLEEAAEWADILYMTRVQRERFDEQEFAK
CEEEECCCCCCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
IQGKFNLEASMLARAKPNLRVLHPLPRVDEIHPDVDATPHAYYFEQATNGVYARMAILSL
HCCCCCCHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCEEHHHHCCCHHHHHHHHHH
VLNEEV
HHHCCC
>Mature Secondary Structure 
PNPLYRQHIISISDLSREQLECLLQTALKLKAHPRGDLLEGKLIGSCFFEPSTRTRLSF
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHEEECCCCCCEECH
ETAVQCLGGKVIGFSDGANTSAKKGETLADTARIISGYTDAIIQRHPKDGAARVAAEFSR
HHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
VPVINAGDGTNQHPSQTLLDLVTIYETQGRLDKLKIAMAGDLKYGRTVHSLCQALKRWGC
CCEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHCCC
EFAFVSPPSLAMPDYITEELDEAGCRYRILGSLEEAAEWADILYMTRVQRERFDEQEFAK
CEEEECCCCCCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
IQGKFNLEASMLARAKPNLRVLHPLPRVDEIHPDVDATPHAYYFEQATNGVYARMAILSL
HCCCCCCHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCEEHHHHCCCHHHHHHHHHH
VLNEEV
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA