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The map label for this gene is def [H]

Identifier: 161870945

GI number: 161870945

Start: 2083344

End: 2083847

Strand: Reverse

Name: def [H]

Synonym: NMCC_2039

Alternate gene names: 161870945

Gene position: 2083847-2083344 (Counterclockwise)

Preceding gene: 161870947

Following gene: 161870944

Centisome position: 96.77

GC content: 55.56

Gene sequence:

>504_bases
ATGGCTTTATTGAATATCTTGCAATATCCCGACGAGCGTCTGCACACGGTGGCAAAGCCTGTCGAACAAGTCGACGAGCG
CATCCGGAAGCTGATTGCCGATATGTTTGAAACGATGTACGAATCGCGCGGCATCGGGCTGGCGGCGACGCAGGTCGATG
TGCACGAGCGCGTGGTCGTGATGGATTTGACCGAAGACCGCAGCGAACCGCGCGTGTTCATCAACCCCGTCATCGTTGAA
AAAGACGGCGAAACCACTTACGAAGAGGGCTGCCTGTCCGTGCCGGGCATTTACGACACCGTAACCCGCGCCGAACGCGT
CAAGGTCGAGGCTTTGAACGAAAAAGGCGAAAAGTTCACGCTGGAGGCGGACGGCTTGCTGGCGATTTGCGTGCAGCACG
AGTTGGACCACCTGATGGGCATCGTGTTTGTCGAACGCCTTTCCCAACTCAAGCAGGGGCGGATTAAGACCAAGCTGAAA
AAACGTCAGAAACATACGATTTGA

Upstream 100 bases:

>100_bases
GCGTGATAAAAAATGTTCCGCATTTTAACATCGAATTATCCGCACCATCACGGTAATTATGAAAAACAGGCGGCGTATCC
GCCGAAGGAAAGAGAAAATT

Downstream 100 bases:

>100_bases
CCCTTTTGCCGTGCCGTCTGAACGCTGCAAAGTTTTTCAGACGGCACGGTCTTGTCCGACAATTTTACGCACACGCAGGA
ACACGCTATGAAAGTCATCT

Product: peptide deformylase

Products: NA

Alternate protein names: PDF; Polypeptide deformylase [H]

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MALLNILQYPDERLHTVAKPVEQVDERIRKLIADMFETMYESRGIGLAATQVDVHERVVVMDLTEDRSEPRVFINPVIVE
KDGETTYEEGCLSVPGIYDTVTRAERVKVEALNEKGEKFTLEADGLLAICVQHELDHLMGIVFVERLSQLKQGRIKTKLK
KRQKHTI

Sequences:

>Translated_167_residues
MALLNILQYPDERLHTVAKPVEQVDERIRKLIADMFETMYESRGIGLAATQVDVHERVVVMDLTEDRSEPRVFINPVIVE
KDGETTYEEGCLSVPGIYDTVTRAERVKVEALNEKGEKFTLEADGLLAICVQHELDHLMGIVFVERLSQLKQGRIKTKLK
KRQKHTI
>Mature_166_residues
ALLNILQYPDERLHTVAKPVEQVDERIRKLIADMFETMYESRGIGLAATQVDVHERVVVMDLTEDRSEPRVFINPVIVEK
DGETTYEEGCLSVPGIYDTVTRAERVKVEALNEKGEKFTLEADGLLAICVQHELDHLMGIVFVERLSQLKQGRIKTKLKK
RQKHTI

Specific function: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions

COG id: COG0242

COG function: function code J; N-formylmethionyl-tRNA deformylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polypeptide deformylase family [H]

Homologues:

Organism=Homo sapiens, GI11641243, Length=163, Percent_Identity=31.2883435582822, Blast_Score=85, Evalue=3e-17,
Organism=Escherichia coli, GI1789682, Length=161, Percent_Identity=57.7639751552795, Blast_Score=197, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24645728, Length=146, Percent_Identity=30.1369863013699, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000181 [H]

Pfam domain/function: PF01327 Pep_deformylase [H]

EC number: =3.5.1.88 [H]

Molecular weight: Translated: 19115; Mature: 18984

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLNILQYPDERLHTVAKPVEQVDERIRKLIADMFETMYESRGIGLAATQVDVHERVVV
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHEEEE
MDLTEDRSEPRVFINPVIVEKDGETTYEEGCLSVPGIYDTVTRAERVKVEALNEKGEKFT
EEECCCCCCCEEEEEEEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEE
LEADGLLAICVQHELDHLMGIVFVERLSQLKQGRIKTKLKKRQKHTI
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALLNILQYPDERLHTVAKPVEQVDERIRKLIADMFETMYESRGIGLAATQVDVHERVVV
CHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHEEEE
MDLTEDRSEPRVFINPVIVEKDGETTYEEGCLSVPGIYDTVTRAERVKVEALNEKGEKFT
EEECCCCCCCEEEEEEEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEE
LEADGLLAICVQHELDHLMGIVFVERLSQLKQGRIKTKLKKRQKHTI
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA