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The map label for this gene is prlC [H]

Identifier: 161870848

GI number: 161870848

Start: 1982935

End: 1984971

Strand: Reverse

Name: prlC [H]

Synonym: NMCC_1931

Alternate gene names: 161870848

Gene position: 1984971-1982935 (Counterclockwise)

Preceding gene: 161870849

Following gene: 161870842

Centisome position: 92.18

GC content: 57.19

Gene sequence:

>2037_bases
ATGACTGACAACGCACTGCTCCATTTGGGCGAAGAACCCCGTTTTGATCAAATCAAAACCGAAGACATCAAACCCGCCCT
GCAAACCGCCATCGCTGAAGCGCGCGAACAAATCGCCGCCATCAAAGCCCAAACGCACACCGGCTGGGCAAACACTGTCG
AACCCCTGACCGGCATCACCGAACGCGTCGGCAGGATTTGGGGCGTGGTGTCGCACCTCAACTCCGTCGCCGACACGCCC
GAACTGCGCGCCGTCTATAACGAACTGATGCCCGAAATCACCGTCTTCTTCACCGAAATCGGACAAGACATCGAGCTGTA
CAACCGCTTCAAAACCATCAAAAACTCCCCCGAGTTCGACACCCTCTCCCCCGCGCAAAAAACCAAACTCAACCACGATC
TGCGCGATTTCGTCCTCAGCGGCGCGGAACTGCCGCCCGAACAGCAGGCAGAACTGGCAAAACTGCAAACCGAAGGCGCG
CAACTTTCCGCCAAATTCTCCCAAAACGTCCTAGACGCGACCGACGCGTTCGGCATTTACTTTGACGATGCCGCACCGCT
TGCCGGCATTCCCGAAGACGCGCTCGCCATGTTTGCCGCTGCCGCGCAAAGCGAAGGCAAAACAGGCTACAAAATCGGTT
TGCAGATTCCGCACTACCTCGCCGTCATCCAATACGCCGACAACCGCGAACTGCGCGAACAAATCTACCGCGCCTACGTT
ACCCGCGCCAGCGAACTTTTAGACGGCGGCAAATTCGACAACACCGCCAACATCGACCGCACGCTCGCAAACGCCCTGCA
AACCGCCAAACTGCTCGGCTTCAAAAACTACGCCGAATTGTCGCTGGCAACCAAAATGGCGGACACCCCCGAACAAGTTT
TAAACTTCCTGCACGACCTCGCCCGCCGCGCCAAACCCTACGCCGAAAAAGACCTCGCCGAAGTCAAAGCCTTCGCCCGC
GAAAGCCTGAACCTCGCCGATTTGCAACCGTGGGACTTGGGCTACGCCAGCGAAAAACTGCGCGAAGCCAAATACGCGTT
CAGCGAAACCGAAGTCAAAAAATACTTCCCCGTCGGCAAAGTATTAAACGGACTGTTCGCCCAAATCAAAAAACTCTACG
GCATCGGATTTACCGAAAAAACCGTCCCCGTCTGGCACAAAGACGTGCGCTATTTTGAATTGCAACAAAACGGCGAAACC
ATAGGCGGCGTCTATATGGACCTCTACGCCCGCGAAGGCAAACGCGGCGGCGCGTGGATGAACGACTACAAAGGTCGCCG
CCGTTTTTCAGACGGCACGCTGCAACTGCCCACCGCCTACCTCGTCTGCAACTTCGCCCCACCCGTCGGCGGCAGGGAAG
CCCGCCTGAGCCATGACGAAATCCTCACCCTCTTCCACGAAACCGGCCACGGCCTGCACCACCTGCTTACCCAAGTGGAC
GAACTGGGCGTGTCCGGTATCAACGGCGTAGAATGGGACGCGGTCGAACTGCCCAGCCAGTTTATGGAAAATTTCGTTTG
GGAATACAATGTATTGGCGCAAATGTCCACCCACGAAGAAACCGGCGAGCCCCTGCCGAAAGAACTCTTCGACAAAATGC
TCGCCGCCAAAAACTTCCAACGCGGAATGTTCCTCGTCCGCCAGATGGAGTTCGCCCTCTTCGATATGATGATTTACAGC
GAAGACGACGAAGGCCGTCTGAAAAACTGGCAACAGGTTTTAGACAGCGTGCGCAAAGAAGTCGCCGTCATCCAACCGCC
CGAATACAACCGCTTCGCCTTGAGCTTCGGCCACATCTTCGCAGGCGGCTATTCCGCAGGCTATTACAGCTACGCGTGGG
CGGAAGTATTGAGCGCGGACGCATACGCCGCCTTTGAAGAAAGCGACGATGTCGCCGCCACAGGCAAACGCTTTTGGCAG
GAAATCCTCGCCGTCGGCGGATCGCGCAGCGCGGCAGAATCCTTCAAAGCCTTCCGCGGCCGCGAACCGAGCATAGACGC
ACTCTTGCGCCACAGCGGTTTCGACAACGCGGCTTGA

Upstream 100 bases:

>100_bases
CGAAACACTTTAACTTTCCCCGACCGACCCCATTTCCGGCTTCAGACGGCATATTGCCGATATGCTGTCTGAAGCACAAC
ACGCAAAGGAAACCCATCTT

Downstream 100 bases:

>100_bases
TCGATGTGAACAAAAAATGCCGTCTGAAACAATCAAACAGTGTTTCAGACGGCATCAGCATTTGCGCGGTTTCGCCATTT
TCACAAAAACAGTAAGCCAA

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 678; Mature: 677

Protein sequence:

>678_residues
MTDNALLHLGEEPRFDQIKTEDIKPALQTAIAEAREQIAAIKAQTHTGWANTVEPLTGITERVGRIWGVVSHLNSVADTP
ELRAVYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFDTLSPAQKTKLNHDLRDFVLSGAELPPEQQAELAKLQTEGA
QLSAKFSQNVLDATDAFGIYFDDAAPLAGIPEDALAMFAAAAQSEGKTGYKIGLQIPHYLAVIQYADNRELREQIYRAYV
TRASELLDGGKFDNTANIDRTLANALQTAKLLGFKNYAELSLATKMADTPEQVLNFLHDLARRAKPYAEKDLAEVKAFAR
ESLNLADLQPWDLGYASEKLREAKYAFSETEVKKYFPVGKVLNGLFAQIKKLYGIGFTEKTVPVWHKDVRYFELQQNGET
IGGVYMDLYAREGKRGGAWMNDYKGRRRFSDGTLQLPTAYLVCNFAPPVGGREARLSHDEILTLFHETGHGLHHLLTQVD
ELGVSGINGVEWDAVELPSQFMENFVWEYNVLAQMSTHEETGEPLPKELFDKMLAAKNFQRGMFLVRQMEFALFDMMIYS
EDDEGRLKNWQQVLDSVRKEVAVIQPPEYNRFALSFGHIFAGGYSAGYYSYAWAEVLSADAYAAFEESDDVAATGKRFWQ
EILAVGGSRSAAESFKAFRGREPSIDALLRHSGFDNAA

Sequences:

>Translated_678_residues
MTDNALLHLGEEPRFDQIKTEDIKPALQTAIAEAREQIAAIKAQTHTGWANTVEPLTGITERVGRIWGVVSHLNSVADTP
ELRAVYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFDTLSPAQKTKLNHDLRDFVLSGAELPPEQQAELAKLQTEGA
QLSAKFSQNVLDATDAFGIYFDDAAPLAGIPEDALAMFAAAAQSEGKTGYKIGLQIPHYLAVIQYADNRELREQIYRAYV
TRASELLDGGKFDNTANIDRTLANALQTAKLLGFKNYAELSLATKMADTPEQVLNFLHDLARRAKPYAEKDLAEVKAFAR
ESLNLADLQPWDLGYASEKLREAKYAFSETEVKKYFPVGKVLNGLFAQIKKLYGIGFTEKTVPVWHKDVRYFELQQNGET
IGGVYMDLYAREGKRGGAWMNDYKGRRRFSDGTLQLPTAYLVCNFAPPVGGREARLSHDEILTLFHETGHGLHHLLTQVD
ELGVSGINGVEWDAVELPSQFMENFVWEYNVLAQMSTHEETGEPLPKELFDKMLAAKNFQRGMFLVRQMEFALFDMMIYS
EDDEGRLKNWQQVLDSVRKEVAVIQPPEYNRFALSFGHIFAGGYSAGYYSYAWAEVLSADAYAAFEESDDVAATGKRFWQ
EILAVGGSRSAAESFKAFRGREPSIDALLRHSGFDNAA
>Mature_677_residues
TDNALLHLGEEPRFDQIKTEDIKPALQTAIAEAREQIAAIKAQTHTGWANTVEPLTGITERVGRIWGVVSHLNSVADTPE
LRAVYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFDTLSPAQKTKLNHDLRDFVLSGAELPPEQQAELAKLQTEGAQ
LSAKFSQNVLDATDAFGIYFDDAAPLAGIPEDALAMFAAAAQSEGKTGYKIGLQIPHYLAVIQYADNRELREQIYRAYVT
RASELLDGGKFDNTANIDRTLANALQTAKLLGFKNYAELSLATKMADTPEQVLNFLHDLARRAKPYAEKDLAEVKAFARE
SLNLADLQPWDLGYASEKLREAKYAFSETEVKKYFPVGKVLNGLFAQIKKLYGIGFTEKTVPVWHKDVRYFELQQNGETI
GGVYMDLYAREGKRGGAWMNDYKGRRRFSDGTLQLPTAYLVCNFAPPVGGREARLSHDEILTLFHETGHGLHHLLTQVDE
LGVSGINGVEWDAVELPSQFMENFVWEYNVLAQMSTHEETGEPLPKELFDKMLAAKNFQRGMFLVRQMEFALFDMMIYSE
DDEGRLKNWQQVLDSVRKEVAVIQPPEYNRFALSFGHIFAGGYSAGYYSYAWAEVLSADAYAAFEESDDVAATGKRFWQE
ILAVGGSRSAAESFKAFRGREPSIDALLRHSGFDNAA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=610, Percent_Identity=30.327868852459, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI14149738, Length=610, Percent_Identity=29.1803278688525, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI156105687, Length=620, Percent_Identity=23.2258064516129, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1789913, Length=676, Percent_Identity=49.112426035503, Blast_Score=641, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=677, Percent_Identity=32.0531757754801, Blast_Score=289, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI71999758, Length=521, Percent_Identity=27.447216890595, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI32565901, Length=645, Percent_Identity=22.015503875969, Blast_Score=112, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6319793, Length=662, Percent_Identity=29.0030211480363, Blast_Score=266, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6322715, Length=665, Percent_Identity=23.609022556391, Blast_Score=143, Evalue=7e-35,
Organism=Drosophila melanogaster, GI21356111, Length=551, Percent_Identity=29.4010889292196, Blast_Score=225, Evalue=8e-59,
Organism=Drosophila melanogaster, GI20129717, Length=554, Percent_Identity=25.2707581227437, Blast_Score=159, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76013; Mature: 75882

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDNALLHLGEEPRFDQIKTEDIKPALQTAIAEAREQIAAIKAQTHTGWANTVEPLTGIT
CCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
ERVGRIWGVVSHLNSVADTPELRAVYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFD
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
TLSPAQKTKLNHDLRDFVLSGAELPPEQQAELAKLQTEGAQLSAKFSQNVLDATDAFGIY
CCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEE
FDDAAPLAGIPEDALAMFAAAAQSEGKTGYKIGLQIPHYLAVIQYADNRELREQIYRAYV
ECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHH
TRASELLDGGKFDNTANIDRTLANALQTAKLLGFKNYAELSLATKMADTPEQVLNFLHDL
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHH
ARRAKPYAEKDLAEVKAFARESLNLADLQPWDLGYASEKLREAKYAFSETEVKKYFPVGK
HHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
VLNGLFAQIKKLYGIGFTEKTVPVWHKDVRYFELQQNGETIGGVYMDLYAREGKRGGAWM
HHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCH
NDYKGRRRFSDGTLQLPTAYLVCNFAPPVGGREARLSHDEILTLFHETGHGLHHLLTQVD
HHHCCCCCCCCCCEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
ELGVSGINGVEWDAVELPSQFMENFVWEYNVLAQMSTHEETGEPLPKELFDKMLAAKNFQ
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
RGMFLVRQMEFALFDMMIYSEDDEGRLKNWQQVLDSVRKEVAVIQPPEYNRFALSFGHIF
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEHHHHH
AGGYSAGYYSYAWAEVLSADAYAAFEESDDVAATGKRFWQEILAVGGSRSAAESFKAFRG
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
REPSIDALLRHSGFDNAA
CCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
TDNALLHLGEEPRFDQIKTEDIKPALQTAIAEAREQIAAIKAQTHTGWANTVEPLTGIT
CCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
ERVGRIWGVVSHLNSVADTPELRAVYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFD
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
TLSPAQKTKLNHDLRDFVLSGAELPPEQQAELAKLQTEGAQLSAKFSQNVLDATDAFGIY
CCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEE
FDDAAPLAGIPEDALAMFAAAAQSEGKTGYKIGLQIPHYLAVIQYADNRELREQIYRAYV
ECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHH
TRASELLDGGKFDNTANIDRTLANALQTAKLLGFKNYAELSLATKMADTPEQVLNFLHDL
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHH
ARRAKPYAEKDLAEVKAFARESLNLADLQPWDLGYASEKLREAKYAFSETEVKKYFPVGK
HHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
VLNGLFAQIKKLYGIGFTEKTVPVWHKDVRYFELQQNGETIGGVYMDLYAREGKRGGAWM
HHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCH
NDYKGRRRFSDGTLQLPTAYLVCNFAPPVGGREARLSHDEILTLFHETGHGLHHLLTQVD
HHHCCCCCCCCCCEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
ELGVSGINGVEWDAVELPSQFMENFVWEYNVLAQMSTHEETGEPLPKELFDKMLAAKNFQ
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
RGMFLVRQMEFALFDMMIYSEDDEGRLKNWQQVLDSVRKEVAVIQPPEYNRFALSFGHIF
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEHHHHH
AGGYSAGYYSYAWAEVLSADAYAAFEESDDVAATGKRFWQEILAVGGSRSAAESFKAFRG
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
REPSIDALLRHSGFDNAA
CCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]