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The map label for this gene is pyrD

Identifier: 161870842

GI number: 161870842

Start: 1972189

End: 1973214

Strand: Reverse

Name: pyrD

Synonym: NMCC_1924

Alternate gene names: 161870842

Gene position: 1973214-1972189 (Counterclockwise)

Preceding gene: 161870848

Following gene: 161870841

Centisome position: 91.63

GC content: 53.51

Gene sequence:

>1026_bases
ATGTATCCACTTGCCCGCCGCATCCTGTTTGCACTCGATGCCGAGAAAGCCCACCACTTCACGCTCGACGCGCTCAACAT
GGTTTATAAATTGGGTCTGATTCCCGTAACCGGCAACCGTACCAAACCTGTAAAACTGATGGGTTTGGATTTGCCCAACC
CTGTCGGGCTTGCCGCCGGACTCGATAAAAACGGCGAATATATAGACGCATTGGGCGCGCTCGGCTTCGGTTTCATCGAA
ATCGGCACGGTAACGCCCAACCCGCAGCCCGGCAACCCGCAGCCGCGCCTCTTCCGCGTTCCCGAATATCAAGGCATCAT
CAACCGCATGGGCTTCAACAACCACGGCATCGATGCCATGATTCAAAACATCGAAAAAAGTAAATTCAGCGGCGTATTGG
GCATCAACATCGGCAAAAACGCTGTAACACCGATTGAAAACGCTGCCGATGATTATTTAATCTGCCTCGAAAAAGCCTAC
GCACACGCAAGTTACATTACCGTCAATATTTCCTCGCCCAACACTAAAAACCTCCGCGCGCTGCAAGGTGGCGACGAGTT
GAGCGCATTGCTTGAGGCTTTGAAAAACAAACAGGCACAGCTTGCCTCTGTACACGGGAAATACGTCCCGCTCGCCGTCA
AAATCGCCCCCGATTTGGATGAAGCACAAATCGAAGACATCGCCCACGTTGTCAAATCCGTCGAAATGGACGGCATCATC
GCTACCAATACCACCATCGACAAATCAAGTCTCGGCAGCCATCCGCTCGCAGGCGAGCAGGGCGGTTTGAGCGGGCTGCC
CGTTCATGAAAAAAGTAATCGGGTGTTGAAGCTGTTGGCAGACCACATCGACGGCAAGCTGCCGATTATCGGCGTAGGCG
GCATTATGGAAGGCAGGGACGCGGCAGAGAAAATCCGCTTGGGCGCGACCGCCGTCCAAGTGTACAGCGGATTGATATAC
AAAGGTCCGGCATTGGTCAAAGAATGTTTGAAGGCTTTGGCGCGATCCGCCCAAAATGCCGTCTGA

Upstream 100 bases:

>100_bases
TGCGGCGGGTTTTGTCGTTCAAGTTTGACCTGTGTGCCGTATGTTTGACGGGATTTCGGTTAAAATGACGGCATTTCCAT
CTGAAGCAGAAAGCCCTGTC

Downstream 100 bases:

>100_bases
ACGCACGTTTTGCCGTTCAGACGGCATTTTCATTTCCTTTTTCCGCCTGCCGCCCCTTGAAAATCCCTTACGCGCCGCCC
TGTTTGAAATAAGGCAAACC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MYPLARRILFALDAEKAHHFTLDALNMVYKLGLIPVTGNRTKPVKLMGLDLPNPVGLAAGLDKNGEYIDALGALGFGFIE
IGTVTPNPQPGNPQPRLFRVPEYQGIINRMGFNNHGIDAMIQNIEKSKFSGVLGINIGKNAVTPIENAADDYLICLEKAY
AHASYITVNISSPNTKNLRALQGGDELSALLEALKNKQAQLASVHGKYVPLAVKIAPDLDEAQIEDIAHVVKSVEMDGII
ATNTTIDKSSLGSHPLAGEQGGLSGLPVHEKSNRVLKLLADHIDGKLPIIGVGGIMEGRDAAEKIRLGATAVQVYSGLIY
KGPALVKECLKALARSAQNAV

Sequences:

>Translated_341_residues
MYPLARRILFALDAEKAHHFTLDALNMVYKLGLIPVTGNRTKPVKLMGLDLPNPVGLAAGLDKNGEYIDALGALGFGFIE
IGTVTPNPQPGNPQPRLFRVPEYQGIINRMGFNNHGIDAMIQNIEKSKFSGVLGINIGKNAVTPIENAADDYLICLEKAY
AHASYITVNISSPNTKNLRALQGGDELSALLEALKNKQAQLASVHGKYVPLAVKIAPDLDEAQIEDIAHVVKSVEMDGII
ATNTTIDKSSLGSHPLAGEQGGLSGLPVHEKSNRVLKLLADHIDGKLPIIGVGGIMEGRDAAEKIRLGATAVQVYSGLIY
KGPALVKECLKALARSAQNAV
>Mature_341_residues
MYPLARRILFALDAEKAHHFTLDALNMVYKLGLIPVTGNRTKPVKLMGLDLPNPVGLAAGLDKNGEYIDALGALGFGFIE
IGTVTPNPQPGNPQPRLFRVPEYQGIINRMGFNNHGIDAMIQNIEKSKFSGVLGINIGKNAVTPIENAADDYLICLEKAY
AHASYITVNISSPNTKNLRALQGGDELSALLEALKNKQAQLASVHGKYVPLAVKIAPDLDEAQIEDIAHVVKSVEMDGII
ATNTTIDKSSLGSHPLAGEQGGLSGLPVHEKSNRVLKLLADHIDGKLPIIGVGGIMEGRDAAEKIRLGATAVQVYSGLIY
KGPALVKECLKALARSAQNAV

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=333, Percent_Identity=43.5435435435435, Blast_Score=248, Evalue=7e-66,
Organism=Escherichia coli, GI1787177, Length=329, Percent_Identity=54.7112462006079, Blast_Score=361, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17509475, Length=325, Percent_Identity=41.2307692307692, Blast_Score=227, Evalue=6e-60,
Organism=Drosophila melanogaster, GI281361352, Length=334, Percent_Identity=41.6167664670659, Blast_Score=249, Evalue=1e-66,
Organism=Drosophila melanogaster, GI17137316, Length=334, Percent_Identity=41.6167664670659, Blast_Score=249, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_NEIM0 (A9M3G1)

Other databases:

- EMBL:   CP000381
- RefSeq:   YP_001600015.1
- ProteinModelPortal:   A9M3G1
- SMR:   A9M3G1
- EnsemblBacteria:   EBNEIT00000012722
- GeneID:   5794945
- GenomeReviews:   CP000381_GR
- KEGG:   nmn:NMCC_1924
- GeneTree:   EBGT00050000020898
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- ProtClustDB:   PRK05286
- BioCyc:   NMEN374833:NMCC_1924-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 36359; Mature: 36359

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPLARRILFALDAEKAHHFTLDALNMVYKLGLIPVTGNRTKPVKLMGLDLPNPVGLAAG
CCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCEEECCCCCCCEEEEECCCCCCCCCCCC
LDKNGEYIDALGALGFGFIEIGTVTPNPQPGNPQPRLFRVPEYQGIINRMGFNNHGIDAM
CCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCHHHH
IQNIEKSKFSGVLGINIGKNAVTPIENAADDYLICLEKAYAHASYITVNISSPNTKNLRA
HHHHHHHHHCCEEEEECCCCCCCCCCCCCCHHEEHHHHHHCCEEEEEEEECCCCCCCEEE
LQGGDELSALLEALKNKQAQLASVHGKYVPLAVKIAPDLDEAQIEDIAHVVKSVEMDGII
ECCCHHHHHHHHHHHCCHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEE
ATNTTIDKSSLGSHPLAGEQGGLSGLPVHEKSNRVLKLLADHIDGKLPIIGVGGIMEGRD
EECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCH
AAEKIRLGATAVQVYSGLIYKGPALVKECLKALARSAQNAV
HHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYPLARRILFALDAEKAHHFTLDALNMVYKLGLIPVTGNRTKPVKLMGLDLPNPVGLAAG
CCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCEEECCCCCCCEEEEECCCCCCCCCCCC
LDKNGEYIDALGALGFGFIEIGTVTPNPQPGNPQPRLFRVPEYQGIINRMGFNNHGIDAM
CCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCHHHH
IQNIEKSKFSGVLGINIGKNAVTPIENAADDYLICLEKAYAHASYITVNISSPNTKNLRA
HHHHHHHHHCCEEEEECCCCCCCCCCCCCCHHEEHHHHHHCCEEEEEEEECCCCCCCEEE
LQGGDELSALLEALKNKQAQLASVHGKYVPLAVKIAPDLDEAQIEDIAHVVKSVEMDGII
ECCCHHHHHHHHHHHCCHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEE
ATNTTIDKSSLGSHPLAGEQGGLSGLPVHEKSNRVLKLLADHIDGKLPIIGVGGIMEGRD
EECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCH
AAEKIRLGATAVQVYSGLIYKGPALVKECLKALARSAQNAV
HHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA