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The map label for this gene is nuoM [H]

Identifier: 161870806

GI number: 161870806

Start: 1936742

End: 1938175

Strand: Reverse

Name: nuoM [H]

Synonym: NMCC_1888

Alternate gene names: 161870806

Gene position: 1938175-1936742 (Counterclockwise)

Preceding gene: 161870807

Following gene: 161870805

Centisome position: 90.0

GC content: 52.02

Gene sequence:

>1434_bases
TTGGCGACCGGTAAAGACAGCCGTGCGCCGCTGGCGCGTGTGCTTGCCTTTATGGGTGCGCTTGCCGGTTTCTTGGTAAC
GCTGCCCCTGTTTACCGGTTTCGACCGTTTGAGCGGCGGCTATCAATTTACCGAGTTCCACGAGTGGATTCCGCTGCTGA
AAATCAACTATGCATTGGGCGTGGACGGTATTTCGGTGCTCTTTATCATCTTGAATGCGTTTATTACGCTGTTGGTGGTA
TTGGCCGGTTGGGAAGTTATTCAGAAACGCCCGGCGCAGTATATGGCGGCATTCCTGATGATGTCGGGTTTGATTAACGG
TGCGTTTGCCGCGCAGGATGCGATTCTGTTTTATGTGTTCTTCGAGGGTATGCTGATTCCGCTGTACCTGATTATCGGTG
TATGGGGCGGCCCGCGCCGCGTCTATGCGTCGGTCAAGCTGTTCCTCTATACGCTGATGGGTTCGCTCCTGATGCTGGTT
GCTATGGTTTACCTGTACTATCAAACAGGCAGCTTCTCTATTGTCGATTTCCAAAACATCAAACAGATTCCGTTGGGCGT
ACAGCAGCTTTTGTTTGCGGCATTCTTCCTGTCATTTGCCGTAAAAGTGCCGATGTTCCCCGTACACACTTGGCTGCCGG
ATGCCCACGTTGAAGCGCCGACCGGCGGTTCGATGGTGTTGGCGGCGATTACGCTGAAACTGGGTGCGTATGGTTTCTTG
CGCTTTATCCTGCCGATTATGCCGGACGCGGCACGCTATTTTGCCCCCGTGATCATCGTATTGAGCCTGATTGCCGTAAT
TTATATCGGTATGGTGGCTTTGGTGCAAACCGATATGAAAAAACTGGTGGCGTATTCGTCCATCAGCCATATGGGTTTTG
TAACGCTTGGGATGTTTTTGTTTGTTGACGGGCAGTTGGACGACTGGGCATTGAAAGGTGCAATCATTCAAATGATTTCC
CACGGTTTCGTGTCTGCCGCGATGTTTATGTGTATCGGCGTGATGTACGACCGCCTGCATACGCGCAATATTGCCGATTA
TGGCGGCGTGGTCAATGTGATGCCCAAGTTTGCGGCGTTTATGATGCTGTTCGGTATGGCGAACGCCGGTCTGCCTGCGA
CTTCCGGCTTTGTGGGCGAGTTTATGGTGATTATGGGCGCGGTTAAAGTGAATTTCTGGGTAGGCGCTTTGGCCGCCATG
ACCCTGATTTACGGTGCGTCTTATACCCTGTGGATGTACAAGCGCGTGATTTTCGGCGCGATTCACAATCCGCACGTTGC
CGAAATGAAAGACATCAACTGCCGCGAATTTGCGATTCTGGCGGTGTTGGCGGTTGCTGTTTTGGGTATGGGCCTGTATC
CGAACGCATTTATCGAAGTGGTGCATCAGGCGGCAAACGATTTGATTGCCCATGTGGCACAAAGCAAGATGTGA

Upstream 100 bases:

>100_bases
ACTTTTCCAATAACCTCCAAACCAAACAGGTAACGCAATGTTTTCTAACCATCTTCTCAGCTTGGCAATATGGATACCCA
TTGCCGCAGGTGTGCTGGTT

Downstream 100 bases:

>100_bases
GGTGTGTAAATGAACTGGTCTGATTTGAATTTAATGCCCGCCATGCCCGAAATCGTGCTGCTTGCGCTGCTGGTGTTATT
GTTGCTGGCGGACTTGTGGG

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MATGKDSRAPLARVLAFMGALAGFLVTLPLFTGFDRLSGGYQFTEFHEWIPLLKINYALGVDGISVLFIILNAFITLLVV
LAGWEVIQKRPAQYMAAFLMMSGLINGAFAAQDAILFYVFFEGMLIPLYLIIGVWGGPRRVYASVKLFLYTLMGSLLMLV
AMVYLYYQTGSFSIVDFQNIKQIPLGVQQLLFAAFFLSFAVKVPMFPVHTWLPDAHVEAPTGGSMVLAAITLKLGAYGFL
RFILPIMPDAARYFAPVIIVLSLIAVIYIGMVALVQTDMKKLVAYSSISHMGFVTLGMFLFVDGQLDDWALKGAIIQMIS
HGFVSAAMFMCIGVMYDRLHTRNIADYGGVVNVMPKFAAFMMLFGMANAGLPATSGFVGEFMVIMGAVKVNFWVGALAAM
TLIYGASYTLWMYKRVIFGAIHNPHVAEMKDINCREFAILAVLAVAVLGMGLYPNAFIEVVHQAANDLIAHVAQSKM

Sequences:

>Translated_477_residues
MATGKDSRAPLARVLAFMGALAGFLVTLPLFTGFDRLSGGYQFTEFHEWIPLLKINYALGVDGISVLFIILNAFITLLVV
LAGWEVIQKRPAQYMAAFLMMSGLINGAFAAQDAILFYVFFEGMLIPLYLIIGVWGGPRRVYASVKLFLYTLMGSLLMLV
AMVYLYYQTGSFSIVDFQNIKQIPLGVQQLLFAAFFLSFAVKVPMFPVHTWLPDAHVEAPTGGSMVLAAITLKLGAYGFL
RFILPIMPDAARYFAPVIIVLSLIAVIYIGMVALVQTDMKKLVAYSSISHMGFVTLGMFLFVDGQLDDWALKGAIIQMIS
HGFVSAAMFMCIGVMYDRLHTRNIADYGGVVNVMPKFAAFMMLFGMANAGLPATSGFVGEFMVIMGAVKVNFWVGALAAM
TLIYGASYTLWMYKRVIFGAIHNPHVAEMKDINCREFAILAVLAVAVLGMGLYPNAFIEVVHQAANDLIAHVAQSKM
>Mature_476_residues
ATGKDSRAPLARVLAFMGALAGFLVTLPLFTGFDRLSGGYQFTEFHEWIPLLKINYALGVDGISVLFIILNAFITLLVVL
AGWEVIQKRPAQYMAAFLMMSGLINGAFAAQDAILFYVFFEGMLIPLYLIIGVWGGPRRVYASVKLFLYTLMGSLLMLVA
MVYLYYQTGSFSIVDFQNIKQIPLGVQQLLFAAFFLSFAVKVPMFPVHTWLPDAHVEAPTGGSMVLAAITLKLGAYGFLR
FILPIMPDAARYFAPVIIVLSLIAVIYIGMVALVQTDMKKLVAYSSISHMGFVTLGMFLFVDGQLDDWALKGAIIQMISH
GFVSAAMFMCIGVMYDRLHTRNIADYGGVVNVMPKFAAFMMLFGMANAGLPATSGFVGEFMVIMGAVKVNFWVGALAAMT
LIYGASYTLWMYKRVIFGAIHNPHVAEMKDINCREFAILAVLAVAVLGMGLYPNAFIEVVHQAANDLIAHVAQSKM

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=370, Percent_Identity=34.0540540540541, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI251831117, Length=403, Percent_Identity=23.3250620347395, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1788613, Length=454, Percent_Identity=36.5638766519824, Blast_Score=292, Evalue=3e-80,
Organism=Escherichia coli, GI1788827, Length=279, Percent_Identity=25.089605734767, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788829, Length=358, Percent_Identity=26.8156424581006, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI145693160, Length=355, Percent_Identity=26.1971830985915, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788831, Length=294, Percent_Identity=27.5510204081633, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788614, Length=308, Percent_Identity=29.2207792207792, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI2367154, Length=298, Percent_Identity=25.1677852348993, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 52351; Mature: 52219

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATGKDSRAPLARVLAFMGALAGFLVTLPLFTGFDRLSGGYQFTEFHEWIPLLKINYALG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHEEEHHHC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CCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]