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The map label for this gene is hemN [H]

Identifier: 161870690

GI number: 161870690

Start: 1814592

End: 1816013

Strand: Direct

Name: hemN [H]

Synonym: NMCC_1762

Alternate gene names: 161870690

Gene position: 1814592-1816013 (Clockwise)

Preceding gene: 161870688

Following gene: 161870691

Centisome position: 84.27

GC content: 54.5

Gene sequence:

>1422_bases
ATGAAAATCATTCAGATACAGAACAATCACAATGTAAACGATGACCGCCCCGAGTTTGACCGCGCGCTGATTGCCAGCCT
GCCCGCCAGCGGCCCGCGCTACACTTCCTACCCTACCGCCGACCGTTTCCATGACGGTTTCCGCGAAGGCGAATATATCA
AAGCTTTACATTTGCGCGGTATGGGCGCGTTAAACAAACCGCTTTCCCTTTACATTCACATTCCGTTCTGCAACACCATC
TGCTACTACTGCGGCTGCAACAAAATCATCACCAAAGACAAAAGCCGCGCCGATGCCTACATCGAATATCTTGAAAAAGA
AATGGAACTGCTCGCTCCACATCTGAACGGACGGCACCAGCTTGCCCAACTGCACTTCGGCGGCGGCACGCCGACCTTTT
TGAGCGACGAACAGATCGAACGTGTCTTCCGCATGATACGCAAACATTTCGAGTTAATCCCCACCGGCGAATACTCCATC
GAAATCGACCCGCGCAAAGTCAGCCGCGACACCGTCCTCATGCTCGGCAGACTCGGCTTCAACCGCATGAGCATCGGCAT
TCAGGATTTCGACCCCAAAGTGCAGGCGGCGGTCAACCGCATCCAAAGTTACGAAGAAACCAAAGAAGTCATCGATGCGG
CGCGCGAAGCGGGGTTCAAATCCGTCAGCGTCGATTTGATTTACGGCCTGCCGCACCAGACTTCGGAAAGCATCAAAACC
ACCATCGATACCGTTTTGTCGCTCGATCCCGACCGCCTCGCCCTTTATCACTACGCCCACCTGCCGCACGTGTTCAAACC
GCAACGCCGCATCGATACCGCCGCCGTTCCCGACAGCGAAGAGAAGCTCGATATGCTGCAATACTGCGTCCAAACCCTAA
CCGAACGCGGCTACGTCTTCATCGGCATGGATCATTTCGCCAAACCTGACGACGAACTCTCCATCGCCCTCAAAGAAGGC
TTCCTCCAGCGCAACTTCCAAGGCTATTCGACCTACGCGGATTGCGATTTGGTCGCCATCGGCGTGTCGTCCATCGGCAA
AATCGGCAGCACCTATTCCCAAAACGAACGCGACATCGATGCCTACTATGCCGCCATCGACGAAGGCAGACTGCCCATCA
TGCGCGGTTATCAGCTCAATCAGGACGACATCCTGCGCCGCAACATCATTCAGGATTTGATGTGCCGTTTCGCGCTCGAC
TACCGGATTTACGAAAGTATGTTCGGCATCCCGTTCGACCGCTACTTCAAAGACGAACTGGCGGATTTGGAAAAACTCGC
CGGTTTGGGATTGGTGCGCCTGAACAGCCACGGGCTGACCGTTACCCCGAAAGGACGCTTCCTCATCCGCAACATCGCCA
TGGTCTTCGATTACCACCTGCGCCATAAAGAAACCAAGGCGAAATATTCGCAAACGGTGTGA

Upstream 100 bases:

>100_bases
ATATGTGCTTATTGACACATATCAAGACAGGTTTATCATACTGTGGCATTCTACCAAACTATCCAAAATTTGACTAACAT
CATAAAACCGCACACACACC

Downstream 100 bases:

>100_bases
TTGCGTCTAACGTACAAATGCCGTCTGAAAGGCTTTTTCAGACGGCATTTTGCTGCCGGCAGGATAAGTGTTTTCAAGAA
CAGGCGGCGGCATATCATAA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MKIIQIQNNHNVNDDRPEFDRALIASLPASGPRYTSYPTADRFHDGFREGEYIKALHLRGMGALNKPLSLYIHIPFCNTI
CYYCGCNKIITKDKSRADAYIEYLEKEMELLAPHLNGRHQLAQLHFGGGTPTFLSDEQIERVFRMIRKHFELIPTGEYSI
EIDPRKVSRDTVLMLGRLGFNRMSIGIQDFDPKVQAAVNRIQSYEETKEVIDAAREAGFKSVSVDLIYGLPHQTSESIKT
TIDTVLSLDPDRLALYHYAHLPHVFKPQRRIDTAAVPDSEEKLDMLQYCVQTLTERGYVFIGMDHFAKPDDELSIALKEG
FLQRNFQGYSTYADCDLVAIGVSSIGKIGSTYSQNERDIDAYYAAIDEGRLPIMRGYQLNQDDILRRNIIQDLMCRFALD
YRIYESMFGIPFDRYFKDELADLEKLAGLGLVRLNSHGLTVTPKGRFLIRNIAMVFDYHLRHKETKAKYSQTV

Sequences:

>Translated_473_residues
MKIIQIQNNHNVNDDRPEFDRALIASLPASGPRYTSYPTADRFHDGFREGEYIKALHLRGMGALNKPLSLYIHIPFCNTI
CYYCGCNKIITKDKSRADAYIEYLEKEMELLAPHLNGRHQLAQLHFGGGTPTFLSDEQIERVFRMIRKHFELIPTGEYSI
EIDPRKVSRDTVLMLGRLGFNRMSIGIQDFDPKVQAAVNRIQSYEETKEVIDAAREAGFKSVSVDLIYGLPHQTSESIKT
TIDTVLSLDPDRLALYHYAHLPHVFKPQRRIDTAAVPDSEEKLDMLQYCVQTLTERGYVFIGMDHFAKPDDELSIALKEG
FLQRNFQGYSTYADCDLVAIGVSSIGKIGSTYSQNERDIDAYYAAIDEGRLPIMRGYQLNQDDILRRNIIQDLMCRFALD
YRIYESMFGIPFDRYFKDELADLEKLAGLGLVRLNSHGLTVTPKGRFLIRNIAMVFDYHLRHKETKAKYSQTV
>Mature_473_residues
MKIIQIQNNHNVNDDRPEFDRALIASLPASGPRYTSYPTADRFHDGFREGEYIKALHLRGMGALNKPLSLYIHIPFCNTI
CYYCGCNKIITKDKSRADAYIEYLEKEMELLAPHLNGRHQLAQLHFGGGTPTFLSDEQIERVFRMIRKHFELIPTGEYSI
EIDPRKVSRDTVLMLGRLGFNRMSIGIQDFDPKVQAAVNRIQSYEETKEVIDAAREAGFKSVSVDLIYGLPHQTSESIKT
TIDTVLSLDPDRLALYHYAHLPHVFKPQRRIDTAAVPDSEEKLDMLQYCVQTLTERGYVFIGMDHFAKPDDELSIALKEG
FLQRNFQGYSTYADCDLVAIGVSSIGKIGSTYSQNERDIDAYYAAIDEGRLPIMRGYQLNQDDILRRNIIQDLMCRFALD
YRIYESMFGIPFDRYFKDELADLEKLAGLGLVRLNSHGLTVTPKGRFLIRNIAMVFDYHLRHKETKAKYSQTV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=241, Percent_Identity=28.2157676348548, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI87082341, Length=456, Percent_Identity=47.3684210526316, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1789325, Length=282, Percent_Identity=28.7234042553192, Blast_Score=126, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 54255; Mature: 54255

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIQIQNNHNVNDDRPEFDRALIASLPASGPRYTSYPTADRFHDGFREGEYIKALHLRG
CEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCEEHHHHCC
MGALNKPLSLYIHIPFCNTICYYCGCNKIITKDKSRADAYIEYLEKEMELLAPHLNGRHQ
CCCCCCCEEEEEECCHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEE
LAQLHFGGGTPTFLSDEQIERVFRMIRKHFELIPTGEYSIEIDPRKVSRDTVLMLGRLGF
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHCCHHHHHHHHCCC
NRMSIGIQDFDPKVQAAVNRIQSYEETKEVIDAAREAGFKSVSVDLIYGLPHQTSESIKT
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHH
TIDTVLSLDPDRLALYHYAHLPHVFKPQRRIDTAAVPDSEEKLDMLQYCVQTLTERGYVF
HHHHHHCCCCCHHHHHHHHHCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCEEE
IGMDHFAKPDDELSIALKEGFLQRNFQGYSTYADCDLVAIGVSSIGKIGSTYSQNERDID
EECHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECHHHHHHCCCCCCCCCCCHH
AYYAAIDEGRLPIMRGYQLNQDDILRRNIIQDLMCRFALDYRIYESMFGIPFDRYFKDEL
HHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ADLEKLAGLGLVRLNSHGLTVTPKGRFLIRNIAMVFDYHLRHKETKAKYSQTV
HHHHHHHCCCEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIIQIQNNHNVNDDRPEFDRALIASLPASGPRYTSYPTADRFHDGFREGEYIKALHLRG
CEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCEEHHHHCC
MGALNKPLSLYIHIPFCNTICYYCGCNKIITKDKSRADAYIEYLEKEMELLAPHLNGRHQ
CCCCCCCEEEEEECCHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEE
LAQLHFGGGTPTFLSDEQIERVFRMIRKHFELIPTGEYSIEIDPRKVSRDTVLMLGRLGF
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHCCHHHHHHHHCCC
NRMSIGIQDFDPKVQAAVNRIQSYEETKEVIDAAREAGFKSVSVDLIYGLPHQTSESIKT
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHH
TIDTVLSLDPDRLALYHYAHLPHVFKPQRRIDTAAVPDSEEKLDMLQYCVQTLTERGYVF
HHHHHHCCCCCHHHHHHHHHCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCEEE
IGMDHFAKPDDELSIALKEGFLQRNFQGYSTYADCDLVAIGVSSIGKIGSTYSQNERDID
EECHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECHHHHHHCCCCCCCCCCCHH
AYYAAIDEGRLPIMRGYQLNQDDILRRNIIQDLMCRFALDYRIYESMFGIPFDRYFKDEL
HHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ADLEKLAGLGLVRLNSHGLTVTPKGRFLIRNIAMVFDYHLRHKETKAKYSQTV
HHHHHHHCCCEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9396835 [H]