Click here to switch to the map view.

The map label for this gene is nadB [H]

Identifier: 161870679

GI number: 161870679

Start: 1799874

End: 1801382

Strand: Direct

Name: nadB [H]

Synonym: NMCC_1751

Alternate gene names: 161870679

Gene position: 1799874-1801382 (Clockwise)

Preceding gene: 161870678

Following gene: 161870684

Centisome position: 83.58

GC content: 62.09

Gene sequence:

>1509_bases
ATGCAAACCGATTGCGACGTATTGATTGCCGGAAACGGGCTGGCGGCACTGACGCTCGCCCTGTCGCTGCCTGAATCGTT
CCGCATCGTCATTTTGTGCAAAAACCGGCTGGACGACACCGCCAGCCGTCATGCGCAAGGCGGGATTGCGGCGGCGTGGT
CGGGAGAGGACGACATCGAAAAACACGTCGCCGATACTTTGGAAGCGAGCGCAGGTTTGTGCGACGAAGCCGCCGTCCGC
ACCATCCTGTCGCAGGGCAAACCGGCAATCGAATGGCTGCTGGCGCAGGGCGTGGCGTTCGACCGAAATTATGACGGCCT
GCACCTGACGCGCGAAGGCGGGCACACCTGCCGCCGAATCGCCCACGTCGCCGACTACACGGGCGAAGCCGTCATGCAGA
GCCTGCTTGCCCAAATACGCCGCCGCCCGCACATCCGCGTTTGCGAGCGGCAGATGGCGTTGGACATTCAAACCGAATCA
GGTGTGGCGTGCGGACTGATCGTCCTTGACCGCCGAACGCAAGAAACCTACCTCATCCGCGCCCGCCATACCGTACTCGC
AGGCGGCGGCTTGGGACAGATTTACGCCGCCACCACCACGCCGCCCGAATGCACGGGCGACGCCATCGCCATGGCGATAC
GCGCAGGCTGTGCAGTTGAGAACCTCGAATTTATCCAATTCCACCCCACAGGCTTGGCAAGATCGTCTGAAAACGGCCGT
ACCTTCCTGATTTCCGAAGCCGTGCGCGGCGAAGGCGGCATCCTGACCAACCAAGCGGGCGAACGGTTTATGCCGCATTA
CGACCGCCGCGCCGAACTCGCGCCGCGCGACATCGTTGCCCGCGCCATCGCCGCCGAAATCGCCAAACAAACTCCAGACT
TCGTCTCGCTCGACATCAGCCGCCAACCCGAAGCGTTCGTCCGCCGGCATTTTCCGTCCATCCATCGGCACTGTTTATCC
CAATGCGGCCTGGACATCACGCGCCAAGCCATCCCCGTCCGCCCCGTGCAACACTACACCTGCGGCGGCATCCAAACCGA
CCCCTGCGGCAGAACCTCCCTGCCGCAGCTCTACGCCTTAGGCGAAACCGCCTGCACCGGCTTGCACGGAGCCAACCGCC
TCGCCAGCAACTCCCTGCTCGAATGTGTCGTTACCGCCAGACTTGCCGCCCAAACCATCGCGGACGGACAAGCATTCCAA
GCCAAAACGTCTCCAAGGCCGTCTGAAAACCCCTCCGCCGAAGCAGGCATCTTTGCAGACGACCTTCAAAACACATTCAG
CCGCCCCGTCCTGCAAACGTTCAACCAACGCCATCTCGGCATCCTACGCAGCGATACCGGCCTGCGCCGCGCCATCGCCC
AACTGCGGCTTTGGAAGCAAAACCAAGCCGAACCGCACACCGCGTCCGAATACGAAAACCGCAACCTGCTCGAATGCAGC
CTCGCCGTCGCCCAAGCCGCATACAGGCGGAGACAGAACATCGGCGCGCATTTTAATAGTGATTGTTAA

Upstream 100 bases:

>100_bases
GGCAGGACTCAAACGCGGGGATGTGTTCAACGGCATGGGGCCCGCCTGATTTGCCGTCCATATTGCCGTTTCAGACGACC
TCTCCAACAAGGACAACACC

Downstream 100 bases:

>100_bases
GGTTGGCTGGTTAGAAAAAATCGTTCAAATGAATTTTAATAGCATGGTTAAGAGATTGGCATTCAGTTTTTAGGGTTGCG
TAAGTTGGGTTATCAATCTG

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO; Quinolinate synthase B [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MQTDCDVLIAGNGLAALTLALSLPESFRIVILCKNRLDDTASRHAQGGIAAAWSGEDDIEKHVADTLEASAGLCDEAAVR
TILSQGKPAIEWLLAQGVAFDRNYDGLHLTREGGHTCRRIAHVADYTGEAVMQSLLAQIRRRPHIRVCERQMALDIQTES
GVACGLIVLDRRTQETYLIRARHTVLAGGGLGQIYAATTTPPECTGDAIAMAIRAGCAVENLEFIQFHPTGLARSSENGR
TFLISEAVRGEGGILTNQAGERFMPHYDRRAELAPRDIVARAIAAEIAKQTPDFVSLDISRQPEAFVRRHFPSIHRHCLS
QCGLDITRQAIPVRPVQHYTCGGIQTDPCGRTSLPQLYALGETACTGLHGANRLASNSLLECVVTARLAAQTIADGQAFQ
AKTSPRPSENPSAEAGIFADDLQNTFSRPVLQTFNQRHLGILRSDTGLRRAIAQLRLWKQNQAEPHTASEYENRNLLECS
LAVAQAAYRRRQNIGAHFNSDC

Sequences:

>Translated_502_residues
MQTDCDVLIAGNGLAALTLALSLPESFRIVILCKNRLDDTASRHAQGGIAAAWSGEDDIEKHVADTLEASAGLCDEAAVR
TILSQGKPAIEWLLAQGVAFDRNYDGLHLTREGGHTCRRIAHVADYTGEAVMQSLLAQIRRRPHIRVCERQMALDIQTES
GVACGLIVLDRRTQETYLIRARHTVLAGGGLGQIYAATTTPPECTGDAIAMAIRAGCAVENLEFIQFHPTGLARSSENGR
TFLISEAVRGEGGILTNQAGERFMPHYDRRAELAPRDIVARAIAAEIAKQTPDFVSLDISRQPEAFVRRHFPSIHRHCLS
QCGLDITRQAIPVRPVQHYTCGGIQTDPCGRTSLPQLYALGETACTGLHGANRLASNSLLECVVTARLAAQTIADGQAFQ
AKTSPRPSENPSAEAGIFADDLQNTFSRPVLQTFNQRHLGILRSDTGLRRAIAQLRLWKQNQAEPHTASEYENRNLLECS
LAVAQAAYRRRQNIGAHFNSDC
>Mature_502_residues
MQTDCDVLIAGNGLAALTLALSLPESFRIVILCKNRLDDTASRHAQGGIAAAWSGEDDIEKHVADTLEASAGLCDEAAVR
TILSQGKPAIEWLLAQGVAFDRNYDGLHLTREGGHTCRRIAHVADYTGEAVMQSLLAQIRRRPHIRVCERQMALDIQTES
GVACGLIVLDRRTQETYLIRARHTVLAGGGLGQIYAATTTPPECTGDAIAMAIRAGCAVENLEFIQFHPTGLARSSENGR
TFLISEAVRGEGGILTNQAGERFMPHYDRRAELAPRDIVARAIAAEIAKQTPDFVSLDISRQPEAFVRRHFPSIHRHCLS
QCGLDITRQAIPVRPVQHYTCGGIQTDPCGRTSLPQLYALGETACTGLHGANRLASNSLLECVVTARLAAQTIADGQAFQ
AKTSPRPSENPSAEAGIFADDLQNTFSRPVLQTFNQRHLGILRSDTGLRRAIAQLRLWKQNQAEPHTASEYENRNLLECS
LAVAQAAYRRRQNIGAHFNSDC

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=505, Percent_Identity=33.0693069306931, Blast_Score=216, Evalue=4e-56,
Organism=Escherichia coli, GI1788928, Length=520, Percent_Identity=41.1538461538462, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI1790597, Length=366, Percent_Identity=35.2459016393443, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI1786942, Length=504, Percent_Identity=33.3333333333333, Blast_Score=202, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17550100, Length=502, Percent_Identity=31.2749003984064, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17505833, Length=502, Percent_Identity=31.6733067729084, Blast_Score=201, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71986328, Length=430, Percent_Identity=25.5813953488372, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322416, Length=506, Percent_Identity=33.00395256917, Blast_Score=230, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6322701, Length=509, Percent_Identity=33.0058939096267, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6322511, Length=472, Percent_Identity=25.635593220339, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320788, Length=475, Percent_Identity=26.3157894736842, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17137288, Length=524, Percent_Identity=32.0610687022901, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24655642, Length=524, Percent_Identity=32.0610687022901, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24655647, Length=524, Percent_Identity=32.0610687022901, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24663005, Length=535, Percent_Identity=30.2803738317757, Blast_Score=196, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 54738; Mature: 54738

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTDCDVLIAGNGLAALTLALSLPESFRIVILCKNRLDDTASRHAQGGIAAAWSGEDDIE
CCCCCCEEEECCCCEEHHHHHCCCCCEEEEEEECCCCCHHHHHHHCCCEEEECCCCHHHH
KHVADTLEASAGLCDEAAVRTILSQGKPAIEWLLAQGVAFDRNYDGLHLTREGGHTCRRI
HHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHCCEECCCCCCEEEECCCCHHHHHH
AHVADYTGEAVMQSLLAQIRRRPHIRVCERQMALDIQTESGVACGLIVLDRRTQETYLIR
HHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCCEEEEEEEECCCCCEEEEE
ARHTVLAGGGLGQIYAATTTPPECTGDAIAMAIRAGCAVENLEFIQFHPTGLARSSENGR
EEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCC
TFLISEAVRGEGGILTNQAGERFMPHYDRRAELAPRDIVARAIAAEIAKQTPDFVSLDIS
EEEEEHHHCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
RQPEAFVRRHFPSIHRHCLSQCGLDITRQAIPVRPVQHYTCGGIQTDPCGRTSLPQLYAL
CCCHHHHHHHCHHHHHHHHHHCCCCHHHHCCCCCCCCCEECCCCCCCCCCCCCCCHHHHC
GETACTGLHGANRLASNSLLECVVTARLAAQTIADGQAFQAKTSPRPSENPSAEAGIFAD
CHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCHH
DLQNTFSRPVLQTFNQRHLGILRSDTGLRRAIAQLRLWKQNQAEPHTASEYENRNLLECS
HHHHHHCCHHHHHCCHHHCEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHH
LAVAQAAYRRRQNIGAHFNSDC
HHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQTDCDVLIAGNGLAALTLALSLPESFRIVILCKNRLDDTASRHAQGGIAAAWSGEDDIE
CCCCCCEEEECCCCEEHHHHHCCCCCEEEEEEECCCCCHHHHHHHCCCEEEECCCCHHHH
KHVADTLEASAGLCDEAAVRTILSQGKPAIEWLLAQGVAFDRNYDGLHLTREGGHTCRRI
HHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHCCEECCCCCCEEEECCCCHHHHHH
AHVADYTGEAVMQSLLAQIRRRPHIRVCERQMALDIQTESGVACGLIVLDRRTQETYLIR
HHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCCEEEEEEEECCCCCEEEEE
ARHTVLAGGGLGQIYAATTTPPECTGDAIAMAIRAGCAVENLEFIQFHPTGLARSSENGR
EEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCC
TFLISEAVRGEGGILTNQAGERFMPHYDRRAELAPRDIVARAIAAEIAKQTPDFVSLDIS
EEEEEHHHCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
RQPEAFVRRHFPSIHRHCLSQCGLDITRQAIPVRPVQHYTCGGIQTDPCGRTSLPQLYAL
CCCHHHHHHHCHHHHHHHHHHCCCCHHHHCCCCCCCCCEECCCCCCCCCCCCCCCHHHHC
GETACTGLHGANRLASNSLLECVVTARLAAQTIADGQAFQAKTSPRPSENPSAEAGIFAD
CHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCHH
DLQNTFSRPVLQTFNQRHLGILRSDTGLRRAIAQLRLWKQNQAEPHTASEYENRNLLECS
HHHHHHCCHHHHHCCHHHCEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHH
LAVAQAAYRRRQNIGAHFNSDC
HHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]