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The map label for this gene is bioF [C]

Identifier: 161870602

GI number: 161870602

Start: 1698572

End: 1699606

Strand: Reverse

Name: bioF [C]

Synonym: NMCC_1670

Alternate gene names: 161870602

Gene position: 1699606-1698572 (Counterclockwise)

Preceding gene: 161870604

Following gene: 161870601

Centisome position: 78.93

GC content: 43.96

Gene sequence:

>1035_bases
ATGCTGAATATGTCGTCTAATGATTATTTGGGTTTGGCATCAGATGAAAACTTGCGCCGGTCTTTTTTGCAGCAATACGG
CGGTAATTTTCCCTCTTTTACCAGTTCTTCATCGCGTTTATTAACGGGCAACTTTCCTATTTATACCGATTTGGAAGAGC
TTGTCGCACAACGTTTCCAACGGGAAAGCGCGTTATTGTTCAACAGCGGCTATCACGCCAATCTCGGTATTTTGCCTGCT
TTGACGACGACGAAAAGTTTGATTTTGGCAGATAAATTTGTTCACGCCAGTATGATTGACGGCATCCGTTTGAGCCGGTG
TGCGTTTTTCCGTTATCGTCATAATGATTATGAACATTTGAAAAATCTGCTTGAAAAAAACGTCGGAAAATTTGACCGCA
CTTTTATCGTTACCGAATCTGTTTTCAGTATGGACGGCGATGTGGCGGATTTGAAACAGCTTGTCCAATTAAAAAAACAG
TTTCCCAATACTTATCTTTATGTGGATGAAGCTCACGCAATCGGTGTTTATGGGCAAAACGGATTGGGGATTGCCGAACG
GGATAATTTGATTGCCGAGATTGATTTATTGGTTGGCACTTTCGGTAAAGCCTTAGCCTCGGTGGGGGCGTATGCCGTCT
GCAACCAAGTATTGAAAGAATGTTTGATTAATCAAATGCGCCCATTGATTTTTTCAACCGCATTGCCGCCGTTTAATGTG
GCTTGGACTTATTTTATTTTTGAACGATTGCCGCAATTCTCAAAAGAAAGAAGCCATCTTGAGCAGTTAAGTGCATTTTT
ACGGCGGGAAGTGGCGCATCGGACGCAAATAATGCCGAGCCAAACCTGTATCGTCCCCTATATTTTAGGCGGGAATGAAG
CCACCCTTGCCAAAGCGGAATACCTGCAAAGGCAGGGTTATTATTGCCTGCCCATCAGACCACCGACAGTACCAAAAGGT
ACATCCAGAATACGATTGTCTTTGACGGCAGATATGACAATGGATGAAGTGCGGCAGTTTGCGGCGTGCCTGTAA

Upstream 100 bases:

>100_bases
TTTTAAACAACAGCTTGAACAACTCGGCGCGCAAAACCAATATCGTTCGATTCCGGATTTGATTCATCAAGGGCGGTATA
TTACGCGGGAAAACTGCAAA

Downstream 100 bases:

>100_bases
GGATATGATATGAAAACAAAATTTTACAATCATCAAGGCGAACATTTAATCCTGTATTTTGCAGGTTGGGGAACGCCGCC
CGATGCTGTAAATCATTTGA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MLNMSSNDYLGLASDENLRRSFLQQYGGNFPSFTSSSSRLLTGNFPIYTDLEELVAQRFQRESALLFNSGYHANLGILPA
LTTTKSLILADKFVHASMIDGIRLSRCAFFRYRHNDYEHLKNLLEKNVGKFDRTFIVTESVFSMDGDVADLKQLVQLKKQ
FPNTYLYVDEAHAIGVYGQNGLGIAERDNLIAEIDLLVGTFGKALASVGAYAVCNQVLKECLINQMRPLIFSTALPPFNV
AWTYFIFERLPQFSKERSHLEQLSAFLRREVAHRTQIMPSQTCIVPYILGGNEATLAKAEYLQRQGYYCLPIRPPTVPKG
TSRIRLSLTADMTMDEVRQFAACL

Sequences:

>Translated_344_residues
MLNMSSNDYLGLASDENLRRSFLQQYGGNFPSFTSSSSRLLTGNFPIYTDLEELVAQRFQRESALLFNSGYHANLGILPA
LTTTKSLILADKFVHASMIDGIRLSRCAFFRYRHNDYEHLKNLLEKNVGKFDRTFIVTESVFSMDGDVADLKQLVQLKKQ
FPNTYLYVDEAHAIGVYGQNGLGIAERDNLIAEIDLLVGTFGKALASVGAYAVCNQVLKECLINQMRPLIFSTALPPFNV
AWTYFIFERLPQFSKERSHLEQLSAFLRREVAHRTQIMPSQTCIVPYILGGNEATLAKAEYLQRQGYYCLPIRPPTVPKG
TSRIRLSLTADMTMDEVRQFAACL
>Mature_344_residues
MLNMSSNDYLGLASDENLRRSFLQQYGGNFPSFTSSSSRLLTGNFPIYTDLEELVAQRFQRESALLFNSGYHANLGILPA
LTTTKSLILADKFVHASMIDGIRLSRCAFFRYRHNDYEHLKNLLEKNVGKFDRTFIVTESVFSMDGDVADLKQLVQLKKQ
FPNTYLYVDEAHAIGVYGQNGLGIAERDNLIAEIDLLVGTFGKALASVGAYAVCNQVLKECLINQMRPLIFSTALPPFNV
AWTYFIFERLPQFSKERSHLEQLSAFLRREVAHRTQIMPSQTCIVPYILGGNEATLAKAEYLQRQGYYCLPIRPPTVPKG
TSRIRLSLTADMTMDEVRQFAACL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977440, Length=339, Percent_Identity=34.8082595870207, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI83977442, Length=339, Percent_Identity=34.8082595870207, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI83977444, Length=339, Percent_Identity=34.8082595870207, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI284448556, Length=342, Percent_Identity=31.2865497076023, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI7657118, Length=342, Percent_Identity=31.2865497076023, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI119220554, Length=250, Percent_Identity=33.2, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI4502025, Length=339, Percent_Identity=30.3834808259587, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI40316939, Length=339, Percent_Identity=30.3834808259587, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI4758668, Length=250, Percent_Identity=32.4, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI5454084, Length=253, Percent_Identity=26.8774703557312, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI1786993, Length=341, Percent_Identity=36.3636363636364, Blast_Score=181, Evalue=4e-47,
Organism=Escherichia coli, GI1790046, Length=342, Percent_Identity=31.8713450292398, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71994529, Length=348, Percent_Identity=33.0459770114943, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI32566772, Length=224, Percent_Identity=32.1428571428571, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17560914, Length=170, Percent_Identity=35.8823529411765, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17560912, Length=170, Percent_Identity=35.8823529411765, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI71982625, Length=254, Percent_Identity=26.7716535433071, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71982617, Length=254, Percent_Identity=26.7716535433071, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320438, Length=368, Percent_Identity=28.2608695652174, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320267, Length=355, Percent_Identity=26.1971830985915, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6323954, Length=287, Percent_Identity=28.2229965156794, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24662918, Length=344, Percent_Identity=34.3023255813954, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17137420, Length=338, Percent_Identity=31.9526627218935, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI17136286, Length=363, Percent_Identity=27.8236914600551, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24653280, Length=277, Percent_Identity=28.8808664259928, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24653276, Length=277, Percent_Identity=28.8808664259928, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24653278, Length=277, Percent_Identity=28.8808664259928, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 38873; Mature: 38873

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNMSSNDYLGLASDENLRRSFLQQYGGNFPSFTSSSSRLLTGNFPIYTDLEELVAQRFQ
CCCCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCEECHHHHHHHHHH
RESALLFNSGYHANLGILPALTTTKSLILADKFVHASMIDGIRLSRCAFFRYRHNDYEHL
HHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHH
KNLLEKNVGKFDRTFIVTESVFSMDGDVADLKQLVQLKKQFPNTYLYVDEAHAIGVYGQN
HHHHHHCCCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCEEEEEECCC
GLGIAERDNLIAEIDLLVGTFGKALASVGAYAVCNQVLKECLINQMRPLIFSTALPPFNV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AWTYFIFERLPQFSKERSHLEQLSAFLRREVAHRTQIMPSQTCIVPYILGGNEATLAKAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHH
YLQRQGYYCLPIRPPTVPKGTSRIRLSLTADMTMDEVRQFAACL
HHHHCCCEEEECCCCCCCCCCCEEEEEEEECCCHHHHHHHHHCC
>Mature Secondary Structure
MLNMSSNDYLGLASDENLRRSFLQQYGGNFPSFTSSSSRLLTGNFPIYTDLEELVAQRFQ
CCCCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCEECHHHHHHHHHH
RESALLFNSGYHANLGILPALTTTKSLILADKFVHASMIDGIRLSRCAFFRYRHNDYEHL
HHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHH
KNLLEKNVGKFDRTFIVTESVFSMDGDVADLKQLVQLKKQFPNTYLYVDEAHAIGVYGQN
HHHHHHCCCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCEEEEEECCC
GLGIAERDNLIAEIDLLVGTFGKALASVGAYAVCNQVLKECLINQMRPLIFSTALPPFNV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AWTYFIFERLPQFSKERSHLEQLSAFLRREVAHRTQIMPSQTCIVPYILGGNEATLAKAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHH
YLQRQGYYCLPIRPPTVPKGTSRIRLSLTADMTMDEVRQFAACL
HHHHCCCEEEECCCCCCCCCCCEEEEEEEECCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA