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The map label for this gene is tkt [H]

Identifier: 161870326

GI number: 161870326

Start: 1387341

End: 1389320

Strand: Direct

Name: tkt [H]

Synonym: NMCC_1370

Alternate gene names: 161870326

Gene position: 1387341-1389320 (Clockwise)

Preceding gene: 161870322

Following gene: 161870327

Centisome position: 64.43

GC content: 55.81

Gene sequence:

>1980_bases
ATGTCTCAACTGGCAAACGCAATCCGCTTCCTCTCGGCCGATGCCGTTCAAAAAGCCAATTCCGGCCACCCCGGCGCGCC
TATGGGTATGGCGGAAATGGCGGAAACATTGTGGACGAAATTCCTCAATCACAATCCCGCCAACCCCAAATTCTACAACC
GCGACCGCTTCGTCCTCTCCAACGGCCACGCGTCTATGCTGTTGTACAGCCTGCTGCACCTGACCGGCTACAACCTAAGC
ATTGAAGACTTGAAAAACTTCCGCCAACTGCACAGCAAAACCCCCGGCCACCCCGAATACGGCTACACCGACGGCGTGGA
AACCACGACCGGCCCGTTGGGGCAAGGGATTGCCAACGCGGTGGGTATGGCATTGGCAGAAAAAATCCTTGCCGCCGAAT
TTAATAAAGACGGTTTGAACATCGTCGATCATTACACCTACGTCTTTATGGGCGACGGCTGTCTGATGGAAGGCGTATCG
CACGAAGCCTGTTCGCTCGCCGGCACCTTGGGCTTGGGCAAACTGATTGTTTTGTATGATGACAACAATATTTCCATTGA
TGGTAAAGTGGACGGCTGGTTTACCGAAAACATCCCGCAACGCTTTGAAAGCTACGGCTGGCACGTCGTTCCCAATGTAA
ACGGTCATGACACCGCCGCCATTCAAGCCGCCATCGAAGCCGCACGTGCCGAAACCGGCAAACCGTCCATCATCTGCTGC
AAAACCTTAATCGGCAAAGGCAGTGCCAACAAAGAAGGCAGCCACAAAACCCACGGCGCACCTTTGGGCGCGGACGAAAT
CGAAGCCACGCGCAAACATTTGGGCTGGACTTACCCCGCCTTTGAAATCCCGCAAGAAATTTACGATGCGTGGAATGCCA
AAGAACAAGGCGCGAAACTGGAAGCCGACTGGAACGAACTGTTCGCGCAATATCAAGCCAAATATCCTGCCGAAGCCGCA
GAATTTGTGCGCCGTATGGATAAAAAACTGCCGGAAAACTTTGACGAGTACGTTCAGACGGCATTGAAAGAAGTGTGCGC
CAAAGCCGAAACCATCGCTACCCGCAAAGCCAGCCAAAACAGCATCGAAATCTTGGCAAAAGAGCTGCCCGAACTGGTGG
GCGGTTCGGCCGACCTGACCCCGTCCAACCTGACCGACTGGTCAAACAGCGTCTCCGTTACCCGCGACAAAGGCGGCAAC
TACATCCACTACGGCGTGCGCGAGTTCGGTATGGGTGCGATTATGAACGGTCTTGCCCTGCACGGCGGCGTAAAACCCTT
TGGCGCGACCTTCCTGATGTTTAGCGAATACGAACGCAACGCCTTGCGCATGGCGGCACTGATGAAAATCAACCCTGTAT
TTGTGTTCACCCACGATTCCATCGGTTTGGGCGAAGACGGCCCGACCCACCAGCCGATTGAGCAAACCGCCACCCTGCGC
CTGATTCCGAACATGGACGTATGGCGTCCGTGCGACACCGCCGAATCTCTGGTGGCTTGGGCAGAAGCCGTCAAAGCCGC
CGATCATCCGTCCTGCCTGATTTTCAGCCGTCAAAACCTGAAATTCCAAGCGCGCAGCGAACAACAACTGAACGACATCA
AACGCGGCGGCTACATCATCAGCGAAGCCCAAGGCAACGCGCAAGCCGTCATCATTGCCACCGGTTCCGAAGTTGAGCTG
GCTTTGGAAGCGCAAAAAGCCCTCGCCGCGCAAAACATCGCCGTACGCGTCGTTTCCATGCCGTCCACCAACGTATTCGA
CCGCCAAGACGCCGCCTATCAAGCCACCGTCCTGCCCGAAGGTCTGCCGCGCGTTGCCGTAGAAGCCGGACACGCCGACG
GCTGGTACAAATACGTCGGTCTGAACGGCGCAGTCGTCGGCATCAACCGCTTCGGCGAATCCGCCCCTGCCGACTTACTC
TTCAAAGCATTCGGCTTTACCGTGGACAATGTGGTCGATACAGTGAAATCAGTGCTGTAA

Upstream 100 bases:

>100_bases
CCCCGCGTCCGCCCTTTTCTTGAAAGCATAAGCGAATCGGGCGATAATCAACGCTTTCCGATTATCCACTTATCTGAAAC
ACCAGCAAGGAAAATACAAA

Downstream 100 bases:

>100_bases
CCCCACTCCTAAACAAATGCCGTCTGAACGCTTTTCAGACGGCATTTTTTTGCCCTCCCGCCTTGATGCTTCCTCATTCC
ACCAATCTCCATTATAATAT

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 659; Mature: 658

Protein sequence:

>659_residues
MSQLANAIRFLSADAVQKANSGHPGAPMGMAEMAETLWTKFLNHNPANPKFYNRDRFVLSNGHASMLLYSLLHLTGYNLS
IEDLKNFRQLHSKTPGHPEYGYTDGVETTTGPLGQGIANAVGMALAEKILAAEFNKDGLNIVDHYTYVFMGDGCLMEGVS
HEACSLAGTLGLGKLIVLYDDNNISIDGKVDGWFTENIPQRFESYGWHVVPNVNGHDTAAIQAAIEAARAETGKPSIICC
KTLIGKGSANKEGSHKTHGAPLGADEIEATRKHLGWTYPAFEIPQEIYDAWNAKEQGAKLEADWNELFAQYQAKYPAEAA
EFVRRMDKKLPENFDEYVQTALKEVCAKAETIATRKASQNSIEILAKELPELVGGSADLTPSNLTDWSNSVSVTRDKGGN
YIHYGVREFGMGAIMNGLALHGGVKPFGATFLMFSEYERNALRMAALMKINPVFVFTHDSIGLGEDGPTHQPIEQTATLR
LIPNMDVWRPCDTAESLVAWAEAVKAADHPSCLIFSRQNLKFQARSEQQLNDIKRGGYIISEAQGNAQAVIIATGSEVEL
ALEAQKALAAQNIAVRVVSMPSTNVFDRQDAAYQATVLPEGLPRVAVEAGHADGWYKYVGLNGAVVGINRFGESAPADLL
FKAFGFTVDNVVDTVKSVL

Sequences:

>Translated_659_residues
MSQLANAIRFLSADAVQKANSGHPGAPMGMAEMAETLWTKFLNHNPANPKFYNRDRFVLSNGHASMLLYSLLHLTGYNLS
IEDLKNFRQLHSKTPGHPEYGYTDGVETTTGPLGQGIANAVGMALAEKILAAEFNKDGLNIVDHYTYVFMGDGCLMEGVS
HEACSLAGTLGLGKLIVLYDDNNISIDGKVDGWFTENIPQRFESYGWHVVPNVNGHDTAAIQAAIEAARAETGKPSIICC
KTLIGKGSANKEGSHKTHGAPLGADEIEATRKHLGWTYPAFEIPQEIYDAWNAKEQGAKLEADWNELFAQYQAKYPAEAA
EFVRRMDKKLPENFDEYVQTALKEVCAKAETIATRKASQNSIEILAKELPELVGGSADLTPSNLTDWSNSVSVTRDKGGN
YIHYGVREFGMGAIMNGLALHGGVKPFGATFLMFSEYERNALRMAALMKINPVFVFTHDSIGLGEDGPTHQPIEQTATLR
LIPNMDVWRPCDTAESLVAWAEAVKAADHPSCLIFSRQNLKFQARSEQQLNDIKRGGYIISEAQGNAQAVIIATGSEVEL
ALEAQKALAAQNIAVRVVSMPSTNVFDRQDAAYQATVLPEGLPRVAVEAGHADGWYKYVGLNGAVVGINRFGESAPADLL
FKAFGFTVDNVVDTVKSVL
>Mature_658_residues
SQLANAIRFLSADAVQKANSGHPGAPMGMAEMAETLWTKFLNHNPANPKFYNRDRFVLSNGHASMLLYSLLHLTGYNLSI
EDLKNFRQLHSKTPGHPEYGYTDGVETTTGPLGQGIANAVGMALAEKILAAEFNKDGLNIVDHYTYVFMGDGCLMEGVSH
EACSLAGTLGLGKLIVLYDDNNISIDGKVDGWFTENIPQRFESYGWHVVPNVNGHDTAAIQAAIEAARAETGKPSIICCK
TLIGKGSANKEGSHKTHGAPLGADEIEATRKHLGWTYPAFEIPQEIYDAWNAKEQGAKLEADWNELFAQYQAKYPAEAAE
FVRRMDKKLPENFDEYVQTALKEVCAKAETIATRKASQNSIEILAKELPELVGGSADLTPSNLTDWSNSVSVTRDKGGNY
IHYGVREFGMGAIMNGLALHGGVKPFGATFLMFSEYERNALRMAALMKINPVFVFTHDSIGLGEDGPTHQPIEQTATLRL
IPNMDVWRPCDTAESLVAWAEAVKAADHPSCLIFSRQNLKFQARSEQQLNDIKRGGYIISEAQGNAQAVIIATGSEVELA
LEAQKALAAQNIAVRVVSMPSTNVFDRQDAAYQATVLPEGLPRVAVEAGHADGWYKYVGLNGAVVGINRFGESAPADLLF
KAFGFTVDNVVDTVKSVL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=673, Percent_Identity=26.7459138187221, Blast_Score=179, Evalue=1e-44,
Organism=Homo sapiens, GI4507521, Length=673, Percent_Identity=26.7459138187221, Blast_Score=179, Evalue=1e-44,
Organism=Homo sapiens, GI133778974, Length=579, Percent_Identity=25.9067357512953, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI225637459, Length=590, Percent_Identity=22.7118644067797, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI225637463, Length=483, Percent_Identity=23.8095238095238, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI225637461, Length=483, Percent_Identity=23.8095238095238, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI48994911, Length=658, Percent_Identity=65.3495440729483, Blast_Score=912, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=657, Percent_Identity=61.4916286149163, Blast_Score=855, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=670, Percent_Identity=25.3731343283582, Blast_Score=168, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6325331, Length=666, Percent_Identity=48.4984984984985, Blast_Score=609, Evalue=1e-175,
Organism=Saccharomyces cerevisiae, GI6319593, Length=666, Percent_Identity=45.7957957957958, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI45551847, Length=688, Percent_Identity=26.5988372093023, Blast_Score=172, Evalue=1e-42,
Organism=Drosophila melanogaster, GI45550715, Length=688, Percent_Identity=26.5988372093023, Blast_Score=172, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24645119, Length=653, Percent_Identity=26.1868300153139, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24666278, Length=496, Percent_Identity=26.2096774193548, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 71705; Mature: 71574

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLANAIRFLSADAVQKANSGHPGAPMGMAEMAETLWTKFLNHNPANPKFYNRDRFVLS
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEECCCEEEEE
NGHASMLLYSLLHLTGYNLSIEDLKNFRQLHSKTPGHPEYGYTDGVETTTGPLGQGIANA
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
VGMALAEKILAAEFNKDGLNIVDHYTYVFMGDGCLMEGVSHEACSLAGTLGLGKLIVLYD
HHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCHHCCCCCHHHHHHHHHCCCCEEEEEEC
DNNISIDGKVDGWFTENIPQRFESYGWHVVPNVNGHDTAAIQAAIEAARAETGKPSIICC
CCEEEECCCCCCEEHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEE
KTLIGKGSANKEGSHKTHGAPLGADEIEATRKHLGWTYPAFEIPQEIYDAWNAKEQGAKL
EHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCHHHHHHCCCHHCCCEE
EADWNELFAQYQAKYPAEAAEFVRRMDKKLPENFDEYVQTALKEVCAKAETIATRKASQN
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
SIEILAKELPELVGGSADLTPSNLTDWSNSVSVTRDKGGNYIHYGVREFGMGAIMNGLAL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECHHHHCHHHHHHHHHH
HGGVKPFGATFLMFSEYERNALRMAALMKINPVFVFTHDSIGLGEDGPTHQPIEQTATLR
CCCCCCCCHHEEEHHHHHHHHHHHHHHHEECEEEEEEECCCCCCCCCCCCCCHHHCEEEE
LIPNMDVWRPCDTAESLVAWAEAVKAADHPSCLIFSRQNLKFQARSEQQLNDIKRGGYII
ECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCEEECCCHHHHHHHHHCCEEE
SEAQGNAQAVIIATGSEVELALEAQKALAAQNIAVRVVSMPSTNVFDRQDAAYQATVLPE
EECCCCCEEEEEEECCCEEEEHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCEEEEECCC
GLPRVAVEAGHADGWYKYVGLNGAVVGINRFGESAPADLLFKAFGFTVDNVVDTVKSVL
CCCCCEEECCCCCCEEEEEECCCEEEEEHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHC
>Mature Secondary Structure 
SQLANAIRFLSADAVQKANSGHPGAPMGMAEMAETLWTKFLNHNPANPKFYNRDRFVLS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEECCCEEEEE
NGHASMLLYSLLHLTGYNLSIEDLKNFRQLHSKTPGHPEYGYTDGVETTTGPLGQGIANA
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
VGMALAEKILAAEFNKDGLNIVDHYTYVFMGDGCLMEGVSHEACSLAGTLGLGKLIVLYD
HHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCHHCCCCCHHHHHHHHHCCCCEEEEEEC
DNNISIDGKVDGWFTENIPQRFESYGWHVVPNVNGHDTAAIQAAIEAARAETGKPSIICC
CCEEEECCCCCCEEHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEE
KTLIGKGSANKEGSHKTHGAPLGADEIEATRKHLGWTYPAFEIPQEIYDAWNAKEQGAKL
EHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCHHHHHHCCCHHCCCEE
EADWNELFAQYQAKYPAEAAEFVRRMDKKLPENFDEYVQTALKEVCAKAETIATRKASQN
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
SIEILAKELPELVGGSADLTPSNLTDWSNSVSVTRDKGGNYIHYGVREFGMGAIMNGLAL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECHHHHCHHHHHHHHHH
HGGVKPFGATFLMFSEYERNALRMAALMKINPVFVFTHDSIGLGEDGPTHQPIEQTATLR
CCCCCCCCHHEEEHHHHHHHHHHHHHHHEECEEEEEEECCCCCCCCCCCCCCHHHCEEEE
LIPNMDVWRPCDTAESLVAWAEAVKAADHPSCLIFSRQNLKFQARSEQQLNDIKRGGYII
ECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCEEECCCHHHHHHHHHCCEEE
SEAQGNAQAVIIATGSEVELALEAQKALAAQNIAVRVVSMPSTNVFDRQDAAYQATVLPE
EECCCCCEEEEEEECCCEEEEHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCEEEEECCC
GLPRVAVEAGHADGWYKYVGLNGAVVGINRFGESAPADLLFKAFGFTVDNVVDTVKSVL
CCCCCEEECCCCCCEEEEEECCCEEEEEHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]