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The map label for this gene is fumC [H]

Identifier: 161870327

GI number: 161870327

Start: 1389461

End: 1390849

Strand: Direct

Name: fumC [H]

Synonym: NMCC_1371

Alternate gene names: 161870327

Gene position: 1389461-1390849 (Clockwise)

Preceding gene: 161870326

Following gene: 161870335

Centisome position: 64.52

GC content: 57.24

Gene sequence:

>1389_bases
ATGAACACTCGCACCGAACACGACACCATGGGCAATGTCGAAGTCCCGTCCGAAGCCTATTGGGGCGCGCAGACCCAGCG
CAGCCGCAACAATTTCAAAATCGGCGGCGAAACCCTGCCGCAGCCGCTGATTTATGCTTTGGCGTTGGTGAAAAAAGCCG
CTGCCGCGACCAATGTTTCCCTCGGCAGGATTAAGCCGGAACAGGCGGATTTGATTACGCAGGCGGCGGATGATGTGTTG
AACGGCAAGCTCAACGGACAGTTTCCTTTAGTGGTTTGGCAGACCGGCTCCGGCACGCAGTCCAATATGAACATGAACGA
AGTGCTGGCGAACCGCGCCAACGAAATCGCCGGTACGGGTTTGGCGGCGTATCAGCCCGTCCATCCCAACGACCATGTGA
ACCACGCGCAATCGACCAACGACGCATTCCCGACCGCTATCCACGTTGCCGCCGCGATTGAAATCAACCGCCACCTCATC
CCCGCCGTAAAAGCCCTGCGCGACACCTTGGACAAAAAAGCCCAAGCCTTCGCCCCTATCGTCAAAATCGGCCGCACCCA
CTTGCAGGACGCGACGCCGCTGACTTTAGGCCAAGAATTTTCCGGCTACGTTTCCCAGCTTGATCACGGCTTAGGCCGTC
TGAACGATGCGCTTAAAGACTTGTATGAACTTGCTTTGGGCGGTACGGCGGTCGGCACGGGTTTGAACAGCCATCCCGAA
TACGCCGAAAAAGCCGCCGCCAAACTCGCCGAACTGTCCGGCTTGCCGTTTGTCAGCGCGCCGAACAAATTTGAAGCCTT
AGGCGGACGCGATGCCGCCGTTGCCGCTTCGGGCGCATTGAAAACGCTGGCGGCAAGCCTGAACAAAATCGCCAACGACA
TCCGCTGGCTGGCAAGCGGCCCGCGTTGCGGTTTGGGCGAAATCAAAATCCCCGAAAACGAGCCGGGTTCGTCCATCATG
CCGGGCAAAGTCAACCCGACCCAATGCGAAGCAATGACGATGGTGTGGTGCCAAGTGTTCGGCAACGACGTTACCATCGG
TATGGCGGGCGCGTCGGGCAATTTCGAGCTGAACGTCTATATGCCCGTTATCGCCTACAACCTCTTGCAATCCATCCGCC
TGTTGGGCGACGCGTGCAACAGCTTCAACGAACACTGCGCCGTCGGCATCGAACCCGTACCGGAAAAAATCGACTATTTC
CTGCACCATTCCCTGATGCTCGTTACCGCGTTGAACCGCAAAATCGGTTACGAAAACGCCGCCAAAGTCGCCAAAACCGC
CTACAAAAACAACAAATCGTTGCGCGAAACCGCCGTTGAGTTGGGCTTGCTGACGGGCGAAGAATTTGACGAACTGGTCG
TTCCTGCCGATATGGTTCATCCGCGCTAA

Upstream 100 bases:

>100_bases
GGCATTTTTTTGCCCTCCCGCCTTGATGCTTCCTCATTCCACCAATCTCCATTATAATATTTGCGAATCACTCTTATTCA
CATTTCAAAAGGAGAAACGT

Downstream 100 bases:

>100_bases
TCTTTCCCTCAAATAAAATGCCGTCTGAAACCTCGTTCGGACGGCATTTTCCGTTGCCTGCAAACTAGCGGCGTTTGAAC
AGCCTGTCCCCCACCGCCGC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MNTRTEHDTMGNVEVPSEAYWGAQTQRSRNNFKIGGETLPQPLIYALALVKKAAAATNVSLGRIKPEQADLITQAADDVL
NGKLNGQFPLVVWQTGSGTQSNMNMNEVLANRANEIAGTGLAAYQPVHPNDHVNHAQSTNDAFPTAIHVAAAIEINRHLI
PAVKALRDTLDKKAQAFAPIVKIGRTHLQDATPLTLGQEFSGYVSQLDHGLGRLNDALKDLYELALGGTAVGTGLNSHPE
YAEKAAAKLAELSGLPFVSAPNKFEALGGRDAAVAASGALKTLAASLNKIANDIRWLASGPRCGLGEIKIPENEPGSSIM
PGKVNPTQCEAMTMVWCQVFGNDVTIGMAGASGNFELNVYMPVIAYNLLQSIRLLGDACNSFNEHCAVGIEPVPEKIDYF
LHHSLMLVTALNRKIGYENAAKVAKTAYKNNKSLRETAVELGLLTGEEFDELVVPADMVHPR

Sequences:

>Translated_462_residues
MNTRTEHDTMGNVEVPSEAYWGAQTQRSRNNFKIGGETLPQPLIYALALVKKAAAATNVSLGRIKPEQADLITQAADDVL
NGKLNGQFPLVVWQTGSGTQSNMNMNEVLANRANEIAGTGLAAYQPVHPNDHVNHAQSTNDAFPTAIHVAAAIEINRHLI
PAVKALRDTLDKKAQAFAPIVKIGRTHLQDATPLTLGQEFSGYVSQLDHGLGRLNDALKDLYELALGGTAVGTGLNSHPE
YAEKAAAKLAELSGLPFVSAPNKFEALGGRDAAVAASGALKTLAASLNKIANDIRWLASGPRCGLGEIKIPENEPGSSIM
PGKVNPTQCEAMTMVWCQVFGNDVTIGMAGASGNFELNVYMPVIAYNLLQSIRLLGDACNSFNEHCAVGIEPVPEKIDYF
LHHSLMLVTALNRKIGYENAAKVAKTAYKNNKSLRETAVELGLLTGEEFDELVVPADMVHPR
>Mature_462_residues
MNTRTEHDTMGNVEVPSEAYWGAQTQRSRNNFKIGGETLPQPLIYALALVKKAAAATNVSLGRIKPEQADLITQAADDVL
NGKLNGQFPLVVWQTGSGTQSNMNMNEVLANRANEIAGTGLAAYQPVHPNDHVNHAQSTNDAFPTAIHVAAAIEINRHLI
PAVKALRDTLDKKAQAFAPIVKIGRTHLQDATPLTLGQEFSGYVSQLDHGLGRLNDALKDLYELALGGTAVGTGLNSHPE
YAEKAAAKLAELSGLPFVSAPNKFEALGGRDAAVAASGALKTLAASLNKIANDIRWLASGPRCGLGEIKIPENEPGSSIM
PGKVNPTQCEAMTMVWCQVFGNDVTIGMAGASGNFELNVYMPVIAYNLLQSIRLLGDACNSFNEHCAVGIEPVPEKIDYF
LHHSLMLVTALNRKIGYENAAKVAKTAYKNNKSLRETAVELGLLTGEEFDELVVPADMVHPR

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=60.7375271149675, Blast_Score=557, Evalue=1e-159,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=49.2063492063492, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787896, Length=460, Percent_Identity=62.6086956521739, Blast_Score=581, Evalue=1e-167,
Organism=Escherichia coli, GI87082375, Length=463, Percent_Identity=43.1965442764579, Blast_Score=354, Evalue=6e-99,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=59.4360086767896, Blast_Score=565, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=59.6330275229358, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=58.351409978308, Blast_Score=535, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=57.3593073593074, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=57.3593073593074, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=56.5874730021598, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=56.989247311828, Blast_Score=532, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24583245, Length=464, Percent_Identity=51.0775862068966, Blast_Score=476, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49474; Mature: 49474

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTRTEHDTMGNVEVPSEAYWGAQTQRSRNNFKIGGETLPQPLIYALALVKKAAAATNVS
CCCCCCCCCCCCCCCCCHHHCCCHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCC
LGRIKPEQADLITQAADDVLNGKLNGQFPLVVWQTGSGTQSNMNMNEVLANRANEIAGTG
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
LAAYQPVHPNDHVNHAQSTNDAFPTAIHVAAAIEINRHLIPAVKALRDTLDKKAQAFAPI
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKIGRTHLQDATPLTLGQEFSGYVSQLDHGLGRLNDALKDLYELALGGTAVGTGLNSHPE
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCHH
YAEKAAAKLAELSGLPFVSAPNKFEALGGRDAAVAASGALKTLAASLNKIANDIRWLASG
HHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRCGLGEIKIPENEPGSSIMPGKVNPTQCEAMTMVWCQVFGNDVTIGMAGASGNFELNVY
CCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEE
MPVIAYNLLQSIRLLGDACNSFNEHCAVGIEPVPEKIDYFLHHSLMLVTALNRKIGYENA
HHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
AKVAKTAYKNNKSLRETAVELGLLTGEEFDELVVPADMVHPR
HHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHCCCHHHCCCC
>Mature Secondary Structure
MNTRTEHDTMGNVEVPSEAYWGAQTQRSRNNFKIGGETLPQPLIYALALVKKAAAATNVS
CCCCCCCCCCCCCCCCCHHHCCCHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCC
LGRIKPEQADLITQAADDVLNGKLNGQFPLVVWQTGSGTQSNMNMNEVLANRANEIAGTG
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
LAAYQPVHPNDHVNHAQSTNDAFPTAIHVAAAIEINRHLIPAVKALRDTLDKKAQAFAPI
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKIGRTHLQDATPLTLGQEFSGYVSQLDHGLGRLNDALKDLYELALGGTAVGTGLNSHPE
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCHH
YAEKAAAKLAELSGLPFVSAPNKFEALGGRDAAVAASGALKTLAASLNKIANDIRWLASG
HHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRCGLGEIKIPENEPGSSIMPGKVNPTQCEAMTMVWCQVFGNDVTIGMAGASGNFELNVY
CCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEE
MPVIAYNLLQSIRLLGDACNSFNEHCAVGIEPVPEKIDYFLHHSLMLVTALNRKIGYENA
HHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
AKVAKTAYKNNKSLRETAVELGLLTGEEFDELVVPADMVHPR
HHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]