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The map label for this gene is mutY [H]

Identifier: 161870270

GI number: 161870270

Start: 1314747

End: 1315796

Strand: Direct

Name: mutY [H]

Synonym: NMCC_1311

Alternate gene names: 161870270

Gene position: 1314747-1315796 (Clockwise)

Preceding gene: 161870268

Following gene: 161870271

Centisome position: 61.05

GC content: 56.38

Gene sequence:

>1050_bases
TTGATATTAATGAACACACCCATCCCCTTCTCCGAACGGCTCATCCGCTGGCAAAAACAACACGGTCGCCACCACCTCCC
TTGGCAGGTCAAAAACCCTTATTGCGTCTGGCTTTCCGAAATCATGCTCCAGCAAACGCAGGTCGCCACCGTGTTGGACT
ACTATCCGCGTTTCTTAGAAAAATTCCCGACCGTTCAGACGCTTGCCGCCGCGCCGCAAGACGAAGTGTTGTCGTTGTGG
GCGGGCTTAGGCTATTACAGCCGCGCGCGCAACCTGCACAAAGCCGCGCAACAAGTCGTCGAACAATTCGGCGGCACATT
TCCGTCGGAGCGCAAAGACCTGGAAACCCTCTGCGGCGTAGGCAGAAGCACCGCCGCCGCCATTTGTGCCTTTGCCTTCA
ACCGCCGCGAGACCATTTTGGACGGCAACGTCAAACGCGTGCTCTGCCGCGTGTTCGCCCGCGACGGCAATCCACAGGAC
AAAAAATTTGAAAACACGCTCTGGACGCTCGCCGAAAGCCTGCTGCCGTCTGAAAACGCCGAGATGCCCGCCTACACGCA
AGGCTTGATGGACTTGGGCGCGACCGTGTGCAAACGGACGAAACCCTTGTGCCACCAATGCCCGATGGCGGACATCTGCG
AAGCGAAAAAGCAAAACCGCACCGCCGAGCTGCCGCGCAAAAAAAATGCCGCCGAAGTACCGACCCTGCCGCTTTACTGG
CTGATTGTCCGCAACCGGGACGGCGCGATTTTGCTGGAGAAACGCCCCGCCAAAGGCATTTGGGGCGGTCTGTATTGCGT
GCCGTGTTTTGAAAGTTTGAACGGGCTTTCCGACTTTGCCGCCAAACTCTCCCTGACGATGGCGGATATGGACGAACAAA
CCGCCCTGACCCACCGGCTGACGCACCGGCTGCTGATGATTACGCCGTTTGAAGGGCAAATGCCGTCTGAAAGCCCTTCA
GACGGCATTTGGATAAAGCCGACGCATTTGAAAGATTACGGCCTGCCCAAGCCTTTGGAAATTTATTTAAACGGTAATAG
GTTAGAATAA

Upstream 100 bases:

>100_bases
TTATATGAGTTATATGCCCCTACAAAAAATAAGTCAATAAGAATTATTTTCACAATGTTATACAATAACATACTGTTTTA
AATATAAATAAAACCACCGA

Downstream 100 bases:

>100_bases
ACAAAATAAACCCATTGAACTGTTGTTTGCAGGTATCGCAGCAAGAACAACCGATGAATTTGGGTCGTATTTTAGGCGGC
GGGATAATGTTCAAATGGGA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MILMNTPIPFSERLIRWQKQHGRHHLPWQVKNPYCVWLSEIMLQQTQVATVLDYYPRFLEKFPTVQTLAAAPQDEVLSLW
AGLGYYSRARNLHKAAQQVVEQFGGTFPSERKDLETLCGVGRSTAAAICAFAFNRRETILDGNVKRVLCRVFARDGNPQD
KKFENTLWTLAESLLPSENAEMPAYTQGLMDLGATVCKRTKPLCHQCPMADICEAKKQNRTAELPRKKNAAEVPTLPLYW
LIVRNRDGAILLEKRPAKGIWGGLYCVPCFESLNGLSDFAAKLSLTMADMDEQTALTHRLTHRLLMITPFEGQMPSESPS
DGIWIKPTHLKDYGLPKPLEIYLNGNRLE

Sequences:

>Translated_349_residues
MILMNTPIPFSERLIRWQKQHGRHHLPWQVKNPYCVWLSEIMLQQTQVATVLDYYPRFLEKFPTVQTLAAAPQDEVLSLW
AGLGYYSRARNLHKAAQQVVEQFGGTFPSERKDLETLCGVGRSTAAAICAFAFNRRETILDGNVKRVLCRVFARDGNPQD
KKFENTLWTLAESLLPSENAEMPAYTQGLMDLGATVCKRTKPLCHQCPMADICEAKKQNRTAELPRKKNAAEVPTLPLYW
LIVRNRDGAILLEKRPAKGIWGGLYCVPCFESLNGLSDFAAKLSLTMADMDEQTALTHRLTHRLLMITPFEGQMPSESPS
DGIWIKPTHLKDYGLPKPLEIYLNGNRLE
>Mature_349_residues
MILMNTPIPFSERLIRWQKQHGRHHLPWQVKNPYCVWLSEIMLQQTQVATVLDYYPRFLEKFPTVQTLAAAPQDEVLSLW
AGLGYYSRARNLHKAAQQVVEQFGGTFPSERKDLETLCGVGRSTAAAICAFAFNRRETILDGNVKRVLCRVFARDGNPQD
KKFENTLWTLAESLLPSENAEMPAYTQGLMDLGATVCKRTKPLCHQCPMADICEAKKQNRTAELPRKKNAAEVPTLPLYW
LIVRNRDGAILLEKRPAKGIWGGLYCVPCFESLNGLSDFAAKLSLTMADMDEQTALTHRLTHRLLMITPFEGQMPSESPS
DGIWIKPTHLKDYGLPKPLEIYLNGNRLE

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=225, Percent_Identity=44.4444444444444, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI6912520, Length=225, Percent_Identity=44.4444444444444, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI190358497, Length=225, Percent_Identity=44.4444444444444, Blast_Score=187, Evalue=9e-48,
Organism=Homo sapiens, GI115298650, Length=225, Percent_Identity=44.4444444444444, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI115298654, Length=225, Percent_Identity=44.4444444444444, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI115298652, Length=225, Percent_Identity=44.4444444444444, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI1789331, Length=346, Percent_Identity=44.5086705202312, Blast_Score=286, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39586; Mature: 39586

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILMNTPIPFSERLIRWQKQHGRHHLPWQVKNPYCVWLSEIMLQQTQVATVLDYYPRFLE
CEEECCCCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFPTVQTLAAAPQDEVLSLWAGLGYYSRARNLHKAAQQVVEQFGGTFPSERKDLETLCGV
HCCCHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
GRSTAAAICAFAFNRRETILDGNVKRVLCRVFARDGNPQDKKFENTLWTLAESLLPSENA
CCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
EMPAYTQGLMDLGATVCKRTKPLCHQCPMADICEAKKQNRTAELPRKKNAAEVPTLPLYW
CCCHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEE
LIVRNRDGAILLEKRPAKGIWGGLYCVPCFESLNGLSDFAAKLSLTMADMDEQTALTHRL
EEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHH
THRLLMITPFEGQMPSESPSDGIWIKPTHLKDYGLPKPLEIYLNGNRLE
HHHEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MILMNTPIPFSERLIRWQKQHGRHHLPWQVKNPYCVWLSEIMLQQTQVATVLDYYPRFLE
CEEECCCCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFPTVQTLAAAPQDEVLSLWAGLGYYSRARNLHKAAQQVVEQFGGTFPSERKDLETLCGV
HCCCHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
GRSTAAAICAFAFNRRETILDGNVKRVLCRVFARDGNPQDKKFENTLWTLAESLLPSENA
CCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
EMPAYTQGLMDLGATVCKRTKPLCHQCPMADICEAKKQNRTAELPRKKNAAEVPTLPLYW
CCCHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEE
LIVRNRDGAILLEKRPAKGIWGGLYCVPCFESLNGLSDFAAKLSLTMADMDEQTALTHRL
EEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHH
THRLLMITPFEGQMPSESPSDGIWIKPTHLKDYGLPKPLEIYLNGNRLE
HHHEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]