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The map label for this gene is adh [H]

Identifier: 161870269

GI number: 161870269

Start: 1313553

End: 1314593

Strand: Reverse

Name: adh [H]

Synonym: NMCC_1310

Alternate gene names: 161870269

Gene position: 1314593-1313553 (Counterclockwise)

Preceding gene: 161870274

Following gene: 161870266

Centisome position: 61.05

GC content: 50.62

Gene sequence:

>1041_bases
ATGAAAGCAATGGTTTATCACGGCGCAAACGACATCCGTTTTGAAGAAAAACCCCGTCCGCAGATTATCGATCCGACCGA
TGCGGTGGTGAAAATCGTCAAAACCACGATTTGCGGTACCGACTTGGGTATTTGGAAAGGCAAAAACCCCGAAGTTGCCG
ACGGCCGTATTCTCGGTCATGAGGGCATCGGTATTGTAGAAGAAGTCGGCGAGGCTGTAAAAAACATCAAAGTCGGCGAT
AAAGTCATTATTTCATGCGTCAGCAAATGTTGCACTTGCGACAACTGCAAAACCCAACTCTATTCACACTGCCGTAACGG
CGGTTGGATTTTGGGTTACATGATTGACGGTACTCAGGCCGAATACGTCCGCACGCCTTATGCCGACAACAGCCTCGTTC
CGCTGCCCGATAATGTCAACGAAGAAATCGCCCTGTTGTTGAGCGACGCTTTGCCGACCGCCCACGAAATCGGCGTGCAA
TACGGCGATGTCAAACCCGGCGACACCGTATTCATCGCTGGGGCAGGCCCTGTCGGTATGTCCGCCCTGTTGACCGCCCA
ACTGTACAGTCCCGCCGCCATCATCGTTTGCGATATGGACGAAAACCGTTTGAAACTGGCGAAAGAATTGGGTGCGACCC
ATACCATTAACCCTGCTTCCGGCGAAGTATCCAAACAAGTCTTTGCCATCGTCGGCGAAGACGGCGTGGATTGCGCCATC
GAAGCCGTCGGTATCCCTGCTACATGGAATATGTGCCAAGACATTGTGAAACCCGGCGGCCATATCGCTGTGGTTGGTGT
ACATGGTCAATCCGTTGATTTCAAACTGGAAAAACTCTGGATTAAAAACCTCGCCATTACTACCGGTCTGGTAAACGCCA
ATACCACCGAAATGCTGATGAAGGCGATTTCCAGCAGCTCCGTCGATTACACCAAAATGCTGACCCATCATTTCAAATTC
AGTGAATTGGAAAAAGCCTACGACGTGTTCAAACACGCCGCCGAAAACCAAGTGATGAAAGTGGTTTTGGAAGCGGATTA
A

Upstream 100 bases:

>100_bases
ATAATTCTTATTGACTTATTTTTTGTAGGGGCATATAACTCATATAAAGAAACTTTATTGCGGTATTGAAATTATTTATC
AACAAGCAAGGAGTATCAGC

Downstream 100 bases:

>100_bases
TCGGCGTTGAATCAGTTGTTTTTTTTAAGTGGATGCCGTCTGAATGCGTTTCAGACGGCATTTTTTCAGCCGCGTAGTAT
GGGCTGTCCGGCTGCTGTCG

Product: alcohol dehydrogenase, zinc-containing

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKAMVYHGANDIRFEEKPRPQIIDPTDAVVKIVKTTICGTDLGIWKGKNPEVADGRILGHEGIGIVEEVGEAVKNIKVGD
KVIISCVSKCCTCDNCKTQLYSHCRNGGWILGYMIDGTQAEYVRTPYADNSLVPLPDNVNEEIALLLSDALPTAHEIGVQ
YGDVKPGDTVFIAGAGPVGMSALLTAQLYSPAAIIVCDMDENRLKLAKELGATHTINPASGEVSKQVFAIVGEDGVDCAI
EAVGIPATWNMCQDIVKPGGHIAVVGVHGQSVDFKLEKLWIKNLAITTGLVNANTTEMLMKAISSSSVDYTKMLTHHFKF
SELEKAYDVFKHAAENQVMKVVLEAD

Sequences:

>Translated_346_residues
MKAMVYHGANDIRFEEKPRPQIIDPTDAVVKIVKTTICGTDLGIWKGKNPEVADGRILGHEGIGIVEEVGEAVKNIKVGD
KVIISCVSKCCTCDNCKTQLYSHCRNGGWILGYMIDGTQAEYVRTPYADNSLVPLPDNVNEEIALLLSDALPTAHEIGVQ
YGDVKPGDTVFIAGAGPVGMSALLTAQLYSPAAIIVCDMDENRLKLAKELGATHTINPASGEVSKQVFAIVGEDGVDCAI
EAVGIPATWNMCQDIVKPGGHIAVVGVHGQSVDFKLEKLWIKNLAITTGLVNANTTEMLMKAISSSSVDYTKMLTHHFKF
SELEKAYDVFKHAAENQVMKVVLEAD
>Mature_346_residues
MKAMVYHGANDIRFEEKPRPQIIDPTDAVVKIVKTTICGTDLGIWKGKNPEVADGRILGHEGIGIVEEVGEAVKNIKVGD
KVIISCVSKCCTCDNCKTQLYSHCRNGGWILGYMIDGTQAEYVRTPYADNSLVPLPDNVNEEIALLLSDALPTAHEIGVQ
YGDVKPGDTVFIAGAGPVGMSALLTAQLYSPAAIIVCDMDENRLKLAKELGATHTINPASGEVSKQVFAIVGEDGVDCAI
EAVGIPATWNMCQDIVKPGGHIAVVGVHGQSVDFKLEKLWIKNLAITTGLVNANTTEMLMKAISSSSVDYTKMLTHHFKF
SELEKAYDVFKHAAENQVMKVVLEAD

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=351, Percent_Identity=28.4900284900285, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI71565154, Length=336, Percent_Identity=27.6785714285714, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4501939, Length=332, Percent_Identity=27.1084337349398, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI156523966, Length=332, Percent_Identity=27.1084337349398, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4501929, Length=331, Percent_Identity=26.8882175226586, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI71565152, Length=334, Percent_Identity=25.748502994012, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI34577061, Length=329, Percent_Identity=26.7477203647416, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4501933, Length=330, Percent_Identity=26.0606060606061, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI262073058, Length=342, Percent_Identity=24.8538011695906, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI71743840, Length=342, Percent_Identity=24.8538011695906, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=29.8469387755102, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1790045, Length=356, Percent_Identity=29.4943820224719, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1787863, Length=337, Percent_Identity=27.299703264095, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1788075, Length=366, Percent_Identity=25.1366120218579, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87082125, Length=346, Percent_Identity=28.0346820809249, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788073, Length=311, Percent_Identity=29.903536977492, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI226510992, Length=330, Percent_Identity=24.5454545454545, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788407, Length=354, Percent_Identity=25.7062146892655, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081918, Length=270, Percent_Identity=31.4814814814815, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790718, Length=308, Percent_Identity=25, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786552, Length=345, Percent_Identity=25.5072463768116, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=348, Percent_Identity=29.0229885057471, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17562878, Length=354, Percent_Identity=28.8135593220339, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI25146526, Length=343, Percent_Identity=27.6967930029155, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71997431, Length=342, Percent_Identity=27.1929824561404, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17565904, Length=344, Percent_Identity=27.3255813953488, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=359, Percent_Identity=28.9693593314763, Blast_Score=122, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6319955, Length=359, Percent_Identity=28.9693593314763, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323099, Length=332, Percent_Identity=26.2048192771084, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6319258, Length=279, Percent_Identity=27.9569892473118, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320033, Length=353, Percent_Identity=26.0623229461756, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319257, Length=281, Percent_Identity=28.8256227758007, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=336, Percent_Identity=25.297619047619, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=358, Percent_Identity=26.8156424581006, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737897, Length=334, Percent_Identity=28.1437125748503, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17137530, Length=333, Percent_Identity=28.2282282282282, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI17737895, Length=341, Percent_Identity=26.9794721407625, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221457811, Length=334, Percent_Identity=23.0538922155689, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45550770, Length=334, Percent_Identity=23.0538922155689, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45551930, Length=334, Percent_Identity=23.0538922155689, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37312; Mature: 37312

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMVYHGANDIRFEEKPRPQIIDPTDAVVKIVKTTICGTDLGIWKGKNPEVADGRILGH
CCEEEEECCCCCEECCCCCCCEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECC
EGIGIVEEVGEAVKNIKVGDKVIISCVSKCCTCDNCKTQLYSHCRNGGWILGYMIDGTQA
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCC
EYVRTPYADNSLVPLPDNVNEEIALLLSDALPTAHEIGVQYGDVKPGDTVFIAGAGPVGM
CEEECCCCCCCEECCCCCCCHHHHHHHHHCCCCHHHHCCEECCCCCCCEEEEECCCCCCH
SALLTAQLYSPAAIIVCDMDENRLKLAKELGATHTINPASGEVSKQVFAIVGEDGVDCAI
HHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCEECCCCCCCHHHEEEEEECCCCCCEEE
EAVGIPATWNMCQDIVKPGGHIAVVGVHGQSVDFKLEKLWIKNLAITTGLVNANTTEMLM
EEECCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHEEEEECCCCHHHHHH
KAISSSSVDYTKMLTHHFKFSELEKAYDVFKHAAENQVMKVVLEAD
HHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEECC
>Mature Secondary Structure
MKAMVYHGANDIRFEEKPRPQIIDPTDAVVKIVKTTICGTDLGIWKGKNPEVADGRILGH
CCEEEEECCCCCEECCCCCCCEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECC
EGIGIVEEVGEAVKNIKVGDKVIISCVSKCCTCDNCKTQLYSHCRNGGWILGYMIDGTQA
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCC
EYVRTPYADNSLVPLPDNVNEEIALLLSDALPTAHEIGVQYGDVKPGDTVFIAGAGPVGM
CEEECCCCCCCEECCCCCCCHHHHHHHHHCCCCHHHHCCEECCCCCCCEEEEECCCCCCH
SALLTAQLYSPAAIIVCDMDENRLKLAKELGATHTINPASGEVSKQVFAIVGEDGVDCAI
HHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCEECCCCCCCHHHEEEEEECCCCCCEEE
EAVGIPATWNMCQDIVKPGGHIAVVGVHGQSVDFKLEKLWIKNLAITTGLVNANTTEMLM
EEECCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHEEEEECCCCHHHHHH
KAISSSSVDYTKMLTHHFKFSELEKAYDVFKHAAENQVMKVVLEAD
HHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]