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The map label for this gene is zwf [H]

Identifier: 161870266

GI number: 161870266

Start: 1308661

End: 1310106

Strand: Reverse

Name: zwf [H]

Synonym: NMCC_1307

Alternate gene names: 161870266

Gene position: 1310106-1308661 (Counterclockwise)

Preceding gene: 161870269

Following gene: 161870265

Centisome position: 60.84

GC content: 52.9

Gene sequence:

>1446_bases
ATGAGTACACAAACAAATTTTGATTTGGTGTTGTTCGGTGCGACCGGCGATTTGGCGATGCGCAAGCTGTTGCCCTGTCT
GTACCAGGCGCATGTTGCCGGTCTGCTTCATCCCGAAGGGCGTATTTTGGGGGTCAGCCGCAGCGAGTTGGATACCGAAG
GTTTTCTGGCGAAGGTGGAAACCAGTTCCAAAATCCATGTGAAAGAAAATTTTTCCGATGAGGCTTGGGCATCGTTTGTC
GAACGTCTCGCATATCTCAAAGTCGATGTTACGCAGCCGGACGATTTTGCCGCTTTGGGCGATTTGGTCAAAGCGCGCAA
AGAAACCGACAATGTCGTCATCTATCTTTCCACCGCGCCGAAATTCTTCGCGCAAACATGTGAAAACCTTGCCAAAATCG
GTTTGAACGCCGACAACGTGCGTGTGGTTTTGGAAAAACCGTTGGGTACGGATTTGGCTTCTTCCCAGCAAATCAATACC
GATGTTGCGCGTTATTTCAAAGAAGGGCAAATTTACCGCATCGACCACTACCTTGGCAAAGAAAGCCTGCAAAACCTGCT
TGCGCTGCGTTTTGCCAATGTAATGTTCGAGCCGCTGTGGAACAATAAATACATCGAAAGCGTGCAGTTGACCATCGCCG
AACAGCTCGGTGTGGAAGAGCGCGGCGAGTTTTACGACATTACCGGCGCGTTGCGCGATATGGTGCAAAACCATTTGATG
CAGATGCTGTGCATGACTGCGATGGAAGCCCCCGCCAGCTTGGATGCCGATGCGGTGCGCGATGAAAAAGTCAAAGTCAT
CAAGTCATTGAAGCCGCTGACCGTCGAGTCTGTCAATGAAAACGTCGTGCGCGGACAATATACCGCCGCCAAAGGCATGA
ACGGCTATCTTGAAGAAATCAACGTTCCGCAAGACAGCTTTACCGAAACCTACGTCGCCATTAAAGCCGAAATCGAAAAC
GAACGCTGGAAGGGCGTTCCCTTCTACCTGCGTACCGGCAAGCGCATGGCGGGCAAAGTGGCGGAAATCGTTTTGAACTT
CAAAGATTTGAACAGCCATATTTTTGAAGGCAGCCGCACCGCGCCCAACCGGCTCGTTATCGAGTTGCAACCATATGAAT
CCGTGCGCCTCTATACGCAGATGAAAACCCCGGGGGCAGGAAATAAGGTCGAAACCGTGCCGCTGGCAACCGATTTGGGC
AAAGCATTGGAAGGCCGCCGCGCGGAAGCTTACGAGCGCCTGCTGCTGGACGTGATTAACGGCAAACTCGCTTTGTTCAA
CCGCCGCGACGAACTCGAAGCCGCGTGGGAATATGTGATGCCGATTTTGGAAAACTGGACAAATAACACCACGCCGCCGC
ACGGCTACGGCGCACACTCGTGGGGGCCTGAAGCCGCGCGCGAACTGTTGGCGCGCGACGGACACAAGTGGCACGAAGAG
CAGTAA

Upstream 100 bases:

>100_bases
ATTATGCCGCCTGCCTTTGTTTCCGATATTGCGATGCAGCGTGATGGGGAAAACAGGTTTCAAACGGCATCGAAAAATTC
TTTCCTGACGAGATAATACG

Downstream 100 bases:

>100_bases
TACAATAATGCGTTCAGACGGCATGGGGTTTGAAATGCCGTCTGAACGCAAGTAAAGCAGTATAGTGGATTAACAAAAAT
CAGGACAAGGCGACGAAGCC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MSTQTNFDLVLFGATGDLAMRKLLPCLYQAHVAGLLHPEGRILGVSRSELDTEGFLAKVETSSKIHVKENFSDEAWASFV
ERLAYLKVDVTQPDDFAALGDLVKARKETDNVVIYLSTAPKFFAQTCENLAKIGLNADNVRVVLEKPLGTDLASSQQINT
DVARYFKEGQIYRIDHYLGKESLQNLLALRFANVMFEPLWNNKYIESVQLTIAEQLGVEERGEFYDITGALRDMVQNHLM
QMLCMTAMEAPASLDADAVRDEKVKVIKSLKPLTVESVNENVVRGQYTAAKGMNGYLEEINVPQDSFTETYVAIKAEIEN
ERWKGVPFYLRTGKRMAGKVAEIVLNFKDLNSHIFEGSRTAPNRLVIELQPYESVRLYTQMKTPGAGNKVETVPLATDLG
KALEGRRAEAYERLLLDVINGKLALFNRRDELEAAWEYVMPILENWTNNTTPPHGYGAHSWGPEAARELLARDGHKWHEE
Q

Sequences:

>Translated_481_residues
MSTQTNFDLVLFGATGDLAMRKLLPCLYQAHVAGLLHPEGRILGVSRSELDTEGFLAKVETSSKIHVKENFSDEAWASFV
ERLAYLKVDVTQPDDFAALGDLVKARKETDNVVIYLSTAPKFFAQTCENLAKIGLNADNVRVVLEKPLGTDLASSQQINT
DVARYFKEGQIYRIDHYLGKESLQNLLALRFANVMFEPLWNNKYIESVQLTIAEQLGVEERGEFYDITGALRDMVQNHLM
QMLCMTAMEAPASLDADAVRDEKVKVIKSLKPLTVESVNENVVRGQYTAAKGMNGYLEEINVPQDSFTETYVAIKAEIEN
ERWKGVPFYLRTGKRMAGKVAEIVLNFKDLNSHIFEGSRTAPNRLVIELQPYESVRLYTQMKTPGAGNKVETVPLATDLG
KALEGRRAEAYERLLLDVINGKLALFNRRDELEAAWEYVMPILENWTNNTTPPHGYGAHSWGPEAARELLARDGHKWHEE
Q
>Mature_480_residues
STQTNFDLVLFGATGDLAMRKLLPCLYQAHVAGLLHPEGRILGVSRSELDTEGFLAKVETSSKIHVKENFSDEAWASFVE
RLAYLKVDVTQPDDFAALGDLVKARKETDNVVIYLSTAPKFFAQTCENLAKIGLNADNVRVVLEKPLGTDLASSQQINTD
VARYFKEGQIYRIDHYLGKESLQNLLALRFANVMFEPLWNNKYIESVQLTIAEQLGVEERGEFYDITGALRDMVQNHLMQ
MLCMTAMEAPASLDADAVRDEKVKVIKSLKPLTVESVNENVVRGQYTAAKGMNGYLEEINVPQDSFTETYVAIKAEIENE
RWKGVPFYLRTGKRMAGKVAEIVLNFKDLNSHIFEGSRTAPNRLVIELQPYESVRLYTQMKTPGAGNKVETVPLATDLGK
ALEGRRAEAYERLLLDVINGKLALFNRRDELEAAWEYVMPILENWTNNTTPPHGYGAHSWGPEAARELLARDGHKWHEEQ

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=484, Percent_Identity=38.4297520661157, Blast_Score=298, Evalue=9e-81,
Organism=Homo sapiens, GI109389365, Length=484, Percent_Identity=38.4297520661157, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI52145310, Length=480, Percent_Identity=28.5416666666667, Blast_Score=163, Evalue=3e-40,
Organism=Escherichia coli, GI1788158, Length=481, Percent_Identity=45.7380457380457, Blast_Score=421, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17538218, Length=497, Percent_Identity=37.0221327967807, Blast_Score=311, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6324088, Length=492, Percent_Identity=34.349593495935, Blast_Score=271, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24643352, Length=500, Percent_Identity=36.8, Blast_Score=283, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24643350, Length=500, Percent_Identity=36.8, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI221513548, Length=498, Percent_Identity=27.5100401606426, Blast_Score=201, Evalue=8e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54149; Mature: 54018

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQTNFDLVLFGATGDLAMRKLLPCLYQAHVAGLLHPEGRILGVSRSELDTEGFLAKVE
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHCCCCCCCEEEEE
TSSKIHVKENFSDEAWASFVERLAYLKVDVTQPDDFAALGDLVKARKETDNVVIYLSTAP
CCCEEEEECCCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCH
KFFAQTCENLAKIGLNADNVRVVLEKPLGTDLASSQQINTDVARYFKEGQIYRIDHYLGK
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCEEEEHHHHCH
ESLQNLLALRFANVMFEPLWNNKYIESVQLTIAEQLGVEERGEFYDITGALRDMVQNHLM
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHH
QMLCMTAMEAPASLDADAVRDEKVKVIKSLKPLTVESVNENVVRGQYTAAKGMNGYLEEI
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCHHCCCHHHHCCCCCHHHHC
NVPQDSFTETYVAIKAEIENERWKGVPFYLRTGKRMAGKVAEIVLNFKDLNSHIFEGSRT
CCCCCHHCCEEEEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
APNRLVIELQPYESVRLYTQMKTPGAGNKVETVPLATDLGKALEGRRAEAYERLLLDVIN
CCCEEEEEECCCCCEEEEEEECCCCCCCCEEEEECHHHHHHHHCCCHHHHHHHHHHHHHC
GKLALFNRRDELEAAWEYVMPILENWTNNTTPPHGYGAHSWGPEAARELLARDGHKWHEE
CCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
Q
C
>Mature Secondary Structure 
STQTNFDLVLFGATGDLAMRKLLPCLYQAHVAGLLHPEGRILGVSRSELDTEGFLAKVE
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHCCCCCCCEEEEE
TSSKIHVKENFSDEAWASFVERLAYLKVDVTQPDDFAALGDLVKARKETDNVVIYLSTAP
CCCEEEEECCCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCH
KFFAQTCENLAKIGLNADNVRVVLEKPLGTDLASSQQINTDVARYFKEGQIYRIDHYLGK
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCEEEEHHHHCH
ESLQNLLALRFANVMFEPLWNNKYIESVQLTIAEQLGVEERGEFYDITGALRDMVQNHLM
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHH
QMLCMTAMEAPASLDADAVRDEKVKVIKSLKPLTVESVNENVVRGQYTAAKGMNGYLEEI
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCHHCCCHHHHCCCCCHHHHC
NVPQDSFTETYVAIKAEIENERWKGVPFYLRTGKRMAGKVAEIVLNFKDLNSHIFEGSRT
CCCCCHHCCEEEEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
APNRLVIELQPYESVRLYTQMKTPGAGNKVETVPLATDLGKALEGRRAEAYERLLLDVIN
CCCEEEEEECCCCCEEEEEEECCCCCCCCEEEEECHHHHHHHHCCCHHHHHHHHHHHHHC
GKLALFNRRDELEAAWEYVMPILENWTNNTTPPHGYGAHSWGPEAARELLARDGHKWHEE
CCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
Q
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]