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The map label for this gene is edd [H]

Identifier: 161870267

GI number: 161870267

Start: 1310624

End: 1312459

Strand: Direct

Name: edd [H]

Synonym: NMCC_1308

Alternate gene names: 161870267

Gene position: 1310624-1312459 (Clockwise)

Preceding gene: 161870259

Following gene: 161870268

Centisome position: 60.86

GC content: 57.84

Gene sequence:

>1836_bases
GTGAACACTACTCCTATCCACTCCAAACTCGCCGAAATCACCGGGCGCATTATTGAACGCAGCCGTCCGACGCGTGAAAA
ATATCTGGCGAAGATCCGCAGTGCCAAACAAATGGGACGCTTAGAGCGCAACCAGCTCGGCTGCAGCAACTTGGCACACG
GCTATGCTGCCATGCCTAAAAGTATCAAAATCGAAATGCTTCAGGAAACCGTCCCCAACTTAGGCATCATCACCGCCTAC
AACGACATGGTTTCCGCACACCAGCCGTTTAAAGACTTCCCTGACCAAATCAAAGACGAAGCGCAGAAAAACGGCGCGAC
CGCCCAAGTCGCCGGCGGCACGCCCGCCATGTGCGACGGCATCACGCAAGGCTACGCCGGCATGGAATTGTCGCTGTTCT
CCCGCGACGTGATTGCCATGAGTACCGCCATCGGGCTGTCGCATCAAATGTTTGACGGCAGCCTGTTTATGGGCGTATGC
GACAAAATCGTTCCAGGTTTGATGATAGGCGCGCTTTCGTTCGGTCATATTCCGGGTATCTTCGTCCCCGCAGGCCCGAT
GTCCAGCGGTATCGGCAACAAAGAAAAAGCCCGCACCCGCCAGCTTTTCGCCGAAGGCAAGGTCGGACGCAACGAACTTT
TGAAAAGCGAAATGGGTTCTTACCACAGCCCGGGCACCTGCACTTTCTACGGCACGGCAAACTCCAACCAAATGATGATG
GAAATGATGGGCGTGCACCTGCCTGCCGCCGCCTTCGTCCACCCTTACACCGACCTGCGCGAAGCGCTGACCCGCTACGC
CGCCGGACACCTCGCGCGCGGCATCAAAAACGGCACGATTAAACCTTTGGGCGAAATGTTGACCGAAAAATCCTTTATCA
ACGCCTTGATTGGCCTGATGGCAACCGGCGGTTCGACCAACCACACCATGCACCTCGTCGCTATGGCGCGTGCGGCCGGC
GTGATTTTGAACTGGGACGACTTCGACGAAATTTCCTCCATCATCCCGCTGCTCATCCGCGTTTATCCGAACGGCAAGGC
CGACGTGAATCACTTTACCGCAGCGGGCGGGCTGCCTTTCGTTATCCGCGAATTGCTGAATGCAGGCCTGTTGCACGACG
ATGTCGATACCGTCGTCGGACACGGTATGCGCCACTACACCAAAGAGCCTTTCCTCATCGACGGCAAACTCGAATGGCGC
GAAGCCCCCGAAACCAGCGGCAACGACGACATCCTGCGCAAAGCTGACAACCCGTTCTCCCCCGACGGCGGTCTGCGCCT
GATGAAAGGCAACATCGGACGCGGCGTGATTAAAGTGTCCGCCGTGCGCGAAGGTTGCCGCATCATTGAAGCGCCTGCCA
TCGTGTTCAACGACCAACGCGAAGTGTTGGCTGCGTTTGAACGCGGCGAGTTGGAACGCGATTTTGTGTGCGTCGTCCGC
TACCAAGGCCCGCGTGCCAACGGTATGCCCGAATTGCACAAACTGACCCCGCCTTTGGGCATCCTGCAAGACCGCGGCTT
CAAAGTGGCGCTGCTGACCGACGGCCGTATGTCCGGCGCGTCCGGCAAAGTTCCGGCCTCCATCCACATGACGCCTGAAG
CCTTGATTGGTGGCAACATCGCCAAAATCCGTACCGGCGACCTGATCCGCTTCGACTCCGTTAGCGGCGAACTCAACGTC
CTGATTAACGAAACCGAATGGAATGCCCGCGAAGTCGAAAGCATCGACTTGGGCGCGAACCAACAAGGCTGCGGCCGCGA
ACTCTTCGCCAACTTCCGCAGCATGACCAGCAGCGCAGAAACCGGTGCCATGAGTTTCGGCGGCGAATTTGCCTGA

Upstream 100 bases:

>100_bases
TTGTTAATCCACTATACTTACCGTCTGAATACCCGATACAAAAATCAGAAACGCACAAACAAATCCCCAATACCCCCCCC
GTTCCGACAGGAGACCGACC

Downstream 100 bases:

>100_bases
TGCGCGTTTCAGACGGCCTTTTCAGACCGAAGGCCGTCTGAAAAATTATTGAAGCTGTTTAAACGGATCAGACGCAGCGT
GGGCTTTGCCCGCGAATAAG

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 611; Mature: 611

Protein sequence:

>611_residues
MNTTPIHSKLAEITGRIIERSRPTREKYLAKIRSAKQMGRLERNQLGCSNLAHGYAAMPKSIKIEMLQETVPNLGIITAY
NDMVSAHQPFKDFPDQIKDEAQKNGATAQVAGGTPAMCDGITQGYAGMELSLFSRDVIAMSTAIGLSHQMFDGSLFMGVC
DKIVPGLMIGALSFGHIPGIFVPAGPMSSGIGNKEKARTRQLFAEGKVGRNELLKSEMGSYHSPGTCTFYGTANSNQMMM
EMMGVHLPAAAFVHPYTDLREALTRYAAGHLARGIKNGTIKPLGEMLTEKSFINALIGLMATGGSTNHTMHLVAMARAAG
VILNWDDFDEISSIIPLLIRVYPNGKADVNHFTAAGGLPFVIRELLNAGLLHDDVDTVVGHGMRHYTKEPFLIDGKLEWR
EAPETSGNDDILRKADNPFSPDGGLRLMKGNIGRGVIKVSAVREGCRIIEAPAIVFNDQREVLAAFERGELERDFVCVVR
YQGPRANGMPELHKLTPPLGILQDRGFKVALLTDGRMSGASGKVPASIHMTPEALIGGNIAKIRTGDLIRFDSVSGELNV
LINETEWNAREVESIDLGANQQGCGRELFANFRSMTSSAETGAMSFGGEFA

Sequences:

>Translated_611_residues
MNTTPIHSKLAEITGRIIERSRPTREKYLAKIRSAKQMGRLERNQLGCSNLAHGYAAMPKSIKIEMLQETVPNLGIITAY
NDMVSAHQPFKDFPDQIKDEAQKNGATAQVAGGTPAMCDGITQGYAGMELSLFSRDVIAMSTAIGLSHQMFDGSLFMGVC
DKIVPGLMIGALSFGHIPGIFVPAGPMSSGIGNKEKARTRQLFAEGKVGRNELLKSEMGSYHSPGTCTFYGTANSNQMMM
EMMGVHLPAAAFVHPYTDLREALTRYAAGHLARGIKNGTIKPLGEMLTEKSFINALIGLMATGGSTNHTMHLVAMARAAG
VILNWDDFDEISSIIPLLIRVYPNGKADVNHFTAAGGLPFVIRELLNAGLLHDDVDTVVGHGMRHYTKEPFLIDGKLEWR
EAPETSGNDDILRKADNPFSPDGGLRLMKGNIGRGVIKVSAVREGCRIIEAPAIVFNDQREVLAAFERGELERDFVCVVR
YQGPRANGMPELHKLTPPLGILQDRGFKVALLTDGRMSGASGKVPASIHMTPEALIGGNIAKIRTGDLIRFDSVSGELNV
LINETEWNAREVESIDLGANQQGCGRELFANFRSMTSSAETGAMSFGGEFA
>Mature_611_residues
MNTTPIHSKLAEITGRIIERSRPTREKYLAKIRSAKQMGRLERNQLGCSNLAHGYAAMPKSIKIEMLQETVPNLGIITAY
NDMVSAHQPFKDFPDQIKDEAQKNGATAQVAGGTPAMCDGITQGYAGMELSLFSRDVIAMSTAIGLSHQMFDGSLFMGVC
DKIVPGLMIGALSFGHIPGIFVPAGPMSSGIGNKEKARTRQLFAEGKVGRNELLKSEMGSYHSPGTCTFYGTANSNQMMM
EMMGVHLPAAAFVHPYTDLREALTRYAAGHLARGIKNGTIKPLGEMLTEKSFINALIGLMATGGSTNHTMHLVAMARAAG
VILNWDDFDEISSIIPLLIRVYPNGKADVNHFTAAGGLPFVIRELLNAGLLHDDVDTVVGHGMRHYTKEPFLIDGKLEWR
EAPETSGNDDILRKADNPFSPDGGLRLMKGNIGRGVIKVSAVREGCRIIEAPAIVFNDQREVLAAFERGELERDFVCVVR
YQGPRANGMPELHKLTPPLGILQDRGFKVALLTDGRMSGASGKVPASIHMTPEALIGGNIAKIRTGDLIRFDSVSGELNV
LINETEWNAREVESIDLGANQQGCGRELFANFRSMTSSAETGAMSFGGEFA

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=599, Percent_Identity=58.0968280467446, Blast_Score=732, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=546, Percent_Identity=27.1062271062271, Blast_Score=176, Evalue=5e-45,
Organism=Escherichia coli, GI2367371, Length=486, Percent_Identity=30.4526748971193, Blast_Score=146, Evalue=4e-36,
Organism=Escherichia coli, GI1786464, Length=485, Percent_Identity=28.8659793814433, Blast_Score=135, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6322476, Length=526, Percent_Identity=29.277566539924, Blast_Score=180, Evalue=7e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 66164; Mature: 66164

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTPIHSKLAEITGRIIERSRPTREKYLAKIRSAKQMGRLERNQLGCSNLAHGYAAMPK
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHCCC
SIKIEMLQETVPNLGIITAYNDMVSAHQPFKDFPDQIKDEAQKNGATAQVAGGTPAMCDG
HHHHHHHHHHCCCCEEEEEEHHHHHHCCCHHHCCHHHHHHHHHCCCEEEECCCCCHHHHH
ITQGYAGMELSLFSRDVIAMSTAIGLSHQMFDGSLFMGVCDKIVPGLMIGALSFGHIPGI
HHCCCCCCEEEHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
FVPAGPMSSGIGNKEKARTRQLFAEGKVGRNELLKSEMGSYHSPGTCTFYGTANSNQMMM
EEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCHHHH
EMMGVHLPAAAFVHPYTDLREALTRYAAGHLARGIKNGTIKPLGEMLTEKSFINALIGLM
HHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
ATGGSTNHTMHLVAMARAAGVILNWDDFDEISSIIPLLIRVYPNGKADVNHFTAAGGLPF
HCCCCCCCHHHHEEHHHHCCEEECCCCHHHHHHHHHHHHEECCCCCCCCCEEECCCCHHH
VIRELLNAGLLHDDVDTVVGHGMRHYTKEPFLIDGKLEWREAPETSGNDDILRKADNPFS
HHHHHHHCCCCCCCHHHHHHCCHHHHCCCCEEECCEECCCCCCCCCCCCHHHHCCCCCCC
PDGGLRLMKGNIGRGVIKVSAVREGCRIIEAPAIVFNDQREVLAAFERGELERDFVCVVR
CCCCEEEEECCCCCCEEEEHHHHHCCEEEECCEEEECCHHHHHHHHHHCCCCCCEEEEEE
YQGPRANGMPELHKLTPPLGILQDRGFKVALLTDGRMSGASGKVPASIHMTPEALIGGNI
ECCCCCCCCCHHHHCCCCCHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECHHHHHCCCE
AKIRTGDLIRFDSVSGELNVLINETEWNAREVESIDLGANQQGCGRELFANFRSMTSSAE
EEEECCCEEEEECCCCCEEEEEECCCCCCHHCCEEECCCCCCCCCHHHHHHHHHHHCCCC
TGAMSFGGEFA
CCCCCCCCCCC
>Mature Secondary Structure
MNTTPIHSKLAEITGRIIERSRPTREKYLAKIRSAKQMGRLERNQLGCSNLAHGYAAMPK
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHCCC
SIKIEMLQETVPNLGIITAYNDMVSAHQPFKDFPDQIKDEAQKNGATAQVAGGTPAMCDG
HHHHHHHHHHCCCCEEEEEEHHHHHHCCCHHHCCHHHHHHHHHCCCEEEECCCCCHHHHH
ITQGYAGMELSLFSRDVIAMSTAIGLSHQMFDGSLFMGVCDKIVPGLMIGALSFGHIPGI
HHCCCCCCEEEHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
FVPAGPMSSGIGNKEKARTRQLFAEGKVGRNELLKSEMGSYHSPGTCTFYGTANSNQMMM
EEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCHHHH
EMMGVHLPAAAFVHPYTDLREALTRYAAGHLARGIKNGTIKPLGEMLTEKSFINALIGLM
HHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
ATGGSTNHTMHLVAMARAAGVILNWDDFDEISSIIPLLIRVYPNGKADVNHFTAAGGLPF
HCCCCCCCHHHHEEHHHHCCEEECCCCHHHHHHHHHHHHEECCCCCCCCCEEECCCCHHH
VIRELLNAGLLHDDVDTVVGHGMRHYTKEPFLIDGKLEWREAPETSGNDDILRKADNPFS
HHHHHHHCCCCCCCHHHHHHCCHHHHCCCCEEECCEECCCCCCCCCCCCHHHHCCCCCCC
PDGGLRLMKGNIGRGVIKVSAVREGCRIIEAPAIVFNDQREVLAAFERGELERDFVCVVR
CCCCEEEEECCCCCCEEEEHHHHHCCEEEECCEEEECCHHHHHHHHHHCCCCCCEEEEEE
YQGPRANGMPELHKLTPPLGILQDRGFKVALLTDGRMSGASGKVPASIHMTPEALIGGNI
ECCCCCCCCCHHHHCCCCCHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECHHHHHCCCE
AKIRTGDLIRFDSVSGELNVLINETEWNAREVESIDLGANQQGCGRELFANFRSMTSSAE
EEEECCCEEEEECCCCCEEEEEECCCCCCHHCCEEECCCCCCCCCHHHHHHHHHHHCCCC
TGAMSFGGEFA
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045900; 10984043 [H]