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The map label for this gene is uvrC [H]

Identifier: 161870201

GI number: 161870201

Start: 1231933

End: 1233819

Strand: Direct

Name: uvrC [H]

Synonym: NMCC_1241

Alternate gene names: 161870201

Gene position: 1231933-1233819 (Clockwise)

Preceding gene: 161870200

Following gene: 161870202

Centisome position: 57.21

GC content: 54.58

Gene sequence:

>1887_bases
ATGCCGTCTGAAACCGTTTTTCAAGTAATTGATATGAATAAAGAAACCCGTTTTCCGGAACACTTCGACATCCCACTTTT
CCTCAAAAACCTGCCCAAGCTGCCGGGCGTGTACCGTTTTTTTGACGAAGGCGGCAAAGTCTTATACGTCGGCAAAGCGG
TCAACCTCAAGCGGCGCGTGTCCGGCTATTTCCAAAAAAACGACCATTCGCCGCGCATCGCATTGATGGTAAAACAGGTT
CATCATATCGAAACCACCATCACGCGTTCCGAAGCCGAAGCCCTGATTCTCGAAAACAACCTCATCAAAGCCTTGTCGCC
GAAATACAATATCCTTTTCCGCGACGACAAAAGCTATCCTTATTTGATGCTCAGCGGCCATCAATATCCGCAGATGGCGT
ATTACCGCGGCACGCTGAAAAAGCCAAACCAATACTTCGGCCCGTATCCCAACAGCAACGCCGTGCGCGACAGCATTCAA
GTGTTGCAAAAAGTCTTTATGCTGCGTACCTGCGAAGACAGCGTATTCGAGCATCGTGACCGCCCTTGCCTGCTGTATCA
AATCAAACGCTGCACCGCGCCCTGCGTCGGACACATCAGCGAAGAAGACTACCGCGACAGCGTGCGTCAAGCCGCCACTT
TTCTCAACGGCAAAACCGACGAACTGACCCGCACCCTGCAACACAAAATGCAAACTGCCGCCGCGAATCTGCAATTTGAA
GAAGCCGCCCGCTACCGCGACCAAATCCAAGCACTCGGCATTATGCAGAGCAACCAGTTCATCGACAGCAAAAACCCGAA
CAACCCCAACGATATCGATTTGCTCGCGCTGGCGGTTTCAGACGGCATCGTCTGCGTACACTGGGTCAGCATACGCGGTG
GGCGGCACGTCGGAGACAAAAGTTTCTTCCCCGACACCAAAAACGATCCCGAGCCAAACGGGCAAGACTATGCCGAAGCC
TTCGTCGCCCAACACTATCTGGGCAAAAGCAAACCCGACATTATCATCAACAACTTCCCCGTCCCCGATGCGCTGAAAGA
GGCTTTGGAAGGCGAACACGGCAAACAAATGCAGTTCGTAACCAAAACCATAGGCGAACGCAAAGTCTGGTTGAAAATGG
CGGAGCAAAACGCACAAATGGCGATTGCACAACGCCGCCTGCAACAAAGCAGCCAGCAACACCGCATCGACGAACTCGCC
AAAATCCTCGGTATGGATTCAGACGGCCTCAACCGCCTCGAATGTTTCGACATCAGCCACACCCAAGGCGAGGCCACTAT
TGCGTCCTGCGTTGTGTACGATGAGCAAAACATCCAGCCCTCGCAATACCGCCGCTACAACATCACGACCGCCAAACCCG
GCGACGACTACGCCGCCATGCGCGAAGTGTTGACGCGCCGTTACGGCAAAATGCAGGAGGCCGAAGCCAACGGCGAGACC
GTCAAATGGCCCGATGTCGTATTGATTGACGGCGGCAAAGGGCAAATCGGCGTAGCCGTATCGGTATGGGAAGAACTCGG
GCTGCACATTCCTTTGGTCGGTATCGCCAAAGGCCCGGAGCGCAAAGCCGGTATGGAAGAACTCATACTGCCTTTTACCG
GCGAAGTCTTCCGCCTGCCCCCACACAGCCCGGCCTTGCATCTATTGCAAACCGTACGCGATGAATCGCACCGCTTTGCC
ATCACAGGCCACCGCAAAAAACGCGACAAAGCGCGCGTTACCTCATCCCTCGGCGACATTCCCGGCGTAGGCAGCAAACG
CCGCCAAGCCCTGCTTACCCGCTTCGGCGGTCTGCGCGGCGTGATTGCCGCCAGCCGCGAGGACTTGGAAAAAGTGGAAG
GCATCAGCAAGGCATTGGCGGAAACCATTTATAATCATCTGCATTAG

Upstream 100 bases:

>100_bases
CAATGCCTTGCGCCTGAAACGGGTGAAAATCGATTAGCAGCATGTAACCGCCCTGCAGCCTTGTCCGAACGGATAAGGCT
GTCTCCAGCGATATGGTAAT

Downstream 100 bases:

>100_bases
TATGCCGCCAAAACAAAAACCGTCTGTAAAAATATGATACAGCAGGCCGGTATATCGATATATAGTGGATTAAATTTAAA
CCAGTACGGCGTTGCCTCGC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 628; Mature: 627

Protein sequence:

>628_residues
MPSETVFQVIDMNKETRFPEHFDIPLFLKNLPKLPGVYRFFDEGGKVLYVGKAVNLKRRVSGYFQKNDHSPRIALMVKQV
HHIETTITRSEAEALILENNLIKALSPKYNILFRDDKSYPYLMLSGHQYPQMAYYRGTLKKPNQYFGPYPNSNAVRDSIQ
VLQKVFMLRTCEDSVFEHRDRPCLLYQIKRCTAPCVGHISEEDYRDSVRQAATFLNGKTDELTRTLQHKMQTAAANLQFE
EAARYRDQIQALGIMQSNQFIDSKNPNNPNDIDLLALAVSDGIVCVHWVSIRGGRHVGDKSFFPDTKNDPEPNGQDYAEA
FVAQHYLGKSKPDIIINNFPVPDALKEALEGEHGKQMQFVTKTIGERKVWLKMAEQNAQMAIAQRRLQQSSQQHRIDELA
KILGMDSDGLNRLECFDISHTQGEATIASCVVYDEQNIQPSQYRRYNITTAKPGDDYAAMREVLTRRYGKMQEAEANGET
VKWPDVVLIDGGKGQIGVAVSVWEELGLHIPLVGIAKGPERKAGMEELILPFTGEVFRLPPHSPALHLLQTVRDESHRFA
ITGHRKKRDKARVTSSLGDIPGVGSKRRQALLTRFGGLRGVIAASREDLEKVEGISKALAETIYNHLH

Sequences:

>Translated_628_residues
MPSETVFQVIDMNKETRFPEHFDIPLFLKNLPKLPGVYRFFDEGGKVLYVGKAVNLKRRVSGYFQKNDHSPRIALMVKQV
HHIETTITRSEAEALILENNLIKALSPKYNILFRDDKSYPYLMLSGHQYPQMAYYRGTLKKPNQYFGPYPNSNAVRDSIQ
VLQKVFMLRTCEDSVFEHRDRPCLLYQIKRCTAPCVGHISEEDYRDSVRQAATFLNGKTDELTRTLQHKMQTAAANLQFE
EAARYRDQIQALGIMQSNQFIDSKNPNNPNDIDLLALAVSDGIVCVHWVSIRGGRHVGDKSFFPDTKNDPEPNGQDYAEA
FVAQHYLGKSKPDIIINNFPVPDALKEALEGEHGKQMQFVTKTIGERKVWLKMAEQNAQMAIAQRRLQQSSQQHRIDELA
KILGMDSDGLNRLECFDISHTQGEATIASCVVYDEQNIQPSQYRRYNITTAKPGDDYAAMREVLTRRYGKMQEAEANGET
VKWPDVVLIDGGKGQIGVAVSVWEELGLHIPLVGIAKGPERKAGMEELILPFTGEVFRLPPHSPALHLLQTVRDESHRFA
ITGHRKKRDKARVTSSLGDIPGVGSKRRQALLTRFGGLRGVIAASREDLEKVEGISKALAETIYNHLH
>Mature_627_residues
PSETVFQVIDMNKETRFPEHFDIPLFLKNLPKLPGVYRFFDEGGKVLYVGKAVNLKRRVSGYFQKNDHSPRIALMVKQVH
HIETTITRSEAEALILENNLIKALSPKYNILFRDDKSYPYLMLSGHQYPQMAYYRGTLKKPNQYFGPYPNSNAVRDSIQV
LQKVFMLRTCEDSVFEHRDRPCLLYQIKRCTAPCVGHISEEDYRDSVRQAATFLNGKTDELTRTLQHKMQTAAANLQFEE
AARYRDQIQALGIMQSNQFIDSKNPNNPNDIDLLALAVSDGIVCVHWVSIRGGRHVGDKSFFPDTKNDPEPNGQDYAEAF
VAQHYLGKSKPDIIINNFPVPDALKEALEGEHGKQMQFVTKTIGERKVWLKMAEQNAQMAIAQRRLQQSSQQHRIDELAK
ILGMDSDGLNRLECFDISHTQGEATIASCVVYDEQNIQPSQYRRYNITTAKPGDDYAAMREVLTRRYGKMQEAEANGETV
KWPDVVLIDGGKGQIGVAVSVWEELGLHIPLVGIAKGPERKAGMEELILPFTGEVFRLPPHSPALHLLQTVRDESHRFAI
TGHRKKRDKARVTSSLGDIPGVGSKRRQALLTRFGGLRGVIAASREDLEKVEGISKALAETIYNHLH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=620, Percent_Identity=47.258064516129, Blast_Score=556, Evalue=1e-159,
Organism=Escherichia coli, GI1788037, Length=199, Percent_Identity=30.6532663316583, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF00633 HHH; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 71097; Mature: 70966

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSETVFQVIDMNKETRFPEHFDIPLFLKNLPKLPGVYRFFDEGGKVLYVGKAVNLKRRV
CCCHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHCCCCCEEEEECCCCHHHHH
SGYFQKNDHSPRIALMVKQVHHIETTITRSEAEALILENNLIKALSPKYNILFRDDKSYP
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHCCCCEEEEEECCCCCC
YLMLSGHQYPQMAYYRGTLKKPNQYFGPYPNSNAVRDSIQVLQKVFMLRTCEDSVFEHRD
EEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RPCLLYQIKRCTAPCVGHISEEDYRDSVRQAATFLNGKTDELTRTLQHKMQTAAANLQFE
CCCHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHH
EAARYRDQIQALGIMQSNQFIDSKNPNNPNDIDLLALAVSDGIVCVHWVSIRGGRHVGDK
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEEEECCCCCCCCC
SFFPDTKNDPEPNGQDYAEAFVAQHYLGKSKPDIIINNFPVPDALKEALEGEHGKQMQFV
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHCCCCCCHHHHH
TKTIGERKVWLKMAEQNAQMAIAQRRLQQSSQQHRIDELAKILGMDSDGLNRLECFDISH
HHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCC
TQGEATIASCVVYDEQNIQPSQYRRYNITTAKPGDDYAAMREVLTRRYGKMQEAEANGET
CCCCCEEEEEEEECCCCCCHHHCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHCCCCCE
VKWPDVVLIDGGKGQIGVAVSVWEELGLHIPLVGIAKGPERKAGMEELILPFTGEVFRLP
EECCCEEEEECCCCCEEEEEEEHHHCCCEEEEEEECCCCCHHCCHHHHHCCCCCCEEECC
PHSPALHLLQTVRDESHRFAITGHRKKRDKARVTSSLGDIPGVGSKRRQALLTRFGGLRG
CCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHH
VIAASREDLEKVEGISKALAETIYNHLH
HHHHCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PSETVFQVIDMNKETRFPEHFDIPLFLKNLPKLPGVYRFFDEGGKVLYVGKAVNLKRRV
CCHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHCCCCCEEEEECCCCHHHHH
SGYFQKNDHSPRIALMVKQVHHIETTITRSEAEALILENNLIKALSPKYNILFRDDKSYP
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHCCCCEEEEEECCCCCC
YLMLSGHQYPQMAYYRGTLKKPNQYFGPYPNSNAVRDSIQVLQKVFMLRTCEDSVFEHRD
EEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RPCLLYQIKRCTAPCVGHISEEDYRDSVRQAATFLNGKTDELTRTLQHKMQTAAANLQFE
CCCHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHH
EAARYRDQIQALGIMQSNQFIDSKNPNNPNDIDLLALAVSDGIVCVHWVSIRGGRHVGDK
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEEEECCCCCCCCC
SFFPDTKNDPEPNGQDYAEAFVAQHYLGKSKPDIIINNFPVPDALKEALEGEHGKQMQFV
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHCCCCCCHHHHH
TKTIGERKVWLKMAEQNAQMAIAQRRLQQSSQQHRIDELAKILGMDSDGLNRLECFDISH
HHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCC
TQGEATIASCVVYDEQNIQPSQYRRYNITTAKPGDDYAAMREVLTRRYGKMQEAEANGET
CCCCCEEEEEEEECCCCCCHHHCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHCCCCCE
VKWPDVVLIDGGKGQIGVAVSVWEELGLHIPLVGIAKGPERKAGMEELILPFTGEVFRLP
EECCCEEEEECCCCCEEEEEEEHHHCCCEEEEEEECCCCCHHCCHHHHHCCCCCCEEECC
PHSPALHLLQTVRDESHRFAITGHRKKRDKARVTSSLGDIPGVGSKRRQALLTRFGGLRG
CCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHH
VIAASREDLEKVEGISKALAETIYNHLH
HHHHCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA