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The map label for this gene is clpP [H]

Identifier: 161870184

GI number: 161870184

Start: 1217355

End: 1217969

Strand: Reverse

Name: clpP [H]

Synonym: NMCC_1224

Alternate gene names: 161870184

Gene position: 1217969-1217355 (Counterclockwise)

Preceding gene: 161870185

Following gene: 161870176

Centisome position: 56.56

GC content: 48.78

Gene sequence:

>615_bases
ATGTCTTTTGATAACTATCTTGTCCCTACCGTTATCGAGCAGAGCGGTCGCGGTGAGCGTGCATTCGATATCTATTCTCG
GCTTTTGAAAGAGCGCATCGTATTCTTGGTCGGCCCGGTAACCGACGAGTCCGCCAATCTGGTGGTTGCCCAACTGTTGT
TTTTGGAAAGTGAGAATCCGGATAAGGATATTTTCTTCTATATTAACTCGCCAGGCGGTTCGGTAACGGCCGGTATGTCG
ATTTACGACACCATGAATTTTATCAAGCCCGATGTATCGACTTTGTGCTTGGGGCAGGCAGCAAGTATGGGCGCGTTCTT
ATTGTCGGCAGGCGAAAAAGGCAAACGTTTCGCCCTGCCCAACAGCCGGATTATGATTCACCAGCCTTTAATCAGCGGCG
GCTTGGGCGGTCAGGCATCCGATATTGAAATTCACGCACGCGAACTGTTGAAAATCAAAGAAAAACTCAACCGCCTGATG
GCGAAACATTGCGGCCGCGATTTGGCAGATTTGGAGCGCGACACCGACCGTGATAATTTCATGTCCGCCGAAGAGGCTAA
AGAATATGGTCTGATTGATCAAATCTTGGAGAACCGTGCTTCTTTACAGTTTTAA

Upstream 100 bases:

>100_bases
CCTGATTATCCTGAAAATGCCGTCTTAGGGCAGTTTTTGAAAGCACCGAAGCCGCTTTTAAAGCCCGCTTTGGTGCTTTT
ACATCATGAAAGGAGACGAA

Downstream 100 bases:

>100_bases
TAAGAAATCTGAGAGAAACAAATGCCGTCTGAAAACAGTTCAGACGGCATTTGTCTTATAGGGACTGTATTGGGATGATT
TTGTTCTGGTTGCGTTTGGA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MSFDNYLVPTVIEQSGRGERAFDIYSRLLKERIVFLVGPVTDESANLVVAQLLFLESENPDKDIFFYINSPGGSVTAGMS
IYDTMNFIKPDVSTLCLGQAASMGAFLLSAGEKGKRFALPNSRIMIHQPLISGGLGGQASDIEIHARELLKIKEKLNRLM
AKHCGRDLADLERDTDRDNFMSAEEAKEYGLIDQILENRASLQF

Sequences:

>Translated_204_residues
MSFDNYLVPTVIEQSGRGERAFDIYSRLLKERIVFLVGPVTDESANLVVAQLLFLESENPDKDIFFYINSPGGSVTAGMS
IYDTMNFIKPDVSTLCLGQAASMGAFLLSAGEKGKRFALPNSRIMIHQPLISGGLGGQASDIEIHARELLKIKEKLNRLM
AKHCGRDLADLERDTDRDNFMSAEEAKEYGLIDQILENRASLQF
>Mature_203_residues
SFDNYLVPTVIEQSGRGERAFDIYSRLLKERIVFLVGPVTDESANLVVAQLLFLESENPDKDIFFYINSPGGSVTAGMSI
YDTMNFIKPDVSTLCLGQAASMGAFLLSAGEKGKRFALPNSRIMIHQPLISGGLGGQASDIEIHARELLKIKEKLNRLMA
KHCGRDLADLERDTDRDNFMSAEEAKEYGLIDQILENRASLQF

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=57.8947368421053, Blast_Score=234, Evalue=3e-62,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=72.5388601036269, Blast_Score=301, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17538017, Length=195, Percent_Identity=55.3846153846154, Blast_Score=219, Evalue=7e-58,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=57.8125, Blast_Score=242, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22652; Mature: 22521

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDNYLVPTVIEQSGRGERAFDIYSRLLKERIVFLVGPVTDESANLVVAQLLFLESENP
CCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCC
DKDIFFYINSPGGSVTAGMSIYDTMNFIKPDVSTLCLGQAASMGAFLLSAGEKGKRFALP
CCEEEEEEECCCCCEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECC
NSRIMIHQPLISGGLGGQASDIEIHARELLKIKEKLNRLMAKHCGRDLADLERDTDRDNF
CCEEEEECCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHC
MSAEEAKEYGLIDQILENRASLQF
CCHHHHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SFDNYLVPTVIEQSGRGERAFDIYSRLLKERIVFLVGPVTDESANLVVAQLLFLESENP
CCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCC
DKDIFFYINSPGGSVTAGMSIYDTMNFIKPDVSTLCLGQAASMGAFLLSAGEKGKRFALP
CCEEEEEEECCCCCEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECC
NSRIMIHQPLISGGLGGQASDIEIHARELLKIKEKLNRLMAKHCGRDLADLERDTDRDNF
CCEEEEECCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHC
MSAEEAKEYGLIDQILENRASLQF
CCHHHHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA