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The map label for this gene is nrdA [H]

Identifier: 161870165

GI number: 161870165

Start: 1195243

End: 1197522

Strand: Reverse

Name: nrdA [H]

Synonym: NMCC_1204

Alternate gene names: 161870165

Gene position: 1197522-1195243 (Counterclockwise)

Preceding gene: 161870166

Following gene: 161870164

Centisome position: 55.61

GC content: 52.72

Gene sequence:

>2280_bases
ATGAATACACCGACTGATTTGAAAGTAACCAAACGAGACGGAAGATTAGAAGCCATTGATTTGGATAAGATTCACCGTGT
CGTCACTTGGGCGGCGGACGGATTGGAAAATGTTTCCGTATCTCAGGTCGAGTTGAAATCGCACATCCAGTTCTACAACG
GCATCCGCACCGACGACATCCACGAAACCATCATCAAAGCCGCTGCCGATTTAATTTCGGAAGATACCCCGGACTACCAA
TACCTTGCCGCGCGTTTGGCGATTTTCCATCTGCGTAAAATAGCCTACGGCGAGTACGAGCCGCCGCACCTTTACGACCA
CGTTAAAAAACTTACCGATGCCGCAAAATACGACAGGCATATCCTTGAGGATTACAGCCGCGAAGAATTTGACGAGCTGA
ACGCCTATATCGACCACGAACGCGATATGTCCTTTTCCTATGCCGCTGTCAAACAGCTCGAAGGCAAATATCTGGTACAG
AACCGCGTTACCCGCCAGATTTATGAAACACCGCAGTTCTTATATGTTCTGGTGGCGATGTGTCTTTTCAGCAAATATCC
CAAAGAAACACGCCTCGATTACGTCAAACGGTTTTACGATGCCGTTTCCACATTTAAAGTATCGCTGCCGACCCCGATTA
TGAGCGGCGTGCGTACGCCTACGCGCCAGTTCTCAAGCTGCGTATTGATCGAATGCGACGACAGCCTGGATTCCATCAAC
GCCACCACCAGCGCGATTGTGAAATACGTTTCCCAGCGTGCGGGCATCGGCATCAATGCCGGACGTATCCGCGGACTGGA
CAGCGAAATCCGGGGCGGCGAAGCACGGCATACCGGCTGCATTCCCTTCTTTAAAATGTTTCAGGCGGCAGTCAAATCCT
GTTCGCAAGGTGGCGTGCGCGGCGGCGCGGCAACCTTGTTCTACCCCTTGTGGCATATCGAAGCCGAAAGCCTGCTGGTG
TTGAAAAACAACCGGGGCGTGGAAGACAACCGTATCCGTCAGCTTGATTACGGCGTGCAAATCAACCGCCTGCTGTACAC
CCGCCTGATTAAGGGCGGCAACATTACGCTGTTTTCGCCCAACGAGGTTCCGGGATTGTACGAAGCGTTTTTTGCCGACC
AAGACGAATTTGAGCGGCTCTATACGAAATACGAGCAAGACCCTGATATCCGCAAGCGCATCATTCCGGCTGCCGACCTG
TTTTCCACGCTGATGCAGGAGCGTGCCGGAACCGGGCGCATCTACATTCAAAACGTCGATCACTGCAATACGCACAGCCC
GTTCGATCCGCGCGTCGCGCCTGTTCATCAGTCCAACTTGTGTATGGAAATCGCCCTGCCGACCAAACCGCTGGACAATA
TCAACGATCCGAACGGCGAAATCGCCCTGTGTACACTGTCTGCCTTTAACTTGGGCGCATTAAACAGCTTGGACGAATTG
GAAGGGCTTGCCGACTTGACCGTTCGTGCGCTCGATGCACTTTTAGATTATCAGGGATATCCGGTAGAAGCCGCGCGTAC
CTCTACTATGGGCCGCCGTTCGCTCGGCATCGGCGTGATTAACTATGCGTATTATTTGGCGAAAAACGGTGTCCGCTACA
GCGACGGCTCCGCGCTCGGTCTGACCCACCGTACCTTTGAAGCCATACAGTATTACCTGCTCAAAGCATCGGCAAACCTT
GCCAAAGAATACGGTGCGTGCACGCTCTTTAACCAAACCGTTTATTCGCAAGGCAACCTGCCCATCGACACCTACAAAAA
AGACTTGGACGCTGTGTGTAACGAGCCTTTGCACTACGATTGGGAAAGCCTGCGTGCCGAAATCGTCAAATACGGCCTGC
GCAACTCTACTCTGACCGCACTCATGCCGTCTGAAACCAGCTCTCAAATCGCCAACGCCACCAACGGCATCGAGCCGCCG
CGCGGATTGGTAACGGTCAAAGCATCGAAAGACGGCATTTTGAAACAAGTCGTGCCGGAGTTTGAAACCCTGAAAAATGC
CTATGAAACCCTGTGGCAGCTTCCCGGCAACGAAGGCTACCTGAAACTTGTCGGCGTGATGCAAAAATTCGTCGATCAAT
CGATTTCCGCCAATACCGCCTACGACCCGGGCAAATTCGAAGGCGGCAAAGTTTCTATGAAACAAATGCTCAAAGACCTG
CTGACCGCCTACAAATACGGCGTCAAAACCCTGTACTACCATAACACCCGCGACGGTGCGGACGATACGCAGACCGATAT
TCAGGATGACGGCTGCGCGGGCGGGGCTTGTAAGATTTGA

Upstream 100 bases:

>100_bases
GTTGTCAAGACTGGAGAAAATGCCAAAAATCCACTATATTGTCTGCCTTAATTTATTTGAAAAGACTGTGTCTTGAATAT
CAAGAGTGGAAGAGGAAGCG

Downstream 100 bases:

>100_bases
TGAAAGGGGGAGTTTTCAGATGGCCTTTAGATTAATAAATCATCTGAAATATAAAATATGAAAAATAAAATACAAAATCA
ATTAGATAATATAGTTACCT

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MNTPTDLKVTKRDGRLEAIDLDKIHRVVTWAADGLENVSVSQVELKSHIQFYNGIRTDDIHETIIKAAADLISEDTPDYQ
YLAARLAIFHLRKIAYGEYEPPHLYDHVKKLTDAAKYDRHILEDYSREEFDELNAYIDHERDMSFSYAAVKQLEGKYLVQ
NRVTRQIYETPQFLYVLVAMCLFSKYPKETRLDYVKRFYDAVSTFKVSLPTPIMSGVRTPTRQFSSCVLIECDDSLDSIN
ATTSAIVKYVSQRAGIGINAGRIRGLDSEIRGGEARHTGCIPFFKMFQAAVKSCSQGGVRGGAATLFYPLWHIEAESLLV
LKNNRGVEDNRIRQLDYGVQINRLLYTRLIKGGNITLFSPNEVPGLYEAFFADQDEFERLYTKYEQDPDIRKRIIPAADL
FSTLMQERAGTGRIYIQNVDHCNTHSPFDPRVAPVHQSNLCMEIALPTKPLDNINDPNGEIALCTLSAFNLGALNSLDEL
EGLADLTVRALDALLDYQGYPVEAARTSTMGRRSLGIGVINYAYYLAKNGVRYSDGSALGLTHRTFEAIQYYLLKASANL
AKEYGACTLFNQTVYSQGNLPIDTYKKDLDAVCNEPLHYDWESLRAEIVKYGLRNSTLTALMPSETSSQIANATNGIEPP
RGLVTVKASKDGILKQVVPEFETLKNAYETLWQLPGNEGYLKLVGVMQKFVDQSISANTAYDPGKFEGGKVSMKQMLKDL
LTAYKYGVKTLYYHNTRDGADDTQTDIQDDGCAGGACKI

Sequences:

>Translated_759_residues
MNTPTDLKVTKRDGRLEAIDLDKIHRVVTWAADGLENVSVSQVELKSHIQFYNGIRTDDIHETIIKAAADLISEDTPDYQ
YLAARLAIFHLRKIAYGEYEPPHLYDHVKKLTDAAKYDRHILEDYSREEFDELNAYIDHERDMSFSYAAVKQLEGKYLVQ
NRVTRQIYETPQFLYVLVAMCLFSKYPKETRLDYVKRFYDAVSTFKVSLPTPIMSGVRTPTRQFSSCVLIECDDSLDSIN
ATTSAIVKYVSQRAGIGINAGRIRGLDSEIRGGEARHTGCIPFFKMFQAAVKSCSQGGVRGGAATLFYPLWHIEAESLLV
LKNNRGVEDNRIRQLDYGVQINRLLYTRLIKGGNITLFSPNEVPGLYEAFFADQDEFERLYTKYEQDPDIRKRIIPAADL
FSTLMQERAGTGRIYIQNVDHCNTHSPFDPRVAPVHQSNLCMEIALPTKPLDNINDPNGEIALCTLSAFNLGALNSLDEL
EGLADLTVRALDALLDYQGYPVEAARTSTMGRRSLGIGVINYAYYLAKNGVRYSDGSALGLTHRTFEAIQYYLLKASANL
AKEYGACTLFNQTVYSQGNLPIDTYKKDLDAVCNEPLHYDWESLRAEIVKYGLRNSTLTALMPSETSSQIANATNGIEPP
RGLVTVKASKDGILKQVVPEFETLKNAYETLWQLPGNEGYLKLVGVMQKFVDQSISANTAYDPGKFEGGKVSMKQMLKDL
LTAYKYGVKTLYYHNTRDGADDTQTDIQDDGCAGGACKI
>Mature_759_residues
MNTPTDLKVTKRDGRLEAIDLDKIHRVVTWAADGLENVSVSQVELKSHIQFYNGIRTDDIHETIIKAAADLISEDTPDYQ
YLAARLAIFHLRKIAYGEYEPPHLYDHVKKLTDAAKYDRHILEDYSREEFDELNAYIDHERDMSFSYAAVKQLEGKYLVQ
NRVTRQIYETPQFLYVLVAMCLFSKYPKETRLDYVKRFYDAVSTFKVSLPTPIMSGVRTPTRQFSSCVLIECDDSLDSIN
ATTSAIVKYVSQRAGIGINAGRIRGLDSEIRGGEARHTGCIPFFKMFQAAVKSCSQGGVRGGAATLFYPLWHIEAESLLV
LKNNRGVEDNRIRQLDYGVQINRLLYTRLIKGGNITLFSPNEVPGLYEAFFADQDEFERLYTKYEQDPDIRKRIIPAADL
FSTLMQERAGTGRIYIQNVDHCNTHSPFDPRVAPVHQSNLCMEIALPTKPLDNINDPNGEIALCTLSAFNLGALNSLDEL
EGLADLTVRALDALLDYQGYPVEAARTSTMGRRSLGIGVINYAYYLAKNGVRYSDGSALGLTHRTFEAIQYYLLKASANL
AKEYGACTLFNQTVYSQGNLPIDTYKKDLDAVCNEPLHYDWESLRAEIVKYGLRNSTLTALMPSETSSQIANATNGIEPP
RGLVTVKASKDGILKQVVPEFETLKNAYETLWQLPGNEGYLKLVGVMQKFVDQSISANTAYDPGKFEGGKVSMKQMLKDL
LTAYKYGVKTLYYHNTRDGADDTQTDIQDDGCAGGACKI

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=790, Percent_Identity=28.4810126582279, Blast_Score=246, Evalue=6e-65,
Organism=Escherichia coli, GI2367133, Length=758, Percent_Identity=77.7044854881267, Blast_Score=1257, Evalue=0.0,
Organism=Escherichia coli, GI1789030, Length=573, Percent_Identity=26.7015706806283, Blast_Score=153, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17555242, Length=796, Percent_Identity=27.2613065326633, Blast_Score=239, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6322123, Length=805, Percent_Identity=27.5776397515528, Blast_Score=250, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6320914, Length=792, Percent_Identity=27.3989898989899, Blast_Score=247, Evalue=5e-66,
Organism=Drosophila melanogaster, GI17352481, Length=790, Percent_Identity=26.9620253164557, Blast_Score=247, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 85168; Mature: 85168

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPTDLKVTKRDGRLEAIDLDKIHRVVTWAADGLENVSVSQVELKSHIQFYNGIRTDDI
CCCCCCCEEECCCCCEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHH
HETIIKAAADLISEDTPDYQYLAARLAIFHLRKIAYGEYEPPHLYDHVKKLTDAAKYDRH
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
ILEDYSREEFDELNAYIDHERDMSFSYAAVKQLEGKYLVQNRVTRQIYETPQFLYVLVAM
HHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHH
CLFSKYPKETRLDYVKRFYDAVSTFKVSLPTPIMSGVRTPTRQFSSCVLIECDDSLDSIN
HHHHCCCCHHHHHHHHHHHHHHHHEEEECCCHHHHCCCCCCHHHCCEEEEEECCCCHHHH
ATTSAIVKYVSQRAGIGINAGRIRGLDSEIRGGEARHTGCIPFFKMFQAAVKSCSQGGVR
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GGAATLFYPLWHIEAESLLVLKNNRGVEDNRIRQLDYGVQINRLLYTRLIKGGNITLFSP
CCCHHHHHHHEEECCCEEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCEEEECC
NEVPGLYEAFFADQDEFERLYTKYEQDPDIRKRIIPAADLFSTLMQERAGTGRIYIQNVD
CCCCHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHCCCCCEEEEEECC
HCNTHSPFDPRVAPVHQSNLCMEIALPTKPLDNINDPNGEIALCTLSAFNLGALNSLDEL
CCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHH
EGLADLTVRALDALLDYQGYPVEAARTSTMGRRSLGIGVINYAYYLAKNGVRYSDGSALG
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHCHHHHHHHHHHHCCCCEECCCCEEC
LTHRTFEAIQYYLLKASANLAKEYGACTLFNQTVYSQGNLPIDTYKKDLDAVCNEPLHYD
CHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHCCCCCCHHHHHHHHHHHHCCCCCCC
WESLRAEIVKYGLRNSTLTALMPSETSSQIANATNGIEPPRGLVTVKASKDGILKQVVPE
HHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHH
FETLKNAYETLWQLPGNEGYLKLVGVMQKFVDQSISANTAYDPGKFEGGKVSMKQMLKDL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
LTAYKYGVKTLYYHNTRDGADDTQTDIQDDGCAGGACKI
HHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNTPTDLKVTKRDGRLEAIDLDKIHRVVTWAADGLENVSVSQVELKSHIQFYNGIRTDDI
CCCCCCCEEECCCCCEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHH
HETIIKAAADLISEDTPDYQYLAARLAIFHLRKIAYGEYEPPHLYDHVKKLTDAAKYDRH
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
ILEDYSREEFDELNAYIDHERDMSFSYAAVKQLEGKYLVQNRVTRQIYETPQFLYVLVAM
HHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHH
CLFSKYPKETRLDYVKRFYDAVSTFKVSLPTPIMSGVRTPTRQFSSCVLIECDDSLDSIN
HHHHCCCCHHHHHHHHHHHHHHHHEEEECCCHHHHCCCCCCHHHCCEEEEEECCCCHHHH
ATTSAIVKYVSQRAGIGINAGRIRGLDSEIRGGEARHTGCIPFFKMFQAAVKSCSQGGVR
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GGAATLFYPLWHIEAESLLVLKNNRGVEDNRIRQLDYGVQINRLLYTRLIKGGNITLFSP
CCCHHHHHHHEEECCCEEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCEEEECC
NEVPGLYEAFFADQDEFERLYTKYEQDPDIRKRIIPAADLFSTLMQERAGTGRIYIQNVD
CCCCHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHCCCCCEEEEEECC
HCNTHSPFDPRVAPVHQSNLCMEIALPTKPLDNINDPNGEIALCTLSAFNLGALNSLDEL
CCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHH
EGLADLTVRALDALLDYQGYPVEAARTSTMGRRSLGIGVINYAYYLAKNGVRYSDGSALG
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHCHHHHHHHHHHHCCCCEECCCCEEC
LTHRTFEAIQYYLLKASANLAKEYGACTLFNQTVYSQGNLPIDTYKKDLDAVCNEPLHYD
CHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHCCCCCCHHHHHHHHHHHHCCCCCCC
WESLRAEIVKYGLRNSTLTALMPSETSSQIANATNGIEPPRGLVTVKASKDGILKQVVPE
HHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHH
FETLKNAYETLWQLPGNEGYLKLVGVMQKFVDQSISANTAYDPGKFEGGKVSMKQMLKDL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
LTAYKYGVKTLYYHNTRDGADDTQTDIQDDGCAGGACKI
HHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]