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The map label for this gene is ttcA [H]

Identifier: 161870133

GI number: 161870133

Start: 1162038

End: 1162883

Strand: Direct

Name: ttcA [H]

Synonym: NMCC_1172

Alternate gene names: 161870133

Gene position: 1162038-1162883 (Clockwise)

Preceding gene: 161870132

Following gene: 161870144

Centisome position: 53.96

GC content: 54.26

Gene sequence:

>846_bases
ATGGTCTGCCTCTCCGGCGGCAAAGACAGCTACGCCCTGTTAGACATCCTGCGCCAGCTCCAAGCCAGCGCGCCGATTGA
TTTCGAACTGGTTGCCGTCAATCTCGACCAAAAGCAGCCGGGCTTCCCCGAAGAAGTATTGCCGACCTATCTCGAAAGCA
TAGGCGTGCCGTACAAAATCGTCGAAGAAGACACCTACTCCACCGTCAAACGCGTATTGGACGAAGGCAAAACGACTTGT
TCACTGTGCAGTCGCCTGCGCCGCGGCATCCTCTACCGCACCGCAAAAGAATTAGGCTGCACCAAAATCGCCTTGGGACA
CCACCGCGACGACATCCTCGCTACCATGTTTTTAAATATGTTTTACGGCGGCAAACTCAAAGCCATGCCGCCCAAGCTGG
TGAGCGACAACGGCGAACACATCGTCATCCGTCCGCTGGCGTATGTCAAAGAAAAAGACTTAATCAAATACGCCGAATTG
AAACAGTTCCCGATTATCCCGTGCAACCTCTGCGGCTCGCAGCCCAACCTGCAACGTCAAGTCATCGGCGATATGCTGCG
CGATTGGGACAAACGCTTCCCCGGCCGTATCGAATCGATGTTCTCCGCCCTGCAAAACGTCGTCCCTTCCCACCTTGCCG
ATACCGAACTCTTCGACTTTGCCGGATTGGAACGCGGTCAAACCCTGAAACACGGCGGCGATTTGGCGTTTGACAGCGAA
AAAATGCCCGAACGTTTTTCAGACGGCAGCGAAGAAGACGAAAGCGAAATCAAAATCGCGCCGCAAAAAGCCGAACGCAA
AGTCATCAACATTCTGGCGAACAAGCCGAAAACCTGCGGCGCGTAA

Upstream 100 bases:

>100_bases
CAAACAAGAACTCGAAAACAACAAACTCAGCAAACGCCTGCGCCACGCCGTCGGCGACGCAATTAACGATTTCAACATGA
TCGAGCCGGGCGACAAAATC

Downstream 100 bases:

>100_bases
CCCCCCGCCGTCAAAAGTGTAGATTGCCTCGGTGTTCGCCCCGGCTGTGTCGCTTAGATCAGGGCTTGGCTTGGCTTGGC
TTGGCTTGGCTTGGCTTGGC

Product: C32 tRNA thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MVCLSGGKDSYALLDILRQLQASAPIDFELVAVNLDQKQPGFPEEVLPTYLESIGVPYKIVEEDTYSTVKRVLDEGKTTC
SLCSRLRRGILYRTAKELGCTKIALGHHRDDILATMFLNMFYGGKLKAMPPKLVSDNGEHIVIRPLAYVKEKDLIKYAEL
KQFPIIPCNLCGSQPNLQRQVIGDMLRDWDKRFPGRIESMFSALQNVVPSHLADTELFDFAGLERGQTLKHGGDLAFDSE
KMPERFSDGSEEDESEIKIAPQKAERKVINILANKPKTCGA

Sequences:

>Translated_281_residues
MVCLSGGKDSYALLDILRQLQASAPIDFELVAVNLDQKQPGFPEEVLPTYLESIGVPYKIVEEDTYSTVKRVLDEGKTTC
SLCSRLRRGILYRTAKELGCTKIALGHHRDDILATMFLNMFYGGKLKAMPPKLVSDNGEHIVIRPLAYVKEKDLIKYAEL
KQFPIIPCNLCGSQPNLQRQVIGDMLRDWDKRFPGRIESMFSALQNVVPSHLADTELFDFAGLERGQTLKHGGDLAFDSE
KMPERFSDGSEEDESEIKIAPQKAERKVINILANKPKTCGA
>Mature_281_residues
MVCLSGGKDSYALLDILRQLQASAPIDFELVAVNLDQKQPGFPEEVLPTYLESIGVPYKIVEEDTYSTVKRVLDEGKTTC
SLCSRLRRGILYRTAKELGCTKIALGHHRDDILATMFLNMFYGGKLKAMPPKLVSDNGEHIVIRPLAYVKEKDLIKYAEL
KQFPIIPCNLCGSQPNLQRQVIGDMLRDWDKRFPGRIESMFSALQNVVPSHLADTELFDFAGLERGQTLKHGGDLAFDSE
KMPERFSDGSEEDESEIKIAPQKAERKVINILANKPKTCGA

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=258, Percent_Identity=74.4186046511628, Blast_Score=408, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI193211090, Length=211, Percent_Identity=32.7014218009479, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17540090, Length=212, Percent_Identity=26.4150943396226, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24651972, Length=206, Percent_Identity=31.0679611650485, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 31463; Mature: 31463

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVCLSGGKDSYALLDILRQLQASAPIDFELVAVNLDQKQPGFPEEVLPTYLESIGVPYKI
CEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEE
VEEDTYSTVKRVLDEGKTTCSLCSRLRRGILYRTAKELGCTKIALGHHRDDILATMFLNM
ECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHH
FYGGKLKAMPPKLVSDNGEHIVIRPLAYVKEKDLIKYAELKQFPIIPCNLCGSQPNLQRQ
HCCCCCCCCCCHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCHHHH
VIGDMLRDWDKRFPGRIESMFSALQNVVPSHLADTELFDFAGLERGQTLKHGGDLAFDSE
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCH
KMPERFSDGSEEDESEIKIAPQKAERKVINILANKPKTCGA
HHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MVCLSGGKDSYALLDILRQLQASAPIDFELVAVNLDQKQPGFPEEVLPTYLESIGVPYKI
CEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEE
VEEDTYSTVKRVLDEGKTTCSLCSRLRRGILYRTAKELGCTKIALGHHRDDILATMFLNM
ECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHH
FYGGKLKAMPPKLVSDNGEHIVIRPLAYVKEKDLIKYAELKQFPIIPCNLCGSQPNLQRQ
HCCCCCCCCCCHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCHHHH
VIGDMLRDWDKRFPGRIESMFSALQNVVPSHLADTELFDFAGLERGQTLKHGGDLAFDSE
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCH
KMPERFSDGSEEDESEIKIAPQKAERKVINILANKPKTCGA
HHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA