Click here to switch to the map view.

The map label for this gene is lipB [H]

Identifier: 161870060

GI number: 161870060

Start: 1083507

End: 1084130

Strand: Reverse

Name: lipB [H]

Synonym: NMCC_1096

Alternate gene names: 161870060

Gene position: 1084130-1083507 (Counterclockwise)

Preceding gene: 161870062

Following gene: 161870059

Centisome position: 50.34

GC content: 53.37

Gene sequence:

>624_bases
ATGAAAATCATACACAAAGGTTTGGTCGAATATCTGCCGACTTTTGAAGCGATGAAAACCTTTAATGCCGGACGGAATGC
CGACACCGAAGACGAACTGTGGGTCGTCGAACACCCGCCCGTGTTCACACAAGGACTGGCGGGAAAACCCGAACACCTGC
TGATTCGCGACGACATTCCCGTCGTCCAAATCGACCGGGGCGGGCAGATTACCTATCACGGGCCCGGGCAATTGGTCGTT
TATACGATGATTGATTTCAAACGGCGCAAAACCAGTGTTAGAAACATCGTTTCCGCGCTTGAAAACAGCATCATCGCCAC
ATTGGCAGAATACGGCATCGAAGCGGCGGCAGACCCCAAACGCCCCGGCGTTTATGTCGGAGAACGCAAAATCGCCTCAC
TGGGGCTGCGTATCAAAAACGGCTCCGTCTATCACGGGCTTGCGCTCAACGTCAATATGGATTTAAGCCCGTTTACCCAC
ATCAACCCCTGCGGCTACGCCGGTATGGAAATGACGCAAATCGCGGATTTTGTCCAACCCTGCCCCACGCCGGACGAAGT
CGCCGCCAAACTCACCGCACACCTTGAAACACAATTCACACCGAAAGCAGACAACAATGAGTGA

Upstream 100 bases:

>100_bases
CTGGCGCCACCGTACAGGTAAAGGTTGAAAACCAAGAACAATTGGACAACATCTACCGTGCGCTGACTTCGCACGAACTG
GTCAAAGTGGTACTTTAGAG

Downstream 100 bases:

>100_bases
AATCAAAACCGACGACCCCAAACGCGGCATCAAACTCAGAGGCGCGGACAAAACCGCGCGCATCCCCATCAAAGTCGTCC
CCCTTCAGGAAAAACTGAAA

Product: lipoate-protein ligase B

Products: NA

Alternate protein names: Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MKIIHKGLVEYLPTFEAMKTFNAGRNADTEDELWVVEHPPVFTQGLAGKPEHLLIRDDIPVVQIDRGGQITYHGPGQLVV
YTMIDFKRRKTSVRNIVSALENSIIATLAEYGIEAAADPKRPGVYVGERKIASLGLRIKNGSVYHGLALNVNMDLSPFTH
INPCGYAGMEMTQIADFVQPCPTPDEVAAKLTAHLETQFTPKADNNE

Sequences:

>Translated_207_residues
MKIIHKGLVEYLPTFEAMKTFNAGRNADTEDELWVVEHPPVFTQGLAGKPEHLLIRDDIPVVQIDRGGQITYHGPGQLVV
YTMIDFKRRKTSVRNIVSALENSIIATLAEYGIEAAADPKRPGVYVGERKIASLGLRIKNGSVYHGLALNVNMDLSPFTH
INPCGYAGMEMTQIADFVQPCPTPDEVAAKLTAHLETQFTPKADNNE
>Mature_207_residues
MKIIHKGLVEYLPTFEAMKTFNAGRNADTEDELWVVEHPPVFTQGLAGKPEHLLIRDDIPVVQIDRGGQITYHGPGQLVV
YTMIDFKRRKTSVRNIVSALENSIIATLAEYGIEAAADPKRPGVYVGERKIASLGLRIKNGSVYHGLALNVNMDLSPFTH
INPCGYAGMEMTQIADFVQPCPTPDEVAAKLTAHLETQFTPKADNNE

Specific function: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate

COG id: COG0321

COG function: function code H; Lipoate-protein ligase B

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lipB family [H]

Homologues:

Organism=Homo sapiens, GI221554520, Length=154, Percent_Identity=36.3636363636364, Blast_Score=77, Evalue=8e-15,
Organism=Escherichia coli, GI87081767, Length=189, Percent_Identity=57.6719576719577, Blast_Score=228, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6323268, Length=127, Percent_Identity=35.4330708661417, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355483, Length=154, Percent_Identity=36.3636363636364, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR000544
- InterPro:   IPR020605 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB [H]

EC number: =2.3.1.181 [H]

Molecular weight: Translated: 22841; Mature: 22841

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS01313 LIPB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIHKGLVEYLPTFEAMKTFNAGRNADTEDELWVVEHPPVFTQGLAGKPEHLLIRDDIP
CCCHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEEEEECCCHHHCCCCCCCCEEEEECCCC
VVQIDRGGQITYHGPGQLVVYTMIDFKRRKTSVRNIVSALENSIIATLAEYGIEAAADPK
EEEECCCCEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RPGVYVGERKIASLGLRIKNGSVYHGLALNVNMDLSPFTHINPCGYAGMEMTQIADFVQP
CCCEEECCCEEEEECEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHC
CPTPDEVAAKLTAHLETQFTPKADNNE
CCCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKIIHKGLVEYLPTFEAMKTFNAGRNADTEDELWVVEHPPVFTQGLAGKPEHLLIRDDIP
CCCHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEEEEECCCHHHCCCCCCCCEEEEECCCC
VVQIDRGGQITYHGPGQLVVYTMIDFKRRKTSVRNIVSALENSIIATLAEYGIEAAADPK
EEEECCCCEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RPGVYVGERKIASLGLRIKNGSVYHGLALNVNMDLSPFTHINPCGYAGMEMTQIADFVQP
CCCEEECCCEEEEECEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHC
CPTPDEVAAKLTAHLETQFTPKADNNE
CCCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA