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The map label for this gene is proA [H]

Identifier: 161869953

GI number: 161869953

Start: 986614

End: 987876

Strand: Reverse

Name: proA [H]

Synonym: NMCC_0986

Alternate gene names: 161869953

Gene position: 987876-986614 (Counterclockwise)

Preceding gene: 161869954

Following gene: 161869951

Centisome position: 45.87

GC content: 57.56

Gene sequence:

>1263_bases
ATGTCAAACACACAAAAACAGCTTGCCCTTGCCAAAGCGGCAAAAAAATCCGTCAACACGGCGGATACGGAAGAAAAAAA
CCGCGCGCTGCTTGCTATGGCGGACAGTCTGGAAGCGGCGGCGGCAGATATTTTGGCGGCAAACCGTCAAGACTTGGAAG
CCGCGGCAGGCAACATTCCCGAAAGCATGACCGACCGCCTTTTGTTGGACGGCAAACGCATTTGCGCGATGGCGGACGGC
ATTAGGGCGGTTGCCGCACTGCCCGACCCCGTGGGCGAAATACTGGAAACCTCGACTCTGCCCAACGGCTTGGAAATCGT
CAAAAAGCGTGTGGCGATGGGCGTTATCGGCATTATTTACGAAAGCCGCCCGAACGTTACGTCCGATGCGGCGGCTTTGG
CACTGAAAAGCGGCAGCGCGGTCGTACTCCGCAGCGGCAAAGATGCATTCCAATCCGCACGCGCCATCGTTGCCGCACTC
AAAGCCGGTTTGGCGCAAACCCGCATCGACCCCGACGCGCTCCAGTTGATTGAAGACACAGGGCGTGAGGGCAGTTACGA
AATGATGAGGGCGAAAGATTATCTAGACCTGCTGATTCCGCGCGGCGGGGCGGGGCTGATACGGGCGGTGGTTGAAAATG
CCGTCGTGCCGGTCATTGAAACGGGAACGGGCATTGTCCACATTTATATCGACAAGGACGCGGATTGGGACAAGGCGCTC
CGTATCGTGTACAACGCCAAAACCAGCCGTCCGTCCGTGTGCAACTCGATGGAAGTGCTGCTGGTACATGAAGACATTGC
TGCCGACTTCCTGCCCAAGCTCGAACGGCTGTTGGTTCGCGACCGCATAGAAGCCGGACTGCCGCCCGTCCGCTTCCGTT
TGGATCCGCAGGCGGCGCGGCATATCGGCGGCGAAGCGGCGGGTGCAGACGATTTCGATACCGAGTTTTTAGACTACATC
CTCGCTGTGAAAACCGTCGCTTCGGTCGAAGAGGCGGTCTGGCACATCGAAACCCACAGCACACACCATTCAGACGGCAT
CGTTACCGAAAACCGCCACGCTGCGGACTATTTCACGACTCATATCGATTCTGCCGCCGTGTATGTCAACGCGTCCACGC
GCTTTACCGACGGCGGCGAATTCGGCTTGGGTTGCGAAATGGGCATCTCCACGCAAAAACTCCACGCCCGGGGCCCGATG
GGTTTAAAAGAGCTGACGAGTTACAAATACATCGTACAAGGCACGGGACAGGTTAGGGAATAA

Upstream 100 bases:

>100_bases
ATCGCGTAAGGCGAAAGGCGTGTTCATCCATCGGGACGACTGGATTTCCATCACGCCCGAAATACGCCTGCTTCTGACCG
AATTTTAGAAAAGGAAACCC

Downstream 100 bases:

>100_bases
TCCGAATTCAAACGTCTGATATAGTGGATTAACTTTAAACCGATACGGCATTGCCTCGCCTTAGCTCAAAGAGAACGATT
CTCTAAGGTGCTGAAGCACC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSNTQKQLALAKAAKKSVNTADTEEKNRALLAMADSLEAAAADILAANRQDLEAAAGNIPESMTDRLLLDGKRICAMADG
IRAVAALPDPVGEILETSTLPNGLEIVKKRVAMGVIGIIYESRPNVTSDAAALALKSGSAVVLRSGKDAFQSARAIVAAL
KAGLAQTRIDPDALQLIEDTGREGSYEMMRAKDYLDLLIPRGGAGLIRAVVENAVVPVIETGTGIVHIYIDKDADWDKAL
RIVYNAKTSRPSVCNSMEVLLVHEDIAADFLPKLERLLVRDRIEAGLPPVRFRLDPQAARHIGGEAAGADDFDTEFLDYI
LAVKTVASVEEAVWHIETHSTHHSDGIVTENRHAADYFTTHIDSAAVYVNASTRFTDGGEFGLGCEMGISTQKLHARGPM
GLKELTSYKYIVQGTGQVRE

Sequences:

>Translated_420_residues
MSNTQKQLALAKAAKKSVNTADTEEKNRALLAMADSLEAAAADILAANRQDLEAAAGNIPESMTDRLLLDGKRICAMADG
IRAVAALPDPVGEILETSTLPNGLEIVKKRVAMGVIGIIYESRPNVTSDAAALALKSGSAVVLRSGKDAFQSARAIVAAL
KAGLAQTRIDPDALQLIEDTGREGSYEMMRAKDYLDLLIPRGGAGLIRAVVENAVVPVIETGTGIVHIYIDKDADWDKAL
RIVYNAKTSRPSVCNSMEVLLVHEDIAADFLPKLERLLVRDRIEAGLPPVRFRLDPQAARHIGGEAAGADDFDTEFLDYI
LAVKTVASVEEAVWHIETHSTHHSDGIVTENRHAADYFTTHIDSAAVYVNASTRFTDGGEFGLGCEMGISTQKLHARGPM
GLKELTSYKYIVQGTGQVRE
>Mature_419_residues
SNTQKQLALAKAAKKSVNTADTEEKNRALLAMADSLEAAAADILAANRQDLEAAAGNIPESMTDRLLLDGKRICAMADGI
RAVAALPDPVGEILETSTLPNGLEIVKKRVAMGVIGIIYESRPNVTSDAAALALKSGSAVVLRSGKDAFQSARAIVAALK
AGLAQTRIDPDALQLIEDTGREGSYEMMRAKDYLDLLIPRGGAGLIRAVVENAVVPVIETGTGIVHIYIDKDADWDKALR
IVYNAKTSRPSVCNSMEVLLVHEDIAADFLPKLERLLVRDRIEAGLPPVRFRLDPQAARHIGGEAAGADDFDTEFLDYIL
AVKTVASVEEAVWHIETHSTHHSDGIVTENRHAADYFTTHIDSAAVYVNASTRFTDGGEFGLGCEMGISTQKLHARGPMG
LKELTSYKYIVQGTGQVRE

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=416, Percent_Identity=34.375, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI21361368, Length=416, Percent_Identity=34.375, Blast_Score=255, Evalue=7e-68,
Organism=Escherichia coli, GI1786438, Length=410, Percent_Identity=44.390243902439, Blast_Score=348, Evalue=5e-97,
Organism=Caenorhabditis elegans, GI17569969, Length=402, Percent_Identity=34.3283582089552, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17569967, Length=402, Percent_Identity=34.3283582089552, Blast_Score=228, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6324899, Length=434, Percent_Identity=38.0184331797235, Blast_Score=268, Evalue=1e-72,
Organism=Drosophila melanogaster, GI21357643, Length=412, Percent_Identity=34.7087378640777, Blast_Score=232, Evalue=4e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45154; Mature: 45023

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTQKQLALAKAAKKSVNTADTEEKNRALLAMADSLEAAAADILAANRQDLEAAAGNIP
CCCHHHHHHHHHHHHHCCCCCCCHHHCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHCCCC
ESMTDRLLLDGKRICAMADGIRAVAALPDPVGEILETSTLPNGLEIVKKRVAMGVIGIIY
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEE
ESRPNVTSDAAALALKSGSAVVLRSGKDAFQSARAIVAALKAGLAQTRIDPDALQLIEDT
ECCCCCCCHHHHHEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHC
GREGSYEMMRAKDYLDLLIPRGGAGLIRAVVENAVVPVIETGTGIVHIYIDKDADWDKAL
CCCCCHHHHHHHHHHHHEECCCCHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCHHHHE
RIVYNAKTSRPSVCNSMEVLLVHEDIAADFLPKLERLLVRDRIEAGLPPVRFRLDPQAAR
EEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHH
HIGGEAAGADDFDTEFLDYILAVKTVASVEEAVWHIETHSTHHSDGIVTENRHAADYFTT
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCEECCCCCHHHHHH
HIDSAAVYVNASTRFTDGGEFGLGCEMGISTQKLHARGPMGLKELTSYKYIVQGTGQVRE
HCCCEEEEEECCCEECCCCCCCCCEECCCCHHHHHCCCCCCHHHHHCCEEEEECCCCCCC
>Mature Secondary Structure 
SNTQKQLALAKAAKKSVNTADTEEKNRALLAMADSLEAAAADILAANRQDLEAAAGNIP
CCHHHHHHHHHHHHHCCCCCCCHHHCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHCCCC
ESMTDRLLLDGKRICAMADGIRAVAALPDPVGEILETSTLPNGLEIVKKRVAMGVIGIIY
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEE
ESRPNVTSDAAALALKSGSAVVLRSGKDAFQSARAIVAALKAGLAQTRIDPDALQLIEDT
ECCCCCCCHHHHHEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHC
GREGSYEMMRAKDYLDLLIPRGGAGLIRAVVENAVVPVIETGTGIVHIYIDKDADWDKAL
CCCCCHHHHHHHHHHHHEECCCCHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCHHHHE
RIVYNAKTSRPSVCNSMEVLLVHEDIAADFLPKLERLLVRDRIEAGLPPVRFRLDPQAAR
EEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHH
HIGGEAAGADDFDTEFLDYILAVKTVASVEEAVWHIETHSTHHSDGIVTENRHAADYFTT
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCEECCCCCHHHHHH
HIDSAAVYVNASTRFTDGGEFGLGCEMGISTQKLHARGPMGLKELTSYKYIVQGTGQVRE
HCCCEEEEEECCCEECCCCCCCCCEECCCCHHHHHCCCCCCHHHHHCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA