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The map label for this gene is lepB [H]

Identifier: 161869709

GI number: 161869709

Start: 733663

End: 734682

Strand: Reverse

Name: lepB [H]

Synonym: NMCC_0729

Alternate gene names: 161869709

Gene position: 734682-733663 (Counterclockwise)

Preceding gene: 161869710

Following gene: 161869704

Centisome position: 34.12

GC content: 50.39

Gene sequence:

>1020_bases
ATGAACACTATGCTAATGTCGGGCGCGGCTGCCGCGCTGCTTGCCGGCATCATCCTTTATTTCAAAAGCGACAAAAAGCG
GCAGGAAAACGGTGAATGGAGTTCCGGCCTCGAATACGCCTATATCCTGACAGCGGTCGGCGTGTTTGCCGCTTTGTCCC
TGTTTATGAGCTTTACCGCCGTTTTCCTGATTTTCGTTGTATTGTGCGGTACGGCTTGGGGGGTATATAAATACCGCCTG
AAGACTCATCCCGAAATCTCGGAAAGCAGCCACTTCGGCGATTATTTCGGCAGTTTCTTCCCTACCGTTTTGGTATTGTT
CCTCATCCGGTCGTTTATCGCCGAACCGTTCCAAATCCCGTCCAGCTCAATGCGCCCGGGCCTGATCAAGGGCGATTTCA
TTTTGGTCGGCAAATTTTCCTACGGCTTGCGCGTACCCGTTTTAAACAATATATTTATCCCCACAGGCAAAATCGAACGG
GGCGATGTCGTTGTTTTTAATTATCCTCTGCAGCCGGAGATGACCTACATCAAGCGTATTGTCGGCATTCCGGGCGATGT
GGTCGAATATCGGGATAAGATTTTGACGGTAAATGGCAAACCCACTTCCGATATTCCTAACGGCACATACCGTTATCCCG
ACGATACCGACCCTTCCGAAATCCACAACACGGATATGTTCCGCAGCGGTCTAGACGGCAAATCCTTCAATATTCTGAAA
AAAGAAGGACAGCCTGCCGTTTCCCTGCCCGTATTGGGCAAATATACCTCCGATATTATGTCTGAAAACGGATATTCCAT
AGAGCAAAGCGGTTTGGAACACTGCCAATATGCCGACGACGGCAGCGGTTTCGTGTGCAAAGTTCCCGAAGGACGCTATT
TCGCTATGGGCGACAACCGCGACAACAGTGCCGATTCTCGCTACTGGGGATTTGTGGATGACAAGCTGGTTGTCGGCAAG
GCAATGTTCATTTTGATGAACTTCGGCGATTTCGGCAGGGCCGGTACGGCAATCCGTTAG

Upstream 100 bases:

>100_bases
GCCCTGATTTCAGGGGCACGCGCCCGCAAACAAATTTTGCAATTTGCCGCCTTAAAACGGTTGCACGGACGGGCGGTTTT
TTAAGCATTAAGGAATAACA

Downstream 100 bases:

>100_bases
GCCGGGAAGCCAAGAATGCCGTCTGAAAATAGTTTCAGACGGCATTTGCTATTCCTTACCTTTGCAGGCGGGTCTAACGT
TGTCGGATTTTCCTACCTAT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MNTMLMSGAAAALLAGIILYFKSDKKRQENGEWSSGLEYAYILTAVGVFAALSLFMSFTAVFLIFVVLCGTAWGVYKYRL
KTHPEISESSHFGDYFGSFFPTVLVLFLIRSFIAEPFQIPSSSMRPGLIKGDFILVGKFSYGLRVPVLNNIFIPTGKIER
GDVVVFNYPLQPEMTYIKRIVGIPGDVVEYRDKILTVNGKPTSDIPNGTYRYPDDTDPSEIHNTDMFRSGLDGKSFNILK
KEGQPAVSLPVLGKYTSDIMSENGYSIEQSGLEHCQYADDGSGFVCKVPEGRYFAMGDNRDNSADSRYWGFVDDKLVVGK
AMFILMNFGDFGRAGTAIR

Sequences:

>Translated_339_residues
MNTMLMSGAAAALLAGIILYFKSDKKRQENGEWSSGLEYAYILTAVGVFAALSLFMSFTAVFLIFVVLCGTAWGVYKYRL
KTHPEISESSHFGDYFGSFFPTVLVLFLIRSFIAEPFQIPSSSMRPGLIKGDFILVGKFSYGLRVPVLNNIFIPTGKIER
GDVVVFNYPLQPEMTYIKRIVGIPGDVVEYRDKILTVNGKPTSDIPNGTYRYPDDTDPSEIHNTDMFRSGLDGKSFNILK
KEGQPAVSLPVLGKYTSDIMSENGYSIEQSGLEHCQYADDGSGFVCKVPEGRYFAMGDNRDNSADSRYWGFVDDKLVVGK
AMFILMNFGDFGRAGTAIR
>Mature_339_residues
MNTMLMSGAAAALLAGIILYFKSDKKRQENGEWSSGLEYAYILTAVGVFAALSLFMSFTAVFLIFVVLCGTAWGVYKYRL
KTHPEISESSHFGDYFGSFFPTVLVLFLIRSFIAEPFQIPSSSMRPGLIKGDFILVGKFSYGLRVPVLNNIFIPTGKIER
GDVVVFNYPLQPEMTYIKRIVGIPGDVVEYRDKILTVNGKPTSDIPNGTYRYPDDTDPSEIHNTDMFRSGLDGKSFNILK
KEGQPAVSLPVLGKYTSDIMSENGYSIEQSGLEHCQYADDGSGFVCKVPEGRYFAMGDNRDNSADSRYWGFVDDKLVVGK
AMFILMNFGDFGRAGTAIR

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=246, Percent_Identity=41.4634146341463, Blast_Score=165, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 37646; Mature: 37646

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTMLMSGAAAALLAGIILYFKSDKKRQENGEWSSGLEYAYILTAVGVFAALSLFMSFTA
CCCEECCHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VFLIFVVLCGTAWGVYKYRLKTHPEISESSHFGDYFGSFFPTVLVLFLIRSFIAEPFQIP
HHHHHHHHHCCHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SSSMRPGLIKGDFILVGKFSYGLRVPVLNNIFIPTGKIERGDVVVFNYPLQPEMTYIKRI
CCCCCCCEEECCEEEEEECCCCEECCCCCCEECCCCCCCCCCEEEEECCCCCHHHHHHHH
VGIPGDVVEYRDKILTVNGKPTSDIPNGTYRYPDDTDPSEIHNTDMFRSGLDGKSFNILK
HCCCCHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHCHHHHHCCCCCCCEEEEC
KEGQPAVSLPVLGKYTSDIMSENGYSIEQSGLEHCQYADDGSGFVCKVPEGRYFAMGDNR
CCCCCCEECCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCEEEECCCCCEEEECCCC
DNSADSRYWGFVDDKLVVGKAMFILMNFGDFGRAGTAIR
CCCCCCCCCCCCCCHHHHHHEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MNTMLMSGAAAALLAGIILYFKSDKKRQENGEWSSGLEYAYILTAVGVFAALSLFMSFTA
CCCEECCHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VFLIFVVLCGTAWGVYKYRLKTHPEISESSHFGDYFGSFFPTVLVLFLIRSFIAEPFQIP
HHHHHHHHHCCHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SSSMRPGLIKGDFILVGKFSYGLRVPVLNNIFIPTGKIERGDVVVFNYPLQPEMTYIKRI
CCCCCCCEEECCEEEEEECCCCEECCCCCCEECCCCCCCCCCEEEEECCCCCHHHHHHHH
VGIPGDVVEYRDKILTVNGKPTSDIPNGTYRYPDDTDPSEIHNTDMFRSGLDGKSFNILK
HCCCCHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHCHHHHHCCCCCCCEEEEC
KEGQPAVSLPVLGKYTSDIMSENGYSIEQSGLEHCQYADDGSGFVCKVPEGRYFAMGDNR
CCCCCCEECCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCEEEECCCCCEEEECCCC
DNSADSRYWGFVDDKLVVGKAMFILMNFGDFGRAGTAIR
CCCCCCCCCCCCCCHHHHHHEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]