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The map label for this gene is lepA [H]

Identifier: 161869710

GI number: 161869710

Start: 734825

End: 736618

Strand: Reverse

Name: lepA [H]

Synonym: NMCC_0730

Alternate gene names: 161869710

Gene position: 736618-734825 (Counterclockwise)

Preceding gene: 161869711

Following gene: 161869709

Centisome position: 34.21

GC content: 51.67

Gene sequence:

>1794_bases
ATGAAAAATATCCGAAATTTCTCCATCATTGCCCACATCGACCACGGCAAATCGACGCTTGCCGACCGCTTCATCCAATA
TTGCGGCGGTTTGGATTTGCGCGAAATGAGTACGCAGGTACTCGATTCCATGGACATCGAAAAAGAGCGCGGCATTACCA
TTAAAGCGCAAACCGCCGCGCTCAACTACAAAGCACGCGATGGGCAGGTGTATCAGCTTAATTTGATTGACACGCCGGGA
CACGTCGACTTCTCTTATGAAGTTTCCCGCTCCTTGTCCGCCTGCGAAGGCGCGCTTTTGGTGGTTGACGCGTCGCAAGG
CGTGGAAGCGCAAACCGTGGCGAACTGCTATACCGCGATTGATTTGGGCGTGGAAGTTGTGCCTGTTTTGAACAAAATCG
ACTTGCCTGCCGCCGACCCCGAACGCGTGGAACAGGAAATCGAAGACATCATCGGCATCGATGCCGTCGGTGCAGTACAG
TGTTCCGCCAAAAGCGGTATCGGCGTGGAAGATGTTTTGGAAGAAATTGTTGCCAAAATCCCTGCGCCGACCGGCGACGA
AAACGCGCCGCTGCAAGCGGTTATCGTCGATTCGTGGTTTGACAACTATGTCGGCGTGGTCATGCTGATTCGAGTGAAAA
ACGGCACCATCAAACTGAAAGACAAAGTGCGCTTTATGAGCACCAAGGCGGAAACGCAGGTCGAGCAGCTGGGCGTATTC
ACACCAAAATCAGTTCAAAAACAAGAACTCAAAGCCGGCGAAGTGGGCTTTTTGATTACCGGCGTAAAAGAATTGGGTCA
GGCGAAAGTCGGCGATACGGTTACACTGGTTGCCAACCCTGCCACTGAGCCGCTGCCCGGCTTCCAAGAAGTACAAAGCC
AAGTATTCGCCGGACTTTATCCCGTGGAAAGCCACGACTACGAAGCCTTGCGCGACGCTTTGGAAAAATTGCAGCTTAAC
GACGCTTCGTTGAAATTCGAGCCTGAAGTTTCCCAGGCATTGGGCTTCGGCTTCCGTTGCGGCTTCTTGGGTCTGTTGCA
CTTGGAAATCGTGCAGGAACGCTTGGAGCGCGAGTTCGATATGGATTTGATTACCACCGCGCCGACGGTGGTTTATGAAG
TCGTGTTGAAAAACGGTGAGAAAATCGAAGTTGAAAACCCGTCCAAACTGCCCGACATCGGCAGCATCGAAACCATACTC
GAGCCGATTATTACCGCGACCATCCTTGTGCCGCAGGAATACGTCGGCAACGTCATGACTTTGTGTAACCAAAAGCGCGG
CGTTCAGGTCAATATGCAGTACATGGGCCGCCAAGTGATGCTGACTTACGATTTGCCCATGAACGAAGTCGTCATGGACT
TCTTTGACAAACTCAAATCCACTTCGCGCGGTTATGCTTCGTTGGACTACCATTTCAAAGAGTTCCAACCGTCTGATTTG
ATTAAGCTGGATATTATGGTCAACGGCGAAAAAGTCGATGCGCTGAGCCTGATTGTCCACCGTCAAAGCGCGGTTCACCG
AGGCCGCGAGCTGGCATCGAAAATGCGCGAGCTGATTCCGCGCCAAATGTTCGACATTGCCGTCCAAGCCGCCATCGGCA
GCCAGATTATCGCCCGCGAAAACGTCAAAGCACTGCGTAAAAACGTCTTGGCGAAATGTTACGGCGGCGATATTACGCGT
AAGAAAAAACTGCTTGAAAAACAAAAGGCAGGTAAACGCCGTATGAAACAAGTGGGCAATGTGGAAATTCCGCAAAGCGC
GTTCTTGGCGATTTTGCAGGTGAGCGACAAATAA

Upstream 100 bases:

>100_bases
AATATCGGGCTATTTCCACGTTGCGCCCGATATTTGGACGTACCGCTGTTTGTTCAGACGGCATTTCTAAAACCTACCGT
TCAGCATTAAAAACAACTCA

Downstream 100 bases:

>100_bases
CTCTGGCACACAGGGCGGCGCGTCGGGAACACCCCTCAAACCGCCCTGATTTCAGGGGCACGCGCCCGCAAACAAATTTT
GCAATTTGCCGCCTTAAAAC

Product: GTP-binding protein LepA

Products: NA

Alternate protein names: EF-4; Ribosomal back-translocase LepA [H]

Number of amino acids: Translated: 597; Mature: 597

Protein sequence:

>597_residues
MKNIRNFSIIAHIDHGKSTLADRFIQYCGGLDLREMSTQVLDSMDIEKERGITIKAQTAALNYKARDGQVYQLNLIDTPG
HVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTAIDLGVEVVPVLNKIDLPAADPERVEQEIEDIIGIDAVGAVQ
CSAKSGIGVEDVLEEIVAKIPAPTGDENAPLQAVIVDSWFDNYVGVVMLIRVKNGTIKLKDKVRFMSTKAETQVEQLGVF
TPKSVQKQELKAGEVGFLITGVKELGQAKVGDTVTLVANPATEPLPGFQEVQSQVFAGLYPVESHDYEALRDALEKLQLN
DASLKFEPEVSQALGFGFRCGFLGLLHLEIVQERLEREFDMDLITTAPTVVYEVVLKNGEKIEVENPSKLPDIGSIETIL
EPIITATILVPQEYVGNVMTLCNQKRGVQVNMQYMGRQVMLTYDLPMNEVVMDFFDKLKSTSRGYASLDYHFKEFQPSDL
IKLDIMVNGEKVDALSLIVHRQSAVHRGRELASKMRELIPRQMFDIAVQAAIGSQIIARENVKALRKNVLAKCYGGDITR
KKKLLEKQKAGKRRMKQVGNVEIPQSAFLAILQVSDK

Sequences:

>Translated_597_residues
MKNIRNFSIIAHIDHGKSTLADRFIQYCGGLDLREMSTQVLDSMDIEKERGITIKAQTAALNYKARDGQVYQLNLIDTPG
HVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTAIDLGVEVVPVLNKIDLPAADPERVEQEIEDIIGIDAVGAVQ
CSAKSGIGVEDVLEEIVAKIPAPTGDENAPLQAVIVDSWFDNYVGVVMLIRVKNGTIKLKDKVRFMSTKAETQVEQLGVF
TPKSVQKQELKAGEVGFLITGVKELGQAKVGDTVTLVANPATEPLPGFQEVQSQVFAGLYPVESHDYEALRDALEKLQLN
DASLKFEPEVSQALGFGFRCGFLGLLHLEIVQERLEREFDMDLITTAPTVVYEVVLKNGEKIEVENPSKLPDIGSIETIL
EPIITATILVPQEYVGNVMTLCNQKRGVQVNMQYMGRQVMLTYDLPMNEVVMDFFDKLKSTSRGYASLDYHFKEFQPSDL
IKLDIMVNGEKVDALSLIVHRQSAVHRGRELASKMRELIPRQMFDIAVQAAIGSQIIARENVKALRKNVLAKCYGGDITR
KKKLLEKQKAGKRRMKQVGNVEIPQSAFLAILQVSDK
>Mature_597_residues
MKNIRNFSIIAHIDHGKSTLADRFIQYCGGLDLREMSTQVLDSMDIEKERGITIKAQTAALNYKARDGQVYQLNLIDTPG
HVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTAIDLGVEVVPVLNKIDLPAADPERVEQEIEDIIGIDAVGAVQ
CSAKSGIGVEDVLEEIVAKIPAPTGDENAPLQAVIVDSWFDNYVGVVMLIRVKNGTIKLKDKVRFMSTKAETQVEQLGVF
TPKSVQKQELKAGEVGFLITGVKELGQAKVGDTVTLVANPATEPLPGFQEVQSQVFAGLYPVESHDYEALRDALEKLQLN
DASLKFEPEVSQALGFGFRCGFLGLLHLEIVQERLEREFDMDLITTAPTVVYEVVLKNGEKIEVENPSKLPDIGSIETIL
EPIITATILVPQEYVGNVMTLCNQKRGVQVNMQYMGRQVMLTYDLPMNEVVMDFFDKLKSTSRGYASLDYHFKEFQPSDL
IKLDIMVNGEKVDALSLIVHRQSAVHRGRELASKMRELIPRQMFDIAVQAAIGSQIIARENVKALRKNVLAKCYGGDITR
KKKLLEKQKAGKRRMKQVGNVEIPQSAFLAILQVSDK

Specific function: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- transloc

COG id: COG0481

COG function: function code M; Membrane GTPase LepA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. LepA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=603, Percent_Identity=48.922056384743, Blast_Score=619, Evalue=1e-177,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=45.8646616541353, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI4503483, Length=144, Percent_Identity=42.3611111111111, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI25306283, Length=134, Percent_Identity=46.2686567164179, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI25306287, Length=134, Percent_Identity=46.2686567164179, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI19923640, Length=134, Percent_Identity=46.2686567164179, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI18390331, Length=159, Percent_Identity=38.3647798742138, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI310132016, Length=110, Percent_Identity=43.6363636363636, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI310110807, Length=110, Percent_Identity=43.6363636363636, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI310123363, Length=110, Percent_Identity=43.6363636363636, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI53729339, Length=218, Percent_Identity=28.4403669724771, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI53729337, Length=218, Percent_Identity=28.4403669724771, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI217272894, Length=134, Percent_Identity=35.0746268656716, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI217272892, Length=134, Percent_Identity=35.0746268656716, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI34147630, Length=316, Percent_Identity=26.8987341772152, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1788922, Length=594, Percent_Identity=70.03367003367, Blast_Score=855, Evalue=0.0,
Organism=Escherichia coli, GI48994988, Length=513, Percent_Identity=29.0448343079922, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1789738, Length=157, Percent_Identity=36.9426751592357, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1790835, Length=156, Percent_Identity=33.974358974359, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1789559, Length=258, Percent_Identity=27.906976744186, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17557151, Length=611, Percent_Identity=40.9165302782324, Blast_Score=486, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17556745, Length=462, Percent_Identity=26.1904761904762, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17533571, Length=146, Percent_Identity=36.3013698630137, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17506493, Length=225, Percent_Identity=31.5555555555556, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71988819, Length=134, Percent_Identity=37.3134328358209, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71988811, Length=134, Percent_Identity=37.3134328358209, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17552882, Length=145, Percent_Identity=34.4827586206897, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994658, Length=223, Percent_Identity=28.6995515695067, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI25141371, Length=286, Percent_Identity=29.3706293706294, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17552884, Length=289, Percent_Identity=26.9896193771626, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17569207, Length=289, Percent_Identity=26.9896193771626, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=610, Percent_Identity=45.5737704918033, Blast_Score=553, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6323098, Length=200, Percent_Identity=36.5, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6324707, Length=144, Percent_Identity=40.9722222222222, Blast_Score=104, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320593, Length=144, Percent_Identity=40.9722222222222, Blast_Score=104, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322359, Length=115, Percent_Identity=41.7391304347826, Blast_Score=94, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324166, Length=144, Percent_Identity=37.5, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325337, Length=387, Percent_Identity=25.0645994832041, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319594, Length=387, Percent_Identity=25.0645994832041, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324761, Length=320, Percent_Identity=26.25, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI78706572, Length=604, Percent_Identity=44.0397350993377, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24582462, Length=161, Percent_Identity=37.2670807453416, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24585709, Length=149, Percent_Identity=36.9127516778523, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585711, Length=149, Percent_Identity=36.9127516778523, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585713, Length=149, Percent_Identity=36.9127516778523, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28574573, Length=138, Percent_Identity=42.0289855072464, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI221458488, Length=149, Percent_Identity=39.5973154362416, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357743, Length=133, Percent_Identity=33.0827067669173, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921738, Length=279, Percent_Identity=30.1075268817204, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI281363316, Length=278, Percent_Identity=26.978417266187, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17864358, Length=278, Percent_Identity=26.978417266187, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24652838, Length=169, Percent_Identity=32.5443786982249, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137572, Length=169, Percent_Identity=32.5443786982249, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR006297
- InterPro:   IPR013842
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF06421 LepA_C [H]

EC number: NA

Molecular weight: Translated: 66030; Mature: 66030

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIRNFSIIAHIDHGKSTLADRFIQYCGGLDLREMSTQVLDSMDIEKERGITIKAQTAA
CCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHCCEEEEEEEEE
LNYKARDGQVYQLNLIDTPGHVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTAI
EEEEECCCEEEEEEEECCCCCCEEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHH
DLGVEVVPVLNKIDLPAADPERVEQEIEDIIGIDAVGAVQCSAKSGIGVEDVLEEIVAKI
HCCCCEEEHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHC
PAPTGDENAPLQAVIVDSWFDNYVGVVMLIRVKNGTIKLKDKVRFMSTKAETQVEQLGVF
CCCCCCCCCCEEEEEECCHHHHHEEEEEEEEECCCEEEEECHHHHHHHHHHHHHHHHCCC
TPKSVQKQELKAGEVGFLITGVKELGQAKVGDTVTLVANPATEPLPGFQEVQSQVFAGLY
CCCCHHHHHHCCCCCCEEEECHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCC
PVESHDYEALRDALEKLQLNDASLKFEPEVSQALGFGFRCGFLGLLHLEIVQERLEREFD
CCCCCCHHHHHHHHHHHCCCCCCEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
MDLITTAPTVVYEVVLKNGEKIEVENPSKLPDIGSIETILEPIITATILVPQEYVGNVMT
CHHHHCCHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHEECCHHHHHHHHH
LCNQKRGVQVNMQYMGRQVMLTYDLPMNEVVMDFFDKLKSTSRGYASLDYHFKEFQPSDL
HHCCCCCCEEEHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEECCHHHCCCCCCE
IKLDIMVNGEKVDALSLIVHRQSAVHRGRELASKMRELIPRQMFDIAVQAAIGSQIIARE
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVKALRKNVLAKCYGGDITRKKKLLEKQKAGKRRMKQVGNVEIPQSAFLAILQVSDK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCC
>Mature Secondary Structure
MKNIRNFSIIAHIDHGKSTLADRFIQYCGGLDLREMSTQVLDSMDIEKERGITIKAQTAA
CCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHCCEEEEEEEEE
LNYKARDGQVYQLNLIDTPGHVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTAI
EEEEECCCEEEEEEEECCCCCCEEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHH
DLGVEVVPVLNKIDLPAADPERVEQEIEDIIGIDAVGAVQCSAKSGIGVEDVLEEIVAKI
HCCCCEEEHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHC
PAPTGDENAPLQAVIVDSWFDNYVGVVMLIRVKNGTIKLKDKVRFMSTKAETQVEQLGVF
CCCCCCCCCCEEEEEECCHHHHHEEEEEEEEECCCEEEEECHHHHHHHHHHHHHHHHCCC
TPKSVQKQELKAGEVGFLITGVKELGQAKVGDTVTLVANPATEPLPGFQEVQSQVFAGLY
CCCCHHHHHHCCCCCCEEEECHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCC
PVESHDYEALRDALEKLQLNDASLKFEPEVSQALGFGFRCGFLGLLHLEIVQERLEREFD
CCCCCCHHHHHHHHHHHCCCCCCEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
MDLITTAPTVVYEVVLKNGEKIEVENPSKLPDIGSIETILEPIITATILVPQEYVGNVMT
CHHHHCCHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHEECCHHHHHHHHH
LCNQKRGVQVNMQYMGRQVMLTYDLPMNEVVMDFFDKLKSTSRGYASLDYHFKEFQPSDL
HHCCCCCCEEEHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEECCHHHCCCCCCE
IKLDIMVNGEKVDALSLIVHRQSAVHRGRELASKMRELIPRQMFDIAVQAAIGSQIIARE
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVKALRKNVLAKCYGGDITRKKKLLEKQKAGKRRMKQVGNVEIPQSAFLAILQVSDK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA