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The map label for this gene is lrp [H]

Identifier: 161525409

GI number: 161525409

Start: 2452810

End: 2453298

Strand: Reverse

Name: lrp [H]

Synonym: Bmul_2239

Alternate gene names: 161525409

Gene position: 2453298-2452810 (Counterclockwise)

Preceding gene: 161525411

Following gene: 161525407

Centisome position: 71.14

GC content: 64.21

Gene sequence:

>489_bases
ATGAGAACGCAACGCCAGCCAGTACGCACGCTCGACAAGCTCGACCGCCGCATCCTGAAACTGCTGCAGGAGGACGGCCG
GATGGCGATGAAGGACCTCGCCGAGCAGGTCGGGCTGACCGTCACGCCGTGCATCGAGCGCGTGCGCCGCATGGAGCGCG
ACGGCGTGATCACGGGCTATCACGCGCGCGTCGATCCCGCGCAGCTCGGCGCGGCGCTGCTGGTGTTCGTCGAGATCACG
CTCGGCCACAAGGGCGGCAACATGTTCGAGCAGTTCCGCCGCGAAGTCATGAAGATCGACGAGGTGCTCGAATGCCACCT
CGTGTCGGGCGACTTCGACTATCTGATCAAGGCGCGCATCGGCGAGATGGCCGACTACCGGAAACTGCTCGGCGACATCC
TGCTGCAGTTGCCGGGCGCCGTGCAGTCGAAGAGCTACGTCGTGATGGAAGAGATCAAGGAAACGCTGACGATTTCGGTC
GGCGACTGA

Upstream 100 bases:

>100_bases
CGTCTCCGTGTAACCTCTGACTGATCTAGTTTTTTGCGCTATGGTATTGTCGAATCTGTAGGTTTTGTTATCGTATTTTT
CAGGTTTTCAGCATAAACCA

Downstream 100 bases:

>100_bases
GTAACCGTCTACCAAGTCAAGCCTTATGGAGCGAATCGTCCCAAGGTGTGTTGGATCTGACCATGGCATTAAGTATGGTC
AGAAGCTTGCGCATGCAGGC

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MRTQRQPVRTLDKLDRRILKLLQEDGRMAMKDLAEQVGLTVTPCIERVRRMERDGVITGYHARVDPAQLGAALLVFVEIT
LGHKGGNMFEQFRREVMKIDEVLECHLVSGDFDYLIKARIGEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLTISV
GD

Sequences:

>Translated_162_residues
MRTQRQPVRTLDKLDRRILKLLQEDGRMAMKDLAEQVGLTVTPCIERVRRMERDGVITGYHARVDPAQLGAALLVFVEIT
LGHKGGNMFEQFRREVMKIDEVLECHLVSGDFDYLIKARIGEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLTISV
GD
>Mature_162_residues
MRTQRQPVRTLDKLDRRILKLLQEDGRMAMKDLAEQVGLTVTPCIERVRRMERDGVITGYHARVDPAQLGAALLVFVEIT
LGHKGGNMFEQFRREVMKIDEVLECHLVSGDFDYLIKARIGEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLTISV
GD

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=153, Percent_Identity=54.2483660130719, Blast_Score=182, Evalue=1e-47,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=35.3333333333333, Blast_Score=109, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18431; Mature: 18431

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTQRQPVRTLDKLDRRILKLLQEDGRMAMKDLAEQVGLTVTPCIERVRRMERDGVITGY
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEECC
HARVDPAQLGAALLVFVEITLGHKGGNMFEQFRREVMKIDEVLECHLVSGDFDYLIKARI
CCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLTISVGD
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRTQRQPVRTLDKLDRRILKLLQEDGRMAMKDLAEQVGLTVTPCIERVRRMERDGVITGY
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEECC
HARVDPAQLGAALLVFVEITLGHKGGNMFEQFRREVMKIDEVLECHLVSGDFDYLIKARI
CCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLTISVGD
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]