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The map label for this gene is uvrC [H]

Identifier: 161525331

GI number: 161525331

Start: 2376442

End: 2378466

Strand: Reverse

Name: uvrC [H]

Synonym: Bmul_2161

Alternate gene names: 161525331

Gene position: 2378466-2376442 (Counterclockwise)

Preceding gene: 161525335

Following gene: 161525330

Centisome position: 68.97

GC content: 68.2

Gene sequence:

>2025_bases
ATGACATCCGCAGAAGCCCCCGATACTCCGTTCGAACCGAAGAAGATCCTCGCGCAGCTCCCGCATATGCCGGGCGTCTA
TCGCTATTACGACGCGGCCGGTGCAGTGCTTTACGTCGGCAAGGCCCGCGACCTGAAAAAGCGCGTGTCGAGCTATTTCA
CGAAGACGCAGCTGTCGCCGCGCATCGCGATGATGGTCACGCGCATCGCGCGCATCGAGACGACCGTCACGCGTTCGGAA
GCCGAGGCGCTGCTGCTCGAGAACAACCTGATCAAGGCGCTCGCGCCGCGCTACAACATCCTGTTTCGCGACGACAAGTC
GTATCCGTATCTGAAGCTGACCTCGCATCGCTTTCCGCGGATGGCGTACTACCGCGGCGCGGTCGACAAGCAGAACCAGT
ATTTCGGGCCGTTCCCGAGCGCGTGGGCCGTGCGCGAGAGCATTCAGATCCTGCAGCGCGTGTTCCAGCTGCGCACCTGC
GAGGATTCGGTCTTCAACAACCGCACGCGGCCGTGCCTGCTGCATCAGATCGGGCGCTGCACCGCGCCGTGCGTCGGCGC
GATTTCGGCCGAGGACTACGCCGTCGATGTGTCGAATGCCGCGCGCTTCCTGCTCGGCCGGCAGTCCGAAGTGATGAAGG
AGCTCGAGCAGAAGATGCATGCGTTCGCGGCCGAGCTGAAGTTCGAGCAGGCGGCGGCGGTGCGCAACCAGATGAGCTCG
CTCGCGACCGTGCTCCATCAGCAGGCGATCGAGGTCGGCAGCGACAGCGACGTCGACATCCTCGCGGTGGTCGCACAGGG
CGGGCGCGTGTGCGTGAATCTCGCGATGGTGCGCGGCGGCCGCCATCTCGGCGACAAGGCGTATTTCCCGACTCACGTCG
AAAGCGCGCTGACGCTCGCGGAGGGCGGCCTCGGCGACGATACGGATGCGGACGCGGTCGAGGCGCCCGACGTCCCGGCG
GAAGCGCCCGTCGGCGAGCCGGGCAGCGCGCGCGATACGACGGCGTCGATCGAAGCCGAAGTGCTCGACGCGTTCATCGC
GCAGCACTACCTCGGCAATCGCGTGCCGCCGGTGCTCGTCGTCAGCCACGCGCCGGCGAGCCGCGACCTGCTCGAGCTGC
TGTCCGAGCAGGCCGGCCACAAGGTGTCGCTGGTGCGGCAGCCGCAGGGGCAGCGGCGCGCGTGGCTGTCGATGGCCGAG
CAGAATGCGCAGATCGCGCTCGCGCGGCTGCTGTCCGAGCAGGGCTCGCAGCAGGCGCGCACACGCGCGCTCGCCGAGAC
GCTCGGCCTCGAATGCGACGATCTCGCGACGCTGCGCATCGAATGCTTCGACATCAGCCACACGATGGGCGAGGCGACGC
AGGCGTCGTGCGTCGTCTATCACCATCACAAGATGCAGTCGGGCGAGTATCGCCGTTACAACATCACCGGCATCACGCCC
GGCGACGACTACGCGGCGATGCGCCAGGTGCTCACGCGCCGCTACGAGAAGATGGTGGAGCAGGCCGCGCAGGCGGCGGC
TGCCGACGACGCGGCCGGCATCGACGGCGAATCGACGCGTCAGGCCGAAGCGTCGAGCCTGCTGCCGAACATCGTGCTGA
TCGACGGCGGCAAGGGGCAGGTCGAGATTGCGCGGCAGGTCTTCACGGAACTGGGGCTCGACACGTCGATGCTGGTCGGC
GTCGCGAAGGGCGAGGGGCGCAAGGTCGGTCTCGAGACGCTCGTGTTCGCCGACGGCCGCGCGCCGCTCGAGCTCGGCAA
GGAGAGCGCCGCGCTGATGCTCGTCGCGCAGATCCGCGACGAGGCGCACCGTTTCGCGATCACCGGGATGCGCGCGAAGC
GCGCGAAGGCGCGGCAGACGTCGCGGCTCGAGGAGCTCGAAGGCGTCGGCGCGAAGCGTCGCCAGCGGCTGCTCGCGCGC
TTCGGCGGGTTGCGCGGCGTCGTCGCGGCGAGCGTCGAGGAGCTCGCGAGCGTCGACGGCATTTCGCACGCGCTCGCCGA
GCAGATCTACAAGCAGCTTCACTGA

Upstream 100 bases:

>100_bases
GTGGGCGGGGACGGTGTCGGGCATCGAAGCGGATCGGTGAATGCTCTAAACTGGCGATTCTAATGGACCCGTTCCGCGCC
CGACGGCGCCCGGATCACGC

Downstream 100 bases:

>100_bases
CGCGGCCGCCGCGGGCCGCGCGGCCCGCGCGCCGGCGTTCTTGTAGCGGGCCGGTCGACACGGCACAATTGCGAATCCTT
TACTGTCCCGGATGCCATGC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 674; Mature: 673

Protein sequence:

>674_residues
MTSAEAPDTPFEPKKILAQLPHMPGVYRYYDAAGAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMVTRIARIETTVTRSE
AEALLLENNLIKALAPRYNILFRDDKSYPYLKLTSHRFPRMAYYRGAVDKQNQYFGPFPSAWAVRESIQILQRVFQLRTC
EDSVFNNRTRPCLLHQIGRCTAPCVGAISAEDYAVDVSNAARFLLGRQSEVMKELEQKMHAFAAELKFEQAAAVRNQMSS
LATVLHQQAIEVGSDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPTHVESALTLAEGGLGDDTDADAVEAPDVPA
EAPVGEPGSARDTTASIEAEVLDAFIAQHYLGNRVPPVLVVSHAPASRDLLELLSEQAGHKVSLVRQPQGQRRAWLSMAE
QNAQIALARLLSEQGSQQARTRALAETLGLECDDLATLRIECFDISHTMGEATQASCVVYHHHKMQSGEYRRYNITGITP
GDDYAAMRQVLTRRYEKMVEQAAQAAAADDAAGIDGESTRQAEASSLLPNIVLIDGGKGQVEIARQVFTELGLDTSMLVG
VAKGEGRKVGLETLVFADGRAPLELGKESAALMLVAQIRDEAHRFAITGMRAKRAKARQTSRLEELEGVGAKRRQRLLAR
FGGLRGVVAASVEELASVDGISHALAEQIYKQLH

Sequences:

>Translated_674_residues
MTSAEAPDTPFEPKKILAQLPHMPGVYRYYDAAGAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMVTRIARIETTVTRSE
AEALLLENNLIKALAPRYNILFRDDKSYPYLKLTSHRFPRMAYYRGAVDKQNQYFGPFPSAWAVRESIQILQRVFQLRTC
EDSVFNNRTRPCLLHQIGRCTAPCVGAISAEDYAVDVSNAARFLLGRQSEVMKELEQKMHAFAAELKFEQAAAVRNQMSS
LATVLHQQAIEVGSDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPTHVESALTLAEGGLGDDTDADAVEAPDVPA
EAPVGEPGSARDTTASIEAEVLDAFIAQHYLGNRVPPVLVVSHAPASRDLLELLSEQAGHKVSLVRQPQGQRRAWLSMAE
QNAQIALARLLSEQGSQQARTRALAETLGLECDDLATLRIECFDISHTMGEATQASCVVYHHHKMQSGEYRRYNITGITP
GDDYAAMRQVLTRRYEKMVEQAAQAAAADDAAGIDGESTRQAEASSLLPNIVLIDGGKGQVEIARQVFTELGLDTSMLVG
VAKGEGRKVGLETLVFADGRAPLELGKESAALMLVAQIRDEAHRFAITGMRAKRAKARQTSRLEELEGVGAKRRQRLLAR
FGGLRGVVAASVEELASVDGISHALAEQIYKQLH
>Mature_673_residues
TSAEAPDTPFEPKKILAQLPHMPGVYRYYDAAGAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMVTRIARIETTVTRSEA
EALLLENNLIKALAPRYNILFRDDKSYPYLKLTSHRFPRMAYYRGAVDKQNQYFGPFPSAWAVRESIQILQRVFQLRTCE
DSVFNNRTRPCLLHQIGRCTAPCVGAISAEDYAVDVSNAARFLLGRQSEVMKELEQKMHAFAAELKFEQAAAVRNQMSSL
ATVLHQQAIEVGSDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPTHVESALTLAEGGLGDDTDADAVEAPDVPAE
APVGEPGSARDTTASIEAEVLDAFIAQHYLGNRVPPVLVVSHAPASRDLLELLSEQAGHKVSLVRQPQGQRRAWLSMAEQ
NAQIALARLLSEQGSQQARTRALAETLGLECDDLATLRIECFDISHTMGEATQASCVVYHHHKMQSGEYRRYNITGITPG
DDYAAMRQVLTRRYEKMVEQAAQAAAADDAAGIDGESTRQAEASSLLPNIVLIDGGKGQVEIARQVFTELGLDTSMLVGV
AKGEGRKVGLETLVFADGRAPLELGKESAALMLVAQIRDEAHRFAITGMRAKRAKARQTSRLEELEGVGAKRRQRLLARF
GGLRGVVAASVEELASVDGISHALAEQIYKQLH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=673, Percent_Identity=43.3878157503715, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI1788037, Length=195, Percent_Identity=28.7179487179487, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 73765; Mature: 73634

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAEAPDTPFEPKKILAQLPHMPGVYRYYDAAGAVLYVGKARDLKKRVSSYFTKTQLSP
CCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCH
RIAMMVTRIARIETTVTRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTSHRFPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCH
MAYYRGAVDKQNQYFGPFPSAWAVRESIQILQRVFQLRTCEDSVFNNRTRPCLLHQIGRC
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
TAPCVGAISAEDYAVDVSNAARFLLGRQSEVMKELEQKMHAFAAELKFEQAAAVRNQMSS
CCCHHCCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATVLHQQAIEVGSDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPTHVESALTLA
HHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHH
EGGLGDDTDADAVEAPDVPAEAPVGEPGSARDTTASIEAEVLDAFIAQHYLGNRVPPVLV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
VSHAPASRDLLELLSEQAGHKVSLVRQPQGQRRAWLSMAEQNAQIALARLLSEQGSQQAR
EECCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHHH
TRALAETLGLECDDLATLRIECFDISHTMGEATQASCVVYHHHKMQSGEYRRYNITGITP
HHHHHHHHCCCCCCCEEEEEEEEECHHHHCCCCCCEEEEEEECCCCCCCCEEEEEEECCC
GDDYAAMRQVLTRRYEKMVEQAAQAAAADDAAGIDGESTRQAEASSLLPNIVLIDGGKGQ
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCH
VEIARQVFTELGLDTSMLVGVAKGEGRKVGLETLVFADGRAPLELGKESAALMLVAQIRD
HHHHHHHHHHHCCCHHHEEEEECCCCCEECCEEEEEECCCCCHHHCCCHHHHHHHHHHHH
EAHRFAITGMRAKRAKARQTSRLEELEGVGAKRRQRLLARFGGLRGVVAASVEELASVDG
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ISHALAEQIYKQLH
HHHHHHHHHHHHCC
>Mature Secondary Structure 
TSAEAPDTPFEPKKILAQLPHMPGVYRYYDAAGAVLYVGKARDLKKRVSSYFTKTQLSP
CCCCCCCCCCCHHHHHHHCCCCCCHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCH
RIAMMVTRIARIETTVTRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTSHRFPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCH
MAYYRGAVDKQNQYFGPFPSAWAVRESIQILQRVFQLRTCEDSVFNNRTRPCLLHQIGRC
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
TAPCVGAISAEDYAVDVSNAARFLLGRQSEVMKELEQKMHAFAAELKFEQAAAVRNQMSS
CCCHHCCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATVLHQQAIEVGSDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPTHVESALTLA
HHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHH
EGGLGDDTDADAVEAPDVPAEAPVGEPGSARDTTASIEAEVLDAFIAQHYLGNRVPPVLV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
VSHAPASRDLLELLSEQAGHKVSLVRQPQGQRRAWLSMAEQNAQIALARLLSEQGSQQAR
EECCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHHH
TRALAETLGLECDDLATLRIECFDISHTMGEATQASCVVYHHHKMQSGEYRRYNITGITP
HHHHHHHHCCCCCCCEEEEEEEEECHHHHCCCCCCEEEEEEECCCCCCCCEEEEEEECCC
GDDYAAMRQVLTRRYEKMVEQAAQAAAADDAAGIDGESTRQAEASSLLPNIVLIDGGKGQ
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCH
VEIARQVFTELGLDTSMLVGVAKGEGRKVGLETLVFADGRAPLELGKESAALMLVAQIRD
HHHHHHHHHHHCCCHHHEEEEECCCCCEECCEEEEEECCCCCHHHCCCHHHHHHHHHHHH
EAHRFAITGMRAKRAKARQTSRLEELEGVGAKRRQRLLARFGGLRGVVAASVEELASVDG
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ISHALAEQIYKQLH
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA