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The map label for this gene is moeA [H]

Identifier: 161524594

GI number: 161524594

Start: 1565000

End: 1566280

Strand: Direct

Name: moeA [H]

Synonym: Bmul_1421

Alternate gene names: 161524594

Gene position: 1565000-1566280 (Clockwise)

Preceding gene: 161524593

Following gene: 161524595

Centisome position: 45.38

GC content: 71.66

Gene sequence:

>1281_bases
ATGACGTATTGCGTTCAATCCCCCGATTTCACGATGTCGAATCCGAACCCTGCGGCGCCGCGTGCGCCGATGCTGTCGAC
GGCCGAGGCGCTCGCCGCGCTGCTCGATGCCGCGAAGCCGCTGCCCGGCACCGAAACGGTCGCGACGCTCGACGCGCTCG
GACGCGTGCTCGCGGCCGACGTGAGCTCGCCGCTCGACGTGCCGCCGATGCATATGAGCGCGATGGACGGCTACGCGGTG
CGCGTCGCCGATCTGCTGCACGGCGAGCGGCGGCTGCCGGTGTCGCAGCGGATTCCGGCCGGCCATCCGGCCGCGCCGCT
CGCGGCCGGCACCGCCGCGCGGATCTTCACCGGCGCGCCGGTGCCGCCCGGCGCCGACGCCGTCGTGATGCAGGAGCAGG
CCGCGGCCGACGGCGACGCGGTCGAGATCCTGCATACGCCGAAGCCCGGCGAATGGATCACCGCGCAGGGCGCCGACATC
CGCCGCGGTGCAGTGATCCTGCCGGCCGGCACGCGGCTCACGCCGCAGGCGCTCGGCCTCGCCGCGTCGGTCGGCTGTGC
GACGCTATCGGTCGCACGGCCTGTGCGCGTCGCGGTGTTTTTCACCGGCGACGAACTGACGATGCCCGGCGAGCCGCTGA
AGCCCGGCGCGATCTACAACTCGAATCGCTTCACGCTGCGCGCGCTGCTGCAGCGGCTCGGCTGCCACGTGACCGACTAC
GGGATCGTGCCCGACTCGCTCGCGGCGACGCGCGACACGCTGCGCGCAGCCGCGCGCGATCACGACGTGATCCTGACGAG
CGGCGGCGTGTCGGTCGGCGACGAGGATCACGTGAAACCGGCCGTCGAGGCCGAAGGGCGGCTCGCGCTGTGGCAGATCG
CGATGAAACCCGGCAAGCCGCTCGCGTTCGGCGCGGTGCGGCGCGGCGACGATCTGCCCGACGCGCATTTCATCGGGCTG
CCCGGCAACCCGGTGTCGAGCTTCGTCACGTTCCTGCTGTTCGTGCGGCCGTTCCTGCTGCGTCTGTCCGGCGTGCGCGA
CGTCGCGCCGCGTGCGCTGTCGCTGCGCGCGGACTTCTCGCAGAGCAAGGGCGACCGGCGCAACGAATTCCTGCGTGCGC
GCGTCAACGCGGCGGGCGGTCTCGATCTGTTCCCGAACCAGAGCTCGGCGGTGCTGACCTCGACCGTCTGGGGCGACGGC
CTGATCGACAATCCGCCGCAGCACGCGATCAGCGCGGGCGAGACCGTGCGCTTCATTCCGTTTTCCGAACTGCTGTCGTA
A

Upstream 100 bases:

>100_bases
ATCGGTGCGGCATCGGTGCAGCATCAGTGCGGCGCGTCGGCGCCGATCACAGTTTCCGCATGCCGGCCATATCGCGCGTG
CGCGCGACGGCGTCGCTACA

Downstream 100 bases:

>100_bases
CGCGACGGCTTCCCGACATGAAGATTCGATTGAAATTCTTTGCGAGCGTGCGCGAGGCGCTCGGCGTCGCCGACGAACAG
GCCGACGTGCCGGACGGCAT

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTYCVQSPDFTMSNPNPAAPRAPMLSTAEALAALLDAAKPLPGTETVATLDALGRVLAADVSSPLDVPPMHMSAMDGYAV
RVADLLHGERRLPVSQRIPAGHPAAPLAAGTAARIFTGAPVPPGADAVVMQEQAAADGDAVEILHTPKPGEWITAQGADI
RRGAVILPAGTRLTPQALGLAASVGCATLSVARPVRVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRALLQRLGCHVTDY
GIVPDSLAATRDTLRAAARDHDVILTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAFGAVRRGDDLPDAHFIGL
PGNPVSSFVTFLLFVRPFLLRLSGVRDVAPRALSLRADFSQSKGDRRNEFLRARVNAAGGLDLFPNQSSAVLTSTVWGDG
LIDNPPQHAISAGETVRFIPFSELLS

Sequences:

>Translated_426_residues
MTYCVQSPDFTMSNPNPAAPRAPMLSTAEALAALLDAAKPLPGTETVATLDALGRVLAADVSSPLDVPPMHMSAMDGYAV
RVADLLHGERRLPVSQRIPAGHPAAPLAAGTAARIFTGAPVPPGADAVVMQEQAAADGDAVEILHTPKPGEWITAQGADI
RRGAVILPAGTRLTPQALGLAASVGCATLSVARPVRVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRALLQRLGCHVTDY
GIVPDSLAATRDTLRAAARDHDVILTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAFGAVRRGDDLPDAHFIGL
PGNPVSSFVTFLLFVRPFLLRLSGVRDVAPRALSLRADFSQSKGDRRNEFLRARVNAAGGLDLFPNQSSAVLTSTVWGDG
LIDNPPQHAISAGETVRFIPFSELLS
>Mature_425_residues
TYCVQSPDFTMSNPNPAAPRAPMLSTAEALAALLDAAKPLPGTETVATLDALGRVLAADVSSPLDVPPMHMSAMDGYAVR
VADLLHGERRLPVSQRIPAGHPAAPLAAGTAARIFTGAPVPPGADAVVMQEQAAADGDAVEILHTPKPGEWITAQGADIR
RGAVILPAGTRLTPQALGLAASVGCATLSVARPVRVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRALLQRLGCHVTDYG
IVPDSLAATRDTLRAAARDHDVILTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAFGAVRRGDDLPDAHFIGLP
GNPVSSFVTFLLFVRPFLLRLSGVRDVAPRALSLRADFSQSKGDRRNEFLRARVNAAGGLDLFPNQSSAVLTSTVWGDGL
IDNPPQHAISAGETVRFIPFSELLS

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=403, Percent_Identity=36.4764267990074, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI10880983, Length=403, Percent_Identity=36.4764267990074, Blast_Score=191, Evalue=2e-48,
Organism=Escherichia coli, GI1787049, Length=385, Percent_Identity=43.3766233766234, Blast_Score=275, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI25147659, Length=382, Percent_Identity=30.6282722513089, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17562606, Length=360, Percent_Identity=27.7777777777778, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17136978, Length=405, Percent_Identity=34.8148148148148, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24638841, Length=405, Percent_Identity=34.8148148148148, Blast_Score=164, Evalue=9e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44713; Mature: 44581

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYCVQSPDFTMSNPNPAAPRAPMLSTAEALAALLDAAKPLPGTETVATLDALGRVLAAD
CCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
VSSPLDVPPMHMSAMDGYAVRVADLLHGERRLPVSQRIPAGHPAAPLAAGTAARIFTGAP
CCCCCCCCCCHHHHCCCHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCHHHEEECCC
VPPGADAVVMQEQAAADGDAVEILHTPKPGEWITAQGADIRRGAVILPAGTRLTPQALGL
CCCCCCEEEEEHHHCCCCCEEEEEECCCCCCEEEECCCCCCCCEEEECCCCCCCHHHHHH
AASVGCATLSVARPVRVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRALLQRLGCHVTDY
HHHHHHHHHHHCCCEEEEEEEECCEEECCCCCCCCCEEECCCCHHHHHHHHHHCCCEEEC
GIVPDSLAATRDTLRAAARDHDVILTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKP
CCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
LAFGAVRRGDDLPDAHFIGLPGNPVSSFVTFLLFVRPFLLRLSGVRDVAPRALSLRADFS
EEEHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEECCCC
QSKGDRRNEFLRARVNAAGGLDLFPNQSSAVLTSTVWGDGLIDNPPQHAISAGETVRFIP
CCCCCHHHHHHHHHHCCCCCCEECCCCCCEEEEEECCCCCCCCCCHHHHHCCCCEEEEEC
FSELLS
HHHHHC
>Mature Secondary Structure 
TYCVQSPDFTMSNPNPAAPRAPMLSTAEALAALLDAAKPLPGTETVATLDALGRVLAAD
CEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
VSSPLDVPPMHMSAMDGYAVRVADLLHGERRLPVSQRIPAGHPAAPLAAGTAARIFTGAP
CCCCCCCCCCHHHHCCCHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCHHHEEECCC
VPPGADAVVMQEQAAADGDAVEILHTPKPGEWITAQGADIRRGAVILPAGTRLTPQALGL
CCCCCCEEEEEHHHCCCCCEEEEEECCCCCCEEEECCCCCCCCEEEECCCCCCCHHHHHH
AASVGCATLSVARPVRVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRALLQRLGCHVTDY
HHHHHHHHHHHCCCEEEEEEEECCEEECCCCCCCCCEEECCCCHHHHHHHHHHCCCEEEC
GIVPDSLAATRDTLRAAARDHDVILTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKP
CCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
LAFGAVRRGDDLPDAHFIGLPGNPVSSFVTFLLFVRPFLLRLSGVRDVAPRALSLRADFS
EEEHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEECCCC
QSKGDRRNEFLRARVNAAGGLDLFPNQSSAVLTSTVWGDGLIDNPPQHAISAGETVRFIP
CCCCCHHHHHHHHHHCCCCCCEECCCCCCEEEEEECCCCCCCCCCHHHHHCCCCEEEEEC
FSELLS
HHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]