Click here to switch to the map view.

The map label for this gene is thrC [H]

Identifier: 161524593

GI number: 161524593

Start: 1563304

End: 1564755

Strand: Direct

Name: thrC [H]

Synonym: Bmul_1420

Alternate gene names: 161524593

Gene position: 1563304-1564755 (Clockwise)

Preceding gene: 161524592

Following gene: 161524594

Centisome position: 45.33

GC content: 67.08

Gene sequence:

>1452_bases
ATGAACTACATCTCCACGCGCGGCGCCGGCATCGGCGAGCGCCACACGTTCTCCGACATCCTGCTCGCCGGCCTCGCGAA
GGACGGCGGGCTCTATCTGCCGGCCGAGTATCCGCAGGTGTCGGCCGACGAGCTCGCGCGCTGGCGCGCGCTGCCGTATT
CGGATCTCGCGTTCGAGATCCTGTCGAAGTTCTGCGACGACGTGCCGGCCGACGATCTGCGCGCGATCGCGCGCCGCACC
TATACGGCCGACGTCTACCGCCACACGCGCCACGGCGAAAACGCGGCCGACATCACGCCGCTGAAGACGCTCGGCACCGA
GCACGGCGCGCCGCTCGCGCTGCTCGAACTGTCGAACGGGCCGACGCTCGCGTTCAAGGACATGGCGATGCAGCTGCTCG
GCAACCTGTTCGAGTACACGCTCGCGAAGCACGGCGAGACGCTGAACATCCTCGGCGCGACGTCCGGCGACACGGGCAGC
GCGGCCGAATACGCGATGCGCGGCAAGGCCGGCGTGCGCGTGTTCATGCTGTCGCCGCACAAGAAGATGAGCGCGTTCCA
GACGGCGCAGATGTACAGCCTGCAGGATCCGAACATCTTCAACCTCGCGGTCGAGGGCGTGTTCGACGACTGCCAGGACA
TCGTGAAGGCAGTGTCGAACGATCACGCGTTCAAGGCGCAGCACAAGATCGGCACGGTGAATTCGATCAACTGGGCGCGC
GTCGTCGCGCAGGTCGTCTACTACTTCAAGGGCTATTTCGCGGCCACGCGCTCGAACGACGAGCGCGTGTCGTTCACGGT
GCCGTCGGGCAACTTCGGCAACGTCTGCGCGGGCCACATCGCGCGCATGATGGGGCTGCCGATCGCGAAGCTCGTCGTCG
CGACCAACGAGAACGACGTGCTCGACGAGTTCTTCCGCACCGGCGCGTACCGCGTGCGCAGCGCGGAGAACACCTATCAC
ACGAGCAGCCCGAGCATGGACATCTCGAAGGCGTCGAATTTCGAGCGCTTCGTGTTCGATCTGCTCGGCCGCGATCCGGC
GCGCGTGATGCAGCTGTTCCGCGACGTCGAGGACAAGGGCGGCTTCGATCTGGCGGCAAGCGGCGATTTCGCGCGCGTCG
CCGAGTTCGGCTTCGTGTCGGGCCGCAGCAGCCACGCCGACCGCATCGCGACGATCCGCGACGTGTTCTCGCGCTACGGC
ACGACGATCGATACGCATACGGCCGACGGTGTGAAGGTCGCGCGCGAGCAGCTCGATGCCGGCGTGCCGATGATCGTGCT
CGAGACGGCGCAGCCGATCAAGTTCGGCGAGACGATCCGCGAGGCGCTCGAACGCGAACCCGAGCGGCCCGCGGCGTTCG
ACGGGCTCGAGTCGCTGCCGCAGCGCTTCGAGGTCGTGAAGGCCGACGCGCAGCAGGTGAAGGACTTCATCGCCGCGCAC
ACGCGCGCCTGA

Upstream 100 bases:

>100_bases
AATGCGGCGATCGCGCGTATCGAGAGCCTGTCGACGGTCGTGTCGAAGGTGACGAAGCTGCGCATGGAAGCGCTGAACTG
AGCTGACGACTGAGGACGAC

Downstream 100 bases:

>100_bases
GGGGCGGCCGGGCGCGACGCCCGGCAGCGCGGCACGGCCGGAACGCCGATTCGTCCAACGGATCGCGTTCCGGCCGTTTC
GTTTGGCGACGCCGCCGCGC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MNYISTRGAGIGERHTFSDILLAGLAKDGGLYLPAEYPQVSADELARWRALPYSDLAFEILSKFCDDVPADDLRAIARRT
YTADVYRHTRHGENAADITPLKTLGTEHGAPLALLELSNGPTLAFKDMAMQLLGNLFEYTLAKHGETLNILGATSGDTGS
AAEYAMRGKAGVRVFMLSPHKKMSAFQTAQMYSLQDPNIFNLAVEGVFDDCQDIVKAVSNDHAFKAQHKIGTVNSINWAR
VVAQVVYYFKGYFAATRSNDERVSFTVPSGNFGNVCAGHIARMMGLPIAKLVVATNENDVLDEFFRTGAYRVRSAENTYH
TSSPSMDISKASNFERFVFDLLGRDPARVMQLFRDVEDKGGFDLAASGDFARVAEFGFVSGRSSHADRIATIRDVFSRYG
TTIDTHTADGVKVAREQLDAGVPMIVLETAQPIKFGETIREALEREPERPAAFDGLESLPQRFEVVKADAQQVKDFIAAH
TRA

Sequences:

>Translated_483_residues
MNYISTRGAGIGERHTFSDILLAGLAKDGGLYLPAEYPQVSADELARWRALPYSDLAFEILSKFCDDVPADDLRAIARRT
YTADVYRHTRHGENAADITPLKTLGTEHGAPLALLELSNGPTLAFKDMAMQLLGNLFEYTLAKHGETLNILGATSGDTGS
AAEYAMRGKAGVRVFMLSPHKKMSAFQTAQMYSLQDPNIFNLAVEGVFDDCQDIVKAVSNDHAFKAQHKIGTVNSINWAR
VVAQVVYYFKGYFAATRSNDERVSFTVPSGNFGNVCAGHIARMMGLPIAKLVVATNENDVLDEFFRTGAYRVRSAENTYH
TSSPSMDISKASNFERFVFDLLGRDPARVMQLFRDVEDKGGFDLAASGDFARVAEFGFVSGRSSHADRIATIRDVFSRYG
TTIDTHTADGVKVAREQLDAGVPMIVLETAQPIKFGETIREALEREPERPAAFDGLESLPQRFEVVKADAQQVKDFIAAH
TRA
>Mature_483_residues
MNYISTRGAGIGERHTFSDILLAGLAKDGGLYLPAEYPQVSADELARWRALPYSDLAFEILSKFCDDVPADDLRAIARRT
YTADVYRHTRHGENAADITPLKTLGTEHGAPLALLELSNGPTLAFKDMAMQLLGNLFEYTLAKHGETLNILGATSGDTGS
AAEYAMRGKAGVRVFMLSPHKKMSAFQTAQMYSLQDPNIFNLAVEGVFDDCQDIVKAVSNDHAFKAQHKIGTVNSINWAR
VVAQVVYYFKGYFAATRSNDERVSFTVPSGNFGNVCAGHIARMMGLPIAKLVVATNENDVLDEFFRTGAYRVRSAENTYH
TSSPSMDISKASNFERFVFDLLGRDPARVMQLFRDVEDKGGFDLAASGDFARVAEFGFVSGRSSHADRIATIRDVFSRYG
TTIDTHTADGVKVAREQLDAGVPMIVLETAQPIKFGETIREALEREPERPAAFDGLESLPQRFEVVKADAQQVKDFIAAH
TRA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=452, Percent_Identity=33.8495575221239, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI149193323, Length=476, Percent_Identity=30.4621848739496, Blast_Score=199, Evalue=3e-51,
Organism=Escherichia coli, GI1786185, Length=469, Percent_Identity=27.9317697228145, Blast_Score=182, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6319901, Length=471, Percent_Identity=40.1273885350318, Blast_Score=315, Evalue=1e-86,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 53094; Mature: 53094

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYISTRGAGIGERHTFSDILLAGLAKDGGLYLPAEYPQVSADELARWRALPYSDLAFEI
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHCCCCHHHHHHH
LSKFCDDVPADDLRAIARRTYTADVYRHTRHGENAADITPLKTLGTEHGAPLALLELSNG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCEEEEEECCC
PTLAFKDMAMQLLGNLFEYTLAKHGETLNILGATSGDTGSAAEYAMRGKAGVRVFMLSPH
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCCCCEEEEEECCC
KKMSAFQTAQMYSLQDPNIFNLAVEGVFDDCQDIVKAVSNDHAFKAQHKIGTVNSINWAR
HHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEHHHCCCCCCCCHHHH
VVAQVVYYFKGYFAATRSNDERVSFTVPSGNFGNVCAGHIARMMGLPIAKLVVATNENDV
HHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHH
LDEFFRTGAYRVRSAENTYHTSSPSMDISKASNFERFVFDLLGRDPARVMQLFRDVEDKG
HHHHHHCCCEEEECCCCCEECCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCC
GFDLAASGDFARVAEFGFVSGRSSHADRIATIRDVFSRYGTTIDTHTADGVKVAREQLDA
CEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHC
GVPMIVLETAQPIKFGETIREALEREPERPAAFDGLESLPQRFEVVKADAQQVKDFIAAH
CCCEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRA
CCC
>Mature Secondary Structure
MNYISTRGAGIGERHTFSDILLAGLAKDGGLYLPAEYPQVSADELARWRALPYSDLAFEI
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHCCCCHHHHHHH
LSKFCDDVPADDLRAIARRTYTADVYRHTRHGENAADITPLKTLGTEHGAPLALLELSNG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCEEEEEECCC
PTLAFKDMAMQLLGNLFEYTLAKHGETLNILGATSGDTGSAAEYAMRGKAGVRVFMLSPH
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCCCCEEEEEECCC
KKMSAFQTAQMYSLQDPNIFNLAVEGVFDDCQDIVKAVSNDHAFKAQHKIGTVNSINWAR
HHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEHHHCCCCCCCCHHHH
VVAQVVYYFKGYFAATRSNDERVSFTVPSGNFGNVCAGHIARMMGLPIAKLVVATNENDV
HHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHH
LDEFFRTGAYRVRSAENTYHTSSPSMDISKASNFERFVFDLLGRDPARVMQLFRDVEDKG
HHHHHHCCCEEEECCCCCEECCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCC
GFDLAASGDFARVAEFGFVSGRSSHADRIATIRDVFSRYGTTIDTHTADGVKVAREQLDA
CEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHC
GVPMIVLETAQPIKFGETIREALEREPERPAAFDGLESLPQRFEVVKADAQQVKDFIAAH
CCCEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]