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The map label for this gene is fadA [H]

Identifier: 161524543

GI number: 161524543

Start: 1512528

End: 1513706

Strand: Direct

Name: fadA [H]

Synonym: Bmul_1370

Alternate gene names: 161524543

Gene position: 1512528-1513706 (Clockwise)

Preceding gene: 161524542

Following gene: 161524544

Centisome position: 43.86

GC content: 68.96

Gene sequence:

>1179_bases
ATGACCGAAGCCGTAATCGTATCGACCGCACGCACGCCGCTCGCGAAATCGTGGCGCGGCGCCTTCAACATGACGCACGG
CGCGACGCTCGGCGGCCACGTGGTCGCGGCGGCGCTCGAGCGCGCGAAGCTCGACCCGGCGCGCGTCGAGGACGTGATCA
TCGGCTGTGCGAATCCGGAAGGCGCGACGGGCGGCAATATCGCGCGGCAGATCGCATTGCGTGCGGGGCTGCCGGTCAGC
GTGCCGGGCATGACGGTGAACCGCTTCTGCTCGTCGGGGTTGCAGACGATCGCACTCGCCGCCCAGCGCATCATCGCGGG
CGAGGGCGACGTCTACGTCGCGGGCGGCGTCGAGTCGATCTCGTGCGTGCAGAACGAGATGAACCGGCACATGGCGTACG
AGGGCTGGCTGCTCGAACACAAGCCGGAAATCTACTGGACGATGCTGCAGACGGCCGAGAACGTCGCGAAGCGCTACGGG
ATCTCGAAGGAGCGTCAGGACGAATACGGCGTGAACTCGCAGCTCAAGGCCGCTGCCGCGCAGGAAGCGGGACGCTTTCG
CGACGAGATCGTGCCGATCACCGTGCGCGCCGGCATCGCGGACAAGGCCACCGGCCGCCTGTTCACGAAGGAAGTGACGG
TGTCGGCCGACGAGGGGATCCGTCCGGACACGACGCTCGACGGCGTGTCGAAGATTCGTCCGGCCGTGCCGGGCGGCGTG
ATCACGGCCGGCAATGCGAGCCAGTTTTCCGACGGCGCGGCCGCGTGCGTCGTGATGAGCGCCGCGGCCGCGCAGCGCGA
AGGGCTGCAGCCGCTCGGCGTGTTCCGCGGCTTCGCGGTGGCCGGCTGCGAGCCGGACGAGATGGGCATCGGCCCCGTGT
TCGCGGTGCCGAAGCTGCTGAAGCAGGCAGGGCTCGGCGTCGACGACATCGGGCTCTGGGAGCTGAACGAAGCGTTTGCG
GTGCAGGTGCTCTATTGCCGCGACACGCTCGGGATCCCTGACGATCGCCTGAACGTGAACGGTGGCGCAATCGCGGTCGG
CCACCCGTACGGCGTGTCGGGCACGCGGCTGACCGGCCACGCGCTGATCGAAGGCAAGCGGCGCGGCGTCAAGTATGCGG
TCGTCACGATGTGCATCGGCGGCGGGCAGGGCGCGGCCGGCCTGTTCGAAATCGTCTGA

Upstream 100 bases:

>100_bases
GCGGGCGTCGCACGCGTGACGTCCGATGGCGTGCGCGCCAGCGCATAGCGCCGCCTTTCCACTCGATTCAGCACATCAGG
CAGGAACGAAGGAGACTCGC

Downstream 100 bases:

>100_bases
CGTTTTGCCTGCCGTGCCGGCCGCCGCGCGACCGCGGCGCGCGCGGCACGGCGCTCCCCACGACGGCCGCCGCCTGCATG
CGGCATGCCGGCCGCAATGC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTEAVIVSTARTPLAKSWRGAFNMTHGATLGGHVVAAALERAKLDPARVEDVIIGCANPEGATGGNIARQIALRAGLPVS
VPGMTVNRFCSSGLQTIALAAQRIIAGEGDVYVAGGVESISCVQNEMNRHMAYEGWLLEHKPEIYWTMLQTAENVAKRYG
ISKERQDEYGVNSQLKAAAAQEAGRFRDEIVPITVRAGIADKATGRLFTKEVTVSADEGIRPDTTLDGVSKIRPAVPGGV
ITAGNASQFSDGAAACVVMSAAAAQREGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLLKQAGLGVDDIGLWELNEAFA
VQVLYCRDTLGIPDDRLNVNGGAIAVGHPYGVSGTRLTGHALIEGKRRGVKYAVVTMCIGGGQGAAGLFEIV

Sequences:

>Translated_392_residues
MTEAVIVSTARTPLAKSWRGAFNMTHGATLGGHVVAAALERAKLDPARVEDVIIGCANPEGATGGNIARQIALRAGLPVS
VPGMTVNRFCSSGLQTIALAAQRIIAGEGDVYVAGGVESISCVQNEMNRHMAYEGWLLEHKPEIYWTMLQTAENVAKRYG
ISKERQDEYGVNSQLKAAAAQEAGRFRDEIVPITVRAGIADKATGRLFTKEVTVSADEGIRPDTTLDGVSKIRPAVPGGV
ITAGNASQFSDGAAACVVMSAAAAQREGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLLKQAGLGVDDIGLWELNEAFA
VQVLYCRDTLGIPDDRLNVNGGAIAVGHPYGVSGTRLTGHALIEGKRRGVKYAVVTMCIGGGQGAAGLFEIV
>Mature_391_residues
TEAVIVSTARTPLAKSWRGAFNMTHGATLGGHVVAAALERAKLDPARVEDVIIGCANPEGATGGNIARQIALRAGLPVSV
PGMTVNRFCSSGLQTIALAAQRIIAGEGDVYVAGGVESISCVQNEMNRHMAYEGWLLEHKPEIYWTMLQTAENVAKRYGI
SKERQDEYGVNSQLKAAAAQEAGRFRDEIVPITVRAGIADKATGRLFTKEVTVSADEGIRPDTTLDGVSKIRPAVPGGVI
TAGNASQFSDGAAACVVMSAAAAQREGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLLKQAGLGVDDIGLWELNEAFAV
QVLYCRDTLGIPDDRLNVNGGAIAVGHPYGVSGTRLTGHALIEGKRRGVKYAVVTMCIGGGQGAAGLFEIV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=390, Percent_Identity=43.5897435897436, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=38.5390428211587, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI4557237, Length=401, Percent_Identity=37.6558603491272, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI148539872, Length=402, Percent_Identity=36.318407960199, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI4504327, Length=434, Percent_Identity=30.6451612903226, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=32.3907455012853, Blast_Score=162, Evalue=7e-40,
Organism=Escherichia coli, GI48994986, Length=398, Percent_Identity=40.4522613065327, Blast_Score=264, Evalue=8e-72,
Organism=Escherichia coli, GI1787663, Length=411, Percent_Identity=41.6058394160584, Blast_Score=261, Evalue=5e-71,
Organism=Escherichia coli, GI1788554, Length=405, Percent_Identity=42.7160493827161, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI87082165, Length=402, Percent_Identity=38.8059701492537, Blast_Score=244, Evalue=5e-66,
Organism=Escherichia coli, GI1788683, Length=420, Percent_Identity=29.5238095238095, Blast_Score=169, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI133906874, Length=399, Percent_Identity=38.3458646616541, Blast_Score=243, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=37.5308641975309, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI25147385, Length=398, Percent_Identity=34.9246231155779, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17551802, Length=437, Percent_Identity=29.7482837528604, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17535917, Length=390, Percent_Identity=29.2307692307692, Blast_Score=150, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=37.1212121212121, Blast_Score=224, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6325229, Length=411, Percent_Identity=32.8467153284672, Blast_Score=182, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24655093, Length=400, Percent_Identity=40.25, Blast_Score=258, Evalue=6e-69,
Organism=Drosophila melanogaster, GI17648125, Length=363, Percent_Identity=39.6694214876033, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24640423, Length=401, Percent_Identity=35.6608478802993, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI17137578, Length=433, Percent_Identity=32.1016166281755, Blast_Score=189, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40996; Mature: 40865

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAVIVSTARTPLAKSWRGAFNMTHGATLGGHVVAAALERAKLDPARVEDVIIGCANPE
CCCEEEEECCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHCCEEEEECCCCC
GATGGNIARQIALRAGLPVSVPGMTVNRFCSSGLQTIALAAQRIIAGEGDVYVAGGVESI
CCCCCHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQNEMNRHMAYEGWLLEHKPEIYWTMLQTAENVAKRYGISKERQDEYGVNSQLKAAAA
HHHHHHHHHHEECCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHH
QEAGRFRDEIVPITVRAGIADKATGRLFTKEVTVSADEGIRPDTTLDGVSKIRPAVPGGV
HHHHHHHHCEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHCCCCCCCE
ITAGNASQFSDGAAACVVMSAAAAQREGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCEEECCCCCCCCCCHHHHHHHHH
KQAGLGVDDIGLWELNEAFAVQVLYCRDTLGIPDDRLNVNGGAIAVGHPYGVSGTRLTGH
HHHCCCCCCCCEEECCCCCEEEEEEEECCCCCCCCCEECCCCEEEECCCCCCCCCEEECC
ALIEGKRRGVKYAVVTMCIGGGQGAAGLFEIV
EEECCCCCCCEEEEEEEEECCCCCCCCCEECC
>Mature Secondary Structure 
TEAVIVSTARTPLAKSWRGAFNMTHGATLGGHVVAAALERAKLDPARVEDVIIGCANPE
CCEEEEECCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHCCEEEEECCCCC
GATGGNIARQIALRAGLPVSVPGMTVNRFCSSGLQTIALAAQRIIAGEGDVYVAGGVESI
CCCCCHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQNEMNRHMAYEGWLLEHKPEIYWTMLQTAENVAKRYGISKERQDEYGVNSQLKAAAA
HHHHHHHHHHEECCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHH
QEAGRFRDEIVPITVRAGIADKATGRLFTKEVTVSADEGIRPDTTLDGVSKIRPAVPGGV
HHHHHHHHCEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHCCCCCCCE
ITAGNASQFSDGAAACVVMSAAAAQREGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCEEECCCCCCCCCCHHHHHHHHH
KQAGLGVDDIGLWELNEAFAVQVLYCRDTLGIPDDRLNVNGGAIAVGHPYGVSGTRLTGH
HHHCCCCCCCCEEECCCCCEEEEEEEECCCCCCCCCEECCCCEEEECCCCCCCCCEEECC
ALIEGKRRGVKYAVVTMCIGGGQGAAGLFEIV
EEECCCCCCCEEEEEEEEECCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]